EBioMedicine 2022 Jan 24;76:103825. Epub 2022 Jan 24.
Department of Immunology, Mayo Clinic School of Medicine and Sciences, Rochester, MN, United States; Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, United States; Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, CA; Division of Rheumatology, Department of Medicine, Mayo Clinic School of Medicine and Sciences, Rochester, MN, United States. Electronic address:
Background: Rheumatoid arthritis (RA) is an inflammatory disease that manifests as a preclinical stage of systemic autoimmunity followed by chronic progressive synovitis. Disease-associated genetic SNP variants predominantly map to non-coding, regulatory regions of functional importance in CD4 T cells, implicating these cells as key regulators. A better understanding of the epigenome of CD4 T cells holds the promise of providing information on the interaction between genetic susceptibility and exogenous factors. Read More