ASAIO J 2021 Jun 11. Epub 2021 Jun 11.
From the *Product Development Group Zurich, ETH Zurich, Zurich, Switzerland †Department of Radiology, Stanford University, Stanford, California ‡Cardiovascular Institute, Stanford University, Stanford, California §Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia ¶Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia ‖Division of Cardiovascular Medicine, Department of Medicine, Henry Ford Hospital, Detroit, Michigan #Department of Internal Medicine, Wayne State University, Detroit, Michigan.
Females have increased risk of right-ventricular failure (RVF) and 3 month mortality after left-ventricular assist device (LVAD) implantation. In this translational study, we tested the hypothesis that sex differences in outcomes are driven by pump-induced LV size-volume mismatch, due to a negative impact on interventricular septal (IVS) interdependence. Adult continuous-flow LVAD recipients from the International Society For Heart And Lung Transplantation Mechanically Assisted Circulatory Support registry (n = 15,498) were studied to determine association of female sex with outcomes of 3 month mortality and RVF. Read More