379,027 results match your criteria associated cardiovascular

Thrombosis and Dissection of the Abdominal Arteries Associated with Infarcts of Solid Organs in a Patient with COVID-19: A Novel Clinical Entity.

Hamostaseologie 2021 Jun 22. Epub 2021 Jun 22.

Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland.

The clinical spectrum of patients with coronavirus disease 2019 (COVID-19) ranges from asymptomatic cases to severe pneumonia with acute respiratory distress syndrome. COVID-19 is associated with an increased risk of thromboembolic complications, notably pulmonary embolism and deep vein thrombosis. Arterial cardiovascular complications and myocarditis have also been described in association with COVID-19, but appear to be less prevalent. Read More

View Article and Full-Text PDF

Incidence of cardiac arrhythmias and left ventricular hypertrophy in recreational scuba divers.

Diving Hyperb Med 2021 Jun;51(2):190-198

Divers Alert Network, Durham, North Carolina, USA.

Introduction: The aims of this study were to investigate the potential impact of age, sex and body mass index (BMI) upon the incidence of arrhythmias pre- and post- diving, and to identify the prevalence of left ventricular hypertrophy (LVH) in older recreational divers.

Methods: Divers aged ≥ 40 years participating in group dive trips had ECG rhythm and echocardiograph recordings before and after diving. Arrhythmias were confirmed by an experienced human reader. Read More

View Article and Full-Text PDF

Paternal inheritance predicts earlier cardiovascular event onset in patients with familial hypercholesterolemia.

Atherosclerosis 2021 Jun 11;329:9-13. Epub 2021 Jun 11.

Genetic Dyslipidemias Clinic of the Montreal Clinical Research Institute, Québec, Canada; Department of Medicine, Divisions of Experimental Medicine and Medical Biochemistry, McGill University, Québec, Canada. Electronic address:

Background And Aims: Familial hypercholesterolemia (FH) is a genetic disease, with an autosomal codominant inheritance, predisposing to premature atherosclerotic cardiovascular disease (ASCVD). Paternal or maternal inheritance of the FH-causing mutation may affect the FH phenotype in offspring, but the effect of the genetic transmission on cardiovascular disease risk remains to be established. The aim of the present study is to compare the incidence of cardiovascular events between patients with maternal vs paternal inheritance of familial hypercholesterolemia. Read More

View Article and Full-Text PDF

Transcatheter mitral valve repair may increase eligibility for heart transplant listing in patients with end-stage heart failure and severe secondary mitral regurgitation.

Int J Cardiol 2021 Jun 19. Epub 2021 Jun 19.

Medizinische Klinik und Poliklinik I, Ludwig-Maximilians University, Munich, Germany; Heart Alliance, Partner Site German Center for Cardiovascular Disease (DZHK), Munich, Germany.

Background: Heart transplantation remains the gold standard for treatment of patients with end-stage heart failure and severely reduced ejection fraction (HFrEF). An increased pulmonary vascular resistance (PVR), which is often prevalent in HFrEF patients with secondary mitral regurgitation (SMR), limits the eligibility for transplantation. Therefore, we evaluated whether transcatheter mitral valve repair (TMVr) improves pulmonary circulatory hemodynamics and increases the eligibility for transplantation in end-stage HFrEF patients with severe SMR. Read More

View Article and Full-Text PDF

Review of cadmium exposure and smoking-independent effects on atherosclerotic cardiovascular disease in the general population.

J Intern Med 2021 Jun 22. Epub 2021 Jun 22.

Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

Exposure to cadmium (Cd) via food and smoking is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). Blood and urine levels of Cd are established biomarkers of exposure. Our aim was to review: 1) the smoking-independent associations between Cd exposure and ASCVD, including the possible presence of a non-linear dose-response relationship with Cd exposure; and 2) the causal effects of Cd exposure on different stages of atherosclerosis. Read More

View Article and Full-Text PDF

Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19.

J Geriatr Cardiol 2021 May;18(5):338-345

Cardiovascular Diseases Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Background: Increases in cardiac troponin (cTn) in coronavirus disease 2019 (COVID-19) have been associated with worse prognosis. Nonetheless, data about the significance of cTn in elderly subjects with COVID-19 are lacking.

Methods: From a registry of consecutive patients with COVID-19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020, we selected those ≥ 60 year-old and with cTnI measured within three days from the molecular diagnosis of SARS-CoV-2 infection. Read More

View Article and Full-Text PDF

Demonstration of proof-of-concept of StrokeShield system for complete closure and occlusion of the left atrial appendage for non-valvular atrial fibrillation therapy.

PLoS One 2021 22;16(6):e0253299. Epub 2021 Jun 22.

Cor Habere Corporation, Louisville, Kentucky, United States of America.

In the US, the most significant morbidity and mortality associated with non-valvular atrial fibrillation (NVAF) is embolic stroke, with 90% of thrombus originating from the left atrial appendage (LAA). Anticoagulation is the preferred treatment for the prevention of stroke in NVAF patients, but clinical studies have demonstrated high levels of non-compliance and increased risk of bleeding or ineligibility for anticoagulation therapy, especially in the elderly population where the incidence of NVAF is highest. Alternatively, stroke may be preventing using clinically approved surgical and catheter-based devices to exclude or occlude the LAA, but these devices continue to be plagued by peri-device leaks and thrombus formation because of residual volume. Read More

View Article and Full-Text PDF

Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors.

JCI Insight 2021 Jun 22. Epub 2021 Jun 22.

Weill Cornell Autism Research Program, Weil Cornell Medical College, New York, United States of America.

SCN2A, encoding the neuronal voltage-gated Na+ channel NaV1.2, is one of the most commonly affected loci linked to autism spectrum disorders (ASDs). Most ASD-associated mutations in SCN2A are loss-of-function, but studies examining how such mutations affect neuronal function and whether Scn2a mutant mice display ASD endophenotypes have been inconsistent. Read More

View Article and Full-Text PDF

miRNAs generated from Meg3-Mirg locus are downregulated during aging.

Aging (Albany NY) 2021 Jun 22;13. Epub 2021 Jun 22.

Laboratory of Stem Cell Biology, Institute of Cellular Biology and Pathology “Nicolae Simionescu", Bucharest 050568, Romania.

Aging determines a multilevel functional decline and increases the risk for cardiovascular pathologies. MicroRNAs are recognized as fine tuners of all cellular functions, being involved in various cardiac diseases. The heart is one of the most affected organs in aged individuals, however little is known about the extent and robustness to which miRNA profiles are modulated in cardiac cells during aging. Read More

View Article and Full-Text PDF

Does Size Matter for Female Continuous-flow LVAD Recipients? A Translational Approach to a Decade Long Question.

ASAIO J 2021 Jun 11. Epub 2021 Jun 11.

From the *Product Development Group Zurich, ETH Zurich, Zurich, Switzerland †Department of Radiology, Stanford University, Stanford, California ‡Cardiovascular Institute, Stanford University, Stanford, California §Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia ¶Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia ‖Division of Cardiovascular Medicine, Department of Medicine, Henry Ford Hospital, Detroit, Michigan #Department of Internal Medicine, Wayne State University, Detroit, Michigan.

Females have increased risk of right-ventricular failure (RVF) and 3 month mortality after left-ventricular assist device (LVAD) implantation. In this translational study, we tested the hypothesis that sex differences in outcomes are driven by pump-induced LV size-volume mismatch, due to a negative impact on interventricular septal (IVS) interdependence. Adult continuous-flow LVAD recipients from the International Society For Heart And Lung Transplantation Mechanically Assisted Circulatory Support registry (n = 15,498) were studied to determine association of female sex with outcomes of 3 month mortality and RVF. Read More

View Article and Full-Text PDF

Outcomes of mechanical circulatory support for acute myocardial infarction complicated by cardiogenic shock.

Catheter Cardiovasc Interv 2021 Jun 22. Epub 2021 Jun 22.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

Background: Mechanical circulatory support (MCS) with the Impella device (Abiomed, Danvers, MA) has been associated with higher in-hospital mortality than intra-aortic balloon pump (IABP) in the Premier Healthcare Database and National Cardiovascular Data Registry.

Methods: The objective of this retrospective cohort study was to describe trends and outcomes of Impella usage in acute myocardial infarction complicated by cardiogenic shock (AMICS) treated with MCS (Impella or IABP) using real-world observational data from the National Inpatient Sample (NIS) including hospitalizations for AMICS managed with MCS between January 2012 to December 2017. The primary outcomes included in-hospital mortality, transfusion, acute kidney injury, stroke, total costs, and length of stay. Read More

View Article and Full-Text PDF

Acute stroke intervention for acute embolic procedural strokes performed by cardiologists.

Catheter Cardiovasc Interv 2021 Jun 22. Epub 2021 Jun 22.

CardioVascularCenter (CVC) Frankfurt, Frankfurt, Germany.

Acute ischemic stroke is a feared complication during cardiovascular procedures associated with high morbidity and mortality if not immediately recognized and treated. We conducted a review of cases at our center where patients experienced an acute, procedure-related ischemic stroke and underwent immediate endovascular stroke treatment by the interventional cardiologists trained in acute endovascular stroke intervention. Baseline demographics, procedural and follow-up data were collected. Read More

View Article and Full-Text PDF

Long-term outcomes after deferral of revascularization of in-stent restenosis using fractional flow reserve.

Catheter Cardiovasc Interv 2021 Jun 22. Epub 2021 Jun 22.

Hospital Clínico San Carlos IDISSC, Complutense University of Madrid, Madrid, Spain.

Objectives: To investigate the outcomes of deferred coronary revascularization in patients with non-significant in-stent restenosis (ISR) by physiological assessment.

Background: The pathophysiology and natural history of ISR is markedly different from de-novo stenoses. There is a paucity of data on the safety of deferral of revascularization of ISR using physiological assessment. Read More

View Article and Full-Text PDF

The association between 24-hour ambulatory blood pressure measurement and selected biochemical and anthropometric parameters in women with polycystic ovary syndrome.

Eur Rev Med Pharmacol Sci 2021 Jun;25(11):3947-3954

Department of Endocrinological Gynecology, Medical University of Silesia, Katowice, Poland.

Objective: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorders, which may contribute to the development of cardiovascular diseases. The aim of our study was to evaluate the association between of 24-hour ambulatory blood pressure measurement (ABPM) and selected biochemical and anthropometric parameters in women with PCOS.

Patients And Methods: The study involved 153 Polish, Caucasian women with PCOS hospitalized in the Department of Endocrinology Gynecology from January 2018 to March 2020. Read More

View Article and Full-Text PDF

Appropriateness of aspirin prescribing for primary and secondary prevention of cardiovascular disease in type 2 diabetes in different care settings.

Ir J Med Sci 2021 Jun 22. Epub 2021 Jun 22.

Department of Endocrinology and Diabetes, Cork University Hospital, Wilton, Cork, Ireland.

Background: Type 2 diabetes is associated with an increased cardiovascular risk. Use of aspirin has been shown to be of benefit for secondary prevention of cardiovascular disease in patients with type 2 diabetes; benefits in primary prevention have not been clearly proven.

Aims: This study aims to (a) determine if aspirin is prescribed appropriately in type 2 diabetes for primary or secondary prevention of cardiovascular disease (CVD) and (b) evaluate whether there are differences in aspirin prescribing according to where people receive their care. Read More

View Article and Full-Text PDF

Comparing performance on the Months of the Year Backwards test in hospitalised patients with delirium, dementia, and no cognitive impairment: an exploratory study.

Eur Geriatr Med 2021 Jun 22. Epub 2021 Jun 22.

Geriatric Medicine, Edinburgh Delirium Research Group, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.

Purpose: To investigate performance of the Months of the Year Backwards (MOTYB) test in older hospitalised patients with delirium, dementia, and no cognitive impairment.

Methods: Secondary analysis of data from a case-control study of 149 hospitalised patients aged ≥ 65 years with delirium [with or without dementia (N = 50)], dementia [without delirium (N = 46)], and no cognitive impairment (N = 53). Verbatim transcripts of MOTYB audio recordings were analysed to determine group differences in response patterns. Read More

View Article and Full-Text PDF

The association between temperature and cause-specific mortality in the Klang Valley, Malaysia.

Environ Sci Pollut Res Int 2021 Jun 22. Epub 2021 Jun 22.

Center for Toxicology and Health Risk Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

This study aims to examine the relationship between daily temperature and mortality in the Klang Valley, Malaysia, over the period 2006-2015. A quasi-Poisson generalized linear model combined with a distributed lag non-linear model (DLNM) was used to estimate the association between the mean temperature and mortality categories (natural n=69,542, cardiovascular n= 15,581, and respiratory disease n=10,119). Particulate matter with an aerodynamic diameter below 10 μm (PM) and surface ozone (O) was adjusted as a potential confounding factor. Read More

View Article and Full-Text PDF

Variation of computed tomographic angiography-based fractional flow reserve after transcatheter aortic valve implantation.

Eur Radiol 2021 Jun 22. Epub 2021 Jun 22.

Department of Cardiology, West China Hospital, Sichuan University, #37 Guo Xue Alley, Chengdu, 610041, China.

Objectives: We sought to identify the impact of transcatheter aortic valve implantation (TAVI) on changes of fractional flow reserve computed tomography (FFR) values and the associated clinical impact.

Methods: A retrospective analysis was done with CT obtained pre-TAVI, prior to hospital discharge and at 1-year follow-up, which provided imaging sources for the calculation of FFR values based on an online platform.

Results: A total of 190 patients were enrolled. Read More

View Article and Full-Text PDF

Cardiac autonomic function and cognitive performance in patients with atrial fibrillation.

Clin Res Cardiol 2021 Jun 22. Epub 2021 Jun 22.

Department of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.

Background: Atrial fibrillation (AF) is associated with loss of cognition and dementia. Cardiac autonomic dysfunction has been linked to cognitive decline. We aimed to investigate if reduced cardiac autonomic function (CAF) is associated with cognitive impairment in AF patients. Read More

View Article and Full-Text PDF

Association between the health insurance status and clinical outcomes among patients with acute heart failure in Japan.

Heart Vessels 2021 Jun 22. Epub 2021 Jun 22.

Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.

The relationship between the socioeconomic status, including the health insurance status, and prognosis of heart failure (HF) has been recognized as an important concept for stratifying the risk in HF patients and is gaining increasing attention worldwide even in countries with a universal healthcare system. However, the impact of the Japanese health insurance status on outcomes among patients admitted for acute HF has not been fully clarified. We enrolled 771 patients admitted for acute HF between January 2018 and December 2019 and collected data on the in-hospital mortality, length of the hospital stay, and cardiac events, defined as cardiovascular death and readmission for HF within 1 year after discharge. Read More

View Article and Full-Text PDF

Case-ascertainment of acute myocardial infarction hospitalisations in cancer patients: a cohort study using English linked electronic health data.

Eur Heart J Qual Care Clin Outcomes 2021 Jun 22. Epub 2021 Jun 22.

Biostatistics Research Group, Department of Health Sciences, University of Leicester, Leicester, UK.

Aims: To assess the recording and accuracy of acute myocardial infarction (AMI) hospital admissions between two electronic health record databases within an English cancer population over time and understand the factors that affect case-ascertainment.

Methods And Results: We identified 112,502 hospital admissions for AMI in England 2010-2017 from the Myocardial Ischaemia National Audit Project (MINAP) disease registry and Hospital Episode Statistics (HES) for 95,509 patients with a previous cancer diagnosis up to 15 years prior to admission. Cancer diagnoses were identified from the National Cancer Registration Dataset (NCRD). Read More

View Article and Full-Text PDF

Revisiting characteristics, treatment and outcome of cardiomyopathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss).

Rheumatology (Oxford) 2021 Jun 22. Epub 2021 Jun 22.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Objectives: Eosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing eosinophil-rich vasculitis. Specific cardiomyopathy (CM) was described in old studies as the most important predictor of mortality. We aimed to revisit EGPA-related CM and its outcome in recent decades. Read More

View Article and Full-Text PDF

Exercise programme to improve quality of life for patients with end-stage kidney disease receiving haemodialysis: the PEDAL RCT.

Health Technol Assess 2021 Jun;25(40):1-52

School of Health Sciences, Queen Margaret University, Edinburgh, UK.

Background: Whether or not clinically implementable exercise interventions in haemodialysis patients improve quality of life remains unknown.

Objectives: The PEDAL (PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease) trial evaluated the clinical effectiveness and cost-effectiveness of a 6-month intradialytic exercise programme on quality of life compared with usual care for haemodialysis patients.

Design: We conducted a prospective, multicentre randomised controlled trial of haemodialysis patients from five haemodialysis centres in the UK and randomly assigned them (1 : 1) using a web-based system to (1) intradialytic exercise training plus usual-care maintenance haemodialysis or (2) usual-care maintenance haemodialysis. Read More

View Article and Full-Text PDF

Renal surgery for kidney cancer: is preoperative proteinuria a predictor of functional and survival outcomes after surgery? A systematic review of the literature.

Minerva Urol Nephrol 2021 Jun 22. Epub 2021 Jun 22.

UOC Urologia, Department Materno-Infantile e Scienze Urologiche, AOU Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Introduction: Proteinuria is considered both a known marker for the severity of Chronic Kidney Disease (CKD) and a robust predictor of future renal function and cardiovascular morbidity and mortality in a general population. The urological community has long overlooked proteinuria as a marker of renal function. Recently, the American Urological Association (AUA) clinical practice guideline addressed this issue and suggested introducing proteinuria assessment prior to kidney cancer surgery. Read More

View Article and Full-Text PDF

Identification of sex-specific biomarkers predicting new-onset heart failure.

ESC Heart Fail 2021 Jun 22. Epub 2021 Jun 22.

Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, P. Debyelaan 25, Maastricht, 6229 HX, The Netherlands.

Aims: Heart failure (HF) is common in both men and women, yet disease pathophysiology, presentation, and progression differ between sexes. Studies addressing whether biomarkers predict new onset HF sex-specifically are scarce. This study therefore aims to test the sex-specificity of 252 protein biomarkers for new-onset HF. Read More

View Article and Full-Text PDF

Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism.

Clin Transl Sci 2021 Jun 22. Epub 2021 Jun 22.

Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Hepatocytes store triglycerides (TGs) in the form of lipid droplets (LDs), which are increased in hepatosteatosis. The regulation of hepatic LDs is poorly understood and new therapies to reduce hepatosteatosis are needed. We performed a siRNA kinase and phosphatase screen in HuH-7 cells using high-content automated imaging of LDs. Read More

View Article and Full-Text PDF

Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis.

Nephrology (Carlton) 2021 Jun 22. Epub 2021 Jun 22.

School of Public Health, Curtin University, Perth, WA, Australia.

There is a lack of clarity and guidance for screening peripheral artery disease (PAD) in persons with chronic kidney disease (CKD) and end stage kidney disease (ESKD) despite this group being at excess risk of cardiovascular disease (CVD). In this current study, we performed a systematic review and meta-analysis to examine the prevalence and risk factors for PAD in persons with CKD in Australian cohorts. We used the inverse variance heterogeneity meta-analysis with double arcsine transformation to summarize the prevalence of PAD (with 95% CIs). Read More

View Article and Full-Text PDF

Neck circumference and the burden of metabolic syndrome disease: a population-based sample.

J Public Health (Oxf) 2021 Jun 22. Epub 2021 Jun 22.

Department of Nutrition, Universidade Federal de Santa Catarina, Santa Catarina 88040-900, Brazil.

Background: This study aims to verify the association between neck circumference (NC) and metabolic syndrome and establish NC cut-off points to predict metabolic syndrome.

Methods: Weight, height, NC, waist circumference, body mass index, fasting plasma glucose, HDL cholesterol, triglycerides and blood pressure were measured in a cross-sectional and population-based study with 966 adults. The association between NC and the burden of metabolic syndrome disease was evaluated by multinomial logistic regression. Read More

View Article and Full-Text PDF

Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting.

JCI Insight 2021 Jun 22;6(12). Epub 2021 Jun 22.

Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China.

PDCD10, also known as CCM3, is a gene found to be associated with the human disease cerebral cavernous malformations (CCMs). PDCD10 forms a complex with GCKIII kinases including STK24, STK25, and MST4. Studies in C. Read More

View Article and Full-Text PDF


Wiad Lek 2021 ;74(4):1011-1018


Objective: The aim: To analyse data from recent studies, dedicated to the use of non-steroidal anti-inflammatory drugs (NSAIDs); to evaluate the best clinical practice in the use of NSAIDs in order to prevent side effects (SEs) in different clinical scenarios; to optimise treatment of patients at risk of NSAIDs-related SEs.

Patients And Methods: Materials and methods: A comprehensive bibliographic search was performed using the keywords "NSAIDs", "NSAID gastropathy", "NSAID enteropathy", "complications of NSAID therapy", "cardiovascular disease", "cardiovascular risk" in the PubMed, Web of Science, Cochrane Library, Google Academy databases.

Conclusion: Conclusions: NSAID-induced gastrointestinal lesions are а relevant problem of internal medicine, this is due to the fact that the pathogenic mechanisms of this process are still unclear. Read More

View Article and Full-Text PDF
January 2021