15,943 results match your criteria associated cad


Fast-Strain Encoded Cardiac Magnetic Resonance During Vasodilator Perfusion Stress Testing.

Front Cardiovasc Med 2021 17;8:765961. Epub 2021 Nov 17.

Department of Cardiology, Vascular Medicine and Pneumology, Gesundheitszentren Rhein-Neckar (GRN) Hospital Weinheim, Weinheim, Germany.

Cardiac magnetic resonance perfusion imaging during vasodilator stress is an established modality in patients with suspected and known coronary artery disease (CAD). This study aimed to evaluate the performance of fast-Strain-Encoded-MRI (fast-SENC) for the diagnostic classification and risk stratification of patients with ischemic heart disease. Perfusion and fast-SENC cardiac magnetic resonance (CMR) images were retrospectively analyzed in 111 patients who underwent stress CMR. Read More

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November 2021

Phenotypic Clustering of Patients With Newly Diagnosed Coronary Artery Disease Using Cardiovascular Magnetic Resonance and Coronary Computed Tomography Angiography.

Front Cardiovasc Med 2021 18;8:760120. Epub 2021 Nov 18.

Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Hôpital Privé Jacques CARTIER, Ramsay Santé, Massy, France.

Epidemiological characteristics and prognostic profiles of patients with newly diagnosed coronary artery disease (CAD) are heterogeneous. Therefore, providing individualized cardiovascular (CV) risk stratification and tailored prevention is crucial. Phenotypic unsupervised clustering integrating clinical, coronary computed tomography angiography (CCTA), and cardiac magnetic resonance (CMR) data were used to unveil pathophysiological differences between subgroups of patients with newly diagnosed CAD. Read More

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November 2021

The Association Between Recurrence of Atrial Fibrillation and Revascularization in Patients With Coronary Artery Disease After Catheter Ablation.

Front Cardiovasc Med 2021 19;8:756552. Epub 2021 Nov 19.

Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

The connection between revascularization for coronary artery disease (CAD) and the incidence of recurrent events of atrial fibrillation (AF) after ablation is unclear. This study aimed to explore the relationship between coronary revascularization and AF recurrence in patients who underwent radiofrequency catheter ablation (RFCA). Four hundred and nineteen patients who underwent performed coronary angiography at the same time as RFCA were enrolled in this study. Read More

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November 2021

Associations of Insomnia With Hypertension and Coronary Artery Disease Among Patients With Type 2 Diabetes Mellitus.

Front Cardiovasc Med 2021 19;8:730654. Epub 2021 Nov 19.

National Health Commission (NHC), Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

This study aimed to determine whether insomnia is associated with hypertension (HBP) and coronary artery disease (CAD) in a hospital-based sample of patients with type 2 diabetes mellitus (T2DM). Our present study included 354 patients with T2DM. According to the diagnostic criteria of insomnia, the participants were assigned to three groups based on the duration of T2DM and insomnia diagnosis. Read More

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November 2021

Transcriptome Profiling of the Salt Stress Response in the Leaves and Roots of Halophytic .

Front Genet 2021 18;12:770742. Epub 2021 Nov 18.

Shandong Provincial Key Laboratory of Plant Stress Research, College of Life Science, Shandong Normal University, Jinan, China.

can grow in natural harsh environments; however, the underlying mechanisms for salt tolerance of need to be further understood. Herein, the transcriptome profiling of leaves and roots exposed to 300 mM NaCl is investigated, and the result emphasized the role of genes involved in lignin biosynthesis, autophagy, peroxisome, and sugar metabolism upon salt stress. Furthermore, the expression of the lignin biosynthesis and autophagy-related genes, as well as 16 random selected genes, was validated by qRT-PCR. Read More

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November 2021

Long-term prognostic value of vasodilator stress cardiac magnetic resonance in patients with atrial fibrillation.

ESC Heart Fail 2021 Dec 6. Epub 2021 Dec 6.

Department of Internal Medicine/Cardiology, German Heart Center Berlin, Augustenburgerplatz 1, Berlin, 13533, Germany.

Aims: Although the prevalence of coronary artery disease (CAD) is high among patients with atrial fibrillation (AF), studies on stress perfusion cardiac magnetic resonance (CMR) imaging frequently exclude patients with AF, and its prognostic and diagnostic value in high-risk patients with suspected or known CAD remains unclear.

Methods And Results: In this longitudinal cohort study, we included 164 consecutive patients with AF during vasodilator perfusion CMR. Diagnostic value was evaluated regarding invasive coronary angiography in a subset of patients. Read More

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December 2021

Cardiovascular risks associated with use of non-steroidal anti-inflammatory drugs in patients with non-obstructive coronary artery disease.

Eur Heart J Cardiovasc Pharmacother 2021 Dec 4. Epub 2021 Dec 4.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Aim: To examine whether non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use is associated with increased cardiovascular risks in patients with non-obstructive coronary artery disease (CAD).

Methods And Results: Using Danish medical registries, we conducted a population-based cohort study in Western Denmark during 2008-2017. We identified all patients undergoing first-time coronary computed tomography angiography (CCTA) due to suspected CAD (n = 35,399), with results showing no (n = 28,581) or non-obstructive CAD (n = 6,818). Read More

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December 2021

Reconstruction of medium-size defects of the oral cavity: radial forearm free flap vs facial artery musculo-mucosal flap.

J Otolaryngol Head Neck Surg 2021 Dec 3;50(1):67. Epub 2021 Dec 3.

Division of Otolaryngology-Head and Neck Surgery, Université de Montréal, Hôpital Maisonneuve-Rosemont, Montreal, Canada.

Background: The radial forearm free flap (RFFF) is the most commonly used flap for defects of the oral cavity. The facial artery musculomucosal (FAMM) is a safe and effective method to reconstruct medium sized defects of the oral cavity. No comparison exists between the FAMM flap and RFFF. Read More

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December 2021

Associations of m.5178C>A variant with serum lipids levels: A systematic review and meta-analysis.

Biosci Rep 2021 Dec 3. Epub 2021 Dec 3.

Wuhan University Zhongnan Hospital, Wuhan, China.

Background: Emerging evidence shows that m.5178C>A variant is associated with a lower risk of coronary artery disease (CAD). However, the specific mechanisms remain elusive. Read More

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December 2021

Shared Genetic Liability and Causal Associations Between Major Depressive Disorder and Cardiovascular Diseases.

Front Cardiovasc Med 2021 11;8:735136. Epub 2021 Nov 11.

School of Systems Biology, George Mason University, Fairfax, VA, United States.

Major depressive disorder (MDD) is phenotypically associated with cardiovascular diseases (CVD). We aim to investigate mechanisms underlying relationships between MDD and CVD in the context of shared genetic variations. Polygenic overlap analysis was used to test genetic correlation and to analyze shared genetic variations between MDD and seven cardiovascular outcomes (coronary artery disease (CAD), heart failure, atrial fibrillation, stroke, systolic blood pressure, diastolic blood pressure, and pulse pressure measurement). Read More

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November 2021

Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho.

Int J Gen Med 2021 25;14:8797-8803. Epub 2021 Nov 25.

Department of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, People's Republic of China.

Objective: Earlobe crease (ELC) has been considered as a skin sign of atherosclerosis, and its pathophysiological mechanism is still unclear. Our study aims to test the hypothesis that ELC patients with lower serum levels of the age-suppressing hormone Klotho, which is not only associated with premature aging but also with endothelial dysfunction, may be associated with atherosclerosis.

Methods: A total of 135 patients aged 40-68 years underwent coronary angiography. Read More

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November 2021

MRI of the Lactating Breast: Computer-Aided Diagnosis False Positive Rates and Background Parenchymal Enhancement Kinetic Features.

Acad Radiol 2021 Nov 29. Epub 2021 Nov 29.

Department of Radiology, Sheba Medical Center, Tel Hashomer, 526560, Israel; Sackler School of Medicine, Tel Aviv University, Israel.

Rationale And Objectives: To investigate the application of computer-added diagnosis (CAD) in dynamic contrast-enhanced (DCE) MRI of the healthy lactating breast, focusing on false-positive rates and background parenchymal enhancement (BPE) coloring patterns in comparison with breast cancer features in non-lactating patients.

Materials And Methods: The study population was composed of 58 healthy lactating patients and control groups of 113 healthy premenopausal non-lactating patients and 55 premenopausal non-lactating patients with newly-diagnosed breast cancer. Patients were scanned on 1. Read More

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November 2021

Adoption and patterns of use of invasive physiological assessment of coronary artery disease in a large cohort of 40821 real-world procedures over a 12-year period.

Rev Port Cardiol (Engl Ed) 2021 Oct;40(10):771-781

Hospital Prof. Doutor Fernando da Fonseca, EPE, Cardiology Department, Amadora, Portugal; University Clinic of Cardiology, Faculty of Medicine at University of Lisbon, Lisboa, Portugal.

Introduction And Objectives: Use of invasive physiological assessment in patients with coronary artery disease varies widely and is perceived to be low. We aimed to examine adoption rates as well as patterns and determinants of use in an unselected population undergoing invasive coronary angiography over a long time frame.

Methods: We retrospectively determined the per-procedure prevalence of physiological assessment in 40821 coronary cases performed between 2007 and 2018 in two large-volume centers. Read More

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October 2021

Relation of abnormal cardiac stress testing with outcomes in patients undergoing renal transplantation.

PLoS One 2021 2;16(12):e0260718. Epub 2021 Dec 2.

Cardiovascular Institute, The Warren Alpert Medical School at Brown University, Providence, RI, United States of America.

Cardiovascular risk stratification is often performed in patients considered for renal transplantation. In a single center, we sought to examine the association between abnormal stress testing with imaging and post-renal transplant major adverse cardiovascular events (MACE) using multivariable logistic regression. From January 2006 to May 2016 232 patients underwent renal transplantation and 59 (25%) had an abnormal stress test result. Read More

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December 2021

Influence of polyvascular disease on clinical outcome in patients undergoing transcatheter aortic valve implantation via transfemoral access.

PLoS One 2021 2;16(12):e0260385. Epub 2021 Dec 2.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Background: The influence of polyvascular disease (PVD) on the short- and long-term clinical outcomes of patients undergoing transcatheter aortic valve implantation via trans-femoral access (TF-TAVI) has not been fully elucidated.

Methods: A total of 2167 patients from the Optimized CathEter vAlvular iNtervention-TAVI (OCEAN-TAVI) registry who underwent TF-TAVI was studied. PVD was defined as the presence of at least two of the following vascular bed (VB) diseases: concomitant coronary artery disease (CAD), cerebrovascular disease (CVD), and peripheral artery disease (PAD). Read More

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December 2021

Cost-effectiveness of Cardiac Telerehabilitation With Relapse Prevention for the Treatment of Patients With Coronary Artery Disease in the Netherlands.

JAMA Netw Open 2021 Dec 1;4(12):e2136652. Epub 2021 Dec 1.

Department of Human-Centered Design, Faculty of Industrial Design Engineering, Delft University of Technology, Delft, the Netherlands.

Importance: Cardiac telerehabilitation (CTR) has been found to be a safe and beneficial alternative to traditional center-based cardiac rehabilitation (CR) and might be associated with higher participation rates by reducing barriers to CR use. However, implementation of CTR interventions remains low, which may be owing to a lack of cost-effectiveness analyses of data from large-scale randomized clinical trials.

Objective: To assess the cost-effectiveness of CTR with relapse prevention compared with center-based CR among patients with coronary artery disease. Read More

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December 2021

Association between Plasma Follistatin-like Protein 1 Levels and the Presence and Severity of Coronary Artery Disease.

Int Heart J 2021 ;62(6):1207-1212

Department of Cardiology, National Hospital Organization Tokyo Medical Center.

Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein known for its role in inflammation. However, plasma FSTL1 levels in patients with coronary artery disease (CAD) have not been fully elucidated. Thus, in this study, we investigated the plasma FSTL1 levels of 350 patients who underwent elective coronary angiography. Read More

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January 2021

Nutraceuticals in the Management of Cardiovascular Risk Factors: Where is the Evidence?

Cardiovasc Hematol Disord Drug Targets 2021 Nov 30. Epub 2021 Nov 30.

University of Kentucky College of Medicine, Department of Surgery Professor of Surgery and Bioengineering. 0.

Cardiovascular disease continues to rise at an alarming rate, and research focuses on possible therapies to reduce the risk and slow down its progression. Several epidemiological studies have indicated that dietary modifications, such as increased consumption of fruits and vegetables play an important role in reducing cardiovascular disease risk factors. Food sources rich in antioxidants, anti-inflammatory, hypolipidemic, and hypoglycemic properties are thought to ameliorate the progression of cardiovascular disease and serve as a potential treatment mode. Read More

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November 2021

The impact of subclinical hyperthyroidism on cardiovascular prognosis in patients undergoing PCI.

J Clin Endocrinol Metab 2021 Nov 29. Epub 2021 Nov 29.

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.

Background: Limited studies have focused on the impact of SHyper on poor prognosis in patients with known coronary artery disease (CAD). Hence, we implemented the present study to explore the association between SHyper and adverse cardiovascular events in CAD patients who underwent drug-eluting stent (DES) implantation.

Methods: We consecutively recruited 8,283 CAD patients undergoing percutaneous coronary intervention (PCI). Read More

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November 2021

Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signaling.

Cardiovasc Res 2021 Nov 26. Epub 2021 Nov 26.

Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Aims: Genetic studies have implicated the ARHGEF26 locus in the risk of coronary artery disease (CAD). However, the causal pathways by which DNA variants at the ARHGEF26 locus confer risk for CAD are incompletely understood. We sought to elucidate the mechanism responsible for the enhanced risk of CAD associated with the ARHGEF26 locus. Read More

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November 2021

Healthcare utilization and economic burden in systemic sclerosis: a systematic review.

Rheumatology (Oxford) 2021 Nov 25. Epub 2021 Nov 25.

Schulich School of Medicine and Dentistry, University of Western Ontario, Division of Rheumatology, St. Joseph's Health Care, London, Ontario, Canada.

Objective: Systemic Sclerosis (SSc) is characterized by vasculopathy, fibrosis of skin and internal organs, and autoimmunity with complications including interstitial lung disease, pulmonary hypertension, and digital ulcers with substantial morbidity and disability. Patients with SSc may require considerable healthcare resources with economic impact. The purpose of this systematic review was to provide a narrative synthesis of the economic impact and healthcare resource utilization associated with SSc. Read More

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November 2021

HIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study.

Sci Rep 2021 Nov 30;11(1):23110. Epub 2021 Nov 30.

Department of Radiology, Johns Hopkins University School of Medicine, 601 N Caroline St, Baltimore, MD, 21205, USA.

Our objective was to assess whether human immunodeficiency virus (HIV)-infection directly or indirectly promotes the progression of clinical characteristics of coronary artery disease (CAD). 300 African Americans with asymptomatic CAD (210 male; age: 48.0 ± 7. Read More

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November 2021

Impact of extent of coronary artery disease and percutaneous revascularization assessed by the SYNTAX score on outcomes following transcatheter aortic valve replacement.

BMC Cardiovasc Disord 2021 Nov 30;21(1):568. Epub 2021 Nov 30.

Department of Cardiology, Angiology, Pneumology and Internal Intensive Care, University Hospital Ulm, University of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

Objectives: The aim of the study was to analyze the impact of concomitant coronary artery disease (CAD) assessed by the SYNTAX score (SS) and periprocedural percutaneous coronary intervention (PCI) on outcomes after transcatheter aortic valve replacement (TAVR).

Background: Due to controversial data regarding the effect of CAD on outcomes after TAVR, proper revascularization strategies remain a matter of debate.

Methods: 553 patients with severe aortic stenosis undergoing TAVR were included in this study. Read More

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November 2021

Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease: Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts.

J Am Heart Assoc 2021 Dec 30;10(23):e021995. Epub 2021 Nov 30.

Nightingale Health Plc Helsinki Finland.

Background Peripheral artery disease (PAD) and coronary artery disease (CAD) represent atherosclerosis in different vascular beds. We used detailed metabolic biomarker profiling to identify common and discordant biomarkers and clarify pathophysiological differences for these vascular diseases. Methods and Results We used 5 prospective cohorts from Finnish population (FINRISK 1997, 2002, 2007, and 2012, and Health 2000; n=31 657; median follow-up time of 14 years) to estimate associations between >200 metabolic biomarkers and incident PAD and CAD. Read More

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December 2021

Fibrin to von Willebrand factor ratio in arterial thrombi is associated with plasma levels of inflammatory biomarkers and local abundance of extracellular DNA.

Thromb Res 2021 Nov 18;209:8-15. Epub 2021 Nov 18.

Department of Biochemistry, Semmelweis University, Budapest, Hungary. Electronic address:

Introduction: The composition of thrombi determines their structure, mechanical stability, susceptibility to lysis, and consequently, the clinical outcome in coronary artery disease (CAD), acute ischemic stroke (AIS), and peripheral artery disease (PAD). Fibrin forms the primary matrix of thrombi intertwined with DNA, derived from neutrophil extracellular traps (NETs), and von Willebrand factor (VWF) bridging DNA and platelets. Here we examined the relative content of fibrin, DNA and VWF in thrombi and analyzed their interrelations and quantitative associations with systemic biomarkers of inflammation and clinical characteristics of the patients. Read More

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November 2021

Increased soluble programed cell death-ligand 1 is associated with acute coronary syndrome.

Int J Cardiol 2021 Nov 27. Epub 2021 Nov 27.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences and Center for Metabolic Regulation of Healthy Aging (CMHA), Kumamoto University, Kumamoto, Japan.

Background: Programmed cell death (PD)-1 and its ligand (PD-L1) plays crucial roles in T-cell tolerance as immune checkpoint. Previous studies reported that increased serum levels of soluble PD-L1 (sPD-L1) reflect myocardial and vascular inflammation. However, little is known about the clinical relationship between sPD-L1 and acute coronary syndrome (ACS). Read More

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November 2021

Mortality and Clinical Outcomes among Patients with COVID-19 and Diabetes.

Med Sci (Basel) 2021 10 26;9(4). Epub 2021 Oct 26.

Department of Respiratory, Critical Care and Sleep Medicine, Indraprastha Apollo Hospitals, New Delhi 110076, India.

Diabetes mellitus (DM) is a decisive risk factor for severe illness in coronavirus disease 2019 (COVID-19). India is home to a large number of people with DM, and many of them were infected with COVID-19. It is critical to understand the impact of DM on mortality and other clinical outcomes of COVID-19 infection from this region. Read More

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October 2021

[Gut microbiota and its metabolite trimethylamine-N-oxide (TMAO): a novel regulator in coronary artery disease].

Sheng Wu Gong Cheng Xue Bao 2021 Nov;37(11):3745-3756

College of Physical Education and Sports, Beijing Normal University, Beijing 100875, China.

Coronary artery disease (CAD) is a chronic disease but causes the highest mortality and morbidity among the cardiovascular diseases worldwide. Correlations between CAD and gut microbiota have been observed. This suggests that the gut microbiota could become a vital diagnostic marker of CAD, and restoring the gut habitat may become a promising strategy for CAD therapy. Read More

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November 2021

Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study.

JRSM Cardiovasc Dis 2021 Jan-Dec;10:20480040211059374. Epub 2021 Nov 19.

Department of Clinical Pharmacology, King's College London British Heart Foundation Centre, School of Cardiovascular Medicine & Sciences, St Thomas' Hospital, London, UK.

Background: Susceptibility to and severity of COVID-19 is associated with risk factors for and presence of cardiovascular disease.

Methods: We performed a 2-sample Mendelian randomization to determine whether blood pressure (BP), body mass index (BMI), presence of type 2 diabetes (T2DM) and coronary artery disease (CAD) are causally related to presentation with severe COVID-19. Variant-exposure instrumental variable associations were determined from most recently published genome-wide association and meta-analysis studies (GWAS) with publicly available summary-level GWAS data. Read More

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November 2021

Longitudinal Association Between Angina Pectoris and Quality of Life.

Am J Cardiol 2021 Nov 24. Epub 2021 Nov 24.

Department of Medicine, University of California, San Francisco, SF, CA; San Francisco VA Health Care System, SF, CA.

Angina is a common symptom in patients with coronary artery disease (CAD); however, its impact on patients' quality of life over time is not well understood. We sought to determine the longitudinal association of angina frequency with quality of life and functional status over a 5-year period. We used data from the Heart and Soul Study, a prospective cohort study of 1,023 outpatients with stable CAD. Read More

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November 2021