32,886 results match your criteria associated bypass


Clinical features and treatment outcomes of cerebral arteriovenous malformation associated with moyamoya disease.

World Neurosurg 2021 Jul 27. Epub 2021 Jul 27.

Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Division of Pediatric Radiology, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Korea, (3)Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Republic of Korea. Electronic address:

Purpose: Cerebral arteriovenous malformation (AVM) can rarely occur in conjunction with moyamoya disease (MMD). There is still no consensus on how to treat AVM when accompanied by MMD. In this study, we assessed the clinical features and suggested appropriate management when AVM was combined with MMD. Read More

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Noninvasive Urine Oxygen Monitoring and the Risk of Acute Kidney Injury in Cardiac Surgery.

Anesthesiology 2021 Jul 30. Epub 2021 Jul 30.

Background: Acute kidney injury (AKI) is a common complication of cardiac surgery. An intraoperative monitor of kidney perfusion is needed to identify patients at risk for AKI. The authors created a noninvasive urinary oximeter that provides continuous measurements of urinary oxygen partial pressure and instantaneous urine flow. Read More

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Intraoperative renal hypoxia and risk of cardiac surgery-associated acute kidney injury.

J Card Surg 2021 Jul 29. Epub 2021 Jul 29.

Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Australia.

Background: Acute kidney injury (AKI) is common after cardiac surgery requiring cardiopulmonary bypass. Renal hypoxia may precede clinically detectable AKI. We compared the efficacy of two indices of renal hypoxia, (i) intraoperative urinary oxygen tension (UPO ) and (ii) the change in plasma erythropoietin (pEPO) during surgery, in predicting AKI. Read More

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Association between public media and trends in new acute coronary syndrome presentations during the first COVID‑19 wave in the Netherlands.

Neth Heart J 2021 Jul 29. Epub 2021 Jul 29.

Netherlands Heart Registration, Utrecht, The Netherlands.

Background: We aimed to evaluate the association between public media and trends in new presentations of acute coronary syndrome (ACS) during the first wave of the coronavirus disease 2019 (COVID‑19) in the Netherlands.

Methods: New ACS presentations per week in 73 hospitals during the first half of 2019 and 2020 were retrieved from the national organisation Dutch Hospital Data and incidence rates were calculated. Stratified analyses were performed by region, type of ACS and patient characteristics. Read More

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Physical activity and sedentary behaviour in secondary prevention of coronary artery disease: A review.

Am J Prev Cardiol 2021 Mar 9;5:100146. Epub 2021 Jan 9.

Heart Center, Kuopio University Hospital (KUH), Kuopio, Finland.

Comprehensive management of coronary artery disease (CAD) includes physical exercise as a part of daily lifestyle therapy. Still CAD patients generally have low physical activity (PA) and high sedentary behaviour (SB). This review summarizes the effect of exercise training and habitual PA and SB on physical fitness and quality of life (QoL) as well as on rehospitalizations and mortality in patients with stable CAD, recent acute coronary syndrome (ACS) or recent revascularization. Read More

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Access route selection for percutaneous coronary intervention among Vietnamese patients: Implications for in-hospital costs and outcomes.

Lancet Reg Health West Pac 2021 Apr 2;9:100116. Epub 2021 Mar 2.

School of Public Health, Curtin University, Perth, Australia.

Background: Little is known about rates of access site (transradial (TRI) or transfemoral (TFI)) preference for percutaneous coronary intervention (PCI) and in-hospital costs of patients undergoing these procedures in lower-and middle-countries. Here, we report on access site use, in-hospital costs and outcomes of patients undergoing PCI in Vietnam.

Methods: Information from 868 patients were included in the cohort of 1022 patients recruited into the first PCI registry in Vietnam. Read More

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Anthropometric Measurements and Correlations to Glucometabolic and Cardiovascular Risk in Obese Patients Undergoing Gastric Bypass Surgery.

J Obes 2021 16;2021:6647328. Epub 2021 Jul 16.

Bariatric Clinic, Department of Surgery, Falun Hospital, Falun, Sweden.

Abdominal obesity is associated with hypertension, increased fasting glucose, HbA1c, and cholesterol. Body mass index (BMI) is frequently used to measure and define obesity and as inclusion criteria for bariatric surgery. Sagittal abdominal diameter (SAD) has been suggested to predict the amount of visceral fat, metabolic traits, and cardiometabolic risk superior to BMI. Read More

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A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53.

Elife 2021 Jul 29;10. Epub 2021 Jul 29.

Laboratory of Translational Oncology and Experimental Cancer Therapeutics, The Warren Alpert Medical School, Brown University, Providence, United States.

Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance. CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike other xanthines such as caffeine, pentoxifylline, and theophylline, they do not deregulate the G2 checkpoint. Novel CB002-analogs induce pro-apoptotic Noxa protein in an ATF3/4-dependent manner, whereas caffeine, pentoxifylline, and theophylline do not. Read More

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Psychological Functioning and Health Behaviors Associated with Weight Loss Patterns up to 13.7 Years After Weight Loss Surgery.

J Clin Psychol Med Settings 2021 Jul 29. Epub 2021 Jul 29.

St. Vincent Bariatrics, Ascension St. Vincent Carmel Hospital, Carmel, IN, USA.

Weight loss surgery produces dramatic health improvements immediately after surgery, including rapid declines in diabetes. However, less is known about its long-term effects. 124 St. Read More

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Evaluation of Seizure Risk in Infants After Cardiopulmonary Bypass in the Absence of Deep Hypothermic Cardiac Arrest.

Neurocrit Care 2021 Jul 28. Epub 2021 Jul 28.

Division of Child Neurology, Lucile Packard Children's Hospital at Stanford University, Dr Levy 750 Welch Road Suite 317, Palo Alto, CA, USA.

Background: Guidelines recommend evaluation for electrographic seizures in neonates and children at risk, including after cardiopulmonary bypass (CPB). Although initial research using screening electroencephalograms (EEGs) in infants after CPB found a 21% seizure incidence, more recent work reports seizure incidences ranging 3-12%. Deep hypothermic cardiac arrest was associated with increased seizure risk in prior reports but is uncommon at our institution and less widely used in contemporary practice. Read More

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Predicting Intensive Care Unit Length of Stay After Acute Type A Aortic Dissection Surgery Using Machine Learning.

Front Cardiovasc Med 2021 12;8:675431. Epub 2021 Jul 12.

Department of Radiology, the First Affiliated Hospital, Jinan University, Guangzhou, China.

Patients with acute type A aortic dissection are usually transferred to the intensive care unit (ICU) after surgery. Prolonged ICU length of stay (ICU-LOS) is associated with higher level of care and higher mortality. We aimed to develop and validate machine learning models for predicting ICU-LOS after acute type A aortic dissection surgery. Read More

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Bariatric Surgery Outcomes in Patients with Latent Autoimmune Diabetes of the Adult.

Obes Facts 2021 Jul 28:1-6. Epub 2021 Jul 28.

Endocrine, Cardiovascular & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

Bariatric surgery is a very effective treatment for obesity-associated type 2 diabetes. However, the benefits of bariatric surgery in patients with obesity and autoimmune diabetes, such as type 1 diabetes and latent autoimmune diabetes in adults (LADA), are controversial. We report 3 female patients with obesity and LADA who underwent laparoscopic Roux-en-Y gastric bypass >10 years ago. Read More

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Neurocognitive, Quality of Life, and Behavioral Outcomes for Patients With Covert Stroke After Cardiac Surgery: Exploratory Analysis of Data From a Prospectively Randomized Trial.

Anesth Analg 2021 Jul 28. Epub 2021 Jul 28.

From the Department of Anesthesiology.

Background: Asymptomatic brain ischemic injury detected with diffusion-weighted magnetic resonance imaging (DWI) is reported in more than one-half of patients after cardiac surgery. There are conflicting findings on whether DWI-detected covert stroke is associated with neurocognitive dysfunction after surgery, and it is unclear whether such ischemic injury affects quality of life or behavioral outcomes. The purpose of this study was to perform exploratory analysis on whether covert stroke after cardiac surgery is associated with delayed neurocognitive recovery 1 month after surgery, impaired quality of life, anxiety, or depression. Read More

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Pushing the Limits of the Donor-Acceptor Copolymer Strategy for Intramolecular Singlet Fission.

J Phys Chem Lett 2021 Jul 28:7270-7277. Epub 2021 Jul 28.

Laboratory for Computational Molecular Design, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

Donor-acceptor (D-A) copolymers have shown great potential for intramolecular singlet fission (iSF). Nonetheless, very few design principles exist for optimizing these systems for iSF, with very little knowledge about how to engineer them for this purpose. In recent work, a fundamental trade-off between the main electronic ingredients required for iSF capable D-A coplanar copolymers was revealed. Read More

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Value of preoperative computed tomography for meso-Rex bypass in children with extrahepatic portal vein obstruction.

Insights Imaging 2021 Jul 27;12(1):109. Epub 2021 Jul 27.

Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.

Background: Extrahepatic portal vein obstruction (EHPVO) is the most important cause of hematemesis in children. Intrahepatic left portal vein and superior mesenteric vein anastomosis, also known as meso-Rex bypass (MRB), is becoming the gold standard treatment for EHPVO. We analyzed the value of preoperative computed tomography (CT) in determining whether MRB is feasible in children with EHPVO. Read More

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The role of diffuse correlation spectroscopy and frequency-domain near-infrared spectroscopy in monitoring cerebral hemodynamics during hypothermic circulatory arrests.

JTCVS Tech 2021 Jun 29;7:161-177. Epub 2021 Jan 29.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

Objectives: Real-time noninvasive monitoring of cerebral blood flow (CBF) during surgery is key to reducing mortality rates associated with adult cardiac surgeries requiring hypothermic circulatory arrest (HCA). We explored a method to monitor cerebral blood flow during different brain protection techniques using diffuse correlation spectroscopy (DCS), a noninvasive optical technique which, combined with frequency-domain near-infrared spectroscopy (FDNIRS), also provides a measure of oxygen metabolism.

Methods: We used DCS in combination with FDNIRS to simultaneously measure hemoglobin oxygen saturation (SO), an index of cerebral blood flow (CBF), and an index of cerebral metabolic rate of oxygen (CMRO) in 12 patients undergoing cardiac surgery with HCA. Read More

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The mini-Bentall approach: Comparison with full sternotomy.

JTCVS Tech 2021 Jun 27;7:59-66. Epub 2021 Jan 27.

Department of Cardiothoracic Surgery, Thomas Jefferson University Hospital, Philadelphia, Pa.

Background: The upper mini sternotomy Bentall (mini-Bentall) procedure may result in less trauma and earlier recovery compared with the full sternotomy Bentall procedure (full Bentall). This study compares immediate and 1- and 3-year survival rates after mini- and full Bentall procedures.

Methods: Between February 2009 and July 2019, 48 patients underwent a mini-Bentall and 49 underwent a full Bentall. Read More

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Thoracoabdominal aneurysmectomy: Operative steps for Crawford extent II repair.

JTCVS Tech 2020 Sep 25;3:25-36. Epub 2020 Jun 25.

Department of Cardiac Surgery, St Bartholomew's Hospital, London, United Kingdom.

Background: Open surgical repair remains the gold standard for treatment of thoracoabdominal aortic aneurysm (TAAA). Surgery aims to replace the whole length of the diseased distal aorta while protecting the spinal cord and the visceral organs to limit ischemia-related complications. The substantial associated surgical risks, including death, paraplegia, renal failure requiring permanent dialysis, and respiratory complications leading to prolonged intensive care unit stay, still outweigh the natural history of TAAA with conservative treatment. Read More

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September 2020

Associations between oxygen delivery and cardiac index with hyperlactatemia during cardiopulmonary bypass.

JTCVS Tech 2020 Jun 13;2:92-99. Epub 2020 Apr 13.

Department of Cardiac Surgery, Anthea Hospital, GVM Care & Research, Bari, Italy.

Objective: Metabolism management plays an essential role during cardiopulmonary bypass (CPB). There are different metabolic management devices integrated to heart-lung machines; the most commonly used and accepted metabolic target is indexed oxygen delivery (DO) (280 mL/min/m) and cardiac index (CI) (2.4 L/min/m), which can be managed independently or according to other metabolic parameters. Read More

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Isolated Antineutrophil Cytoplasmic Antibody-Associated Coronary Vasculitis and Valvulitis.

JACC Case Rep 2021 Feb 10;3(2):309-313. Epub 2021 Feb 10.

Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

A 30-year-old woman presented with angina pectoris. Coronary angiography revealed severe stenosis in the left main and right coronary arteries that did not improve with intracoronary nitroglycerin. Coronary computed tomography angiography and positron emission tomography revealed coronary ostia inflammation and aortic root fat stranding. Read More

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February 2021

Eosinophilic Granulomatosis With Polyangiitis Presenting as an Acute Coronary Syndrome.

JACC Case Rep 2020 Jun 17;2(7):1062-1065. Epub 2020 Jun 17.

Division of Cardiology, Hunter Holmes McGuire Veteran Medical Center, Richmond, Virginia.

Eosinophilic granulomatosis with polyangiitis, formerly Churg-Strauss Syndrome, is an uncommon disorder that carries a high mortality when coronary artery disease develops. Early recognition and treatment is crucial. We highlight an unusual presentation of acute coronary syndrome not associated with atherosclerotic coronary disease. Read More

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A Novel Case of Spontaneous Coronary Artery Dissection During Cabergoline Therapy for Prolactinoma.

JACC Case Rep 2020 Sep 15;2(11):1684-1687. Epub 2020 Sep 15.

Division of Cardiothoracic Surgery, Department of Surgery, Maimonides Medical Center, Brooklyn, New York.

We present a case of spontaneous coronary artery dissection associated with cabergoline treatment for prolactinoma. A 31-year-old woman with history of hypertension and prolactinoma, treated with cabergoline, presented with chest pain. She had non-ST-segment elevation myocardial infarction with double vessel coronary artery dissection and was treated with coronary artery bypass grafting. Read More

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September 2020

Risk of cardiovascular intervention after androgen deprivation therapy in prostate cancer patients with a prior history of ischemic cardiovascular and cerebrovascular disease: A nationwide population-based cohort study.

Urol Oncol 2021 Jul 24. Epub 2021 Jul 24.

Department of Urology, Prostate Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Androgen deprivation therapy for prostate cancer is known to increase the risk of cardiovascular disease, but there is controversy regarding the cardiovascular risk in patients with preexisting cardiovascular disease. This study assessed the risk of cardiovascular intervention after androgen deprivation therapy in patients with a history of cardiovascular disease, cerebrovascular disease, and cardiovascular intervention.

Materials And Methods: Between 2008 and 2017, 195,308 men with newly diagnosed prostate cancer were identified from the nationwide claims database in South Korea. Read More

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The Essential Frailty Toolset in Older Adults Undergoing Coronary Artery Bypass Surgery.

J Am Heart Assoc 2021 Jul 28:e020219. Epub 2021 Jul 28.

Centre for Clinical Epidemiology Lady Davis Institute for Medical ResearchJewish General Hospital Montreal QC Canada.

Background The Essential Frailty Toolset (EFT) was shown to be easy to use and predictive of adverse events in patients undergoing aortic valve replacement procedures. The objective of this study was to evaluate the EFT in patients undergoing coronary artery bypass grafting procedures. Methods and Results The McGill Frailty Registry prospectively included patients ≥60 years of age undergoing urgent or elective isolated coronary artery bypass grafting between 2011 and 2018 at 2 hospitals. Read More

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Cardiac surgery and Brugada syndrome: operative considerations.

Interact Cardiovasc Thorac Surg 2021 Jul 27. Epub 2021 Jul 27.

Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton, UK.

Brugada syndrome is an uncommon arrhythmic disease due to abnormality in myocardial transmembrane sodium channels and is associated with sudden death due to ventricular arrhythmias. We report our strategy and highlight precautions to reduce the risk of perioperative arrhythmias in a patient with Brugada pattern who underwent successful coronary artery bypass grafting. Read More

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Albumin use in bleeding cardiac surgical patients and associated patient outcomes.

Can J Anaesth 2021 Jul 26. Epub 2021 Jul 26.

Department of Anesthesia and Pain Management, Toronto General Hospital - University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 200 Elizabeth Street, 3EN-464, Toronto, ON, M5G 2C4, Canada.

Purpose: Albumin solution is a colloid used for resuscitation in cardiac surgical patients, but it is unclear if it offers advantages over crystalloids. We examined current clinical practice across 11 cardiac surgical centres and the association of albumin with outcomes in a cohort of bleeding cardiac surgical patients.

Methods: This was a post hoc analysis of data from the Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery (FIBRES) trial. Read More

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Biliopancreatic Limb Length of Small Intestinal Bypass in Non-obese Goto-Kakizaki (GK) Rats Correlates with Gastrointestinal Hormones, Adipokines, and Improvement in Type 2 Diabetes.

Obes Surg 2021 Jul 26. Epub 2021 Jul 26.

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.

Background: The purpose of this study was to explore the effects on type 2 diabetes, gastrointestinal hormones, and adipokines after the small intestinal bypass of different biliopancreatic limb (BPL) lengths in non-obese type 2 diabetic rats.

Method: Small intestinal bypass with the BPL length at 10cm, 20cm, 30cm, and 40cm, respectively, and sham surgery were performed in non-obese GK rats. Fasting serum was collected at 2 days preoperatively and 1, 3, 6, and 9 weeks postoperatively. Read More

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Perioperative mortality in bariatric surgery: meta-analysis.

Br J Surg 2021 Jul 16. Epub 2021 Jul 16.

Musgrove Park Hospital, Taunton, UK.

Background: Bariatric surgery is an established treatment for severe obesity; however, fewer than 1 per cent of eligible patients undergo surgery. The perceived risk of surgery may contribute to the low uptake. The aim of this study was to determine perioperative mortality associated with bariatric surgery, comparing different operation types and data sources. Read More

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Endoscopic Management of Bariatric Surgery Complications According to a Standardized Algorithm.

Obes Surg 2021 Jul 23. Epub 2021 Jul 23.

Unité d'Endoscopie Interventionnelle, Hôpital Privé des Peupliers, Ramsay Générale de Santé, 8 Place de l'Abbé G. Hénocque, 75013, Paris, France.

Background And Aims: Endoscopy is effective in management of bariatric surgery (BS) adverse events (AEs) but a comprehensive evaluation of long-term results is lacking. Our aim is to assess the effectiveness of a standardized algorithm for the treatment of BS-AE.

Patients And Methods: We retrospectively analyzed 1020 consecutive patients treated in our center from 2012 to 2020, collecting data on demographics, type of BS, complications, and endoscopic treatment. Read More

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LYTACs: An Emerging Tool for the Degradation of Non-Cytosolic Proteins.

ChemMedChem 2021 Jul 23. Epub 2021 Jul 23.

Department of Chemistry, Indian Institute of Science Education and Research, Bhopal Bypass Road, Bhauri, Bhopal, MP 462066, India.

In the last two decades, targeted protein degradation has rapidly gained popularity as a technique to eliminate disease-causing undruggable proteins. Over the years, many tools have been devised to degrade proteins by exploiting natural protein homeostasis machinery available in our body, with LYTACs being the latest to come on board. LYTACs, or lysosome-targeting chimeras, make use of the lysosome degradation pathway by recruiting proteins to lysosome-shuttling receptors located at the cell surface. Read More

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