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Switching from Insulin to Dulaglutide Therapy in Patients with Type 2 Diabetes: A Real-World Data Study.

Diabetes Metab Res Rev 2021 May 6. Epub 2021 May 6.

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Aim: Patients with type 2 diabetes (T2DM) who require injectable therapy have been conventionally treated with insulin. A glucagon-like peptide 1 receptor agonist was recently recommended as first line injectable treatment, but few studies have investigated the effects of switching from insulin to dulaglutide. This study investigated the clinical efficacy and parameters affecting responses to dulaglutide as an alternative to insulin in patients with T2DM in a real-world clinical setting. Read More

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Host immune response against leishmaniasis and parasite persistence strategies: A review and assessment of recent research.

Biomed Pharmacother 2021 May 3;139:111671. Epub 2021 May 3.

Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zgazig, Egypt.

Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains a major public health problem and is linked to tropical and subtropical regions, with an endemic picture in several regions, including East Africa, the Mediterranean basin and South America. The different causative species display a diversity of clinical presentations; therefore, the immunological data on leishmaniasis are both scarce and controversial for the different forms and infecting species of the parasite. Read More

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Medial displacement calcaneal osteotomy versus lateral column lengthening to treat stage II tibialis posterior tendon dysfunction, a prospective randomized controlled study.

Foot (Edinb) 2021 Apr 7;47:101798. Epub 2021 Apr 7.

Orthopedic Department, Assiut University Hospital, Assiut, Egypt. Electronic address:

Purpose: Adult-acquired flatfoot deformity (AAFD) requires optimum planning that often requires several procedures for deformity correction. The objective of this study was to detect the difference between MDCO versus LCL in the management of AAFD with stage II tibialis posterior tendon dysfunction regarding functional, radiographic outcomes, efficacy in correction maintenance, and the incidence of complications.

Patient And Methods: 42 Patients (21 males and 21 females) with a mean age of 49. Read More

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Using Manchester Scale classification of Hallux Valgus as a valuable tool in determining appropriate risk categorization during initial diabetic foot screening in primary health care settings.

Foot (Edinb) 2021 Apr 19;47:101810. Epub 2021 Apr 19.

Dufferin Area Family Health Team (DAFHT), 140 Rolling Hills Dr., Upper Level, Orangeville Ontario, L9W 4X8, Canada. Electronic address:

Limitations have been identified in the current state of primary care practises with regards to identifying and correctly categorizing foot deformity and its associated risk of developing foot ulcers in patients with diabetes. This study aims to bridge these gaps through the implementation of additional categorization tools to be made available for primary care professionals. This study thus analysed the relationship between foot pressure distribution and amount in patients with diabetes with Hallux Valgus foot deformity, and its different stages, in order to better understand the clinical applications of the Manchester Scale. Read More

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Quantitative study of PIMT technique aiming its validation as physical therapy procedure.

Foot (Edinb) 2021 Apr 8;47:101800. Epub 2021 Apr 8.

School of Electrical and Computer Engineering, University of Campinas, Campinas, SP, Brazil. Electronic address:

Background: Valgus hindfoot is a very common postural deviation, and the associated foot pronation can be a triggering factor for diseases such as tarsal tunnel syndrome.

Research Question: This work compares two techniques for hindfoot valgus correction: GPR (Global Postural Reeducation) and PIMT (Postural Integration by Manual Therapy).

Methods: Sixty young adult subjects from the Brazilian Army with unilateral hindfoot valgus were selected and divided into two groups of 30 subjects, one treated with GPR and the other treated with PIMT. Read More

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Ecotoxicological effects of pyraclostrobin on tilapia (Oreochromis niloticus) via various exposure routes.

Environ Pollut 2021 Apr 28;285:117188. Epub 2021 Apr 28.

Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, Shandong Agricultural University, Tai'an, Shandong, 271018, PR China; College of Plant Protection, Shandong Agricultural University, Tai'an, Shandong, 271018, PR China. Electronic address:

Pyraclostrobin is a widely used and highly efficient fungicide that also has high toxicity to aquatic organisms, especially fish. Although some research has reported the toxic effects of pyraclostrobin on fish, the main toxic pathways of pyraclostrobin in fish remain unclear. The present study has integrated histopathological, biochemical and hematological techniques to reveal the main toxic pathways and mechanisms of pyraclostrobin under different exposure routes. Read More

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Role of lymphadenectomy for apparent early stage uterine sarcoma; a comprehensive analysis of the National Cancer Database.

Surg Oncol 2021 Apr 24;38:101589. Epub 2021 Apr 24.

Division of Gynecologic Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.

Objective: Investigate the role of lymphadenectomy for patients with apparent stage I uterine sarcoma.

Methods: The National Cancer Database was accessed and patients without a history of another tumor diagnosed between 2004 and 2015 with an apparent early stage leiomyosarcoma, adenosarcoma, low-grade endometrial stromal and high-grade endometrial stromal/undifferentiated sarcoma who underwent hysterectomy with or without lymphadenectomy were identified. Overall survival was assessed after stratification by histology with the log-rank test while Cox models were constructed to control for confounders. Read More

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The feasibility of solar-powered small-scale brackish water desalination units in a coastal aquifer prone to saltwater intrusion: A comparison between electrodialysis reversal and reverse osmosis.

J Environ Manage 2021 May 3;290:112604. Epub 2021 May 3.

Baha and Walid Bassatne Department of Chemical Engineering and Advanced Energy, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Bliss Street, Beirut, Lebanon. Electronic address:

In the face of increasing water shortages worldwide, water desalination has the potential to expand the available freshwater supply options in many water stressed regions. This paper assesses the feasibility of adopting photovoltaic powered small-scale brackish water desalination units in a coastal aquifer facing saltwater intrusion and chronic water shortages. Moreover, a detailed cost comparison, which incorporates the associated environmental costs, is conducted between the Electrodialysis Reversal (EDR) technique and Reverse Osmosis (RO). Read More

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Percutaneous gastrostomy compared with esophageal stenting for the treatment of esophageal cancer with dysphagia.

J Vasc Interv Radiol 2021 May 3. Epub 2021 May 3.

Minimally Invasive and Interventional Department, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan, China. Electronic address:

Purpose: To compare the outcomes of self-expandable metal stent and percutaneous gastrostomy (PG) for treatment of patients with esophageal cancer (EC) and dysphagia.

Materials And Methods: This retrospective observational study consisted of 113 patients with EC and dysphagia who underwent either stent insertion (n = 47) or PG (n = 66) at a single center between June 2014 and June 2018.

Results: There were 63 men and 50 women with the mean age of 76. Read More

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Right prefrontal activation predicts ADHD and its severity: A TMS-EEG study in young adults.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 3:110340. Epub 2021 May 3.

Life Science Department and the Zlotowski Center for Neuroscience, Ben Gurion University in the Negev, Beer Sheva, Israel.

Objective: Here we bring a neurophysiological diagnostic tool, based on pathophysiologically-relevant brain region, that is critical for reducing the variability between clinicians, and necessary for quantitative measures of ADHD severity.

Methods: 54 healthy and 57 ADHD adults participated in the study. Electroencephalography (EEG) was recorded when combined with transcranial magnetic stimulation (TMS) over the right prefrontal cortex and also recorded during the Stop Signal task. Read More

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Minimally Invasive Short-Segment Anteroposterior Surgery for Thoracolumbar Osteoporotic Fractures with Canal Compromise: A Prospective Study with a Minimum 2-Year Follow-up.

Asian Spine J 2021 May 7. Epub 2021 May 7.

Department of Spine Surgery, Zentralklinik Bad Berka, Bad Berka, Germany.

Study Design: A prospective study with a minimum follow-up of 24 months.

Purpose: This study aimed to evaluate the results of minimally invasive anteroposterior surgery for osteoporotic vertebral fractures (OVFs) associated with bony spinal canal compromise in elderly patients.

Overview Of Literature: There is a recent increase in the incidence of osteoporosis with OVFs, causing an increasing burden on medical systems. Read More

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Risk factors for very preterm delivery out of a level III maternity unit: The EPIPAGE-2 cohort study.

Paediatr Perinat Epidemiol 2021 May 6. Epub 2021 May 6.

Obstetrical, Perinatal, and Pediatric Epidemiology Team, Center of Research in Epidemiology and Statistics (U1153), Université de Paris, INSERM, Paris, France.

Background: Regionalisation programmes aim to ensure that very preterm infants are born in level III units (inborn) through antenatal referral or transfer. Despite widespread knowledge about better survival without disability for inborn babies, 10%-30% of women deliver outside these units (outborn).

Objective: To investigate risk factors associated with outborn deliveries and to estimate the proportion that were probably or possibly avoidable. Read More

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The utility of lung weight to heart weight ratio as a means to identify suspected drug intoxication deaths in a medico-legal autopsy population.

J Forensic Sci 2021 May 6. Epub 2021 May 6.

The National Board of Forensic Medicine, Stockholm, Sweden.

Fatal intoxications are common in a medico-legal autopsy setting and are associated with sparse findings during autopsy. It has been suggested that an increased lung weight may be associated with such fatalities. Previous literature is generally limited to a descriptive approach, including only opioid deaths, and lacking a definition of "heavy" lungs. Read More

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Challenges and stresses experienced by athletes and coaches leading up to the Paralympic Games.

PLoS One 2021 6;16(5):e0251171. Epub 2021 May 6.

School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Australia.

The demands of high-performance sport are exacerbated during the lead up to the Major Games (i.e., Paralympics). Read More

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Psychological, sociocultural and economic coping strategies of mothers or female caregivers of children with a disability in Belu district, Indonesia.

PLoS One 2021 6;16(5):e0251274. Epub 2021 May 6.

College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

Caring for children with a disability can cause a range of psychological and socioeconomic challenges for parents and caregivers, such as anxiety, depression, inability to find affordable and appropriate childcare, loss of income and expenses related to disability specific treatment. As part of a study exploring the impacts of childhood disability on mothers or female caregivers and families, and the copy strategies they used, this paper describes strategies employed by mothers or female caregivers to cope with challenges associated with childhood disability within their family in Belu district, Indonesia. A qualitative approach using one-on-one in-depth interviews was used to collect data from participants (n = 22) who were recruited using a combination of purposive and snowball sampling techniques. Read More

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Rhythm and groove as cognitive mechanisms of dance intervention in Parkinson's disease.

PLoS One 2021 6;16(5):e0249933. Epub 2021 May 6.

Department of Biology, Wesleyan University, Middletown, Connecticut, United States of America.

Parkinson's disease (PD) is associated with a loss of internal cueing systems, affecting rhythmic motor tasks such as walking and speech production. Music and dance encourage spontaneous rhythmic coupling between sensory and motor systems; this has inspired the development of dance programs for PD. Here we assessed the therapeutic outcome and some underlying cognitive mechanisms of dance classes for PD, as measured by neuropsychological assessments of disease severity as well as quantitative assessments of rhythmic ability and sensorimotor experience. Read More

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The Healthy Taiwanese Eating Approach is inversely associated with all-cause and cause-specific mortality: A prospective study on the Nutrition and Health Survey in Taiwan, 1993-1996.

PLoS One 2021 6;16(5):e0251189. Epub 2021 May 6.

Institute of Population Health Science, National Health Research Institutes, Miaoli, Taiwan, R.O.C.

Background: Few longitudinal studies have investigated the association between foods/dietary pattern and mortality risk in the Asian population. We investigated the prospective association between foods/dietary pattern and risk of death among ethnic Chinese adults in Taiwan.

Methods: The study population included 2475 young and middle-aged adults (aged 18-65 years at baseline) who completed the questionnaires and physical examinations in the Nutrition and Health Survey in Taiwan from 1993 to 1996. Read More

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Pramipexole to Improve Cognition in Bipolar Disorder: A Randomized Controlled Trial.

J Clin Psychopharmacol 2021 May 6. Epub 2021 May 6.

From the Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks Feinstein Institutes for Medical Research, Institute for Behavioral Science, Manhasset Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead Icahn School of Medicine at Mount Sinai, New York, NY Brigham and Women's Hospital, Mood and Psychosis Research Program, Boston Department of Psychiatry, Harvard Medical School, Cambridge, MA.

Background: Adults with bipolar disorder (BD) often experience neurocognitive impairment that negatively impacts functioning and quality of life. Previous trials have found that dopamine agonist agents improve cognition in healthy volunteers and that adults with BD who have stable mood and mild cognitive deficits may also benefit. We hypothesized that pramipexole, a dopamine agonist, would improve neurocognitive function in patients with BD. Read More

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Identifying new predictive factors for survival after surgery for spinal metastases: an exploratory in-depth retrospective analysis.

Acta Clin Belg 2021 May 6:1-10. Epub 2021 May 6.

Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.

: In selected patients with symptomatic spinal metastasis from solid tumors, surgery improves quality of life. Since selection is key, inaccurate survival prognostication may result in poor decisions and outcomes. However, most prognostic scores suffer from suboptimal external validation and subsequent mediocre performance. Read More

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Cohesiveness in previously deployed Army National Guard units: Implications for postdeployment behavioral health.

James Griffith

Psychol Serv 2021 May 6. Epub 2021 May 6.

National Center for Veterans Studies, University of Utah.

A major health policy concern of deployed U.S. military personnel has been the observed high occurrence of postdeployment behavioral health problems. Read More

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Does peer relationship matter? A multilevel investigation of the effects of peer and supervisory relationships on group supervision outcomes.

J Couns Psychol 2021 May 6. Epub 2021 May 6.

Department of Educational Psychology, The Chinese University of Hong Kong.

Research in clinical supervision has primarily focused on the contribution of supervisors to training outcome. However, peers may also play a significant role in trainees' development, particularly during group supervision. Fifty-three trainees from 10 supervision groups completed measures of peer relationship, supervisory working alliance (SWA), supervision satisfaction (SAT), and counseling self-efficacy (CSE) at three time points during a 20-week counseling practicum at a department clinic in Hong Kong. Read More

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Novel antimicrobial ointment for infected wound healing in an in vitro and in vivo porcine model.

Wound Repair Regen 2021 May 6. Epub 2021 May 6.

Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Microbial contamination of wounds is a significant problem that delays healing, particularly when bacterial biofilms are present. A novel combination of pectinic acid (PG) + caprylic acid (CAP) was previously found in vitro to be highly effective in eradicating various pathogens in biofilms with minimal cytotoxicity. In this study, a novel wound ointment was formulated with PG + CAP and first assessed in vitro using a well-established biofilm eradication model. Read More

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Risk of Excessive Daytime Sleepiness Associated to Major Depression in Adolescents.

Psychiatr Q 2021 May 6. Epub 2021 May 6.

Department of Psychiatry and Sleep Laboratory, Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium.

Given the limited data currently available in the literature, the aim of this study was to investigate the risk of excessive daytime sleepiness (EDS) associated with major depression in a large sample of adolescents. The clinical and polysomnographic data of 105 adolescents recruited from the database of the Erasme Hospital sleep laboratory were analysed. A score > 10 on the Epworth Sleepiness Scale was used as cut-off for the diagnosis of EDS. Read More

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Integr Comp Biol 2021 May 6. Epub 2021 May 6.

Programa de Pós-Graduação em Ecologia, Instituto Nacional de Pesquisas da Amazônia, Manaus, AM 69067-375, Brazil.

Birds with delayed plumage maturation exhibit a drab predefinitive plumage, often despite gonad maturation, before developing the definitive plumage associated with increased reproductive success. Manakins are a diverse clade of neotropical lekking birds with extreme sexual dichromatism, radical sexual displays, and a unique diversity in the predefinitive plumages of males across species. Here, we provide the first full review of the natural history of manakin predefinitive plumages as the basis for qualitatively addressing the six major hypotheses about the production and function of predefinitive plumages. Read More

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Detection of Genetic Variability in Borrelia miyamotoi (Spirochaetales: Spirochaetaceae) Between and Within the Eastern and Western United States.

J Med Entomol 2021 May 6. Epub 2021 May 6.

Bacterial Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.

Borrelia miyamotoi is a hard tick-associated relapsing fever spirochete that is geographically widespread in Ixodes spp. (Acari: Ixodidae) ticks, but typically occurs at low prevalence. Genetic variability has been described among strains derived from Asia, Europe, and North America, and among tick species that carry the infection, but little variability has been described within foci or tick species. Read More

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Gender Differences and Mortality Trends After Transcatheter Aortic Valve Implantation: A 10-Year Analysis From a Single Tertiary Center.

J Invasive Cardiol 2021 May 6. Epub 2021 May 6.

Division of Interventional Cardiology of MedStar, Cardiovascular Research Network at MedStar Washington Hospital Center, 110 Irving Street, Suite 4B-1, Washington, D.C., 20010.

Aim: To evaluate gender differences and mortality trends in a population undergoing transcatheter aortic valve implantation (TAVI) and to analyze the correlates to all-cause mortality at follow-up.

Methods: The study comprises a prospective cohort of 592 TAVI patients (53.4% female) treated between 2008 and 2018. Read More

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Electronic Tools to Bridge the Language Gap in Health Care for People Who Have Migrated: Systematic Review.

J Med Internet Res 2021 May 6;23(5):e25131. Epub 2021 May 6.

Patient-Reported Outcomes Unit (PROQOL), UMR 1123, Université de Paris, INSERM, F-75004, Paris, France.

Background: People who have migrated or with a language barrier may face significant hurdles in accessing health care. Some apps have been specifically developed to facilitate the dialogue between health care professionals and people who have migrated who have low-level language proficiency or to promote health among people who have migrated.

Objective: We conducted a systematic review to investigate development, acceptability, and effectiveness of these types of apps. Read More

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