61,376 results match your criteria associated aggressive

Cytotoxicity, anti-tumor effects and structure-activity relationships of nickel and palladium S,C,S pincer complexes against double and triple-positive and triple-negative breast cancer (TNBC) cells.

Bioorg Med Chem Lett 2021 May 12:128107. Epub 2021 May 12.

Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Biotechnology, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Triple-Negative Breast Cancer (TNBC) is a highly aggressive form of breast cancer. The high rate of metastasis associated with TNBC is attributed to its multidrug resistance, making the treatment of this metastatic condition difficult. The development of metal-based antitumor agents was launched with the discovery of cisplatin, followed by the development of related antitumor drugs such as carboplatin and oxaliplatin. Read More

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Prognostic value of non-smoking, non-alcohol drinking status in oral cavity cancer.

Clin Oral Investig 2021 May 15. Epub 2021 May 15.

Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China.

Objectives: To compare the treatment response and prognosis of oral cavity cancer between non-smoking and non-alcohol-drinking (NSND) patients and smoking and alcohol-drinking (SD) patients.

Methods: A total of 313 consecutively treated patients from 2000 to 2019 were included. Demographic, clinicopathologic, treatment, and prognosis information were obtained. Read More

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Skip metastases in high-grade intramedullary appendicular osteosarcoma: an indicator of more aggressive disease?

Skeletal Radiol 2021 May 14. Epub 2021 May 14.

Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill Stanmore, HA7 4LP, Middlesex, UK.

Objective: To determine whether skip metastases (SM) in high-grade appendicular osteosarcoma (HG-OS) are an indicator of more aggressive disease.

Materials And Method: Retrospective review of patients with histologically confirmed diagnosis HG-OS of the long bones from 2007 to 2020, who had whole-bone MRI to identify SM. Data collected included patient age/gender, bone involved, the presence of SM, the presence of lung metastases from chest CT, the presence of distant bone metastases from whole-body bone scintigraphy or whole-body MRI, and chemotherapy response from resection specimen histology. Read More

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EGR1 as a potential marker of prognosis in extranodal NK/T-cell lymphoma.

Sci Rep 2021 May 14;11(1):10342. Epub 2021 May 14.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Extranodal natural killer T-cell lymphoma (ENKTL) is an aggressive malignancy with a dismal prognosis. In the present study, gene expression profiling was performed to provide more information on ENKTL molecular signature and offer a rationale for further investigation of prognostic markers in ENKTL. NanoString nCounter Analysis encompassing 133 target genes was used to compare gene expression levels of 43 ENKTL tumor samples. Read More

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SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress.

J Exp Clin Cancer Res 2021 May 14;40(1):168. Epub 2021 May 14.

Department of Endocrine and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, #1 You-Yi Rd., Yu-zhong District, Chongqing, 400016, China.

Background: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with poor prognosis and limited treatment options. Hypoxia is a key hallmark of TNBC. Metabolic adaptation promotes progression of TNBC cells that are located within the hypoxic tumor regions. Read More

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Dangle protocols in lower extremity reconstruction.

J Surg Res 2021 May 11;266:77-87. Epub 2021 May 11.

Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY. Electronic address:

Introduction: Dangling protocols are known to vary by surgeon and center, and their specific regimen is often largely based on single surgeon or institutional experience. A systematic review was conducted to derive evidence-based recommendations for dangling protocols according to patient-specific and flap-specific considerations.

Methods: A systematic review was performed using PubMed, Embase-OVID and Cochrane-CENTRAL. Read More

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Toward a holistic view of value and social processing in the amygdala: Insights from primate behavioral neurophysiology.

Behav Brain Res 2021 May 11:113356. Epub 2021 May 11.

Department of Psychology, Yale University, New Haven, CT, 06520, United States; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06510, United States; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT, 06511, United States.

Located medially within the temporal lobes, the amygdala is a formation of heterogenous nuclei that has emerged as a target for investigations into the neural bases of both primitive and complex behaviors. Although modern neuroscience has eschewed the practice of assigning broad functions to distinct brain regions, the amygdala has classically been associated with regulating negative emotional processes (such as fear or aggression), primarily through research performed in rodent models. Contemporary studies, particularly those in non-human primate models, have provided evidence for a role of the amygdala in other aspects of cognition such as valuation of stimuli or shaping social behaviors. Read More

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Cytomegalovirus infection of glioblastoma cells leads to NF-κB dependent upregulation of the c-MET oncogenic tyrosine kinase.

Cancer Lett 2021 May 11. Epub 2021 May 11.

Harvey Cushing Neurooncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Cytomegalovirus (CMV) is widespread in humans and has been implicated in glioblastoma (GBM) and other tumors. However, the role of CMV in GBM remains poorly understood and the mechanisms involved are not well-defined. The goal of this study was to identify candidate pathways relevant to GBM that may be modulated by CMV. Read More

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Hyperleukocytosis in Solid Tumors: A Rare Paraneoplastic Syndrome Associated with Poor Prognosis.

Am J Med Sci 2021 May 11. Epub 2021 May 11.

Department of Anatomical Pathology, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal. Electronic address:

Hematological paraneoplastic syndromes are fairly uncommon. While mild leukocytosis in solid tumors is well reported, white blood cell (WBC) count over 50,000 u/L, described as paraneoplastic leukemoid reaction (PLR), is not. Indeed, when found, it is usually associated with a higher burden of disease, tumor activity and worse clinical outcomes. Read More

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Compounds from plantar foot sweat, nesting material, and urine show strain patterns associated with agonistic and affiliative behaviors in group housed male mice, Mus musculus.

PLoS One 2021 14;16(5):e0251416. Epub 2021 May 14.

Department of Animal Science, Purdue University, West Lafayette, Indiana, United States of America.

Excessive home cage aggression often results in severe injury and subsequent premature euthanasia of male laboratory mice. Aggression can be reduced by transferring used nesting material during cage cleaning, which is thought to contain aggression appeasing odors from the plantar sweat glands. However, neither the composition of plantar sweat nor the deposits on used nesting material have been evaluated. Read More

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Accidental Deaths Involving Trees: Professional and Nonprofessional Woodcutting and Tree Failures With Autopsy Findings.

Am J Forensic Med Pathol 2021 May 11. Epub 2021 May 11.

From the Department of Pathology, Yale University School of Medicine, New Haven, CT Connecticut Office of the Chief Medical Examiner, Farmington.

Abstract: We examined all deaths in Connecticut involving tree mishaps (struck by a tree/tree limb, injuries associated with tree removal operations). Records of the Connecticut Office of the Chief Medical Examiner including autopsy, toxicology, and investigators' reports of deaths from 2004 to 2019 were reviewed. All underwent autopsy examination. Read More

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The changing landscape of cardiac rehabilitation; .

John P Buckley

Disabil Rehabil 2021 May 14:1-8. Epub 2021 May 14.

Centre for Active Living, University Centre Shrewsbury/University of Chester, Chester, UK.

Aim: This paper aims to demonstrate how the rationale and delivery of cardiac rehabilitation (CR), in those countries with long term established standards of practice, has changed over the past eight decades.

Methods: A narrative report based on the evolution of key published guidelines, systematic reviews and medical policies since the 1940s.

Results: Case reports of the value of exercise in cardiac disease can be dated back to 1772. Read More

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MRI features of breast implant-associated anaplastic large cell lymphoma: a pictorial review.

Br J Radiol 2021 May 14:20210093. Epub 2021 May 14.

Division of Breast Radiology, IEO - European Institute of Oncology IRCCS, Milan, Italy.

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare and newly recognized subtype of T cell Non-Hodgkin Lymphoma (NHLs) associated with breast implants.The mechanism involved in the development of this kind of lymphoma is still uncertain.BIA-ALCL is generally an indolent disease localized to the breast implant and its capsule and effectively treated with capsulectomy alone without chemotherapy. Read More

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spp. associated with root rot and stunting of winter crops in North Carolina.

Plant Dis 2021 May 14. Epub 2021 May 14.

North Carolina State University, 6798, Department of Entomology and Plant Pathology, Raleigh, North Carolina, United States;

Annual double-crop rotation systems that incorporate winter wheat, clary sage, or a cover crop are common in eastern North Carolina. Stunting and root rot of clary sage ( L.) reduce yields of this crop, especially in wet soils. Read More

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Karyotypic complexity, TP53 pathogenic variants, and increased number of variants on Next-Generation Sequencing are associated with disease progression in a North American Adult T-Cell Leukemia/Lymphoma cohort.

Int J Lab Hematol 2021 May 14. Epub 2021 May 14.

Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Introduction: Adult T-Cell Leukemia/Lymphoma (ATLL) is an aggressive T-cell malignancy without known characteristic cytogenetic abnormalities. Recurrent mutations in TP53, APC, and epigenetic and histone-modifying genes have been identified in North American ATLL. Their roles in disease progression are not yet fully elucidated. Read More

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Extramedullary multiple myeloma patient derived orthotopic xenograft with high disturbed genome: combined exhaustive molecular and therapeutic studies.

Dis Model Mech 2021 May 14. Epub 2021 May 14.

Department of Clinical Hematology, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Universitat de Barcelona, L'Hospitalet del Llobregat Barcelona, Spain.

Extramedullary multiple myeloma (EMM) has an overall survival of 6 months and occurs in 20% of multiple myeloma (MM) patients. Genetic and epigenetic mechanisms involved in EMM and the therapeutic role of new agents for MM are not well established. Besides, well characterized preclinical models for EMM are not available. Read More

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Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross-talk with p53 to activate p21.

IUBMB Life 2021 May 14. Epub 2021 May 14.

Department of Experimental Medicine, "Sapienza" University of Rome, Italy. Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Italy.

Statins are inhibitors of the mevalonate pathway that besides being cholesterol lowering agents, display anti-cancer properties. This is because cholesterol is an essential component of cell membranes but also because the mevalonate pathway controls protein farnesylation and geranylation, processes essential for the activity of GTPase family proteins. In this study, we found that Lovastatin exerted a dose- and time-dependent cytotoxic effect against PEL cells, an aggressive B cell lymphoma strictly associated with the gammaherpesvirus KSHV and characterized by a poor response to conventional chemotherapies. Read More

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The neglected biliary mucus and its phosphatidylcholine content: a putative player in pathogenesis of primary cholangitis-a narrative review article.

Ann Transl Med 2021 Apr;9(8):738

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

Primary sclerosing cholangitis (PSC) is a rare progressive cholangitis resulting in cirrhosis and cholangiocellular carcinoma. The pathogenesis is unclear and an effective medical therapy is not available. It is highly associated to ulcerative colitis for which recently a disturbance of the tight junction (TJ) barrier has been claimed as etiologic feature. Read More

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PSMD12 promotes glioma progression by upregulating the expression of Nrf2.

Ann Transl Med 2021 Apr;9(8):700

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Glioma is the most common and aggressive primary brain tumor in adults. Proteasome 26S subunit, non-ATPase 12 (PSMD12), an important subunit in the 26S proteasome, is known to be involved in the growth and apoptosis of breast cancer cells. However, its exact function and underlying molecular mechanisms in glioma remain unknown. Read More

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Whole-exome sequencing identifies somatic mutations associated with lung cancer metastasis to the brain.

Ann Transl Med 2021 Apr;9(8):694

Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Lung cancer is the most aggressive cancer, resulting in one-quarter of all cancer-related deaths, and its metastatic spread accounts for >70% of these deaths, especially metastasis to the brain. Metastasis-associated mutations are important biomarkers for metastasis prediction and outcome improvement.

Methods: In this study, we applied whole-exome sequencing (WES) to identify potential metastasis-related mutations in 12 paired lung cancer and brain metastasis samples. Read More

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A prognostic nomogram for women with primary ovarian signet-ring cell carcinoma.

Ann Transl Med 2021 Apr;9(7):525

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.

Background: Primary ovarian signet-ring cell carcinoma (POSRCC) is a rare subtype of ovarian carcinoma that is characterized by abundant mucin accumulation. POSRCC is aggressive, and the prognostic factors associated with its clinical outcome remain poorly defined. This study aimed to elucidate the clinical characteristics and survival of patients with POSRCC, and to establish an effective prognostic nomogram and risk stratification model to predict the risks associated with patient outcomes. Read More

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Triple-negative breast cancer: A run-through of features, classification and current therapies.

Oncol Lett 2021 Jul 5;22(1):512. Epub 2021 May 5.

Department of Biotechnology, Institute of Bioinformatics and Applied Biotechnology, Bengaluru, Karnataka 560100, India.

Breast cancer is the most prevalent cancer in women worldwide. Triple-negative breast cancer (TNBC) is characterized by the lack of expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. It is the most aggressive subtype of breast cancer and accounts for 12-20% of all breast cancer cases. Read More

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Cost-Effectiveness of Repository Corticotropin Injection versus Standard of Care for the Treatment of Active Rheumatoid Arthritis.

Clinicoecon Outcomes Res 2021 6;13:349-358. Epub 2021 May 6.

Mallinckrodt Pharmaceuticals, Hampton, NJ, USA.

Introduction: Patients with active rheumatoid arthritis (RA) often have inadequately controlled symptoms and are unable to achieve remission or low disease activity despite aggressive treatment. This results in irreversible joint damage, adversely affecting patients' physical and social functioning. The objective was to estimate the cost-effectiveness of repository corticotropin injection (RCI) versus standard of care (SoC) in patients with active RA from the United States (US) payer and societal perspectives over two to three years. Read More

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Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase.

Cell Death Differ 2021 May 13. Epub 2021 May 13.

Translational Medicine, School of Science, Engineering and Environment (SEE), University of Salford, Greater Manchester, UK.

Here, we provide evidence that high ATP production by the mitochondrial ATP-synthase is a new therapeutic target for anticancer therapy, especially for preventing tumor progression. More specifically, we isolated a subpopulation of ATP-high cancer cells which are phenotypically aggressive and demonstrate increases in proliferation, stemness, anchorage-independence, cell migration, invasion and multi-drug resistance, as well as high antioxidant capacity. Clinically, these findings have important implications for understanding treatment failure and cancer cell dormancy. Read More

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Mastermind Like Transcriptional Coactivator 3 (MAML3) drives neuroendocrine tumor progression.

Mol Cancer Res 2021 May 13. Epub 2021 May 13.

Department of Medicine, Division of Endocrinology, Metabolism and Diabetes and Division of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus

Metastatic disease in pheochromocytomas and paragangliomas (PCC/PGL) is not well-understood. The Cancer Genome Atlas discovered recurrent MAML3 fusion genes in a subset of tumors that lacked known germline or somatic driver mutations and were associated with aggressive disease. Here, we aimed to investigate the role of MAML3 in tumorigenesis. Read More

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Higher mortality in lung cancer patients with COVID-19? A systematic review and meta-analysis.

Lung Cancer 2021 May 5. Epub 2021 May 5.

Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China. Electronic address:

Objective: Given that the coronavirus disease 2019 (COVID-19) mainly spreads through the respiratory system and is associated with severe pulmonary complications, lung cancer patients may have worse outcomes than those with other tumors. There is no confirmed evidence about the mortality comparison between COVID-19 patients with lung cancer and other tumors. We performed a systematic review and pooled analysis to provide precise estimates of the mortality rate of COVID-19 patients with lung cancer and other tumors. Read More

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Patterns of Clinical Progression in Radiorecurrent High-risk Prostate Cancer.

Eur Urol 2021 May 10. Epub 2021 May 10.

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

The natural history of radiorecurrent high-risk prostate cancer (HRPCa) is not well-described. To better understand its clinical course, we evaluated rates of distant metastases (DM) and prostate cancer-specific mortality (PCSM) in a cohort of 978 men with radiorecurrent HRPCa who previously received either external beam radiation therapy (EBRT, n = 654, 67%) or EBRT + brachytherapy (EBRT + BT, n = 324, 33%) across 15 institutions from 1997 to 2015. In men who did not die, median follow-up after treatment was 8. Read More

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The impact of race, comorbid conditions and obesity on survival endpoints in women with high grade endometrial carcinoma.

Gynecol Oncol 2021 May 10. Epub 2021 May 10.

Wayne State University School of Medicine, Department of Oncology, Detroit, MI, USA; Karmanos Cancer Institute, Population Studies and Disparities Research Program, Detroit, MI, USA. Electronic address:

Objective: To estimate overall survival, disease-specific survival, and progression-free survival among high grade endometrial carcinoma cases and to determine factors impacting survival for non-Hispanic white and non-Hispanic black women.

Methods: We identified high grade endometrial carcinoma cases among non-Hispanic white and non-Hispanic black women from ongoing institutional studies, and determined eligibility through medical record and pathologic review. We estimated effects of demographic and clinical variables on survival outcomes using Kaplan Meier methods and Cox proportional hazards modelling. Read More

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Surgical management of congenital lobar emphysema associated with CHD.

Cardiol Young 2021 May 14:1-3. Epub 2021 May 14.

Department of Cardiovascular Surgery, Hyogo Prefectural Kobe Children's Hospital, 1-6-7, Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo650-0047, Japan.

Congenital lobar emphysema is often associated with CHD in early infancy; however, the surgical strategy for this condition is still controversial. We report three successful cases of emphysematous lung lobectomy before the surgical repair of associated CHD. Aggressive lobectomy preceding cardiac interventions is advised when the management of congenital lobar emphysema is difficult. Read More

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