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Mat pilates method improve postural alignment women undergoing hormone therapy adjunct to breast cancer treatment. Clinical trial.

Complement Ther Clin Pract 2021 Jun 1;44:101424. Epub 2021 Jun 1.

Department of Physical Education at the Center for Health Sciences and Sports and Professor Postgraduate Program in Human Movement Sciences, Santa Catarina State University, Brazil.

The purpose of the study is to analyze the effects of a mat Pilates intervention on the postural alignment and balance of breast cancer women receiving hormone therapy. A two-arm randomized clinical trial included 34 breast cancer survivors divided randomly between a mat Pilates group (n = 18), that performed 16 weeks of mat Pilates exercises, and a control group (n = 16), who were invited to maintain their daily routine activities and received three educational sessions. Data collection occurred at baseline and at post-intervention time. Read More

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Are muscle parameters obtained by computed tomography associated with outcome after esophagectomy for cancer?

Clin Nutr 2021 May 1;40(6):3729-3740. Epub 2021 May 1.

Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Background & Aims: Esophageal cancer patients often suffer from cancer-related malnutrition and, as a result, sarcopenia. Whether sarcopenia worsens the outcome after esophagectomy is unclear. Inconsistent study results are partly caused by varying cut-off values used for defining sarcopenia. Read More

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The effectiveness of digital self-management interventions on health outcomes among childhood cancer survivors: A systematic review and meta-analysis.

J Adv Nurs 2021 Jun 15. Epub 2021 Jun 15.

College of Nursing, Research Institute of Nursing Science, Jeonbuk National University, Jeonju, South Korea.

Aims: The study aimed to review the evidence about existing digital interventions for childhood cancer survivors and examine their effectiveness on health outcomes.

Design: Systematic review and meta-analysis.

Data Sources: PUBMED, EMBASE, Cochrane, CINAHL, Web of Science, PsycArticles, SCOPUS and PQDT Global databases were searched, and the date last searched was 16 September 2019. Read More

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Efficacy of continuous positive airway pressure in neonates with respiratory distress syndrome: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26406

Department of Pediatrics, The First People's Hospital of Jiangxia District.

Background: Respiratory distress syndrome (RDS) is a condition caused by a deficiency in pulmonary surfactant. Many interventions, including pulmonary surfactant, non-invasive respiratory support, and other supportive treatments have been used to prevent RDS. However, recent studies have focused on the continuous positive airway pressure as a significant potential agent for preventing RDS. Read More

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Toujie Quwen granule used with conventional western therapy for coronavirus disease 2019: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26370

Academician Workstation, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.

Background: Coronavirus disease 2019 (COVID-19) is an epidemic infectious disease resulted from 2019 novel coronavirus (2019-nCoV). Up till now, COVID-19 has swept globally. Currently, due to many high-profiled benefits, clinical studies on Toujie Quwen granule (TJQW) have been increasing. Read More

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Joint effects of children's emotional problems and parental depressive symptoms on the occurrence of internet gaming disorder among children and adolescents: A longitudinal study.

J Behav Addict 2021 Jun 15. Epub 2021 Jun 15.

6Department of Biostatistics, Clinical Research Coordinating Center, The Catholic University of Korea, Seoul, Korea.

Background And Aims: Parental depressive symptoms may aggravate the effects of children's emotional problems on risks for Internet gaming disorder (IGD). Here we examined the joint effects of children's emotional problems and parents' depressive symptoms on the incidence of IGD.

Methods: A large prospective, population-based cohort tested potential interactions between children's emotional problems, parents' depressive symptoms, and incidence of high risk of IGD (HRIGD). Read More

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Myocardial strain and left ventricular geometry: a meta- echocardiographic studies in systemic hypertension.

J Hypertens 2021 Jun 14. Epub 2021 Jun 14.

University Hospital 'Dr Dragisa Misovic - Dedinje' Department of Cardiology, Belgrade, Serbia Department of Clinical Sciences and Community Health, University of Milano and Fondazione Ospedale Maggiore IRCCS Policlinico di Milano Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.

Aim: Evidence on systolic dysfunction, as assessed by left ventricular (LV) mechanics, in hypertensive heart disease phenotyped by abnormal LV geometric patterns is still limited. Thus, we performed a systematic meta-analysis of 2D/3D speckle-tracking studies in order to provide an updated comprehensive information on this topic.

Methods: The PubMed, OVID-MEDLINE, and Cochrane library databases were analyzed to search for articles published from the inception up to 31 January 2021. Read More

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Associations of circulating mediators of inflammation, cell regulation and immune response with esophageal squamous cell carcinoma.

J Cancer Res Clin Oncol 2021 Jun 14. Epub 2021 Jun 14.

Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.

Background: Esophageal squamous cell carcinoma (ESCC) is the most common histologic subtype of esophageal cancer globally. The development of squamous cell carcinoma has important inflammatory influences and effects. We, therefore, examined circulating levels of inflammation- and immune-related proteins for associations with ESCC. Read More

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Statistical and sequence learning lead to persistent memory in children after a one-year offline period.

Sci Rep 2021 Jun 14;11(1):12418. Epub 2021 Jun 14.

Institute of Psychology, ELTE Eötvös Loránd University, Izabella utca 46, 1064, Budapest, Hungary.

Extraction of environmental patterns underlies human learning throughout the lifespan and plays a crucial role not only in cognitive but also perceptual, motor, and social skills. At least two types of regularities contribute to acquiring skills: (1) statistical, probability-based regularities, and (2) serial order-based regularities. Memory performance of probability-based and/or serial order-based regularities over short periods (from minutes to weeks) has been widely investigated across the lifespan. Read More

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Functional Threshold Power as an Alternative to Lactate Thresholds in Road Cycling.

J Strength Cond Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Physiatry and Nursery, Section of Physical Education and Sports, Faculty of Health and Sport Sciences, University of Zaragoza, Huesca, Spain; and National Institute of Physical Education of Catalonia (INEFC), University of Lleida (UdL), Lleida, Spain.

Abstract: Sitko, S, Cirer-Sastre, R, Corbi, F, and López-Laval, I. Functional threshold power as an alternative to lactate thresholds in road cycling. J Strength Cond Res XX(X): 000-000, 2021-This study assessed the relationship between functional threshold power (FTP) and 7 lactate landmarks (Dmax, modified Dmax, fixed blood lactate concentrations of 2 and 4 mmol·L-1, lactate increases of 1 and 2 mmol·L-1 above baseline, and lactate increases of 1. Read More

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Diet Quality as Measured by the Healthy Eating Index 2015 and Oral and Pharyngeal Cancer Risk.

J Acad Nutr Diet 2021 Jun 11. Epub 2021 Jun 11.

Background: Alcohol and tobacco are the major risk factors for oral and pharyngeal cancer, but diet is likely to have a role, too.

Objective: The objective was to analyze the relationship between adherence to the 2015-2020 Dietary Guidelines for Americans (DGA), as measured by the Healthy Eating Index 2015 (HEI-2015), and oral and pharyngeal cancer risk. Moreover, this work aimed to quantify the number of avoidable cases under different scenarios of increased adherence to the DGA, with the use of the potential impact fraction. Read More

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Flapped versus flapless alveolar ridge preservation: a systematic review and meta-analysis.

Int J Oral Maxillofac Surg 2021 Jun 11. Epub 2021 Jun 11.

Ras Al-Khaimah Dental Center, Ministry of Health and Prevention, United Arab Emirates.

Alveolar ridge preservation (ARP) procedures can limit bone changes following tooth extraction. Flapped and flapless surgical approaches have been used for ARP; however, there is a lack of strong scientific evidence regarding their specific influences on the clinical outcomes of ARP. The aim of this systematic review and meta-analysis was to evaluate the effects of flapped and flapless surgical approaches on the dimensional changes of hard and soft tissues and patient-reported outcomes following ARP. Read More

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A new approach for interpretability and reliability in clinical risk prediction: Acute coronary syndrome scenario.

Artif Intell Med 2021 Jul 13;117:102113. Epub 2021 May 13.

Cardiology Department, Leiria Hospital Centre, Leiria, Portugal. Electronic address:

Introduction: The risk prediction of the occurrence of a clinical event is often based on conventional statistical procedures, through the implementation of risk score models. Recently, approaches based on more complex machine learning (ML) methods have been developed. Despite the latter usually have a better predictive performance, they obtain little approval from the physicians, as they lack interpretability and, therefore, clinical confidence. Read More

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Socioeconomic Status and Rurality Among Patients With Head and Neck Cancer.

Otolaryngol Head Neck Surg 2021 Jun 15:1945998211019278. Epub 2021 Jun 15.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Southern Illinois University, Springfield, Illinois, USA.

Objective: Describe the relationship among rurality, socioeconomic status (SES), and patient/tumor characteristics in patients presenting with head and neck cancer.

Study Design: Retrospective single-institution study.

Setting: Academic tertiary-level medical center. Read More

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Intravesical gemcitabine for non-muscle invasive bladder cancer.

Cochrane Database Syst Rev 2021 Jun 14;6:CD009294. Epub 2021 Jun 14.

Urology Section, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.

Background: It remains unclear whether people with non-muscle invasive bladder cancer (NMIBC) benefit from intravesical gemcitabine compared to other agents in the primary or recurrent setting following transurethral resection of a bladder tumor. This is an update of a Cochrane Review first published in 2012. Since that time, several randomized controlled trials (RCTs) have been reported, making this update relevant. Read More

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Accuracy of registration techniques and vascular imaging modalities in fusion imaging for aortic endovascular interventions: a phantom study.

CVIR Endovasc 2021 Jun 14;4(1):51. Epub 2021 Jun 14.

Department for Radiology and Neuroradiology, Sana Hospital, Lübeck, Germany.

Background: This study aimed to assess the error of different registration techniques and imaging modalities for fusion imaging of the aorta in a standardized setting using a anthropomorphic body phantom.

Materials And Methods: A phantom with the 3D printed vasculature of a patient suffering from an infrarenal aortic aneurysm was constructed. Pulsatile flow was generated via an external pump. Read More

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[Contact endoscopy with narrow-band imaging for detection of perpendicular vascular changes in benign, dysplastic, and malignant lesions of the vocal folds].

HNO 2021 Jun 14. Epub 2021 Jun 14.

Universitätsklinik für Hals‑, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Medizinische Fakultät, Otto-von-Guericke-Universität, Leipziger Straße 44, 39120, Magdeburg, Deutschland.

Background: Perpendicular vascular changes (PVC) are markers of tumor-induced neoangiogenesis at the vocal folds. Contact endoscopy with narrow-band imaging (CE-NBI) allows a detailed analysis of such vascular changes.

Objective: This work intends to evaluate the potential of CE-NBI for diagnosis of benign, dysplastic, and malignant lesions of the vocal folds. Read More

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Nicotine Patch Prescription Fulfillment Rates for Emergency Department Patients.

West J Emerg Med 2021 May 14;22(3):648-652. Epub 2021 May 14.

Case Western Reserve University, Department of Emergency Medicine, Cleveland, Ohio.

Introduction: Smoking cessation has significant health benefits, and the emergency department (ED) can be an important venue for smoking cessation counseling. Nicotine replacement therapy with transdermal patches has been shown to be associated with smoking cessation in a variety of studies. This study evaluated fulfillment rates for prescriptions for nicotine replacement transdermal patches (NRT-P) from the ED. Read More

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Evaluation of preoperative ultrasonographic parameters to predict renal recovery in long-term survivors after treatment of feline ureteral obstructions: 2012-2019.

J Feline Med Surg 2021 Jun 14:1098612X211023645. Epub 2021 Jun 14.

Lamb Statistical Consulting, West Saint Paul, MN, USA.

Objectives: The aim of this study was to determine whether preoperative ultrasound imaging characteristic(s) in cats suffering from unilateral benign ureteral obstructions are predictive of outcome after successful renal decompression with a subcutaneous ureteral bypass (SUB) device.

Methods: This was a retrospective study of 37 cats with unilateral, benign ureteral obstruction. Preoperative imaging characteristics (including renal pelvis diameter, parenchymal thickness [transverse plane], renal length and pelvic size:overall renal size) and biochemical data were evaluated for all cats diagnosed with a unilateral ureteral obstruction treated with a SUB device. Read More

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Assessment of Psychological Distress in Health-care Workers during and after the First Wave of COVID-19: A Canadian Longitudinal Study: Évaluation de la Détresse Psychologique Chez Les Travailleurs de la Santé Durant et Après la Première Vague de la COVID-19: une étude longitudinale canadienne.

Can J Psychiatry 2021 Jun 14:7067437211025217. Epub 2021 Jun 14.

Centre de recherche de 26612l'Institut universitaire en santé mentale de Montréal (CR-IUSMM), Québec, Canada.

Objectives: Health-care workers (HCW) exposed to COVID-19 are at risk of experiencing psychological distress. Although several cross-sectional studies have been carried out, a longitudinal perspective is needed to better understand the evolution of psychological distress indicators within this population. The objectives of this study were to assess the evolution of psychological distress and to identify psychological distress trajectories of Canadian HCW during and after the first wave of COVID-19. Read More

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Nationwide Subjective and Objective Assessments of Potential Talent Predictors in Elite Youth Soccer: An Investigation of Prognostic Validity in a Prospective Study.

Front Sports Act Living 2021 28;3:638227. Epub 2021 May 28.

Institute of Sports Science, Eberhard Karls University of Tübingen, Tübingen, Germany.

Recent studies have provided empirical evidence on the prognostic relevance of objective performance diagnostics in the soccer talent identification and development process. However, little is known about the prognostic validity of coaches' subjective evaluations of performance. This study evaluated objective and subjective assessments within a nationwide talent development program and addressed motor, perceptual skill, and personality-related performance factors. Read More

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Supplementation of Diets With Influences Immune and Gut Function in Dogs.

Front Nutr 2021 28;8:667072. Epub 2021 May 28.

Nestlé Purina Research, One Checkerboard Square, St. Louis, MO, United States.

refers to two species of blue green algae (, and ) consumed by humans as food for centuries. While, has been shown to have immune enhancing properties in several animal and human studies, there are no systematic studies in dogs. The aim of this study was to evaluate the immunomodulatory effect of dietary supplementation with in dogs. Read More

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Management of a Chronic Skin Disease in Primary Care: An Analysis of Early-Career General Practitioners' Consultations Involving Psoriasis.

Dermatol Pract Concept 2021 May 20;11(3):e2021055. Epub 2021 May 20.

The University of Newcastle, School of Medicine and Public Health, Callaghan, NSW, Australia.

Background: The management of psoriasis by general practitioners (GPs) is vital, given its prevalence, chronicity, and associated physical and psychosocial co-morbidities. However, there is little information on how GPs (including early-career GPs) manage psoriasis.

Objectives: This study assessed the frequency with which Australian specialist GP vocational trainees ('registrars') provide psoriasis care and the associations of that clinical experience. Read More

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The effect of morning versus evening administration of empagliflozin on its pharmacokinetics and pharmacodynamics characteristics in healthy adults: a two-way crossover, non-randomised trial.

F1000Res 2021 26;10:321. Epub 2021 Apr 26.

Clinical Pharmacy Department, Faculty of Pharmacy, AinShms University, Cairo, 11566, Egypt.

: Empagliflozin is an SGLT2 inhibitor approved for use in patients with diabetes mellitus type 2 (DMT2) with or without other cardiovascular disease. Empagliflozin is taken once daily without rationale on the optimal timing for administration. This study aimed to determine the chronopharmacological effects of morning vs evening administration of empagliflozin (10 mg) in healthy Egyptian adults, by investigating the pharmacokinetics and pharmacodynamics parameters of empagliflozin depending on the intake time. Read More

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Proximal Fibular Osteotomy: Is it Really an Option for Medial Compartmental Osteoarthritis Knee? Our Experience at Tertiary Centre.

Indian J Orthop 2021 May 28;55(Suppl 1):228-233. Epub 2020 Oct 28.

Department of Orthopaedic Surgery, Jawahar Lal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002 India.

Introduction: The medial compartment is commonly involved in age-related osteoarthritis knee because weight-bearing axis passes close to the medial condyle and its large surface area. Various treatments have been proposed ranging from conservative to total knee arthroplasty which is an expensive and complex treatment. Recently, proximal fibular osteotomy (PFO) for medial compartment knee osteoarthritis became popular as a treatment modality. Read More

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Normal and reconstituted high-density lipoprotein protects differentiated monocytes from oxidized low-density lipoprotein-induced apoptosis.

ARYA Atheroscler 2020 Nov;16(6):269-277

Professor, Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: The progression of atherosclerosis is an ongoing struggle between cell division and cell death. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a novel receptor for oxidized low-density lipoprotein (ox-LDL), mediates ox-LDL-induced apoptosis of monocytes. The anti-atherogenic function of plasma high-density lipoprotein (HDL) includes the ability to inhibit apoptosis of macrophage, although the exact mechanism and consequences of apoptosis in the development and progression of this disease are still controversial. Read More

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November 2020

Association of Angiotensin-Converting Enzyme gene polymorphism in Pakistani women with the atypical steroidogenesis in Polycystic ovarian syndrome: A case-control study.

Saudi J Biol Sci 2021 Jun 14;28(6):3483-3489. Epub 2021 Mar 14.

Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.

Background: Polymorphism in the angiotensin-converting enzyme gene (ACE) is responsible for elevated ACE concentrations in plasma. High ACE levels induce insulin resistance and hyperandrogenism, which are the main attributes of polycystic ovary syndrome (PCOS). Therefore, it was hypothesized that I/D polymorphism plays a role in the pathogenesis of PCOS. Read More

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Hepatic Steatosis Has No Effect in Diagnosis Accuracy of LI-RADS v2018 Categorization of Hepatocellular Carcinoma in MR Imaging.

J Magn Reson Imaging 2021 Jun 13. Epub 2021 Jun 13.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Background: In clinical practice, hepatocellular carcinoma (HCC) is widely diagnosed by using MRI, however, whether the imaging features are affected by hepatic steatosis (HS) is still unknown.

Purpose: To investigate and compare the differences in HCC related imaging features between with- and without-HS groups, and to further determine whether HS affects the diagnosis accuracy of Liver Imaging Reporting and Data System (LI-RADS) v2018 of HCC in MRI.

Study Type: Prospective. Read More

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Feasibility of Velocity-Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast-Enhanced Perfusion Imaging.

J Magn Reson Imaging 2021 Jun 13. Epub 2021 Jun 13.

C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.

Background: Dynamic contrast-enhanced (DCE) MRI is the most sensitive method for detection of breast cancer. However, due to high costs and retention of intravenously injected gadolinium-based contrast agent, screening with DCE-MRI is only recommended for patients who are at high risk for developing breast cancer. Thus, a noncontrast-enhanced alternative to DCE is desirable. Read More

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Quantitative Evaluation of Upright Posture by x-Ray and 3D Stereophotogrammetry with a New Marker Set Protocol in Late Onset Pompe Disease.

J Neuromuscul Dis 2021 Jun 10. Epub 2021 Jun 10.

University of Campania "Luigi Vanvitelli", Department of Advanced Medical and Surgical Sciences, 2nd Division of Neurology, Center for Rare Diseases and Inter University Center for Research in Neurosciences, Naples, Italy.

Background: Late Onset Pompe Disease(LOPD) is a rare myopathy characterized by prevailing weakness of trunk and pelvic girdle muscles that causes motor disabilities. Spinal deformities have been reported unclearly on clinical examination. No study quantitatively assessed upright posture defining specific alterations of LOPD various phenotype. Read More

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