11,523 results match your criteria assessed nasal

Anterior chamber angle features in primary congenital glaucoma infants using hand-held anterior segment-oct.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Faculty of Medicine, Ophthalmology department, Cairo University, Cairo, Egypt.

Purpose: To describe anterior chamber angle (ACA) structures and parameters in primary congenital glaucoma (PCG) and normal infant eyes, using Hand-held anterior segment optical coherence tomography (HH AS-OCT), as an in-office, non-contact technique.

Methods: Normal and PCG-infants <24 months were examined, using HH AS-OCT (RTVue RT- 100, Optovue Inc., Fremont, CA). Read More

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A blood RNA transcriptome signature for COVID-19.

BMC Med Genomics 2021 Jun 11;14(1):155. Epub 2021 Jun 11.

Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore.

Background: COVID-19 is a respiratory viral infection with unique features including a more chronic course and systemic disease manifestations including multiple organ involvement; and there are differences in disease severity between ethnic groups. The immunological basis for disease has not been fully characterised. Analysis of whole-blood RNA expression may provide valuable information on disease pathogenesis. Read More

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Phosphodiesterase-5 inhibitors in Pregnancy: Systematic review and meta-analysis of maternal and perinatal safety and clinical outcomes.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Mater Research Institute - University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia; Faculty of Medicine, University of Medicine, Whitty Building, Annerley Road, South Brisbane, Queensland 4101, Australia; NHMRC Stillbirth Centre For Research Excellence, Mater Research Institute, South Brisbane, Queensland 4101, Australia. Electronic address:

Objective: Phosphodiesterase-5 inhibitors have recently been used for the treatment of severe early onset pre-eclampsia and fetal growth restriction. There are however concerns that they may increase the risk of neonatal morbidity and mortality. The aim of this systematic review was to assess the safety profile and clinical outcomes of phosphodiesterase-5 inhibitors use in pregnancy. Read More

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Patient characteristics, biomarkers, and exacerbation risk in severe, uncontrolled asthma.

Eur Respir J 2021 Jun 10. Epub 2021 Jun 10.

AstraZeneca, Gaithersburg, Maryland.

Background: Greater precision in asthma exacerbation risk prediction may improve outcomes. We sought to identify clinical characteristics and biomarkers associated with elevated exacerbation risk in patients with severe, uncontrolled asthma.

Methods: Data were pooled from seven similarly designed Phase II and III randomized controlled clinical trials of biologic therapies for the treatment of severe, uncontrolled asthma that enrolled comparable patient populations. Read More

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Comparison of high-flow nasal oxygen cannula therapy versus a standard oxygen face mask in patients with hypostatic pneumonia.

J Int Med Res 2021 Jun;49(6):3000605211022279

Department of Respiratory and Critical Care Medicine, Harrison International Peace Hospital Affiliated to Hebei Medical University, Hengshui, China.

Objective: We assessed the clinical effects of high-flow nasal cannula (HFNC) oxygen therapy and a standard oxygen atomizer mask on the respiratory tract in patients with hypostatic pneumonia.

Methods: We included patients with hypostatic pneumonia in this retrospective cohort study. Patients were provided continuous airway humidification by continuous oxygen atomization using either an HFNC or standard oxygen mask. Read More

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Low level SARS-CoV-2 RNA detected in plasma samples from a cohort of Nigerians: Implications for blood transfusion.

PLoS One 2021 10;16(6):e0252611. Epub 2021 Jun 10.

Centre for Human Virology and Genomics, Microbiology Department, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.

The present global pandemic triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has lingered for over a year in its devastating effects. Diagnosis of coronavirus disease 2019 (COVID-19) is currently established with a polymerase chain reaction (PCR) test by means of oropharyngeal-, nasopharyngeal-, anal-swabs, sputum and blood plasma. However, oral and nasal swabs are more commonly used. Read More

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Efficacy of high-flow nasal cannula therapy in bedridden patients.

Pediatr Int 2021 Jun 9. Epub 2021 Jun 9.

Shiga General Hospital, Moriyama, Japan.

Background: A growing number of studies have demonstrated the efficacy of high-flow nasal cannula therapy (HFNC) for treating children with acute respiratory distress. However, it remains unknown whether HFNC is effective in bedridden patients with acute respiratory distress.

Method: We retrospectively reviewed the medical records of bedridden patients with acute respiratory distress that were treated with HFNC using a home ventilator in continuous positive airway pressure (CPAP) mode at our center between March 2014 and August 2016. Read More

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A Randomized, Controlled Trial of Notched Music Therapy for Tinnitus Patients.

J Int Adv Otol 2021 May;17(3):221-227

Division of Otology Neurotology Audiology and Balance, Department of Otorhinolaryngology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Objective: To compare the tinnitus treatment outcomes of tailor-made notched music therapy and ordinary music.

Methods: A double-blind, randomized, controlled trial was conducted on 104 Thai patients with chronic subjective tinnitus. Tinnitus matching was done on all subjects before they were randomly allocated to one of 2 groups: a treatment group (listening to tailor-made notched music) and a control group (listening to ordinary music). Read More

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The Diagnostic Yield of Excisional Biopsy in Cervical Lymphadenopathy: A Retrospective Analysis of 158 Biopsies in Adults.

Ear Nose Throat J 2021 Jun 7:1455613211023009. Epub 2021 Jun 7.

Department of Otorhinolaryngology, 14903Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Objectives: Cervical lymph nodes are the most common site of peripheral lymphadenopathy. The underlying etiologies are usually benign and self-limiting but may include malignancies or other severe life-threatening diseases. The aim of the current study was to investigate the various underlying pathologies of cervical lymphadenopathy as assessed by the diagnostic yield of excisional lymph node biopsies of the neck in a tertiary adult practice. Read More

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-Related Frontonasal Dysplasias: Clinical Characteristics and Surgical Management.

Cleft Palate Craniofac J 2021 Jun 8:10556656211019621. Epub 2021 Jun 8.

37515Hacettepe University Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Ankara, Turkey.

Aim: The term frontonasal dysplasia (FND) represents a spectrum of anomalies and its genetics have not been well defined. Recently, the critical role of the aristaless-like homeobox () gene family on the craniofacial development has been discovered. In the present study, we aimed to propose a systematic surgical treatment plan for the -related FNDs according to the genotypic classification as well as demonstrating their clinical characteristics to help surgeons diagnose the underlying pathology accurately. Read More

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Evaluation of postoperative visual function based on the preoperative inner layer structure in the epiretinal membrane.

Graefes Arch Clin Exp Ophthalmol 2021 Jun 7. Epub 2021 Jun 7.

Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 951-8510, Japan.

Purpose: To evaluate the postoperative visual function using a preoperative epiretinal membrane (ERM) classification based on the status of the inner layer structure.

Methods: We assessed 62 eyes, one from each patient undergoing vitrectomy with internal limiting membrane (ILM) peeling for unilateral ERM. The inclusion criteria were as follows: (1) the presence of idiopathic ERM based on optical coherence tomography and a healthy contralateral eye, (2) successful surgery after 25- or 27-gauge transconjunctival 3-port pars plana vitrectomy with ILM peeling, and (3) a minimum follow-up period of 12 months. Read More

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Emergency medicine: magnesium sulphate injections and their pharmaceutical quality concerns.

Heliyon 2021 May 22;7(5):e07099. Epub 2021 May 22.

Department of Pharmaceutical Science, North Carolina Central University, Durham, NC, 27707, USA.

Objectives: World Health Organization has recognized magnesium sulphate as the drug of choice for prevention and treatment of fits associated with preeclampsia and eclampsia which are amongst the leading causes of maternal morbidity and mortality. In this study, the pharmaceutical quality of magnesium sulphate injections marketed in Anambra state was assessed.

Methods: Ninety samples of magnesium sulphate obtained from the 3 senatorial zones in Anambra state were subjected to identification tests, microbiological analysis consisting of Growth promotion test, sterility and endotoxin test. Read More

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Automatic Facial Recognition of Williams-Beuren Syndrome Based on Deep Convolutional Neural Networks.

Front Pediatr 2021 19;9:648255. Epub 2021 May 19.

Department of Pediatric Cardiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, China.

Williams-Beuren syndrome (WBS) is a rare genetic syndrome with a characteristic "elfin" facial gestalt. The "elfin" facial characteristics include a broad forehead, periorbital puffiness, flat nasal bridge, short upturned nose, wide mouth, thick lips, and pointed chin. Recently, deep convolutional neural networks (CNNs) have been successfully applied to facial recognition for diagnosing genetic syndromes. Read More

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Safety and efficacy of high flow nasal cannula therapy in acute hypercapnic respiratory failure - a retrospective audit.

Intern Med J 2021 Jun 6. Epub 2021 Jun 6.

Department of Thoracic Medicine, The Prince Charles Hospital, Chermside, Queensland, Australia.

Background: While the role of high flow nasal cannulae (HFNC) in the management of respiratory failure continues to expand, few studies describe its use in acute hypercapnic respiratory failure.

Aims: In this retrospective study we assessed the safety and efficacy of HFNC for treatment of acute hypercapnic respiratory failure.

Methods: Admissions with acute hypercapnic respiratory failure to a thoracic medicine unit at a tertiary centre between January and August 2018 were included if treated with either HFNC or non-invasive ventilation (NIV). Read More

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Observational study investigating Ectoin Rhinitis Nasal Spray as natural treatment option of acute rhinosinusitis compared to treatment with Xylometazoline.

Eur Arch Otorhinolaryngol 2021 Jun 4. Epub 2021 Jun 4.

, Hermann-Ehlers-Weg 4, 25337, Elmshorn, Germany.

Introduction: Symptomatic relief of acute rhinosinusitis is commonly achieved with nasal decongestants. The current observational study investigated the efficacy and safety of treatment of acute rhinosinusitis with Ectoin Rhinitis Spray compared to or in combination with Xylometazoline-containing decongesting nasal spray.

Methods: Patients with acute rhinosinusitis applied either Ectoin Rhinitis Spray, Xylometazoline nasal spray or a combination of both products. Read More

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A network meta-analysis of psychosocial interventions for refugees and asylum seekers with PTSD.

BMJ Glob Health 2021 Jun;6(6)

Cochrane Global Mental Health and WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.

Introduction: Refugees and asylum seekers are vulnerable to common mental disorders, including post-traumatic stress disorder (PTSD). Using a network meta-analysis (NMA) approach, the present systematic review compared and ranked psychosocial interventions for the treatment of PTSD in adult refugees and asylum seekers.

Methods: Randomised studies of psychosocial interventions for adult refugees and asylum seekers with PTSD were systematically identified. Read More

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Wood Dust Exposure Levels and Respiratory Symptoms 6 Years Apart: An Observational Intervention Study Within the Danish Furniture Industry.

Ann Work Expo Health 2021 Jun 4. Epub 2021 Jun 4.

Department of Public Health, Section of Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Bartholins Alle, Aarhus C, Denmark.

Objectives: Occupational exposure to wood dust can cause respiratory diseases, but few studies have evaluated the impact of declining exposure on health outcome. This study aimed to investigate whether a decline in wood dust exposure between two cross sectional studies performed in 1997-1998 and 2003-2004 was related to the prevalences of respiratory symptoms among woodworkers in a well-defined geographical area.

Methods: Two thousand and thirty-two woodworkers from 54 plants in study 1 and 1889 woodworkers from 52 plants in study 2 returned a questionnaire on respiratory diseases and symptoms, employment and smoking habits. Read More

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Non-invasive Oxygenation Strategies for Respiratory Failure with COVID-19: A concise narrative review of literature in pre and mid-COVID-19 era.

Anaesth Crit Care Pain Med 2021 Jun 1:100897. Epub 2021 Jun 1.

Intensive Care Unit, Jikei University Hospital, Tokyo, Japan. Electronic address:

The coronavirus disease 2019 (COVID-19) has spread globally and can cause a shortage of medical resources, in particular, mechanical ventilators. High-flow nasal cannula oxygen therapy (HFNC) and non-invasive positive pressure ventilation (NPPV) are frequently used for acute respiratory failure patients as alternatives to invasive mechanical ventilation. They are drawing attention because of a potential role to save mechanical ventilators. Read More

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Pharmacokinetic and pharmacodynamic evaluation of nasal liposome and nanoparticle based rivastigmine formulations in acute and chronic models of Alzheimer's disease.

Naunyn Schmiedebergs Arch Pharmacol 2021 Jun 4. Epub 2021 Jun 4.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

With the increasing aging population and progressive nature of the disease, Alzheimer's disease (AD) poses to be an oncoming epidemic with limited therapeutic strategies. It is characterized by memory loss, behavioral instability, impaired cognitive function, predominantly, cognitive inability manifested due to the accumulation of β-amyloid, with malfunctioned cholinergic system. Rivastigmine, a reversible dual cholinesterase inhibitor, is a more tolerable and widely used choice of drug for AD. Read More

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Speech Outcomes Following Orticochea Pharyngoplasty in Patients With History of Cleft Palate and Noncleft Velopharyngeal Dysfunction.

Cleft Palate Craniofac J 2021 Jun 4:10556656211010623. Epub 2021 Jun 4.

South Thames Cleft Service, Evelina London, 8945Guys and St Thomas' NHS Foundation Trust, Northern Ireland, United Kingdom.

Objective: To report speech outcomes following Orticochea pharyngoplasty in 43 patients with cleft palate and noncleft velopharyngeal dysfunction.

Design: A retrospective surgical audit of patients undergoing Orticochea pharyngoplasty between 2004 and 2012, with speech as a primary outcome measure.

Setting: Patients known to a regional UK cleft center. Read More

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Risk factors for adverse outcomes among 35 879 veterans with and without diabetes after diagnosis with COVID-19.

BMJ Open Diabetes Res Care 2021 06;9(1)

Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.

Introduction: Risk factors and mediators of associations of diabetes with COVID-19 outcomes are unclear.

Research Design And Methods: We identified all veterans receiving Department of Veterans Affairs healthcare with ≥1 positive nasal swab for SARS-CoV-2 (28 February-31 July 2020; n=35 879). We assessed associations of diabetes (with and without insulin use) with hospitalization, intensive care unit (ICU) admission, or death at 30 days, and with hazard of death until the censoring date. Read More

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Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons.

Neurobiol Dis 2021 May 31;156:105408. Epub 2021 May 31.

Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China. Electronic address:

Presbycusis contributes to cognitive decline and Alzheimer's disease. However, most research in this area involves clinical observations and statistical modeling, and few studies have examined the relationship between hearing loss and the molecular changes that lead to cognitive dysfunction. The present study investigated whether hearing loss contributes to dementia in the absence of aging and noise using a mouse model of severe bilateral hearing loss induced by kanamycin (1000 mg/kg) and furosemide (400 mg/kg). Read More

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Characteristics, Comorbidities, Complications, and Outcomes Among 802 Patients With Severe Acute Respiratory Syndrome Coronavirus 2 in a Community Hospital in Florida.

Crit Care Explor 2021 May 12;3(5):e0416. Epub 2021 May 12.

Division of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL.

Objectives: Coronavirus disease 2019 continues to increase throughout the United States. Despite the rapid progression of the disease, there is limited information of the factors associated with mortality in Florida. This study aims to review the demographics, characteristics, comorbidities, complications, and outcomes of hospitalized patients, and their association with mortality. Read More

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Hepatic lipid signatures of little brown bats (Myotis lucifugus) and big brown bats (Eptesicus fuscus) at early stages of white-nose syndrome.

Sci Rep 2021 Jun 2;11(1):11581. Epub 2021 Jun 2.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, 20057, USA.

White-nose syndrome (WNS) is an emergent wildlife fungal disease of cave-dwelling, hibernating bats that has led to unprecedented mortalities throughout North America. A primary factor in WNS-associated bat mortality includes increased arousals from torpor and premature fat depletion during winter months. Details of species and sex-specific changes in lipid metabolism during WNS are poorly understood and may play an important role in the pathophysiology of the disease. Read More

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The effect of high flow nasal oxygen therapy in intensive care units: A systematic review and meta-analysis.

Expert Rev Respir Med 2021 Jun 3. Epub 2021 Jun 3.

Zhujiang Hospital, Guangzhou, 510280 China.

Background: High flow nasal oxygen (HFNO) therapy has been widely used in intensive care units (ICU); however, its efficacy remains inconclusive. This systematic review and meta-analysis aimed to compare the efficacy of HFNO therapy with that of alternative noninvasive oxygen therapies such as conventional oxygen therapy (COT) and noninvasive ventilation (NIV) in ICU.

Methods: A Pubmed, Embase, Web of Science, Cochrane Library database search, which identified studies that assessed the outcomes of HFNO in adult ICU patients, was performed in March 2020. Read More

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Effectiveness of the Treatment of Rhinogenic Headache Caused by Intranasal Contact.

Ear Nose Throat J 2021 Jun 2:1455613211019706. Epub 2021 Jun 2.

Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Belgrade, Serbia.

Objectives: The aim of the study is to evaluate the effectiveness of the surgical and nonsurgical treatment of headache caused by contact points (CPs) between the nasal septum and inferior or middle turbinate.

Methods: The research was designed as a prospective clinical case-series study. The patients with CP headaches were offered to choose between 2 treatment options, surgery and medical treatment. Read More

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Free flap for soft palate reconstruction: long-term functional evaluation of a new technique.

Eur Arch Otorhinolaryngol 2021 Jun 2. Epub 2021 Jun 2.

Department of Otorhinolaryngology and Head and Neck Surgery, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, Service d'ORL, BH 10 CHUV, Avenue du Bugnon, 46-1011, Lausanne, Switzerland.

Purpose: The soft palate (SP) has a complex anatomy and physiology. Reconstruction after tumour resection is a challenge, and procedures that only restore bulk don't give good results. We aim to present a new technique for the in-setting and the functional outcomes. Read More

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Evaluation of oral fluids for surveillance of foodborne and zoonotic pathogens in pig farms.

J Vet Diagn Invest 2021 Jun 2:10406387211021599. Epub 2021 Jun 2.

Department of Farm Animals, Division of Swine Medicine, University of Zurich, Zurich, Switzerland.

The use of oral fluid (OF) to detect zoonotic pathogens in pigs has been only scarcely assessed. We evaluated OF as a potential specimen for detection by culture of methicillin-resistant (MRSA) and , and the detection of antibodies against spp. and hepatitis E virus (HEV) using commercial ELISAs. Read More

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Vocal Disorders in Patients with COVID 19 in Egypt.

Indian J Otolaryngol Head Neck Surg 2021 May 28:1-7. Epub 2021 May 28.

Phoniatrics Department, National Hearing and Speech Institute (HSI), General Organization for Teaching Hospitals and Institutes (GOTHI), Giza, Egypt.

COVID-19 is considered a respiratory disease which has many symptoms associated with the larynx and the lungs infections. COVID-19 has wide spectrum of clinical features starting from mild symptoms to severe illness. Otolaryngological symptoms as nasal obstruction, loss of smell, taste dysfunction, sore throat, sticky mucus, and dysphagia are common in COVID-19 patients. Read More

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