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Impact of Hearing Disability and Ear Discharge on Quality-of-Life in Patients with Chronic Otitis Media: Data from the Multinational Collaborative COMQ-12 Study.

Otol Neurotol 2021 Jul 28. Epub 2021 Jul 28.

Department of Otolaryngology, Norfolk & Norwich University Hospital Norwich Clinical Trials Unit, Norwich Medical School, University of East Anglia, Norwich Department of Otolaryngology, Ipswich Hospital, East Suffolk and North Essex Foundation Trust, Ipswich, UK Department of Otolaryngology - Head and Neck Surgery, Istanbul University, Istanbul, Turkey Department of Otolaryngology - Head and Neck Surgery, Yonsei University Wonju College of Medicine, Gangwon-do, South Korea Otolaryngology Unit, Department of Biomedical Sciences, Neuroscience and Sensory Organs, University of Bari "Aldo Moro," Bari, Italy Fundacion Santa Fe de Bogota, Universidad de Los Andes School of Medicine, Bogota, Colombia Department of Otolaryngology, Pitié-Salpêtrière Group Hospital, Paris, France Department of Otology and Skull Base Surgery, Eye and Ear Nose and Throat Hospital, Fudan University, Shanghai, China Department of Otolaryngology, Lariboisière University Hospital Department of Otolaryngology - Head and Neck Surgery, Necker-Enfants Malades Hospital, Paris, France Department of Otolaryngology - Head and Neck Surgery, University of Miyazaki, Miyazaki, Japan.

Objective: This study aimed to assess how two disease-related factors, hearing disability and ear discharge, affect health-related quality-of-life (HRQoL) in patients with chronic otitis media (COM).

Study Design: Multinational prospective cohort study.

Setting: Nine otology referral centers in eight countries. Read More

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Predicting Clinical Improvement for Patients with Low Back Pain: Keeping it Simple for Patients Seeking Physical Therapy Care.

Phys Ther 2021 Jul 28. Epub 2021 Jul 28.

Rehabilitation Services, Intermountain Healthcare, Salt Lake City, Utah.

Objective: Develop and validate an original prediction formula that estimated the probability of success for patients with LBP to achieve a minimal clinical important difference (MCID) on the Modified Low Back Disability Questionnaire (MDQ).

Methods: Patients were 10 to 90 years old in this retrospective cohort study. Data was extracted from Intermountain Healthcare's registry, Rehabilitation Outcomes Management System (ROMS): 62,858 patients admitted to physical therapy from 2002 to 2013 formed the training dataset and 15,128, patients admitted 2015 to 2016 formed the verification dataset. Read More

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Impact of orthognathic surgery on quality of life in patients with different dentofacial deformities: longitudinal study of the Oral Health Impact Profile (OHIP-14) with at least 1 year of follow-up.

Oral Maxillofac Surg 2021 Jul 29. Epub 2021 Jul 29.

Department of Oral and Maxillofacial Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Objective: The objective of this study was to assess the impact of orthognathic surgery for dental facial deformities on oral health-related quality of life (OHRQoL) in the immediate postoperative period up to at least 1 year after surgery.

Study Design: This prospective study evaluated data from 85 patients. OHRQoL was assessed using the Dutch version of the Oral Health Impact Profile questionnaire (OHIP-14NL) preoperatively (T), each day for 7 days postoperatively (T-T) and 4 weeks (T), 6 months (T), and at least 1 year (T) after surgery. Read More

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Prevalence of Common Mental Disorders among pregnant women-Evidence from population-based study in rural Haryana, India.

J Family Med Prim Care 2021 Jun 2;10(6):2319-2324. Epub 2021 Jul 2.

Centre for Community Medicine, AIIMS, New Delhi, India.

Background: Mental disorders during pregnancy is one of the major public health problem because of its effect on both mother and child.

Objectives: The objective of the study was to assess the burden of common mental disorders (CMDs) among pregnant women in rural Haryana, North India.

Methods: A community-based cross-sectional study was conducted in 28 villages of rural Haryana in 2016. Read More

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Evidence of slow and variable choice-stepping reaction time in cancer survivors with chemotherapy-induced peripheral neuropathy.

Gait Posture 2021 Jul 21;89:178-185. Epub 2021 Jul 21.

Prince of Wales Clinical School, University of New South Wales, Kensington, Australia; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is reported to affect up to 70 % of cancer survivors. Despite evidence that CIPN-related impairments often translate into balance and mobility deficits, the effects on stepping and quality of gait, well-documented risk factors for falls, are unclear.

Aims: (i) Establish choice-stepping reaction time (CSRT) performance in survivors with CIPN compared to young and older healthy controls and people with Parkinson's disease; (ii) document walking stability; (iii) investigate relationships between stepping and gait data to objective and patient-reported outcomes. Read More

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Immersive virtual reality enables technical skill acquisition for scrub nurses in complex revision total knee arthroplasty.

Arch Orthop Trauma Surg 2021 Jul 28. Epub 2021 Jul 28.

MSk Lab, Sir Michael Uren Biomedical Engineering Research Hub, Imperial College London, White City Campus, 86 Wood Lane, London, W12 0BZ, UK.

Introduction: Immersive Virtual Reality (iVR) is a novel technology which can enhance surgical training in a virtual environment without supervision. However, it is untested for the training to select, assemble and deliver instrumentation in orthopaedic surgery-typically performed by scrub nurses. This study investigates the impact of an iVR curriculum on this facet of the technically demanding revision total knee arthroplasty. Read More

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Validity and reliability of the simplified Chinese patient-reported outcomes version of the common terminology criteria for adverse events.

BMC Cancer 2021 Jul 27;21(1):860. Epub 2021 Jul 27.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.

Background: The psychometric properties of the simplified Chinese version of the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) have not been assessed. Therefore, we aimed to assess its validity, reliability, and responsiveness.

Patients And Methods: A Chinese version of the PRO-CTCAE and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (QLQ-C30) were distributed to 1580 patients from four cancer hospitals in China. Read More

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A different point of view: the evaluation of motor imagery perspectives in patients with sensorimotor impairments in a longitudinal study.

BMC Neurol 2021 Jul 27;21(1):297. Epub 2021 Jul 27.

Research Department, Reha Rheinfelden, Salinenstrasse 98, 4310, Rheinfelden, Switzerland.

Background: Motor imagery (MI) has been successfully applied in neurological rehabilitation. Little is known about the spontaneous selection of the MI perspectives in patients with sensorimotor impairments. What perspective is selected: internal (first-person view), or external (third-person view)? The aim was to evaluate the MI perspective preference in patients with sensorimotor impairments. Read More

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Patient-Reported Outcomes and Patient-Reported Experience of Patients With Atrial Fibrillation in the IMPACT-AF Clinical Trial.

J Am Heart Assoc 2021 Jul 28:e019783. Epub 2021 Jul 28.

Department of Health Research Methods, Evidence and Impact McMaster University Hamilton ON Canada.

Background The IMPACT-AF (Integrated Management Program Advancing Community Treatment of Atrial Fibrillation) trial is a prospective, randomized, cluster design trial comparing atrial fibrillation management with a computerized clinical decision support system with usual care (control) in the primary care setting of Nova Scotia, Canada. The objective of this analysis was to assess and compare patient-reported health-related quality of life and patient-reported experience with atrial fibrillation care between clinical decision support and control groups. Methods and Results Health-related quality of life was measured using the EuroQol 5-dimensional 5-level scale, whereas patient-reported experience was assessed using a self-administered satisfaction questionnaire, both assessed at baseline and 12 months. Read More

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The Prevalence of Depression, Anxiety and Associated Factors among the General Public during COVID-19 Pandemic: a Cross-sectional Study in Korea.

J Korean Med Sci 2021 Jul 26;36(29):e214. Epub 2021 Jul 26.

Department of Psychiatry, Dong-A University Hospital, Busan, Korea.

Background: Since its first case confirmed on January 20, 2020, Korea has been through three waves of the COVID-19 pandemic. Fears of the fourth wave persist as new cases continue to emerge. In such unpredictable times, the mental well-being of people is of crucial importance. Read More

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Defining successful non-invasive ventilation initiation: Data from a real-life cohort.

Respirology 2021 Jul 26. Epub 2021 Jul 26.

Institute for Research and Innovation in Biomedicine (IRIB), Normandie University, UNIRouen, Rouen, France.

Background And Objective: When home non-invasive ventilation (NIV) is initiated, five goals need to be achieved: a daily use >4 h/day, an improvement in gas exchange, health-related quality of life (HRQL) and sleep quality without side effects. Our aim was to assess how frequently these five goals were reached and the factors predictive of achievement.

Methods: We conducted a monocentric cohort study that included patients electively established on home NIV over 2 years. Read More

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Student and faculty perceptions of integrated therapeutics courses in a doctor of pharmacy program.

Curr Pharm Teach Learn 2021 Aug 22;13(8):905-913. Epub 2021 Jun 22.

Western New England University College of Pharmacy and Health Sciences, 1215 Wilbraham Road, Springfield, MA 01119, United States. Electronic address:

Introduction: There has been a movement in clinical education towards integrating foundational and applied course content. It remains unclear what best practices are for integration or how meaningful integration is for improving learning. We assessed the impact and perceptions of different degrees of integration in Integrated Pharmacy Care and Patient Management (IPC) courses. Read More

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Efficacy of a Smart Insulin Pen Cap for the Management of Patients with Uncontrolled Type 2 Diabetes: A Randomized Cross-Over Trial.

J Diabetes Sci Technol 2021 Jul 22:19322968211033837. Epub 2021 Jul 22.

Emory University School of Medicine, Division of Endocrinology and Diabetes, Grady Memorial Hospital, Atlanta, GA, USA.

Background: We studied a smart insulin pen cap that can be plugged to several brand of insulin pens, to track insulin administration via smart-phone Bluetooth technology, with alarm/reminder system aiming.

Methods: This pilot randomized, cross-over design study assessed the use of a smart insulin pen cap in improving adherence, glycemic control and patient satisfaction in insulin-treated patients with poorly controlled type 2 diabetes. Eighty patients on basal insulin ± oral agents with hemoglobin A1C (HbA1c) between 7. Read More

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The association of clinical and structural knee osteoarthritis with physical activity in the middle-aged population: The NEO study.

Osteoarthritis Cartilage 2021 Jul 23. Epub 2021 Jul 23.

Department of Rheumatology, Leiden University Medical Center, the Netherlands. Electronic address:

Objective: To investigate if knee osteoarthritis (OA) is associated with lower physical activity in the general middle-aged Dutch population, and if physical activity is associated with patient-reported outcomes in knee OA.

Design: Clinical knee OA was defined in the Netherlands Epidemiology of Obesity population using the ACR criteria, and structural knee OA on MRI. We assessed knee pain and function with the Knee Injury and Osteoarthritis Score (KOOS), health-related quality of life (HRQoL) with the Short Form-36, and physical activity (in Metabolic Equivalent of Task (MET) hours) with the Short Questionnaire to Assess Health-enhancing physical activity. Read More

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Sense of coherence, social support and religiosity as resources for medical personnel during the COVID-19 pandemic: A web-based survey among 4324 health care workers within the German Network University Medicine.

PLoS One 2021 26;16(7):e0255211. Epub 2021 Jul 26.

Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, University Hospital Bonn, Bonn, Germany.

Introduction: The COVID-19 pandemic resulted in severe detrimental effects on the mental well-being of health care workers (HCW). Consequently, there has been a need to identify health-promoting resources in order to mitigate the psychological impact of the pandemic on HCW.

Objective: Our objective was to investigate the association of sense of coherence (SOC), social support and religiosity with self-reported mental symptoms and increase of subjective burden during the COVID-19 pandemic in HCW. Read More

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Work and social functioning in frontline healthcare workers during the covid-19 pandemic in Italy: role of acute post-traumatic stress, depressive and anxiety symptoms.

Riv Psichiatr 2021 Jul-Aug;56(4):189-197

Department of Occupational Health, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

Background: Evidence highlights healthcare workers (HCWs) facing outbreaks, particularly the ongoing covid-19 pandemic, are at increased risk of negative mental health outcomes, particularly post-traumatic stress symptoms (PTSS), anxiety and depression. Data from previous outbreaks highlighted the risk for a negative impact on HCWs' social and occupational functioning, but scant data have investigated this issue in the framework of the covid-19 pandemic. A number of effective interventions have been proposed to support mental health and well-being of HCWs in emerging infectious outbreaks, but it is important to acknowledge the differential impact of mental disorders on different dimensions of functioning. Read More

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Actigraphy prior to MSLT: nighttime total sleep time predicts sleep onset latency.

J Clin Sleep Med 2021 Jul 26. Epub 2021 Jul 26.

VA Great Los Angeles Healthcare System, Geriatric Research, Education and Clinical Center, North Hills, CA.

Study Objectives: To evaluate the clinical utility of actigraphy as compared to sleep questionnaires prior to the Multiple Sleep Latency Test (MSLT) in a sleep disorders clinic population.

Methods: Twenty-eight clinically referred participants (mean age 42.3±18. Read More

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Outcomes of Tibialis Anterior Tendon Reconstruction with Autograft or Allograft.

Foot Ankle Int 2021 Jul 26:10711007211029956. Epub 2021 Jul 26.

Department of Orthopaedics, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.

Background: In cases of tibialis anterior tendon (TAT) ruptures associated with significant tendon defect, an interposition graft is often needed for reconstruction. Both auto- and allograft reconstructions have been described in the literature. Our hypothesis was that both graft types would have a good integrity and provide comparable outcomes. Read More

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Pilot Study on Reducing Symptoms of Anxiety with a Heart Rate Variability Biofeedback Wearable and Remote Stress Management Coach.

Appl Psychophysiol Biofeedback 2021 Jul 25. Epub 2021 Jul 25.

Saybrook University, Pasadena, USA.

We assessed the feasibility of using a consumer friendly, heart rate variability biofeedback (HRVB) wearable device in conjunction with a remote stress management coach to reduce symptoms of anxiety. We utilized a discreet, continuously wearable electrocardiogram device, the Lief Smart Patch, which measures and records heart rate and HRV in real time, and guides HRVB exercises using vibrations and visual cues. During the 8-week study, participants (N = 14) wore the Lief Smart Patch, participated in HRVB with the device, utilized the mobile app, and communicated with a remote stress management coach. Read More

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Health-Related Quality of Life and Its Influencing Factors in Patients with Hepatitis B: A Cross-Sectional Assessment in Southeastern China.

Can J Gastroenterol Hepatol 2021 7;2021:9937591. Epub 2021 Jul 7.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

Health-related quality of life (HRQoL) is an important aspect in the management of patients with hepatitis B (HB), which remains a serious health problem in China. There have been relatively few HRQoL studies involving Chinese patients with HB. The aim of this study was to analyze HRQoL in patients diagnosed with HB living in Zhejiang Province, China. Read More

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Evaluation of the effectiveness of delirium prevention care protocol for the patients with hip fracture: A randomised controlled study.

J Clin Nurs 2021 Jul 23. Epub 2021 Jul 23.

Geriatrics Department, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Aims And Objectives: This study aimed to investigate the effectiveness of a delirium prevention care protocol on pain, functional status, sleep quality and delirium prevention in patients with hip fractures.

Background: The development of delirium following hip fracture is common among older patients. According to the National Institute for Health and Care Excellence, 30% of delirium cases are preventable. Read More

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Factors Influencing Patient Compliance during Clear Aligner Therapy: A Retrospective Cohort Study.

J Clin Med 2021 Jul 14;10(14). Epub 2021 Jul 14.

Department of Oral Diagnostics, Digital Health and Health Services Research, Charité-Universitätsmedizin Berlin, Aßmannshauser Straße 4-6, 14197 Berlin, Germany.

Compliance is highly relevant during clear aligner therapy (CAT). In this retrospective cohort study, we assessed compliance and associated covariates in a large cohort of CAT patients. A comprehensive sample of 2644 patients (75. Read More

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COVID-19 Pandemic-Related Anxiety in Pregnant Women.

Int J Environ Res Public Health 2021 Jul 6;18(14). Epub 2021 Jul 6.

Department of Obstetrics and Gynecology, Institute of Mother and Child, Kasprzaka 17a, 01-211 Warsaw, Poland.

The COVID-19 pandemic outbreak influenced general and mental health worldwide. The objective of this study was to assess the anxiety level during the COVID-19 pandemic among pregnant women and compare it between COVID-infected and non-infected groups. We prospectively assessed the daily routine and anxiety level using a bespoke questionnaire and GAD-7 scale validated for pregnant women. Read More

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High prevalence of somatisation in ICD-11 complex PTSD: A cross sectional cohort study.

J Psychosom Res 2021 Jul 16;148:110574. Epub 2021 Jul 16.

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, UK.

Background: While research demonstrates that somatisation is highly correlated with post-traumatic stress disorder (PTSD), the relationship between International Classification of Diseases 11th edition (ICD-11) PTSD, complex PTSD (CPTSD) and somatisation has not previously been determined.

Objective: To determine the relationship between frequency and severity of somatisation and ICD-11 PTSD/CPTSD.

Method: This cross-sectional study included 222 individuals recruited to the National Centre for Mental Health (NCMH) PTSD cohort. Read More

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Naldemedine Improves Patient-Reported Outcomes of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain in the COMPOSE Phase 3 Studies.

J Pain Res 2021 16;14:2179-2189. Epub 2021 Jul 16.

Upstate Clinical Research Associates, Williamsville, NY, USA.

Objective: Opioid-induced constipation is among the most common side effects associated with opioid use in patients with chronic non-cancer pain, and it can have a significant negative impact on health-related quality of life (QOL). This analysis evaluated the effect of naldemedine 0.2 mg on patient-reported outcomes in three phase 3 clinical studies. Read More

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Combined transarterial embolization, and percutaneous sclerotherapy as treatment for refractory and non resectable aneurysmal bone cysts.

J Vasc Interv Radiol 2021 Jul 19. Epub 2021 Jul 19.

Clinic for Radiology, University Hospital Muenster, Muenster, Germany; Department of Radiology, University Hospital LMU Munich, Germany.

Purpose: To evaluate safety and effectiveness of combined transarterial embolization and percutaneous sclerotherapy in treatment for refractory and non-resectable aneurysmal bone cysts (ABCs) as assessed by imaging and clinical outcomes.

Materials And Methods: This retrospective single center study included n=16 consecutive patients (f=9, m=7; age: median 17 (6-25) years) undergoing combined transarterial embolization (using ethylene vinyl alcohol) and percutaneous sclerotherapy (ethanol-gel and polidocanol) for refractory and non-resectable ABCs. Median follow-up was 27. Read More

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Return to Work and Associated Costs after Treatment for Dupuytren's Disease.

Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

From the Departments of Plastic, Reconstructive, and Hand Surgery, Rehabilitation Medicine, Biostatistics, and Public Health, Erasmus University Medical Centre; the Hand and Wrist Centre, Xpert Clinic; and the Department of Plastic, Reconstructive and Hand Surgery, Amsterdam University Medical Center.

Background: Return to work is potentially an important factor in assessing the success of treatment. However, little is known about the return to work after treatment for Dupuytren's contracture. Therefore, the primary aim of this study was to assess return to work after limited fasciectomy and percutaneous needle fasciotomy. Read More

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Cross-cultural adaptation of the SWAL-QOL and the Sydney Swallow Questionnaire (SSQ) into French-Canadian and preliminary assessment for their use in an oculopharyngeal muscular dystrophy (OPMD) population.

Qual Life Res 2021 Jul 22. Epub 2021 Jul 22.

Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Québec, Canada.

Purpose: Patient-reported outcomes (PRO) assessing dysphagia are an essential component of clinical trials to consider how patients feel and function in response to treatments. The selected PRO needs to be translated in several languages using a systematic process ensuring its validity and equivalence for use in multicenter clinical trials. The main objectives were to translate the SWAL-QOL and the Sydney Swallow Questionnaire (SSQ) into French Canadian (SWAL-QOL-FC and SSQ-FC) and to assess their appropriateness for patients with oculopharyngeal muscular dystrophy (OPMD). Read More

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