1,131 results match your criteria assessed appreciated


Children living with long-term conditions illness: A meta-aggregation of parental experiences of partnership nursing.

J Clin Nurs 2021 Apr 7. Epub 2021 Apr 7.

School of Nursing, Midwifery and Public Health, University of Canberra, Bruce, ACT, Australia.

Aim: To explore how parents of children with long-term conditions experience partnership in paediatric and neonatal nursing care and to identify existing partnership barriers and facilitators.

Background: Parent-nurse partnership is fundamental to paediatric and neonatal nursing. Partnership is characterised by five attributes: parental participation, negotiation, mutual trust and respect, shared roles and decision-making, and communication. Read More

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Body Composition and Metabolic Assessment After Motor Complete Spinal Cord Injury: Development of a Clinically Relevant Equation to Estimate Body Fat.

Top Spinal Cord Inj Rehabil 2021 ;27(1):11-22

Spinal Cord Injury and Disorders Center, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia.

Obesity is at epidemic proportions in the population with spinal cord injury (SCI), and adipose tissue (AT) is the mediator of the metabolic syndrome. Obesity, however, has been poorly appreciated in SCI because of the lack of sensitivity that body mass index (BMI) conveys for obesity risk in SCI without measuring AT. The specific objectives were to compare measures of body composition assessment for body fat with the criterion standard 4-compartment (4C) model in persons with SCI, to develop a regression equation that can be utilized in the clinical setting to estimate fat mass (FM), and to determine cardiometabolic risk using surrogates of obesity in a current model of metabolic syndrome. Read More

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January 2021

Histopathological and Immune Prognostic Factors in Colo-Rectal Liver Metastases.

Cancers (Basel) 2021 Mar 3;13(5). Epub 2021 Mar 3.

Department of Immunology and Inflammation, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.

Prognostic studies are increasingly providing new tools to stratify colo-rectal liver metastasis patients into clinical subgroups, with remarkable implications in terms of clinical management and therapeutic choice. Here, the strengths and hurdles of current prognostic tools in colo-rectal liver metastasis are discussed. Alongside more classic histopathological parameters, which capture features related to the tumor component, such as tumor invasion, tumor growth pattern and regression score, we will discuss immune mediators, which are starting to be considered important features. Read More

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[Acceptability and satisfaction with pregnancy and newborn diagnostic assessment (PANDA) system providing prenatal care in Burkina Faso].

Pan Afr Med J 2020 21;37:361. Epub 2020 Dec 21.

Institut de Recherche en Sciences de la Santé (IRSS), Wemtenga, Ouagadougou, Burkina Faso.

Introduction: mobile health technologies are increasingly being used as innovative solutions to improve antenatal care in Primary Care Services (PCSs). This study assessed the acceptability and satisfaction with PANDA system used in PCSs in Burkina Faso.

Methods: we conducted a cross-sectional mixed-methods study of 35 users of PCSs and 35 health workers in the Koupela Health District, in the Central East region of Burkina Faso in September 2017. Read More

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December 2020

Carbon dioxide and bicarbonate accumulation in caiman erythrocytes during diving.

J Exp Biol 2021 Mar 26. Epub 2021 Mar 26.

Zoophysiology, Department of Biology, Aarhus University, Aarhus, Denmark.

The ability of crocodilian haemoglobins to bind HCO has been appreciated for more than half a century, but the functional implication of this is exceptional mechanism has not previously been assessed Therefore, the goal of the present study was to address the hypothesis that CO primarily binds to Hb, rather than being accumulated in plasma as in other vertebrates, during diving in caimans. Here, we demonstrate that CO primarily accumulates within the erythrocyte during diving and that most of the accumulated CO is bound to haemoglobin. Furthermore, we show that this HCO-binding is tightly associated with the progressive blood deoxygenation during diving, therefore, crocodilians differ from the classic vertebrate pattern, where HCO accumulates in the plasma upon excretion from the erythrocytes by the Cl-HCO-exchanger. Read More

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Beyond PPE: a mixed qualitative-quantitative study capturing the wider issues affecting doctors' well-being during the COVID-19 pandemic.

BMJ Open 2021 03 22;11(3):e050223. Epub 2021 Mar 22.

Neurology, West Suffolk NHS Foundation Trust, Bury Saint Edmunds, UK

The COVID-19 pandemic has brought unprecedented challenges to the medical workforce. This has put them at increased risk of burnout at a time when levels are already worryingly high in the profession, with recent studies consistently showing that around half of doctors meet the validated criteria for burnout.

Objectives: To understand the wider factors influencing and impacting upon hospital doctors' well-being during the COVID-19 pandemic in England. Read More

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Satisfaction and Acceptability of Telemonitored Home-Based Exercise in Patients With Intermittent Claudication: Pragmatic Observational Pilot Study.

JMIR Rehabil Assist Technol 2021 Mar 22;8(1):e18739. Epub 2021 Mar 22.

Department of Rehabilitation Sciences, Group Rehabilitation for Internal Disorders, KU Leuven, Leuven, Belgium.

Background: Current guidelines recommend supervised exercise training (SET) as a first-line treatment in patients with intermittent claudication (IC). SET has been shown to be more effective than home-based exercise therapy (HBET). However, the lack of available SET programs hampers broad SET implementation in clinical practice. Read More

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The role of neuraminidase 1 (NEU1) in cytokine release by primary mouse mesangial cells and disease outcomes in murine lupus nephritis.

Autoimmunity 2021 Mar 22:1-13. Epub 2021 Mar 22.

Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, USA.

The importance of altered glycosphingolipid (GSL) metabolism is increasingly gaining attention as a characteristic of multiple chronic kidney diseases. Previously, we reported elevated levels of GSLs and neuraminidase (NEU) enzyme activity/expression in the urine or kidney of lupus patients and lupus-prone mice, and demonstrated NEU activity mediates the production of cytokines by lupus-prone mouse primary mesangial cells. This mediation occurs in part through TLR4 and p38/ERK MAPK signalling in response to lipopolysaccharide (LPS) and lupus serum (LS). Read More

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Outcomes of Patellar Tendon Imbrication With Distal Femoral Extension Osteotomy for Treatment of Crouch Gait.

J Pediatr Orthop 2021 May-Jun 01;41(5):e356-e366

Motion Analysis Center, Shriners Hospitals for Children, Greenville, SC.

Background: Crouch gait is a frequent gait abnormality observed in children with cerebral palsy. Distal femoral extension osteotomy (DFEO) with the tightening of the extensor mechanism is a common treatment strategy to address the pathologic knee flexion contracture and patella alta. The goal of this study was to review the results of a patellar tendon imbrication (PTI) strategy to address quadriceps insufficiency in the setting of children undergoing DFEO. Read More

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Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis.

Br J Cancer 2021 Mar 15. Epub 2021 Mar 15.

Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Activation of mTORC1 plays a significant role in cancer development and progression. However, the metabolic mechanisms to sustain mTORC1 activation of cancer cells within stressed environments are still under-appreciated. We recently revealed high autophagy activity in tumour cells with mTORC1 hyper-activation. Read More

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Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer's disease.

Neurol Res 2021 Mar 10:1-12. Epub 2021 Mar 10.

Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX USA.

Background: The cerebellum's involvement in AD has been under-appreciated by historically labeling as a normal control in AD research.

Methods: We determined the involvement of the cerebellum in AD progression. Postmortem human and APPswe/PSEN1dE9 mice cerebellums were used to assess the cerebellar Purkinje cells (PC) by immunohistochemistry. Read More

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Strategies for fortified sustainable food: the case of watermelon-based candy.

J Food Sci Technol 2021 Mar 8;58(3):894-901. Epub 2020 Jul 8.

Department of Agricultural Sciences, Food and the Environment, University of Foggia, Via Napoli, 25, 71122 Foggia, Italy.

The aim of this research was to design a new product, in particular a watermelon-based jelly candy, without generating waste. The study was divided in two steps: (i) optimization of candy formulation in terms of amount of rind, pulp and juice; (ii) fortification of the jelly candy with different concentrations of orange by-products (albedo and flavedo flours). The fortified jelly samples were assessed for sensory quality and chemical properties, before and after digestion. Read More

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Exploring rehabilitation potential in older people living with frailty: a qualitative focus group study.

BMC Geriatr 2021 Mar 6;21(1):165. Epub 2021 Mar 6.

School of Medicine, University of Nottingham, Nottingham, UK.

Background: Rehabilitation interventions are frequently cited as key in supporting frail older people's recovery following periods of decompensation and acute ill-health. Clinicians are required to make decisions about a patient's potential to respond to rehabilitation. 'Rehabilitation potential' decisions can determine access to services. Read More

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Integration of a Virtual Dispensing Simulator "MyDispense" in an Experiential Education Program to Prepare Students for Community Introductory Pharmacy Practice Experience.

Pharmacy (Basel) 2021 Feb 27;9(1). Epub 2021 Feb 27.

University of Connecticut School of Pharmacy, Department of Pharmacy Practice, Storrs, CT 06269, USA.

Background: Technology is increasingly used to enhance pharmacy education. We sought to evaluate student learning and preparedness for community introductory pharmacy practice experiences (IPPEs) after implementation of "MyDispense" into experiential education.

Methods: Both first-year pharmacy students and assigned community IPPE preceptors were eligible. Read More

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February 2021

Effectiveness of face-to-face, blended and e-learning in teaching the application of local anaesthesia: a randomised study.

BMC Med Educ 2021 Feb 27;21(1):137. Epub 2021 Feb 27.

Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, D-52074, Aachen, Germany.

Background: Local anaesthesia plays a key role in many aspects of a dentist's work. The required skills to perform anaesthesia successfully are acquired at university. To take advantage of the possibilities for new teaching formats, a blended learning concept for the local anaesthesia course was developed. Read More

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February 2021

[Hematuria as the first sign of pelvic chondrosarcoma].

Acta Ortop Mex 2020 Sep-Oct;34(5):313-318

Servicio de Radiodiagnóstico. Hospital Universitario Sant Joan d' Alacant. Alicante, España.

Chondrosarcoma is a malignant tumor which often affects the pelvic ring and its symptomathology is non-specific and insidious. We display a case of a right iliopubic branch chondrosarcoma in a 62-year-old male whose first sing was a four-year history of sporadic macroscopic haematuria, related to efforts. After being studied by the Urology Department by cystoscopy and biopsy of bladder tumor, chondral cells were appreciated. Read More

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Patient Satisfaction With the Quality of Counseling Provided by Advanced Practice Nurses Specialized in Multiple Sclerosis: A Quantitative Analysis.

J Neurosci Nurs 2021 Apr;53(2):99-103

Abstract: BACKGROUND: The challenges in dealing with multiple sclerosis (MS) have increased considerably in recent years. In addition to neurologists, MS nurse specialists are key to the management of MS patients, but there is a lack of evidence regarding their quality of counseling. METHODS: The data collection took place between October 2018 and March 2019 in the outpatient clinic of a university hospital. Read More

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Reception of Dietary and Other Health-Related Lifestyle Advice to Address Non-communicable Diseases in a Primary Care Context: A Mixed-Method Study in Central Argentina.

Front Nutr 2021 27;8:622543. Epub 2021 Jan 27.

Center for Health Sciences Research, School of Medicine and Health Sciences, Universidad Adventista del Plata, Libertador San Martín, Argentina.

An effective way to address risk factors for non-communicable chronic diseases (NCD) and reduce healthcare costs is by using sound health-related advice (HRA) to promote healthy lifestyle habits. In Argentina, however, few studies have examined the context in which HRA is communicated and undertaken by patients at the primary care level. In this study, we assessed the reception of HRA using a mixed-method approach in a central area of Argentina. Read More

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January 2021

Improving Self-Reflection Assessment Practices: Comparative Judgment as an Alternative to Rubrics.

Teach Learn Med 2021 Feb 11:1-11. Epub 2021 Feb 11.

Skills Lab at the Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

Background: Medical practitioners' reflective skills are increasingly considered important and therefore included in the medical education curriculum. However, assessing students' reflective skills using rubrics does not appear to guarantee adequate inter-rater reliabilities. Recently, comparative judgment was introduced as a new method to evaluate performance assessments. Read More

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February 2021

The Quality of Emulsions with New Synthetized Lipids Stabilized by Xanthan Gum.

Biomolecules 2021 Feb 3;11(2). Epub 2021 Feb 3.

Department of Non-Food Product Quality and Safety, Cracow University of Economics, Rakowicka St. 27, 31-510 Cracow, Poland.

The study investigated the quality of emulsions containing rabbit fat modified with vegetable oil. The modification of the fat and introducing it as a fatty base into the emulsion was dictated by consumer preferences. Emulsion systems containing various fatty bases and viscosity modifier contents were evaluated in the terms of their stability (by means of Turbiscan test), texture properties, color, and viscosity. Read More

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February 2021

Stillbirth: are we making more progress than we think? A retrospective cohort study.

BJOG 2021 Feb 4. Epub 2021 Feb 4.

The Ritchie Centre, Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia.

Objective: To quantify how the changing stillbirth risk profile of women is affecting the interpretation of the stillbirth rate.

Design: A retrospective, population-based cohort study from 1983 to 2018.

Setting: Victoria, Australia. Read More

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February 2021

Evaluation of the efficacy and tolerance of a cosmetic mask containing 89% of vichy volcanic mineralizing water and hyaluronic acid after facial laser procedures.

J Cosmet Dermatol 2021 Feb 3. Epub 2021 Feb 3.

Laboratoires Vichy International, Levallois-Perret, France.

Background: M89 M (Mineral 89 mask, Laboratoires Vichy, France), containing 89% Vichy volcanic mineralizing water and hyaluronic acid, aims to strengthen and repair skin barrier.

Aims: To assess the efficacy, tolerance, patient satisfaction, and quality of life (QOL) using M89 M after laser procedures (LP).

Methods: M89 M was applied immediately post-LP for 10 minutes, then daily for 5 days and 2-3 times a week, up to 28 days on the faces of 51 women. Read More

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February 2021

Association Between Statin Use at the Time of Intra-abdominal Surgery and Postoperative Adhesion-Related Complications and Small-Bowel Obstruction.

JAMA Netw Open 2021 02 1;4(2):e2036315. Epub 2021 Feb 1.

Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia.

Importance: Adhesion-related complications (ARCs), including small-bowel obstruction, are common complications of intra-abdominal surgery. Statins, which have antifibrotic pleiotropic effects, inhibit adhesion formation in murine models but have not been assessed in humans.

Objective: To assess whether statin use at the time of intra-abdominal surgery is associated with a reduction in ARCs. Read More

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February 2021

Cerebral visual impairment-related vision problems in primary school children: a cross-sectional survey.

Dev Med Child Neurol 2021 Feb 3. Epub 2021 Feb 3.

Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK.

Aim: To estimate how many children in mainstream primary schools have cerebral visual impairment (CVI)-related vision problems and to investigate whether some indicators might be useful as red flags, if they were associated with increased risk for these problems.

Method: We conducted a survey of primary school children aged 5 to 11 years, using whether they were getting extra educational help and/or teacher- and parent-reported behaviour questionnaires to identify children at risk for CVI. These and a random 5% sample were assessed for CVI-related vision problems. Read More

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February 2021

Sleep and cardiometabolic risk: a cluster analysis of actigraphy-derived sleep profiles in adults and children.

Sleep 2021 Jan 30. Epub 2021 Jan 30.

Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, Australia.

Study Objectives: Sleep plays an important role in cardiometabolic health. While the importance of considering sleep as a multidimensional construct is widely appreciated, studies have largely focused on individual sleep characteristics. The association between actigraphy-derived sleep profiles and cardiometabolic health in healthy adults and children has not been examined. Read More

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January 2021

Real-time quality control of nuchal translucency measurements using the exponentially weighted moving average chart.

Taiwan J Obstet Gynecol 2021 Jan;60(1):84-89

The Czech Academy of Sciences, Institute of Computer Science, Prague, Czech Republic.

Objective: The establishment of ongoing audits for first-trimester nuchal translucency (NT) measurements is of paramount importance. The exponentially weighted moving average (EWMA) chart has been published as an efficient tool for NT quality control with the advantages of being suitable for real-time long-term monitoring. This study aimed to assess the efficacy of real-time NT quality control using EWMA charts. Read More

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January 2021

Concomitant tricuspid valve surgery is beneficial at the time of left-sided valve surgery.

J Card Surg 2021 Mar 24;36(3):981-989. Epub 2021 Jan 24.

Division of Cardiac Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: This study evaluates the impact of secondary functional tricuspid regurgitation (TR) and concomitant tricuspid valve repair (TVr) at the time of left-sided valve operations.

Methods: Adults undergoing left-sided valve operations between 2010 and 2019 at a multihospital academic institution were included. Patients were stratified into three groups: less-than-moderate TR without TVr (Group 1), moderate-or-greater TR without TVr (Group 2), and moderate-or-greater TR with TVr (Group 3). Read More

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Nutritional and Functional Advantages of the Use of Fermented Black Chickpea Flour for Semolina-Pasta Fortification.

Foods 2021 Jan 18;10(1). Epub 2021 Jan 18.

Department of Environmental Biology, Sapienza University of Rome, 00185 Roma, Italy.

Pasta represents a dominant portion of the diet worldwide and its functionalization with high nutritional value ingredients, such as legumes, is the most ideal solution to shape consumers behavior towards healthier food choices. Aiming at improving the nutritional quality of semolina pasta, semi-liquid dough of a Mediterranean black chickpea flour, fermented with T0A10, was used at a substitution level of 15% to manufacture fortified pasta. Fermentation with the selected starter enabled the release of 20% of bound phenolic compounds, and the conversion of free compounds into more active forms (dihydrocaffeic and phloretic acid) in the dough. Read More

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January 2021

Process evaluations of early childhood obesity prevention interventions delivered via telephone or text messages: a systematic review.

Int J Behav Nutr Phys Act 2021 01 9;18(1):10. Epub 2021 Jan 9.

Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Background: Increasingly, public health interventions are delivered via telephone and/or text messages. Recent systematic reviews of early childhood obesity prevention interventions have not adequately reported on the way interventions are delivered and the experiences/perceptions of stakeholders. We aimed to summarise the literature in early childhood obesity prevention interventions delivered via telephone or text messages for evidence of application of process evaluation primarily to evaluate stakeholders' acceptability of interventions. Read More

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January 2021

Wireless Remote Home Monitoring of Vital Signs in Patients Discharged Early After Esophagectomy: Observational Feasibility Study.

JMIR Perioper Med 2020 Dec 4;3(2):e21705. Epub 2020 Dec 4.

Department of Anesthesiology, University Medical Center Utrecht, Utrecht, Netherlands.

Background: Hospital stays after major surgery are shorter than ever before. Although enhanced recovery and early discharge have many benefits, some complications will now first manifest themselves in home settings. Remote patient monitoring with wearable sensors in the first days after hospital discharge may capture clinical deterioration earlier but is largely uncharted territory. Read More

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December 2020