5 results match your criteria assayed diketone

  • Page 1 of 1

Sensorial Impact and Distribution of 3-Methyl-2,4-nonanedione in Cognacs and Spirits.

J Agric Food Chem 2021 Apr 8;69(15):4509-4517. Epub 2021 Apr 8.

Unité de recherche OEnologie, EA 4577, USC 1366 INRAE, ISVV, Univ. Bordeaux, 33882 Villenave d'Ornon cedex, France.

The aim of this study was to improve our knowledge on the chemical markers of Cognac aromas. We report results concerning the distribution and sensorial impact of 3-methyl-2,4-nonanedione (MND), a well-known compound in aged red wine, reminiscent of anise or "dried fruit", according to its concentration. We assayed first this diketone (solid-phase microextraction (SPME)-gas chromatography (GC)/mass spectrometry (MS), chemical ionization (CI)) in many Cognac samples followed by grappa, brandy, rum, whisky, vodka, and fruit spirits, and concentrations ranged from traces to 11. Read More

View Article and Full-Text PDF

Fine mapping and metabolic and physiological characterization of the glume glaucousness inhibitor locus Iw3 derived from wild wheat.

Theor Appl Genet 2014 Apr 13;127(4):831-41. Epub 2014 Feb 13.

College of Agronomy, Northwestern A&F University, Yangling, 712100, Shaanxi, China.

Key Message: This research provided the first view of metabolic and physiological effect of a tissue-specific glaucousness inhibitor in wheat and laid foundation for map-based cloning of the Iw3 locus. Cuticular wax constitutes the outermost layer of plant skin, and its composition greatly impacts plant appearance and plant-environment interaction. Epicuticular wax in the upper part of adult wheat plants can form the glaucousness, which is associated with drought tolerance. Read More

View Article and Full-Text PDF

Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.

J Med Chem 2007 Nov 20;50(23):5833-9. Epub 2007 Oct 20.

Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland.

A series of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives, prepared by two synthetic routes, were in vitro assayed against three Trypanosoma strains, Leishmania donovani, and Plasmodium falciparum K1. Seven out of 17 compounds showed moderate to very good activity against blood stage T. b. Read More

View Article and Full-Text PDF
November 2007

Total synthesis and anti-leishmanial activity of some curcumin analogues.

Arzneimittelforschung 2002 ;52(9):695-8

Universidade Federal Rural do Rio de Janeiro, Departamento de Química-Instituto de Ciências Exatas, Seropédica, RJ, Brazil.

Curcumin (1) an important yellow dye isolated from Curcuma longa rhizomes, exhibits a variety of pharmacological effects such as anti-inflammatory, antioxidant and antiviral activity. Ten curcuminoids (2-11) were synthesized by the condensation of 2,4-pentanedione with differently substituted benzaldehydes, using the boron complex approach, which avoided Knoevenagel condensation at C-3 of the diketone. The curcuminoids were assayed in vitro against Leishmania amazonensis promastigotes using pentamidine isethionate (CAS 140-64-7) as the reference drug. Read More

View Article and Full-Text PDF
November 2002

In vitro quantitative structure-activity relationship assessment of pyrrole adducts production by gamma-diketone-forming neurotoxic solvents.

Toxicol In Vitro 1995 Oct;9(5):783-7

National Institute of Toxicology, PO Box 863, 41080-Seville, Spain.

Organic solvents that are metabolically transformable into gamma-diketones produce central- peripheral distal axonopathy. One of the mechanisms proposed to explain the development of this neuropathy has been the formation of pyrrole adducts between gamma-diketone metabolites and -amine groups of lysine residues on the neuronal cytoskeletal proteins. In vivo studies on the neurotoxic capability of different solvents, derivatives of n-hexane and n-heptane, have previously established the quantitative structure-activity sequence. Read More

View Article and Full-Text PDF
October 1995
  • Page 1 of 1