4,102 results match your criteria aspirin subjects

Application of Age, Body Mass Index, Chronic Kidney Disease, Diabetes, and Genotyping Score for Efficacy of Clopidogrel: Secondary Analysis of the CHANCE Trial.

Stroke 2021 Oct 20:STROKEAHA120033049. Epub 2021 Oct 20.

China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, China. (L.D., J.X., H.Y., Z.C., Y.P., X.M., H.L., Y.W.).

Background And Purpose: The age, body mass index, chronic kidney disease, diabetes, and genotyping (ABCD-GENE) score is a validated risk score integrating CYP2C19 genotypes with clinical risk factors influencing clopidogrel response that would allow the more precise identification of subjects at risk for high platelet reactivity and adverse clinical outcomes. Our objective was to further verify application of the ABCD-GENE score and investigate appropriate cutoff value in patients with minor stroke or transient ischemic attack.

Methods: In this post-analysis of the CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events), the ABCD-GENE score was calculated for all patients enrolled in this study. Read More

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October 2021

Prevention of ischaemic events in subjects with polydistrict vascular disease.

Eur Heart J Suppl 2021 Oct 8;23(Suppl E):E103-E108. Epub 2021 Oct 8.

University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy.

The incidence of new cardiovascular events in patients with chronic coronary syndrome remains high, particularly in the presence of concomitant high thrombotic risk factors (diabetes mellitus, renal failure, multivessel coronary artery disease, multiple district atherosclerosis, recurrent events, heart failure). The risk of such recurrent events can be reduced by implementing various strategies, which include careful individual stratification of ischaemic and haemorrhagic risk and the choice of the most appropriate antithrombotic therapy for the individual patient, also by combining aspirin with a second antiplatelet agent/a low-dose anticoagulant, in order to achieve the maximum net clinical benefit. Read More

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October 2021

Efficacy and safety of aspirin for cardiovascular risk prevention in younger and older age: an updated systematic review and meta-analysis.

Thromb Haemost 2021 Oct 12. Epub 2021 Oct 12.

Cardiology Unit, University of Catania, Catania, Italy.

Aims - The efficacy and safety of aspirin for primary cardiovascular disease (CVD) prevention is controversial. The aim of this study was to investigate the merits of aspirin in subjects with no overt CVD, with a focus on age as a treatment modifier. Methods and results - Randomized trials comparing aspirin use versus no aspirin use or placebo were included. Read More

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October 2021

Risk Factors for High-Risk Adenoma on the First Lifetime Colonoscopy Using Decision Tree Method: A Cross-Sectional Study in 6,047 Asymptomatic Koreans.

Front Med (Lausanne) 2021 23;8:719768. Epub 2021 Sep 23.

Division of Gastroenterology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

As risk of colorectal neoplasm is varied even in persons with "average-risk," risk evaluation and tailored screening are needed. This study aimed to evaluate the risk factors of high-risk adenoma (HRA) in healthy individuals and determine the characteristics of advanced neoplasia (AN) among individual polyps. Asymptomatic adults who underwent the first lifetime screening colonoscopy at the Seoul National University Hospital Healthcare System Gangnam Center (SNUH GC) were recruited from 2004 to 2007 as SNUH GC Cohort and were followed for 10 years. Read More

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September 2021

Appraisal of the Real-World Effectiveness of Biologic Therapies in Aspirin-Exacerbated Respiratory Disease.

J Allergy Clin Immunol Pract 2021 Sep 28. Epub 2021 Sep 28.

Division of Allergy, Asthma, and Immunology, Scripps Clinic, San Diego, Calif. Electronic address:

Background: There are no head-to-head studies for patients with aspirin-exacerbated respiratory disease (AERD) comparing any of the 5 Food and Drug Administration-approved respiratory biologic therapies.

Objective: Explore outcomes in subjects with AERD using biologic therapies in a real-world clinic setting.

Methods: A retrospective pilot study was conducted for subjects with AERD who had been prescribed omalizumab (anti-IgE), mepolizumab (anti-IL-5), reslizumab (anti-IL-5), benralizumab (anti-IL-5 receptor alpha [anti-IL-5Rα]), or dupilumab (anti-IL-4 receptor alpha [anti-IL-4Rα]). Read More

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September 2021

Expression in Peripheral Blood as a Potential Biomarker in Adult Patients with Asthma.

J Pers Med 2021 Aug 24;11(9). Epub 2021 Aug 24.

Grupo Alergología, Instituto de Investigación Biomédica de Salamanca (IBSAL), 37007 Salamanca, Spain.

Background: Precision medicine is a promising strategy to identify biomarkers, stratify asthmatic patients according to different endotypes, and match them with the appropriate therapy. This proof-of-concept study aimed to investigate whether gene expression in peripheral blood could provide a valuable noninvasive approach for the molecular phenotyping of asthma.

Methods: We performed whole-transcriptome RNA sequencing on peripheral blood of 30 non-atopic non-asthmatic controls and 30 asthmatic patients. Read More

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Emerging agents for the treatment and prevention of stroke: progress in clinical trials.

Expert Opin Investig Drugs 2021 Oct 13:1-11. Epub 2021 Oct 13.

Second Department of Neurology, National & Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.

Introduction: Recent years have witnessed unprecedented progress in stroke care, but unmet needs persist regarding the efficacy of acute treatment and secondary prevention. Novel approaches are being tested to enhance the efficacy of thrombolysis or provide neuroprotection in non-thrombolized patients.

Areas Covered: The current review highlights pharmaceutical agents under evaluation in clinical trials concerning the acute, subacute, and chronic phase post-stroke. Read More

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October 2021

Correlation of aspirin resistance with serological indicators in patients with coronary heart disease in the plateau.

Am J Transl Res 2021 15;13(8):9024-9031. Epub 2021 Aug 15.

Department of Cardiology, Qinghai Provincial People's Hospital Xining, Qinghai Province, China.

Objective: To explore the incidence rate of aspirin resistance (AR) in patients with coronary heart disease (CHD) in the plateau, and analyze its correlation with clinical influencing factors and serological indicators.

Methods: In this retrospective study, 90 patients with CHD who had lived in the plateau for a long time (>10 years) and received treatment were selected as the subjects. Patients were divided into the AR group (11-dehydrothromboxane B2 (11-DH-TXB) >1500 pg/mg) and aspirin sensitivity group (AS group, 11-DH-TXB ≤1500 pg/mg) according to the content of 11-DH-TXB in the urine. Read More

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Effect of modifiable risk factors in Parkinson's disease: A case-control study looking at common dietary factors, toxicants, and anti-inflammatory medications.

Chronic Illn 2021 Sep 8:17423953211039789. Epub 2021 Sep 8.

Department of Clinical Specialties, 43984New York Institute of Technology College of Osteopathic Medicine, USA.

Objective: To investigate how common modifiable exposures, including dietary factors, select toxicants, and anti-inflammatory medications, may affect Parkinson's disease.

Methods: Using surveys, a case-control study was conducted at a medical center, comparing Parkinson's disease patients (  =  149) and healthy controls (  =  105). Subjects reported exposure to red meats, vegetables, alcohol, tobacco, anti-inflammatory medications, and pesticides. Read More

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September 2021

Transcriptome Analysis Identifies Doublesex and Mab-3 Related Transcription Factor (DMRT3) in Nasal Polyp Epithelial Cells of Patients Suffering from Non-Steroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease (AERD).

Biomolecules 2021 07 23;11(8). Epub 2021 Jul 23.

Instituto Nacional de EnfermedadesRespiratorias Ismael Cosío Villegas, Calz. de Tlalpan 4502, Belisario Domínguez Secc 16, Mexico City 14080, Mexico.

Background: Aspirin-exacerbated respiratory disease (AERD) is a syndrome characterised by chronic rhinosinusitis, nasal polyps, asthma and aspirin intolerance. An imbalance of eicosanoid metabolism with anover-production of cysteinyl leukotrienes (CysLTs) has been associated with AERD. However, the precise mechanisms underlying AERD are unknown. Read More

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Effect of TGF-β1 on eosinophils to induce cysteinyl leukotriene E4 production in aspirin-exacerbated respiratory disease.

PLoS One 2021 26;16(8):e0256237. Epub 2021 Aug 26.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

Cysteinyl leukotriene (cysLT) overproduction and eosinophil activation are hallmarks of aspirin-exacerbated respiratory disease (AERD). However, pathogenic mechanisms of AERD remain to be clarified. Here, we aimed to find the significance of transforming growth factor beta 1 (TGF-β1) in association with cysteinyl leukotriene E4 (LTE4) production, leading to eosinophil degranulation. Read More

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Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID-exacerbated respiratory disease.

Clin Exp Allergy 2021 Aug 24. Epub 2021 Aug 24.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

Background: Genetic variants of dipeptidyl peptidase 10 (DPP10) have been suggested to contribute to the development of NSAID-exacerbated respiratory disease (NERD). However, the mechanisms of how DPP10 contributes to NERD phenotypes remain unclear.

Objective: To demonstrate the exact role of DPP10 in the pathogenesis of NERD. Read More

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Population-wide impacts of aspirin, statins, and metformin use on prostate cancer incidence and mortality.

Sci Rep 2021 08 9;11(1):16171. Epub 2021 Aug 9.

Department of Urology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu-si, Republic of Korea.

We evaluated the association between aspirin, statins, and metformin use and prostate cancer (PC) incidence and mortality using a large population-based dataset. 388,760 men who participated in national health screening program in Korea during 2002-2003 were observed from 2004 to 2013. Hazard ratios of aspirin, statins, and metformin use for PC incidence and PC mortality were calculated with adjustment for simultaneous drug use. Read More

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Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients.

Mol Diagn Ther 2021 Aug 6. Epub 2021 Aug 6.

Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 580, Sao Paulo, 05508-000, Brazil.

Anticoagulant and antiplatelet drugs effectively prevent thrombotic events in patients with cardiovascular diseases, ischemic stroke, peripheral vascular diseases, and other thromboembolic diseases. However, genetic and non-genetic factors affect the response to antithrombotic therapy and can increase the risk of adverse events. This narrative review discusses pharmacogenomic studies on antithrombotic drugs commonly prescribed in Brazil. Read More

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Vascular endothelial Tissue Factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis.

Cardiovasc Res 2021 Aug 5. Epub 2021 Aug 5.

Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute.

Aims: Gut microbiota and their generated metabolites impact the host vascular phenotype. The metaorganismal metabolite trimethylamine N-oxide (TMAO) is both associated with adverse clinical thromboembolic events, and enhances platelet responsiveness in subjects. The impact of TMAO on vascular tissue factor (TF) in vivo is unknown. Read More

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Common drugs, vitamins, nutritional supplements and COVID-19 mortality.

Int J Funct Nutr 2021 Jan-Feb;2(1). Epub 2021 Mar 18.

Severn Health Solutions, Severna Park, MD 21146, USA.

The FDA has approved only one drug, remdesivir, for the treatment of COVID-19. The FDA has granted an emergency use authorization for the rheumatoid arthritis treatment drug, baricitinib (Olumiant), for the treatment of COVID-19 in some cases. For this reason, investigators have paid considerable attention to the association between commonly used drugs and the outcome of patients with COVID-19. Read More

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Pharmacodynamic effects of indobufen compared with aspirin in patients with coronary atherosclerosis.

Eur J Clin Pharmacol 2021 Jul 31. Epub 2021 Jul 31.

Departments of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Purpose: This study aimed to investigate the pharmacodynamic effects of indobufen and low-dose aspirin in patients with coronary atherosclerosis.

Methods: In the first phase, 218 patients with coronary atherosclerosis were randomly assigned to receive aspirin 100 mg once daily (standard dose); 100 mg once every 2 days; 100 mg once every 3 days; 50 mg twice daily; 75 mg once daily; 50 mg once daily; or indobufen 100 mg twice daily for 1 month. In the second phase, 20 healthy subjects were treated with indobufen 100 mg twice daily for 1 week followed after a 2-week washout by aspirin 100 mg once daily for 1 week. Read More

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Association Between Low-Dose Aspirin and Uric Acid in the Elderly: An Observational Retrospective Cross-Sectional Study.

Int J Gen Med 2021 20;14:3635-3643. Epub 2021 Jul 20.

Department of Geriatrics, Peking University First Hospital, Beijing, 100034, People's Republic of China.

Purpose: Uric acid is an independent factor for arteriosclerotic cardiovascular disease (ASCVD). Although aspirin is one of the most widely used agent in patients with ASCVD, there were only a few studies focusing on the effects of low-dose aspirin on uric acid metabolism with controversial results. The present study aimed to investigate an association between low-dose aspirin treatment for more than one month and serum uric acid (SUA) with its urinary excretion in elderly patients. Read More

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An observational study of a cohort of citizens receiving the AZD1222 vaccine against SARS-CoV-2.

Future Sci OA 2021 Sep 15;7(8):FSO739. Epub 2021 Jun 15.

Centro di Referenza Nazionale per l'Analisi e Studio di Correlazione tra Ambiente, Animale e Uomo, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, 80055, Italy.

In this retrospective study, a cohort of 67 subjects vaccinated with AZD1222 was retrospectively observed. Consistently with published findings, no serious adverse event was reported, and all adverse events reported (fever, muscle ache and/or pain in the site of injection) had resolved by day 8. Of note, some citizens were prescribed low-dose aspirin and even heparin for thrombosis prevention. Read More

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September 2021

NSAID hypersensitivity in CSU in the light of its pathogenesis.

R Asero

Eur Ann Allergy Clin Immunol 2021 Jul 21. Epub 2021 Jul 21.

Allergology Clinic, Clinica San Carlo, Paderno Dugnano, Milan, Italy.

Summary: Up to 15% of patients with chronic spontaneous urticaria (CSU) experience severe exacerbations of their baseline cutaneous disease after taking nonsteroidal anti-inflammatory drugs that inhibit cycloxygenase-1 (COX-1) enzyme. These subjects are defined as having a NECD (NSAID-exacerbated cutaneous disease). The way NSAID hypersensitivity correlates with the different pathogenic mechanisms of CSU has not been investigated so far. Read More

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Fibrin Clot Properties in Atherosclerotic Vascular Disease: From Pathophysiology to Clinical Outcomes.

J Clin Med 2021 Jul 5;10(13). Epub 2021 Jul 5.

John Paul II Hospital, 31-202 Kraków, Poland.

Fibrin is a major component of thrombi formed on the surface of atherosclerotic plaques. Fibrin accumulation as a consequence of local blood coagulation activation takes place inside atherosclerotic lesions and contributes to their growth. The imbalance between thrombin-mediated fibrin formation and fibrin degradation might enhance atherosclerosis in relation to inflammatory states reflected by increased fibrinogen concentrations, the key determinant of fibrin characteristics. Read More

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Efficacy and Safety of Aspirin Combined with Low-Dose P2Y12 Receptor Antagonists in East Asian Patients Undergoing PCI.

Int Heart J 2021 Jul 6;62(4):742-751. Epub 2021 Jul 6.

Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University.

Previous studies have indicated that low-dose new generation of P2Y12 receptor antagonists may be more suitable compared with clopidogrel at a standard dose for the dual antiplatelet therapy (DAPT) for East Asian patients receiving percutaneous coronary intervention (PCI). However, there remains no consensus in clinical practice. Thus, in this study, we aimed to determine the efficacy and safety of low-dose P2Y12 receptor antagonists, compared to clopidogrel at a standard dose, in DAPT in East Asian patients after PCI. Read More

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Clinical Study for Safety Evaluation of GXN Tablets Combined with Aspirin in Long-Term Treatment of Coronary Heart Disease.

Evid Based Complement Alternat Med 2021 7;2021:6658704. Epub 2021 Jun 7.

Institute of Clinical Pharmacology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.

Background: GXN tablets are composed of Danshen and Chuanxiong, with the functions of activating blood circulation, removing blood stasis, invigorating the pulse, and nourishing the heart, which are used for CHD patients with stable exertional angina Grade I or II (according to traditional Chinese medicine, it is a syndrome of heart and blood stasis with chest pain and dark purple lips and tongue). Clinical trials have shown satisfactory effects on coronary heart disease (CHD). 90. Read More

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Atrial pacing in Fontan patients: The effect of transvenous lead on clot burden.

Heart Rhythm 2021 Jun 25. Epub 2021 Jun 25.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts. Electronic address:

Background: Transvenous permanent pacemaker (PPM) implantation is an available option for Fontan patients with sinus node dysfunction. However, the thrombogenic potential of leads within the Fontan baffle is unknown.

Objective: The purpose of this study was to compare the clot burden in Fontan patients with a transvenous atrial PPM to those without a PPM and those with an epicardial PPM. Read More

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Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease.

J Allergy Clin Immunol 2021 08 16;148(2):574-584. Epub 2021 Jun 16.

Department of Medicine, Harvard Medical School, the Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass. Electronic address:

Background: Eosinophilic asthma and nasal polyposis are hallmarks of aspirin-exacerbated respiratory disease (AERD), and IL-5 inhibition has been shown to provide therapeutic benefit. However, IL-5Rα is expressed on many cells in addition to eosinophils, and the mechanisms by which IL-5 inhibition leads to clinical benefit in eosinophilic asthma and nasal polyposis are unlikely to be due exclusively to antieosinophil effects.

Objective: We sought to identify the mechanisms by which anti-IL-5 treatment with mepolizumab improves respiratory inflammation in AERD. Read More

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Serum Human β-Defensin 2 Is Increased in Angioedema Accompanying Chronic Spontaneous Urticaria.

Int Arch Allergy Immunol 2021 Jun 17:1-6. Epub 2021 Jun 17.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.

Introduction: Chronic spontaneous urticaria (CSU) is a common cutaneous disease caused by mast-cell degranulation. Human β-defensin 2 (HBD2) is a well-known antimicrobial peptide that is also a pruritogen inducing vascular permeability via non-IgE-mediated mast-cell degranulation.

Objective: We investigated the associations between serum HBD2 levels and the clinical characteristics of CSU patients. Read More

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Aspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.

PLoS One 2021 16;16(6):e0252969. Epub 2021 Jun 16.

Department of Pharmacy, Lishui City People's Hospital, Lishui, Zhejiang, China.

We aimed to examine whether the use of aspirin is associated with change in cognitive performance over time, and whether this association is modified by the cognitive stages. This study included a total of 1866 subjects, including 509 subjects with normal cognition (NC), 985 subjects with mild cognitive impairment (MCI), and 372 patients with Alzheimer's disease (AD). In each group, we further categorized our subjects into two groups based on their aspirin using conditions: Aspirin users and non-aspirin users. Read More

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Vascular Endothelial Repair and the Influence of Circulating Antiplatelet Drugs in a Carotid Coil Model.

J Cent Nerv Syst Dis 2021 20;13:11795735211011786. Epub 2021 May 20.

Department of Neurosurgery, Kindai University Hospital, Faculty of Medicine, Osakasayama, Osaka, Japan.

Background: Clinicians may choose to administer antiplatelet medications to patients with cerebral aneurysms following endovascular coiling to prevent thrombus formation and vascular occlusion, if they fear a thrombus will form on the platinum wire where it diverges into the vessel from the aneurysm sac. However, the mechanism by which vascular endothelial cells repair a vessel in the living body in the event of a coil deviation and the effects of antiplatelet drugs on these cells have not been fully elucidated. We aimed to investigate the association between endothelial progenitor cells (EPCs) and endothelium formation at the surface of the platinum coils deployed in the carotid artery of rats, and to determine the effects of different antiplatelet drugs on this process. Read More

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Serum tenascin-C predicts resistance to steroid combination therapy in high-risk Kawasaki disease: a multicenter prospective cohort study.

Pediatr Rheumatol Online J 2021 Jun 5;19(1):82. Epub 2021 Jun 5.

Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Background: Tenascin-C (TN-C) is an extracellular matrix glycoprotein related to tissue inflammation. Our previous retrospective study conducted in 2016 revealed that the serum tenascin-C level was higher in patients with Kawasaki disease (KD) who were resistant to intravenous immunoglobulin (IVIG) and developed coronary artery lesions (CALs). The present study is a prospective cohort study to assess if the serum level of tenascin-C could be used as a novel biomarker to predict the risk of resistance to initial treatment for high-risk patients. Read More

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Effect of a proton-pump inhibitor on intestinal microbiota in patients taking low-dose aspirin.

Eur J Clin Pharmacol 2021 Nov 4;77(11):1639-1648. Epub 2021 Jun 4.

Second Department of Internal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki City, Osaka, 569-8686, Japan.

Background And Aim: Low-dose aspirin (LDA) administration prevents cerebral infarction and myocardial infarction, but many studies found an association with mucosal injury. Proton-pump inhibitors (PPIs) can prevent gastric and duodenal mucosal damage, but they may exacerbate small-intestinal mucosal injury by altering the microbiota. We aimed to assess the effect of PPIs on the intestinal flora of LDA users. Read More

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November 2021