2,614 results match your criteria aspirin resistance


An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial Protection.

Cardiovasc Drugs Ther 2021 Apr 12. Epub 2021 Apr 12.

Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 211189, Jiangsu, People's Republic of China.

Purpose: Hypoxic microenvironment plays a vital role in myocardial ischemia injury, generally leading to the resistance of chemotherapeutic drugs. This induces an intriguing study on mechanism exploration and prodrug design to overcome the hypoxia-induced drug resistance.

Methods: In this study, we hypothesized that the overexpression of carbonic anhydrase 9 (CAIX) in myocardial cells is closely related to the drug resistance. Read More

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Low-dose aspirin treatment improves endometrial receptivity in the midluteal phase in unexplained recurrent implantation failure.

Int J Gynaecol Obstet 2021 Apr 8. Epub 2021 Apr 8.

Department of Obstetrics and Gynecology, School of Medicine, Renji Hospital, Shanghai JiaoTong University, Shanghai, China.

Objective: To compare endometrial receptivity in patients with and without unexplained recurrent implantation failure (URIF) and the benefits of low-dose aspirin treatment in women with URIF.

Methods: A retrospective study was conducted at Ren Ji Hospital, Shanghai, from January 2014 to January 2017. Endometrial thickness, pulsatility index (PI), resistive index (RI), and systolic-to-diastolic ratio (S/D) values of endometrial and uterine perfusion were recorded and compared between women with and without URIF. Read More

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Preventing Recurrent Preeclampsia by Tailored Treatment of Nonphysiologic Hemodynamic Adjustments to Pregnancy.

Hypertension 2021 Apr 5:HYPERTENSIONAHA12016502. Epub 2021 Apr 5.

Department of Obstetrics and Gynecology (E.G.M., E.C., V.A.L.v.B., V.M.M.M.S., R.-J.A., M.E.A.S.).

Preeclampsia is often preceded by abnormal hemodynamic changes with heterogeneous patterns in the first half of pregnancy. We assessed the effect of timely tailored correction of nonphysiological hemodynamic changes on preventing preeclampsia in a high-risk population. Primiparous women with a history of preeclampsia were invited to participate in a longitudinal program in their next pregnancy, including repeated hemodynamic assessments at 12-, 16-, 20- and 30-week gestation additional to regular pregnancy checkups. Read More

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[Effect of combined treatment with acupuncture, moxibustion and medication on endometrial receptivity and expression of serum HOXA10 in polycystic ovary syndrome of kidney deficiency and blood stagnation].

Zhongguo Zhen Jiu 2020 Nov;40(11):1154-8

School of Acupuncture and Moxibustion, Fujian University of TCM.

Objective: To compare the clinical effect of the combined treatment of acupuncture, moxibustion, Chinese herbal medicine and western medication and simple western medication on polycystic ovary syndrome (PCOS) of kidney deficiency and blood stagnation pattern and explore the effect on endometrial receptivity and the expression of serum homeobox gene A10 (HOXA10).

Methods: A total of 60 patients with PCOS of kidney deficiency and blood stagnation pattern were randomized into a combined treatment group and a western medication group, 30 cases in each one. In the western medication group, on the fifth day of menstruation, clomiphene citrate tablets were taken orally, 50 mg each time, once daily, consecutively for 5 days. Read More

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November 2020

Successful therapy with ticagrelor in three-vessel stent thrombosis related to clopidogrel resistance.

Can J Cardiol 2021 Mar 25. Epub 2021 Mar 25.

Regional Cardiocerebrovascular Center, Wonkwang University Hospital, Iksan, Korea.

A 65-year-old man developed three-vessel stent thrombosis after percutaneous coronary intervention with aspirin and clopidogrel. Platelet tests revealed clopidogrel resistance, which resolved after changing clopidogrel to ticagrelor. Although routine platelet tests after stenting are not recommended, these tests may be considered to identify the cause of stent thrombosis and modify antiplatelet therapy. Read More

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The expression profile of platelet-derived miRNA in coronary artery disease patients with clopidogrel resistance.

Pharmacol Res Perspect 2021 Apr;9(2):e00751

Department of Cardiology, Ningbo First Hospital, Ningbo, Zhejiang, China.

Clopidogrel is widely used for antiplatelet therapy in patients with coronary artery disease (CAD), but clopidogrel resistance (CR) is relatively common in these patients. The goal of our study was to explore the platelet-derived miRNA expression profile of CR in CAD patients. In this study, 66 CAD patients treated with dual antiplatelet therapy (clopidogrel 75 mg once daily plus aspirin 100 mg once daily) were included. Read More

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An integrated model of preeclampsia: a multifaceted syndrome of the maternal cardiovascular-placental-fetal array.

Am J Obstet Gynecol 2021 Mar 9. Epub 2021 Mar 9.

Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Maternal tolerance of the semiallogenic fetus necessitates conciliation of competing interests. Viviparity evolved with a placenta to mediate the needs of the fetus and maternal adaptation to the demands of pregnancy and to ensure optimal survival for both entities. The maternal-fetal interface is imagined as a 2-dimensional porous barrier between the mother and fetus, when in fact it is an intricate multidimensional array of tissues and resident and circulating factors at play, encompassing the developing fetus, the growing placenta, the changing decidua, and the dynamic maternal cardiovascular system. Read More

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Overview of Aspirin and Platelet Biology.

Am J Cardiol 2021 04;144 Suppl 1:S2-S9

AtheroThrombosis Research Unit. Icahn School of Medicine at Mount Sinai Mount Sinai Heart. Mount Sinai Hospital, New York, New York. Electronic address:

Aspirin (ASA) has historically been one of the most important drugs in cardiology and has long been the cornerstone of antiplatelet therapy. Although its role in acute coronary syndrome remains undisputed, emerging data suggest that reappraisal of the efficacy of long-term ASA in some primary and secondary prevention may be warranted. The aim of this review is to place these new results in the context of previous evidence on aspirin by appraising the current body of evidence on its use of for cardiovascular diseases. Read More

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Unfavorable Changes of Platelet Reactivity on Clopidogrel Therapy Assessed by Impedance Aggregometry Affect a Larger Volume of Acute Ischemic Lesions in Stroke.

Diagnostics (Basel) 2021 Feb 27;11(3). Epub 2021 Feb 27.

Center of Neurology, Vilnius University, LT-08661 Vilnius, Lithuania.

Background: High on-treatment platelet reactivity or its equivalent-resistance to the antiplatelet agent-significantly reduces the efficacy of the therapy, contributing to a negative impact on stroke course. Previous studies demonstrated that aspirin resistance is associated with a larger size of acute ischemic infarct. Due to the increasing use of clopidogrel in the secondary prevention of stroke, we aimed to assess the impact of clopidogrel resistance on the size and extent of ischemic lesions, both acute and chronic. Read More

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February 2021

Influence of low-dose aspirin, resistance exercise, and sex on human skeletal muscle PGE /COX pathway activity.

Physiol Rep 2021 Mar;9(5):e14790

Human Performance Laboratory, Ball State University, Muncie, IN, USA.

Prostaglandin (PG) E  has been linked to increased inflammation and attenuated resistance exercise adaptations in skeletal muscle. Nonaspirin cyclooxygenase (COX) inhibitors have been shown to reduce these effects. This study examined the effect of low-dose aspirin on skeletal muscle COX production of PGE at rest and following resistance exercise. Read More

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[Helicobacter pylori: When to look for an infection and treat it in adults?]

Authors:
J-D de Korwin

Rev Med Interne 2021 Feb 26. Epub 2021 Feb 26.

Université de Lorraine, CHRU-Nancy, département de médecine interne et immunologie clinique-BPC, rue du Morvan, 54511 Vandœuvre-Lès-Nancy cedex, France. Electronic address:

Helicobacter pylori infection is acquired during childhood mainly within the family. It causes active chronic gastritis associated with the development of many digestive and extra digestive diseases. Its expression results from interactions between the bacteria, the host and environmental factors modulating the evolution of gastritis and acid secretion. Read More

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February 2021

Left atrial appendage closure device implantation via transhepatic vascular access: a case report.

Eur Heart J Case Rep 2020 Dec 2;4(6):1-5. Epub 2020 Dec 2.

Aventura Hospital and Medical Center, Aventura, FL, USA.

Background: In patients with non-valvular atrial fibrillation, an estimated 90% of thrombi are located in the left atrial appendage. The WATCHMAN device is a left atrial appendage closure device that is an alternative therapeutic option to reduce the risk of systemic embolization in patients who are intolerant of long-term oral anticoagulation. It can be deployed in the left atrial appendage using a transseptal approach via the femoral vein. Read More

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December 2020

2021 Update on the Clinical Management and Diagnosis of Kawasaki Disease.

Curr Infect Dis Rep 2021 6;23(3). Epub 2021 Feb 6.

Division of Pediatric Infectious Diseases, Children's Hospital of Michigan, Detroit, MI USA.

Purpose Of Review: Provide an updated review of the clinical management and diagnosis of Kawasaki disease with inclusion of potential diagnostic difficulties with multisystem inflammatory syndrome in children (MIS-C) given the ongoing COVID-19 pandemic.

Recent Findings: Adjunctive corticosteroid therapy has been shown to reduce the rate of coronary artery dilation in children at high risk for IVIG resistance in multiple Japanese clinical studies (most notably RAISE study group). Additional adjunctive therapies (etanercept, infliximab, cyclosporin) may also provide limited benefit, but data is limited to single studies and subgroups of patients with cardiac abnormalities. Read More

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February 2021

Clinical Post-operative Bleeding During Minor Oral Surgical Procedure and In Vitro Platelet Aggregation in Patients on Aspirin Therapy: Are they Coherent?

J Maxillofac Oral Surg 2021 Mar 20;20(1):132-137. Epub 2020 Aug 20.

Department of Dentistry, All India Institute of Medical Sciences, Jodhpur, Jodhpur, India.

Aim: The risk of excessive bleeding prompts physicians to discontinue aspirin in patients on low-dose, long-term therapy which in turn puts them at the risk from adverse cardiovascular and thrombotic events. Effect of low-dose aspirin therapy on platelet function was assessed using platelet aggregation method. The aim was to correlate the laboratory platelet function with cutaneous and clinical oral bleeding time (BT). Read More

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COVID-19 and cytokine storm syndrome: can what we know about interleukin-6 in ovarian cancer be applied?

J Ovarian Res 2021 Feb 8;14(1):28. Epub 2021 Feb 8.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Improving early diagnosis along with timely and effective treatment of COVID-19 are urgently needed. However, at present, the mechanisms underlying disease spread and development, defined prognosis, and immune status of patients with COVID-19 remain to be determined. Patients with severe disease state exhibit a hyperinflammatory response associated with cytokine storm syndrome, hypercoagulability, and depressed cell-mediated immunity. Read More

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February 2021

Two Cases of Severe Hypertension in JAK2 Mutation-Positive Myeloproliferative Neoplasms.

Case Rep Vasc Med 2020 9;2020:8887423. Epub 2020 Nov 9.

Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK.

Background: Myeloproliferative neoplasms are a heterogeneous group of disorders resulting from the abnormal proliferation of one or more terminal myeloid cells-established complications include thrombosis and haemorrhagic events; however, there is limited evidence to suggest an association with arterial hypertension. Herein, we report two independent cases of severe hypertension in JAK2 mutation-positive myeloproliferative neoplasms. . Read More

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November 2020

The Effect of Enhanced External Counterpulsation on Platelet Aggregation in Patients with Coronary Heart Disease.

Cardiovasc Drugs Ther 2021 Jan 21. Epub 2021 Jan 21.

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Background: Resistance to antiplatelet therapy, especially aspirin or clopidogrel, triggers other therapies for patients with coronary heart disease (CHD). Enhanced external counterpulsation (EECP) is a noninvasive, pneumatic technique that provides beneficial effects for patients with CHD. However, the physiological effects of EECP have not been fully studied, and the role of EECP on platelet function remains poorly understood. Read More

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January 2021

Prognostic significance of BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1, DARC, MSH2 and PMS2 in colorectal cancer treated with FOLFOX chemotherapy with or without aspirin.

PLoS One 2021 19;16(1):e0245581. Epub 2021 Jan 19.

Department of Veterinary Surgery and Radiology, Veterinary Teaching Hospital, Ahmadu Bello University Zaria, Zaria, Nigeria.

Evasion of apoptosis is associated with treatment resistance and metastasis in colorectal cancer (CRC). Various cellular processes are associated with evasion of apoptosis. These include overexpression of pro-apoptotic proteins (including p53 and PD-L1), anti-apoptotic proteins (BIRC7/Livin and Bcl-2), chemokine receptors (including DARC), and dysregulation of DNA mismatch repair proteins (including MSH2 and PMS2). Read More

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January 2021

Association between insulin resistance and aspirin or clopidogrel resistance in Chinese patients with recent ischemic stroke/TIA.

Neurol Res 2021 Jan 17:1-6. Epub 2021 Jan 17.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University , Beijing, China.

: This study aims to discover whether insulin resistance is an independent predictor for antiplatelet drug resistance in patients with ischemic cerebrovascular disease. : This study used a prospective cohort method. Patients diagnosed as minor ischemic stroke or transient ischemic attack (TIA) were enrolled successively. Read More

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January 2021

Low miR-19b-1-5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio- Cerebrovascular Events in Patients With Acute Coronary Syndrome.

J Am Heart Assoc 2021 Jan 14;10(2):e017120. Epub 2021 Jan 14.

Departments of Clinical Epidemiology, Biostatistics and Bio-informaticsAmsterdam UMC, location AMC Amsterdam The Netherlands.

Background Because of a nonresponse to aspirin (aspirin resistance), patients with acute coronary syndrome (ACS) are at increased risk of developing recurrent event. The in vitro platelet function tests have potential limitations, making them unsuitable for the detection of aspirin resistance. We investigated whether miR-19b-1-5p could be utilized as a biomarker for aspirin resistance and future major adverse cardio-cerebrovascular (MACCE) events in patients with ACS. Read More

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January 2021

Multifactorial Background for a Low Biological Response to Antiplatelet Agents Used in Stroke Prevention.

Authors:
Adam Wiśniewski

Medicina (Kaunas) 2021 Jan 10;57(1). Epub 2021 Jan 10.

Department of Neurology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Skłodowskiej 9 Street, 85-094 Bydgoszcz, Poland.

Effective platelet inhibition is the main goal of the antiplatelet therapy recommended as a standard treatment in the secondary prevention of non-embolic ischemic stroke. Acetylsalicylic acid (aspirin) and clopidogrel are commonly used for this purpose worldwide. A low biological response to antiplatelet agents is a phenomenon that significantly reduces the therapeutic and protective properties of the therapy. Read More

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January 2021

The Impact of Kinase Insert Domain (KDR) Gene Polymorphism rs2305948 on Clopidogrel Resistance in Iraqi Patients Undergoing Elective Percutaneous Coronary Intervention (PCI).

Acta Inform Med 2020 Sep;28(3):202-208

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa.

Introduction: Clopidogrel, the first-choice antiplatelet agent for patient undergoing Percutaneous Coronary Intervention (PCI) along with Aspirin. Clopidogrel resistance is one of the major obstacles that cause MACE and failure of PCI. Kinase Insert Domain (KDR) gene responsible for VEGFR2 coding, the major receptor that translates VEGF ligand. Read More

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September 2020

Clinical effectiveness and safety of salvia miltiorrhiza depside salt combined with aspirin in patients with stable angina pectoris: A multicenter, pragmatic, randomized controlled trial.

Phytomedicine 2021 Jan 10;81:153419. Epub 2020 Dec 10.

Department of Epidemiology, University of California-Los Angeles, 405 Hilgard Avenue, California 90095, USA. Electronic address:

Background: Salvia Miltiorrhiza Depside Salt (SMDS) was extracted from Salvia miltiorrhiza with high-quality control of active principles. In 2005, China's FDA approved the use of SMDS for stable angina pectoris (SAP), but the evidence of SMDS combined with aspirin remains unclear.

Purpose: The aim of this study was to assess the clinical effectiveness and safety of SMDS combined with aspirin in patients with SAP. Read More

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January 2021

Differences in thromboembolism after stent-assisted coiling for unruptured aneurysms between aspirin plus clopidogrel and ticagrelor.

J Clin Neurosci 2020 Dec 7;82(Pt A):128-133. Epub 2020 Nov 7.

Department of Neurosurgery, Inje University Haeundae Paik Hospital, Busan, Republic of Korea. Electronic address:

Purpose: To reduce procedural thromboembolisms, tailored antiplatelet drug preparation has been used according to antiplatelet resistance for endovascular coiling of unruptured aneurysms. We compared an aspirin plus clopidogrel group with a ticagrelor group using diffusion-weighted imaging (DWI) after stent-assisted coiling for unruptured aneurysms.

Methods: From October 2018 to April 2019, 72 patients with 78 aneurysms underwent stent-assisted coiling, with aspirin plus clopidogrel (n = 20 patients with 22 aneurysms) or ticagrelor (n = 52 patients with 56 aneurysms) as an antiplatelet preparation, and were enrolled in our study. Read More

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December 2020

CYP2C19 Loss-of-Function is Associated with Increased Risk of Ischemic Stroke after Transient Ischemic Attack in Intracranial Atherosclerotic Disease.

J Stroke Cerebrovasc Dis 2021 Feb 24;30(2):105464. Epub 2020 Nov 24.

Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, United States.

Objectives: Intracranial atherosclerotic disease (ICAD) is responsible for 8-10% of acute ischemic strokes, and resistance to antiplatelet therapy is prevalent. CYP2C19 gene loss-of-function (up to 45% of patients) causes clopidogrel resistance. For patients with asymptomatic ICAD and ICAD characterized by transient ischemic attack (TIA), this study measures the effect of CYP2C19 loss-of-function on ischemic stroke risk during clopidogrel therapy. Read More

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February 2021

Effect of prediabetes on asprin or clopidogrel resistance in patients with recent ischemic stroke/TIA.

Neurol Sci 2020 Nov 11. Epub 2020 Nov 11.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S 4th Ring W Rd, Fengtai District, Beijing, 100070, China.

Objective: Diabetes mellitus (DM) had been discovered as an independent risk factor for high on-treatment platelet reactivity (HPR) in patients with ischemic stroke. However, studies on the relationship between prediabetes and the occurrence of HPR remain scarce. This study is aimed at clarifying the association between prediabetes and HPR among patients with recent ischemic stroke or transient ischemic stroke (TIA). Read More

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November 2020

Low-dose or no aspirin administration in acute-phase Kawasaki disease: a meta-analysis and systematic review.

Arch Dis Child 2020 Nov 10. Epub 2020 Nov 10.

Division of Hematology Oncology, Department of Pediatrics, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

Objective: To compare the efficacy of low-dose or no aspirin with conventional high-dose aspirin for the initial treatment in the acute-phase of Kawasaki disease (KD).

Design: A meta-analysis and systematic review of randomised control trials and cohort studies.

Methods: All available articles that compared different dosage of aspirin in the acute-phase of KD published until 20 September 2019 were included from the databases of PubMed, Embase and Cochrane Central Register of Controlled Trials Central without language restrictions. Read More

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November 2020

Effect of acetylsalicylic acid on inflamed adipose tissue. Insulin resistance and hepatic steatosis in a mouse model of diet-induced obesity.

Life Sci 2021 Jan 24;264:118618. Epub 2020 Oct 24.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, via Trentacoste 2, Milan, Italy. Electronic address:

Aims: Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several diseases, such as cardiovascular diseases, insulin resistance, type-II diabetes, liver steatosis and cancer. Since obesity causes inflammation, we tested the ability of acetylsalicylic acid (ASA), a potent anti-inflammatory drug, in counteracting this inflammatory process and in mitigating obesity-associated health complications. Read More

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January 2021