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Diagnostic utility of rapid on-site evaluation of endobronchial ultrasound-guided transbronchial needle aspiration samples: A study in a region of high tuberculosis burden.

Cytopathology 2021 Apr 13. Epub 2021 Apr 13.

Department of Pathology, Dr. Ram Manohar Lohia Hospital & ABVIMS, New Delhi, India.

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a very useful tool for precise diagnosis of thoracic lesions. However, the procedure sometimes has a poor yield. Rapid on-site evaluation (ROSE) in EBUS-TBNA has been shown to be helpful to improve its diagnostic yield and minimise the need for repeat procedures. Read More

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Liver Abscess in Children-experience From a Single Tertiary Care Center of North India: Etiology, Clinical Profile and Predictors of Complications.

Pediatr Infect Dis J 2021 May;40(5):e179-e184

Department of Medical Parasitology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Liver abscess (LA), a common problem in children in the tropics, is believed to be mostly pyogenic (PLA), sometimes amebic (ALA). We aimed to analyze the clinical profile, etiology, risk factors for complications, management and outcomes of LA in children.

Methods: The details of 81 children with LA managed in a tertiary set up over a period of 3 years were analyzed. Read More

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The influence of preoperative biopsy on the surgical method in breast cancer patients: a single-center experience of 3,966 cases in China.

Gland Surg 2021 Mar;10(3):1038-1045

Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: The National Surgical Adjuvant Breast and Bowel Project (NSABP) B32 trial reported that the detection rate of sentinel lymph nodes by core needle biopsy (CNB) is higher than that by segmental resection. However, there are few reports regarding the detection rate of sentinel lymph nodes by vacuum-assisted breast biopsy (VABB). Therefore, we analyzed the impact of preoperative biopsy methods on the surgical modes of 3,966 patients with breast cancer in our center. Read More

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A randomized single-center controlled trial of synchronized intermittent mandatory ventilation with heliox in newborn infants with meconium aspiration syndrome.

Pediatr Pulmonol 2021 Apr 8. Epub 2021 Apr 8.

Department of Neonatology, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Objective: This study aimed to investigate the beneficial effects of synchronized intermittent mandatory ventilation (SIMV) with heliox in newborn infants with meconium aspiration syndrome (MAS).

Methods: Seventy-one newborn infants with MAS in the neonatal intensive care unit (NICU) of Daping Hospital of Army Medical University were enrolled in the trial. Infants treated with SIMV were randomized and divided into the heliox group (n = 35) and control group (n = 36). Read More

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Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity.

Int J Clin Pract 2021 Apr 7:e14211. Epub 2021 Apr 7.

Endocrinology Section, Hospital General de Granollers, Granollers, Spain.

Purpose: It has been suggested, on a theoretical basis, that ultrasound screening of thyroid nodules in obese patients with additional risk factors (family history, chronic autoimmune thyroiditis or high thyrotropin) might be cost-effective for the early detection and treatment of thyroid cancer. The present study evaluates if this approach can be validated in a real clinical setting.

Methods: Patients with obesity attended in hospital-based clinics were evaluated for risk factors of thyroid cancer and ultrasound screened for thyroid nodularity. Read More

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Introducing image-guided synovial aspiration and biopsy in assessing peri-prosthetic joint infection: an early single-centre experience.

Skeletal Radiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, HA7 4LP, UK.

Aim: Synovial sampling can be used in the diagnosis of peri-prosthetic joint infection (PJI). The purpose of this study was to establish the role of simultaneous image-guided synovial aspiration and biopsy (SAB) during an initial 2-year experience at our institution.

Methods: Retrospective review of consecutive SABs performed during 2014-2016 at a tertiary referral musculoskeletal centre. Read More

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A Comparison of Outcomes Based on Vessel Type (Native Artery vs. Bypass Graft) and Artery Location (Below-Knee Artery vs. Non-Below-Knee Artery) Using a Combination of Multiple Endovascular Techniques for Acute Lower Limb Ischemia.

Ann Vasc Surg 2021 Apr 2. Epub 2021 Apr 2.

Department of Radiology, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo, Tokyo 113-8603, Japan. Electronic address:

Background: To evaluate outcomes of endovascular treatment (EVT) using a combination of multiple endovascular techniques for acute lower limb ischemia (ALLI) and to compare outcomes based on vessel type and artery location.

Methods: A total of 95 consecutive patients with ALLI (mean age, 72.0 years; 65 males; 104 lower limbs) who received emergency EVT using a combination of multiple endovascular techniques including thrombolysis, aspiration thrombectomy, stenting, and balloon angioplasty with or without surgical thromboembolectomy, between January 2005 and December 2017 were included. Read More

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[Treatment of patients with abscess of prostate gland by the method of percutaneous punction].

Urologiia 2021 Mar(1):45-49

Educational Institution Grodno State Medical University, Grodno, Republic of Belarus.

Objectives: Demonstrate the treatment of prostatic abscess with a minimally invasive method - abscess puncture with aspiration of purulent fluid and injection of an antibiotic into abscess cavity.

Materials And Methods: Diagnosis of prostatic abscess of 23 patients using ultrasonography, computed tomography and magnetic resonance imaging of the pelvic region. 19 patients with the abscess within the prostatic capsule were treated with perineal percutaneous puncture method with aspiration of the abscess fluid and injection of antibiotics into cavity. Read More

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Prehospital Intubations Are Associated with Elevated Endotracheal Tube Cuff Pressures: A Cross-Sectional Study Characterizing ETT Cuff Pressures at a Tertiary Care Emergency Department.

Prehosp Disaster Med 2021 Apr 5:1-4. Epub 2021 Apr 5.

Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MassachusettsUSA.

Introduction: Emergency Medical Services (EMS) providers are trained to place endotracheal tubes (ETTs) in the prehospital setting when indicated. Endotracheal tube cuffs are traditionally inflated with 10cc of air to provide adequate seal against the tracheal lumen. There is literature suggesting that many ETTs are inflated well beyond the accepted safe pressures of 20-30cmH2O, leading to potential complications including ischemia, necrosis, scarring, and stenosis of the tracheal wall. Read More

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SOFIA catheter for direct aspiration of large vessel occlusion stroke: A single-center cohort and meta-analysis.

Interv Neuroradiol 2021 Apr 4:15910199211005328. Epub 2021 Apr 4.

Department of Neuroradiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background And Purpose: Direct aspiration (DA) using large-bore distal aspiration catheters is an established strategy for the endovascular thrombectomy (EVT) of large-vessel occlusion stroke (LVOS). However, the performance of individual catheters like SOFIA has yet to be examined.

Methods: We present a cohort of 144 consecutive patients treated with first-line DA and SOFIA 6 F Plus catheter for LVOS. Read More

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Dysphagia after cardiac surgery: Prevalence, risk factors, and associated outcomes.

J Thorac Cardiovasc Surg 2021 Mar 3. Epub 2021 Mar 3.

Division of Cardiothoracic Surgery, Department of Surgery, University of Florida, Gainesville, Fla.

Objectives: The study objectives were to determine the prevalence of swallowing impairment in adults after cardiac surgery and examine associated risk factors and health-related outcomes.

Methods: A prospective single-center study was conducted in postoperative adult cardiac surgery patients with no history of dysphagia. A standardized fiberoptic endoscopic evaluation of swallowing was performed within 72 hours of extubation. Read More

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Repeat Fine Needle Aspiration Cytology Refines the Selection of Thyroid Nodules for Afirma Gene Expression Classifier Testing.

Thyroid 2021 Apr 3. Epub 2021 Apr 3.

Beth Israel Deaconess Medical Center, 1859, Division of Endocrinology, Department of Medicine, Boston, Massachusetts, United States.

Background: Molecular testing (MT) refines risk stratification for thyroid nodules that are indeterminate for cancer by fine needle aspiration (FNA) cytology. Criteria for selecting nodules for MT vary and remain largely untested, raising questions about the best strategy for maximizing the usefulness of MT while minimizing the harms of overtesting. We used a unique data set to examine the effects of repeat FNA cytology-based criteria for MT on management decisions and nodule outcomes. Read More

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Leukocyte Esterase Versus ICM 2018 Criteria in the Diagnosis of Periprosthetic Joint Infection.

J Arthroplasty 2021 Mar 5. Epub 2021 Mar 5.

Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.

Background: A leukocyte esterase (LE) test is inexpensive and provides real-time information about patients suspected of periprosthetic joint infections (PJIs). The 2018 International Consensus Meeting (ICM) recommends it as a diagnostic tool with a 2+ cutoff. There is still a lack of data revealing LE utility versus the ICM 2018 criteria for PJI. Read More

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Switch Strategy from Direct Aspiration First Pass Technique to Solumbra Improves Technical Outcome in Endovascularly Treated Stroke.

Int J Environ Res Public Health 2021 Mar 6;18(5). Epub 2021 Mar 6.

Department of Diagnostic, UOC of Neuroradiology and Interventional Neuroradiology, San Camillo-Forlanini Hospital, 00152 Rome, Italy.

Background: The major endovascular mechanic thrombectomy (MT) techniques are: Stent-Retriever (SR), aspiration first pass technique (ADAPT) and Solumbra (Aspiration + SR), which are interchangeable (defined as switching strategy (SS)). The purpose of this study is to report the added value of switching from ADAPT to Solumbra in unsuccessful revascularization stroke patients.

Methods: This is a retrospective, single center, pragmatic, cohort study. Read More

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Expectant management for early pregnancy miscarriage after radical trachelectomy: A single hospital-based study.

Acta Obstet Gynecol Scand 2021 Apr 2. Epub 2021 Apr 2.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Introduction: Women who have undergone radical trachelectomy as a fertility-sparing treatment for early-stage cervical cancer may be at higher risk for retained tissues after early-term miscarriage due to cervical cerclage or cervical necrosis. Dilatation and curettage or aspiration may present additional risks in these women. The aim of this study was to assess the efficacy of expectant management for early pregnancy miscarriage after radical trachelectomy. Read More

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Sonographic Evaluation of Incidental Synchronous Masses in Patients with Breast Cancer: Clinical Significance and Diagnostic Workup.

Eur J Breast Health 2021 Jan 24;17(1):28-35. Epub 2020 Dec 24.

Department of Breast Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Objective: This study aimed to evaluate the diagnostic accuracy of breast ultrasonography in classifying incidental satellite masses as benign or malignant in patients with breast cancer and to assess its effect on their surgical management.

Materials And Methods: Ultrasound-guided fine needle aspiration/biopsy was performed in 288 satellite masses of 225 patients with breast cancer. Two radiologists retrospectively reviewed the sonograms of these masses and classified them as benign or malignant and compared this feature with the results of the histopathological examination. Read More

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January 2021

Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study.

Front Oncol 2021 15;11:621012. Epub 2021 Mar 15.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: The purpose of our study was to analyze the clinicopathologic features and surgical and oncological outcomes of adenoid cystic carcinoma (ACC) of the breast and to provide the basis for a clinical therapeutic schedule.

Methods: A total of 14 patients with primary breast adenoid cystic carcinoma treated at Cancer Hospital of the Chinese Academy of Medical Sciences from January 2000 to December 2017 were included. Data on clinical presentation, treatment strategy, and outcome, as well as the pathological features of ACC, were reviewed and analyzed. Read More

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Design and implementation of botulinum toxin on cricopharyngeal dysfunction guided by a combination of catheter balloon, ultrasound, and electromyography (BECURE) in patients with stroke: study protocol for a randomized, double-blinded, placebo-controlled trial.

Trials 2021 Mar 31;22(1):238. Epub 2021 Mar 31.

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong Province, China.

Background: Cricopharyngeal dysfunction (CPD) occurs in various neurological disorders, especially stroke. The treatment approaches of CPD include swallowing training, cricopharyngeal dilation, botulinum toxin (BTX) injection, and cricopharyngeal myotomy. BTX injection into the cricopharyngeal muscle is effective and safe for some patients with dysphagia, with a success rate between 43 and 100% (mean = 76%). Read More

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Role of fine needle aspiration in malignant parotid tumors at a single-center experience: A retrospective cohort study.

Ann Med Surg (Lond) 2021 Apr 15;64:102229. Epub 2021 Mar 15.

Department of Otolaryngology-Head and Neck Surgery, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.

Background: Parotid gland tumors are mostly benign with good prognosis. On the other hand, malignant tumors of the parotid gland often have poor prognosis and metastasize. Mucoepidermoid carcinoma is the most common cancer in the parotid gland accounting for nearly 40-50% of the cases. Read More

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Assessment of remifentanil for rapid sequence induction and intubation in patients at risk of pulmonary aspiration of gastric contents compared to rapid-onset paralytic agents: study protocol for a non-inferiority simple blind randomized controlled trial (the REMICRUSH study).

Trials 2021 Mar 30;22(1):237. Epub 2021 Mar 30.

Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, F-44093, France.

Background: Rapid-onset paralytic agents are recommended to achieve muscle relaxation and facilitate tracheal intubation during rapid sequence induction in patients at risk of pulmonary aspiration of gastric contents. However, opioids are frequently used in this setting. The study's objective is to demonstrate the non-inferiority of remifentanil compared to rapid-onset paralytic agents, in association with an hypnotic drug, for tracheal intubation in patients undergoing  procedure under general anesthesia and at risk of pulmonary aspiration of gastric contents. Read More

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Cervical Lymph Node Evaluation in Oral Squamous Cell Carcinoma Patients Using Ultrasound-Guided Fine-Needle Aspiration Cytology - A Descriptive Diagnostic Evaluation Study in a Tertiary Care Center.

Contemp Clin Dent 2020 Jul-Sep;11(3):256-260. Epub 2020 Nov 26.

Department of Oral Medicine and Radiology, Government Dental College, Alappuzha, India.

Background: Oral cancer is the most frequent type of cancer of the head and neck area, with squamous cell carcinoma (SCC) being the most common single entity. Worldwide, oral cancer accounts for 2%-4% of all cancer cases, the prevalence being highest in India. Lymph node metastases occur in about 40% of patients with oral cancer. Read More

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November 2020

Correlation between Thyroid Imaging Reporting and Data System and Bethesda System of Reporting of Thyroid Cytopathology of Thyroid Nodule: A Single Center Experience.

J Cytol 2020 Oct-Dec;37(4):193-199. Epub 2020 Sep 16.

Department of Endocrinology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Background: The incidence of thyroid cancer has been increasing worldwide. Thyroid imaging reporting and data system (TIRADS) has been proposed for risk stratification of thyroid nodules to improve categorical management. Fine needle aspiration cytology based on Bethesda system for reporting of thyroid cytopathology (BSRTC) plays a fundamental role in the evaluation of thyroid nodule microscopically. Read More

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September 2020

Molecular Testing for and Mutations from Cytoscrapes of Thyroid Fine Needle Aspirates: A Single-Center Pilot Study.

J Cytol 2020 Oct-Dec;37(4):174-181. Epub 2020 Nov 7.

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Context And Aim: Molecular testing of thyroid FNA has been advocated in the indeterminate categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) 2018. The utility of cytoscrapes of thyroid FNA samples for V600E and mutations was evaluated in this pilot study.

Methods And Materials: Thyroid FNA samples between 2015 and 2018 from TBSRTC categories 3-6 were included. Read More

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November 2020

Diagnostic renal mass biopsy is associated with individual categories of PADUA and RENAL nephrometry scores: Analysis of diagnostic and concordance rates with surgical resection.

Urol Oncol 2021 Mar 24. Epub 2021 Mar 24.

Vanderbilt University Medical Center, Department of Pathology, Immunology, and Microbiology; Nashville, TN. Electronic address:

Background: Renal mass biopsy (RMB) is a safe and accurate method for diagnosis and clinical management of renal masses. However, the non-diagnostic rate is a limiting factor. We tested the hypothesis that imaging characteristics and anatomic complexity of the mass may impact RMB diagnostic outcome using the preoperative aspects and dimensions used for an anatomical (PADUA) classification and radius-exophytic/endophytic-nearness-anterior/posterior-location (RENAL) score. Read More

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Single pass, 1 needle actuation versus single pass 3 actuation technique for EUS-guided liver biopsy: a randomized prospective trial (with video).

Gastrointest Endosc 2021 Mar 23. Epub 2021 Mar 23.

Geisinger Medical Center. 100 N. Academy Ave, 21-11 Danville, PA 17822. Electronic address:

Background And Aims: Several reports have validated endoscopic ultrasound-guided liver biopsy (EUS-LB) as safe and effective. Nineteen-gauge EUS aspiration (fine-needle aspiration [FNA]) or core (fine-needle biopsy [FNB]) needles are used, but different needle techniques can yield variable outcomes. Some data shows 1 pass (single liver puncture) with 1 actuation (one to-and-fro needle movement) may be enough to obtain a satisfactory specimen. Read More

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Detection of intracellular lamellar bodies as a screening marker for fibrotic lesions.

Toxicol Appl Pharmacol 2021 05 23;418:115501. Epub 2021 Mar 23.

Department of Chemical and Biological Engineering, Korea University, 0284, Republic of Korea; Graduate School of Energy and Environment, Korea University, 0284, Republic of Korea. Electronic address:

With the rapid increase in application of disinfectants worldwide as a method to block the spread of coronavirus, many new products are being introduced into the market without thorough verification of their impacts on human health and the environment. In the present study, we aimed to propose a screening marker for materials that can induce fibrotic lung disease using disinfectants, which had been demonstrated as causative materials of chronic inflammation and interstitial fibrosis. We first calculated the corresponding LC level based on results from cell viability test and exposed the LC level of disinfectants to human bronchial epithelial cells for 24 h. Read More

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SINGLE INSTITUTION EXPERIENCE WITH AFIRMA AND THYROSEQ TESTING IN INDETERMINATE THYROID NODULES.

Thyroid 2021 Mar 25. Epub 2021 Mar 25.

Baystate Health, 7476, Medicine, 759 Chestnut Street, Springfield, Massachusetts, United States, 01199;

Background: Thyroid nodules are a very common, often incidental finding on physical exam or imaging. Of those that undergo fine needle aspiration, cytology is indeterminate in up to 15%. Molecular testing is increasingly being used to help identify which nodules may be high risk for malignancy and guide management in regard to clinical follow up or surgical intervention. Read More

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