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Raisonnement clinique : Avortement septique à Neisseria meningitidis.

J Obstet Gynaecol Can 2021 Apr;43(4):500-502

Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, N-É.

Le choc septique post-avortement est une cause mondiale importante de mortalité maternelle, mais on l'observe rarement dans les pays développés. Nous décrivons ici un cas d'avortement septique associé à un nouvel agent pathogène : Neisseria meningitidis. Une femme multipare de 30 ans s'est trouvée en choc septique après un avortement spontané incomplet. Read More

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A Randomized Study of the Impact of a Corneal Pre-Cut During Cataract Surgery on Wound Architecture and Corneal Astigmatism.

Ophthalmol Ther 2021 Mar 11. Epub 2021 Mar 11.

VIROS-Vienna Institute for Research in Ocular Surgery, a Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.

Introduction: The aim of the current study was to assess the effect of a 600-µm corneal pre-cut on wound architecture and its impact on surgically induced astigmatism. The images were acquired intraoperatively and postoperatively with high-resolution spectral-domain optical coherence tomography (SD-OCT).

Methods: This study included patients scheduled for cataract surgery. Read More

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Totally implantable venous access port insertion via open Seldinger approach of the internal jugular vein-a retrospective risk stratification of 500 consecutive patients.

Langenbecks Arch Surg 2021 Feb 7. Epub 2021 Feb 7.

Department of General, Visceral and Transplant Surgery, University Hospital Münster, Waldeyerstrasse 1, 48149, Münster, Germany.

Purpose: Modern oncological treatment algorithms require a central venous device in form of a totally implantable venous access port (TIVAP). While most commonly used techniques are surgical cutdown of the cephalic vein or percutaneous puncture of the subclavian vein, there are a relevant number of patients in which an additional strategy is needed. The aim of the current study is to present a surgical technique for TIVAP implantation via an open Seldinger approach of the internal jugular vein and to characterize risk factors, associated with primary failure as well as short- (< 30 days) and long-term (> 30 days) complications. Read More

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February 2021

Glyphosate poisoning - a case report.

J Postgrad Med 2021 Jan-Mar;67(1):36-38

Department of Emergency Medicine, Capital Hospital, Poranki, Vijayawada, Andhra Pradesh, India.

Glyphosate is the most commonly used broad-spectrum, non-selective herbicide in the world. The toxicity is supposed to be due to uncoupling of oxidative phosphorylation and the surfactant polyoxyethylene amine (POEA)- mediated cardiotoxicity. Clinical features of this herbicide poisoning are varied, ranging from asymptomatic to even death. Read More

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Utility of the Milan system for reporting salivary gland cytopathology: A retrospective 5 years study.

Diagn Cytopathol 2021 Apr 14;49(4):500-508. Epub 2021 Jan 14.

Department of Pathology, Seth Gordhandas Sunderdas Medical College and KEM Hospital, Mumbai, India.

Background: Fine-needle aspiration cytology (FNAC) is an established technique for preoperative diagnosis of salivary gland lesions; however, lack of a uniform reporting system has been a handicap. The main aims of this study were to evaluate the utility of the - "The Milan System for Reporting Salivary Gland Cytopathology" (MSRSGC) and ascertain the risk of malignancy (ROM) for each category.

Methods: All salivary gland FNACs over 5 years (January 2014-December 2018) were reviewed and assigned a diagnostic category from the MSRSGC. Read More

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Comparison between EUS-guided fine-needle aspiration cytology and EUS-guided fine-needle biopsy histology for the evaluation of pancreatic neuroendocrine tumors.

Pancreatology 2021 Mar 24;21(2):443-450. Epub 2020 Dec 24.

Department of Diagnostics and Public Health, G.B. Rossi University Hospital, Verona, Italy.

Background/objectives: Studies comparing EUS-guided fine-needle aspiration (EUS-FNA) with EUS-guided fine-needle biopsy (EUS-FNB) for the evaluation of pancreatic neuroendocrine tumors (pNETs) are lacking. We aimed at comparing EUS-FNA with EUS-FNB in terms of Ki-67 proliferative index (PI) estimation capability, cellularity of the samples, and reliability of Ki-67 PI/tumor grading compared with surgical specimens.

Methods: Patients diagnosed with pNETs on EUS and/or surgical specimens were retrospectively identified. Read More

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High-throughput drug screening of fine-needle aspiration-derived cancer organoids.

STAR Protoc 2020 Dec 16;1(3):100212. Epub 2020 Dec 16.

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.

Generation of fine-needle aspiration (FNA)-derived cancer organoids has allowed us to develop a number of downstream applications. In this protocol, we start with organoids cultured in a semi-solid format. We dissociate organoids into single cells and then plate in a 384-well format for high-throughput drug screening. Read More

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December 2020

Dramatic complication of pneumothorax treatment requiring lifesaving open-heart surgery.

Radiol Case Rep 2021 Mar 18;16(3):500-503. Epub 2020 Dec 18.

Desert Radiology, Las Vegas, NV, USA.

Pneumothorax is an extremely common entity that is typically readily diagnosed and treated. Standard treatment for a small pneumothorax in an otherwise healthy patient is oxygen and observation. For many cases of pneumothorax (those that are larger, more symptomatic, occur in patients with underlying lung disease, or occur in patients who live far from an emergency facility), treatment includes needle aspiration or chest tube placement. Read More

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Pilot Study of the Performance of 19-G Needle in Endobronchial Ultrasound-guided Transbronchial Aspiration for the Diagnosis and Testing of Molecular Markers in Lung Cancer.

J Bronchology Interv Pulmonol 2020 Dec 2;Publish Ahead of Print. Epub 2020 Dec 2.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Department of Pathology, Duke University Medical Center Department of Biostatistics and Bioinformatics, Duke University, Durham Department of Medicine, Wake Med Hospital, Raleigh, NC Department of Pathology and Immunology Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become the standard for diagnosis and staging of lung cancer. Historically, 21- and 22-G needles have been paired with EBUS. We evaluated the performance of EBUS-TBNA using a larger 19-G needle in the assessment of tumor tissue obtained and success of testing for molecular markers. Read More

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December 2020

Paediatric Agranulocytosis Associated with Metamizole Treatment.

Paediatr Drugs 2021 Jan 28;23(1):105-110. Epub 2020 Nov 28.

Department of Pediatrics, Eskişehir Osmangazi University Medical Faculty, Eskişehir, Turkey.

Purpose: Metamizole, which has antipyretic and pain-relieving properties, is generally used to treat fever in children who do not respond to paracetamol treatment. The most remarkable side effect of metamizole is that it causes myelotoxicity independently of dose. In this study, we aimed to present the clinical features of paediatric patients who developed agranulocytosis after the use of metamizole and draw attention to this side effect. Read More

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January 2021

Pleural Space Elastance and Its Relation to Success Rates of Pleurodesis in Malignant Pleural Effusion.

Tuberc Respir Dis (Seoul) 2021 Jan 9;84(1):67-73. Epub 2020 Nov 9.

Department of Chest Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Pleurodesis fails in 10%-40% of patients with recurrent malignant pleural effusions malignant pleural effusion and dyspnea. This study aimed to assess the values of pleural elastance (PEL) after the aspiration of 500 mL of pleural fluid and their relation to the pleurodesis outcome, and to compare the pleurodesis outcome with the chemical characteristics of pleural fluid.

Methods: A prospective study was conducted in Kasr El-Aini Hospital, Cairo University, during the period from March 2019 to January 2020. Read More

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January 2021

Upper Esophageal Sphincter Response to Laryngeal Adductor Reflex Elicitation in Humans.

Laryngoscope 2020 Oct 28. Epub 2020 Oct 28.

Department of Phoniatrics and Pediatric Audiology, Hannover Medical School, Hannover, Germany.

Objective: The laryngeal adductor reflex (LAR) is an important mechanism to secure the airways from potential foreign body aspiration. An involvement of the upper esophageal sphincter (UES) in terms of a laryngo-UES contractile reflex has been identified after laryngeal mucosa stimulation. However, the LAR-UES relationship has not yet been fully explained. Read More

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October 2020

Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods.

Parasit Vectors 2020 Oct 15;13(1):516. Epub 2020 Oct 15.

Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Burkina Faso.

Background: One of the promising current approaches to curb malaria lies in genetic vector control, the implementation of which will require an improved understanding of the movement of genetic constructs among mosquito populations. To predict potential gene flow from one area to another, it is important to begin to understand mosquito dynamics outside of the commonly-sampled village areas, and thus how genes may move between villages. This study assessed the presence and relative abundance of mosquitoes in a 6-km corridor between two villages in western Burkina Faso. Read More

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October 2020

endophthalmitis following routine cataract surgery: the first reported case in the United Kingdom.

Access Microbiol 2020 23;2(6):acmi000124. Epub 2020 Mar 23.

Consultant ophthalmologist, Royal Bournemouth Hospital, Bournemouth, UK.

Introduction: is a fastidious organism that has been implicated in severe infections such as endocarditis in immunocompetent patients. Modern tools are available to aid identification, but the main challenge remains clinical suspicion of .

Case Presentation: An otherwise fit and well 65-year-old female presented with reduced vision, red eye and discomfort 2 days following routine left cataract surgery. Read More

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Splenic Primary Solid Tumors : Does a Preoperative Histopathology Diagnosis Really Matter?

Am Surg 2021 Feb 16;87(2):316-320. Epub 2020 Sep 16.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, México.

Background: The present study aims to present a case series of patients who underwent splenectomy for splenic primary solid tumors without preoperative histopathologic diagnosis.

Methods: From 2013 to 2019, 12 patients underwent splenectomy for solid primary splenic tumors at 3 different academic medical centers. All electronic medical records were retrospectively reviewed. Read More

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February 2021

The development of cloned sheep embryos treated with Scriptaid and Trichostatin (A).

Saudi J Biol Sci 2020 Sep 29;27(9):2280-2286. Epub 2020 Apr 29.

Department of Biology, College of Science, Immam Mohammad Ibn Saud Islamic University Riyadh, Saudi Arabia.

Although, it has been success in the generation of animal clones from somatic cells in various animal species, the information related to nuclear reprogramming of cloned embryos is found to be limited. This study aims to compares the effect of both Scriptaid (SCR) and Trichostatin (A) treatments in improving cloning efficiency, and embryos developmental rate of cloned sheep embryos . Three groups were formed, i. Read More

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September 2020

Social Distancing, Safe Spaces and the Demand for Quarantine.

Frank Furedi

Society 2020 Jul 19:1-6. Epub 2020 Jul 19.

The University of Kent, Canterbury, CT2 7NY UK.

Social distance has been a topic of interest in sociology for more than a century before the outbreak of the COVID-19 pandemic. Whereas in the past it referred to the distance between groups in more recent times it signifies the space between individuals. The aspiration for safe space and personal boundaries in recent years indicated that social distancing has acquired an increasingly individuated and privatised form. Read More

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Evaluation of the Bethesda System and the ACR TIRADS in an Endemic Goiter Region.

Endocr Res 2020 Nov 30;45(4):226-232. Epub 2020 Jul 30.

Department of General Surgery, Kayseri City Hospital , Kayseri, Turkey.

Background: Various factors can affect incidence of thyroid disorders and disease profiles may show abrupt changes in endemic goitrous areas. In this study, it was aimed to analyze the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) in terms of risk of malignancy and general recommendations in an endemic goiter region (EGR).

Methods: In this retrospective study, a total of 500 patients who had thyroidectomy following thyroid fine needle aspiration biopsy were enrolled. Read More

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November 2020

Computer tomographic assessment of gastric volume in major trauma patients: impact of pre-hospital airway management on gastric air.

Scand J Trauma Resusc Emerg Med 2020 Jul 28;28(1):72. Epub 2020 Jul 28.

Departement of Anaesthesiology and Intensive Care Medicine AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Dr.-Franz-Rehrl-Platz 5, 5010, Salzburg, Austria.

Background: Gastric dilation is frequently observed in trauma patients. However, little is known about average gastric volumes comprising food, fluids and air. Although literature suggests a relevant risk of gastric insufflation when endotracheal intubation (ETI) is required in the pre-hospital setting, this assumption is still unproven. Read More

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Essential Thrombocythemia Presenting with Recurrent Priapism: A Case Report and Review of Literature.

Am J Case Rep 2020 Jul 28;21:e924455. Epub 2020 Jul 28.

Department of Clinical Hematology, King George's Medical University, Lucknow, Uttar Pradesh, India.

BACKGROUND Priapism is rarely reported as a complication in patients with essential thrombocythemia at presentation. We could find very few such cases of essential thrombocythemia while searching the literature. A combined modality of treatment is used in the form of chemotherapy and procedures like repeated aspiration and instillation of phenylephrine to treat essential thrombocythemia presenting with recurrent priapism. Read More

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Feasibility of laryngeal mask anesthesia combined with nerve block in adult patients undergoing internal fixation of rib fractures: a prospective observational study.

BMC Anesthesiol 2020 07 15;20(1):170. Epub 2020 Jul 15.

Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yishan Rd., Shanghai, China.

Background: The laryngeal mask airway (LMA) is occasionally used in internal fixation of rib fractures. We evaluated the feasibility of general anesthesia with an LMA associated to a thoracic paravertebral block (TPB) and/or an erector spinae plane block (ESPB) for internal fixation of rib fractures.

Methods: Twenty patients undergoing unilateral rib fracture fixation surgery were enrolled. Read More

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Pathogenic genetic variations of C. acnes are associated with clinically relevant orthopedic shoulder infections.

J Orthop Res 2020 12 20;38(12):2731-2739. Epub 2020 Jul 20.

Department of Orthopaedics, State University of New York, Buffalo, New York.

Many surgeons continue to face the clinical dilemma of interpreting a positive aspiration or unexpected positive Cutibacterium acnes (C. acnes) culture. There are factors that complicate the interpretation of positive cultures including variations in both frequency of false positive cultures and virulence properties. Read More

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December 2020

Distribution and phylogenetic diversity of Anopheles species in malaria endemic areas of Honduras in an elimination setting.

Parasit Vectors 2020 Jul 1;13(1):333. Epub 2020 Jul 1.

Microbiology Research Institute, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.

Background: Anopheles mosquitoes are the vectors of malaria, one of the most important infectious diseases in the tropics. More than 500 Anopheles species have been described worldwide, and more than 30 are considered a public health problem. In Honduras, information on the distribution of Anopheles spp. Read More

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Effects of Diluents, Saliva and Other Organics on the Microbicidal Activity of Cetylpyridinium Chloride and Povidone-iodine.

Biocontrol Sci 2020 ;25(2):45-53

Sunstar Shizuoka Innovation Center, Sunstar Inc.

Povidone-iodine (PVP-I) is used for infection control and preoperative sterilization of the oral and pharyngeal regions. Marketed preparations containing cetylpyridinium chloride (CPC) are used to inhibit growth of oral bacteria. We conducted an in vitro study of the sterilizing effects of these microbicides on 10 oral bacterial strains and fungi related to pneumonia and periodontal disease, after dilution with phosphate-buffered saline (PBS), saliva, and components in saliva. Read More

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Thrombectomy Technique Predicts Outcome in Posterior Circulation Stroke-Insights from the STAR Collaboration.

Neurosurgery 2020 10;87(5):982-991

Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina.

Background: Randomized controlled trials evaluating mechanical thrombectomy (MT) for acute ischemic stroke predominantly studied anterior circulation patients. Both procedural and clinical predictors of outcome in posterior circulation patients have not been evaluated in large cohort studies.

Objective: To investigate technical and clinical predictors of functional independence after posterior circulation MT while comparing different frontline thrombectomy techniques. Read More

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October 2020

Dual-color immunocytochemistry (Ki-67 with LCA) for precise grading of pancreatic neuroendocrine tumors with applicability to small biopsies and cell blocks.

Cytojournal 2020 31;17. Epub 2020 Mar 31.

Wayne State University School of Medicine, Karmanos Cancer Center, and Detroit Medical Center, Detroit, Michigan, USA.

Ki-67 (MIB-1) immunostaining to quantify the proliferative index of neuroendocrine tumors (NETs) has been recommended (especially for small biopsies). However, this has a number of challenges with nonrepresentative Ki-67 index due to interference by Ki-67 immunoreactive proliferating lymphocytes infiltrating the tumor and also some proliferating stromal cells including endothelial cells in the background. Our pilot project showed that dual-color immunostaining with inclusion of leukocyte common antigen (LCA) (Ki-67: nuclear brown; LCA: cytoplasmic red) can facilitate the weeding out of lymphocyte interference. Read More

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Effect of recombinant bovine somatotropin (rbST) treatment on follicular population and development in non-lactating dairy cows.

Anim Reprod 2019 Nov 18;16(4):914-922. Epub 2019 Nov 18.

Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.

The aim of this study was to evaluate the long-term effects of recombinant bovine somatotropin (rbST) on follicle population and ovulatory follicle development in non-lactating dairy cows. Twenty-one Jersey cows were allocated in rbST (n=11) or control (n=10) groups. On day -60, cows in rbST group received 500 mg of somatotropin (s. Read More

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November 2019

Volume and concentration dosing in picolitres using a two-channel microfluidic AFM cantilever.

Nanoscale 2020 May;12(18):10292-10305

Department of Precision and Microsystems Engineering, Delft University of Technology, The Netherlands.

We introduce a two-channel microfluidic atomic force microscopy (AFM) cantilever that combines the nanomechanical sensing functionality of an AFM cantilever with the ability to manipulate fluids of picolitres or smaller volumes through nanoscale apertures near the cantilever tip. Each channel is connected to a separate fluid reservoir, which can be independently controlled by pressure. Various systematic experiments with fluorescent liquids were done by either injecting the liquids from the on-chip reservoir or aspirating directly through the nanoscale apertures at the tip. Read More

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Effects on phacoemulsification efficiency and chatter at variable longitudinal ultrasound settings when combined with constant torsional energy.

J Cataract Refract Surg 2020 05;46(5):774-777

From the Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah (Bohner, Peterson, Wright, Mamalis, Bernhisel, Zaugg, Barlow, Olson, Pettey), University of Utah School of Medicine (Bohner, Peterson, Wright), Salt Lake City, USA.

Purpose: To evaluate longitudinal power settings for optimally efficient lens fragment removal, using the Centurion machine.

Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, USA. Read More

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Micronucleus Test for Diagnosing Uncertain Cases (BI-RADS 3) in Breast Cancer Screening: A Review and Preliminary Results.

Gulf J Oncolog 2020 Jan;1(32):45-50

Pavia University Italy.

Introduction: BI-RADS in mammography screening is the guide to give a standardized terminology in mammary images. The BI-RADS 3 (uncertain cases) protocol requires anew mammography after six months. This matter of time usually generates much concern and anxiety in patients and in the Radiologists. Read More

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January 2020