507,214 results match your criteria aspects

Classification of certain vertebral degenerations using MRI image features.

Biomed Phys Eng Express 2021 May 13. Epub 2021 May 13.

Engineering Design, IIT Madras, IIT Madras, Chennai, 600036, INDIA.

This article describes a fully automatic system for classifying various spinal degenerative phenotypes namely Modic changes, endplate defects and focal changes which are associated with lower back pain. These are obtained from T1/T2 Magnetic Resonance Imaging (MRI) scans. Lower back pain is a predominantly occurring ailment, which is prone to have various roots including the anatomical and pathophysiological aspects. Read More

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Can the combination of TasP and PrEP eliminate HIV among MSM in British Columbia, Canada?

Epidemics 2021 Apr 6;35:100461. Epub 2021 Apr 6.

British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada; Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Introduction: In British Columbia (BC), the HIV epidemic continues to disproportionally affect the gay, bisexual and other men who have sex with men (MSM). In this study, we aimed to evaluate how Treatment as Prevention (TasP) and pre-exposure prophylaxis (PrEP), if used in combination, could lead to HIV elimination in BC among MSM.

Methods: Considering the heterogeneity in HIV transmission risk, we developed a compartmental model stratified by age and risk-taking behaviour for the HIV epidemic among MSM in BC, informed by clinical, behavioural and epidemiological data. Read More

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Role of surgery and hyperthermic intraperitoneal chemotherapy in ovarian cancer.

S I Kim J-W Kim

ESMO Open 2021 May 10;6(3):100149. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Ovarian cancer is one of the deadliest gynaecological malignancies and tends to be diagnosed at an advanced stage. Similar to many malignancies, surgery plays a critical role in many aspects of ovarian cancer management. Hyperthermic intraperitoneal chemotherapy (HIPEC) involves the induction of hyperthermia and delivery of intraperitoneal chemotherapy directly into the peritoneal cavity. Read More

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The Burden of Caring for and Treating Glaucoma: The Patient Perspective.

Ophthalmol Glaucoma 2021 May 10. Epub 2021 May 10.

Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA; Center for Eye Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA.

Purpose: To understand the treatment burden experienced by patients receiving care for primary open-angle glaucoma.

Design: Semi-structured, one-on-one, qualitative interviews PARTICIPANTS: Patients with primary open-angle glaucoma and age ≥40 who were scheduled for a follow-up glaucoma appointment at the Kellogg Eye Center (Ann Arbor, Michigan, USA). Researchers used purposeful sampling to ensure that there was representation of a range of ages, disease stages, total number of medical conditions, distance traveled to clinic, history of prior glaucoma surgery, employment, and education. Read More

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The diverse roles of myeloid derived suppressor cells in mucosal immunity.

Cell Immunol 2021 Apr 9;365:104361. Epub 2021 Apr 9.

The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel. Electronic address:

The mucosal immune system plays a vital role in protecting the host from the external environment. Its major challenge is to balance immune responses against harmful and harmless agents and serve as a 'homeostatic gate keeper'. Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of undifferentiated cells that are characterized by an immunoregulatory and immunosuppressive phenotype. Read More

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Masculinity and misinformation: Social dynamics of liver fluke infection risk in Thailand.

Parasitol Int 2021 May 10:102382. Epub 2021 May 10.

Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Thailand.

Liver fluke infection through the consumption of raw or undercooked freshwater fish is a major public health problem in the Mekong Region. Despite the extensive efforts of liver fluke health campaigns, Northeast Thailand still reports high human infection prevalence as consumption of raw fish dishes has diminished but not ceased. This study examines the roles of social-cultural factors, particularly the influences of masculinity and misinformation, on liver fluke infection risk. Read More

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J Minim Invasive Gynecol 2021 May 10. Epub 2021 May 10.

Gynaecology Department. Institute Clinic of Gynaecology, Obstetrics and Neonatology, Hospital Clinic. Faculty of Medicine, University of Barcelona, Institut d`Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain.

Study Objective: We performed a long-term follow-up to quantify the impairment of sexual quality of life (SQL) and health-related quality of life (HRQL) in sexually active women following laparoscopic excision of deep infiltrating endometriosis (DIE).

Design: Prospective case-control study.

Setting: Hospital Clinic of Barcelona. Read More

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Cardiovascular responses to putative chemoreceptor stimulation of embryonic common snapping turtles (Chelydra serpentina) chronically incubated in hypoxia (10% O).

Comp Biochem Physiol A Mol Integr Physiol 2021 May 10:110977. Epub 2021 May 10.

Department of Biological Sciences, University of North Texas, 1155 Union Circle #310559, Denton, TX 76203, United States of America. Electronic address:

Developmental hypoxia has been shown to result in significant changes in cardiovascular development of American alligators and common snapping turtles. These include similar effects on cardiac mass and aspects of cardiovascular function. However, given the distant phylogenetic relationship between crocodilians and chelonians, we hypothesized that snapping turtles would also exhibit differences in the effects of developmental hypoxia on cardiovascular regulation. Read More

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Prevalence, predictors and correlates of religious and spiritual struggles in palliative cancer patients.

J Pain Symptom Manage 2021 May 10. Epub 2021 May 10.

Department of Religion, Health and Human Values, Rush University Medical Center, Chicago, Illinois.

Context: Religion and spirituality (r/s) are important resources in coping with cancer. However, there are aspects of r/s, such as religious and spiritual struggles, found to be associated with poorer outcomes. A new measure has been adapted from the Religious and Spiritual Struggles Scale (RSS) to assess r/s struggles: the RSS-14. Read More

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Cancer-Associated Mutations Perturb the Disordered Ensemble and Interactions of the Intrinsically Disordered p53 Transactivation Domain.

J Mol Biol 2021 May 10:167048. Epub 2021 May 10.

Department of Chemistry; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address:

Intrinsically disordered proteins (IDPs) are key components of regulatory networks that control crucial aspects of cell decision making. The intrinsically disordered transactivation domain (TAD) of tumor suppressor p53 mediates its interactions with multiple regulatory pathways to control the p53 homeostasis during the cellular response to genotoxic stress. Many cancer-associated mutations have been discovered in p53-TAD, but their structural and functional consequences are poorly understood. Read More

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Evolution of life cycle dimorphism: an example of sacoglossan sea slugs.

J Theor Biol 2021 May 10:110760. Epub 2021 May 10.

Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda-shi, Hyogo 669-1337, Japan.

Many sea slugs of Sacoglossa (Mollusca: Heterobranchia) are sometimes called "solar-powered sea slugs" because they keep chloroplasts obtained from their food algae and receive photosynthetic products (termed kleptoplasty). Some species show life cycle dimorphism, in which a single species has some individuals with a complex life cycle (the mother produces planktotrophic larvae, which later settle in the adult habitat) and others with a simple life cycle (mothers produce benthic offspring by direct development or short-term nonfeeding larvae in which feeding planktonic stages are skipped). Life cycle dimorphism is not common among marine species. Read More

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Relationship of negative emotion with leptin and food intake among overweight women.

Physiol Behav 2021 May 10:113457. Epub 2021 May 10.

Nutrition and Metabolism, Health Sciences Department, Ribeirão Preto Medical School, University of São Paulo (USP), Brazil; Laboratory of Food Practices and Behavior - PrátiCA, University of São Paulo (USP), Brazil. Electronic address:

Negative emotions can influence food intake. Leptin (an anorectic hormone) levels may change in response to psychological stressors. This study aimed to explore the relationship between leptin and food intake triggered by negative emotions in overweight women. Read More

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Application of the SMALP technology to the isolation of GPCRs from low-yielding cell lines.

Biochim Biophys Acta Biomembr 2021 May 10:183641. Epub 2021 May 10.

Department of Biopharmacy, Medical University of Lublin, ulica W. Chodźki 4a, Lublin, Poland. Electronic address:

The ability of styrene-maleic acid (SMAc) co-polymers to spontaneously insert into biological membranes can be exploited to extract G protein-coupled receptors (GPCRs) embedded in styrene-maleic acid lipid particles (SMALPs), preserving the native environment around the protein and thus enhancing the feasibility of functional studies. So far, the SMALP technology has been primarily employed on non-mammalian cells and protocols are not optimized for adherent human cell lines, which cannot be harvested in large amounts. In this work, a fine investigation of key parameters affecting the formation of SMALPs was undertaken with the purpose of maximizing the yield of extraction of a recombinant form of human β-adrenergic receptor (rhβAR) from HEK293T cells. Read More

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"The pharmacological profile of SGLT2 inhibitors: Focus on mechanistic aspects and pharmacogenomics".

Eur J Pharmacol 2021 May 10:174169. Epub 2021 May 10.

Department of Human Genetics and Molecular Medicine Central University of Punjab, Bathinda, 151001, India. Electronic address:

Diabetes, characterized by high glucose levels, has been listed to be one of the world's major causes of death. Around 1.6 million deaths are attributed to this disease each year. Read More

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Identifying Childhood Expressive Language Features That Best Predict Adult Language and Communication Outcome in Individuals With Autism Spectrum Disorder.

J Speech Lang Hear Res 2021 May 13:1-15. Epub 2021 May 13.

Department of Communication Sciences and Disorders, Emerson College, Boston, MA.

Purpose Several studies have reported that "useful speech" at 5 years of age predicts outcomes in individuals with autism spectrum disorder (ASD), but this skill has been vaguely defined. This study investigates which specific aspects of expressive language in children with ASD best predict adult language and communication outcomes. Method Language samples from 29 children (ages 47-72 months) enrolled in a longitudinal project (e. Read More

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Transparent, Compliant 3D Mesostructures for Precise Evaluation of Mechanical Characteristics of Organoids.

Adv Mater 2021 May 13:e2100026. Epub 2021 May 13.

Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA.

Recently developed methods for transforming 2D patterns of thin-film materials into 3D mesostructures create many interesting opportunities in microsystems design. A growing area of interest is in multifunctional thermal, electrical, chemical, and optical interfaces to biological tissues, particularly 3D multicellular, millimeter-scale constructs, such as spheroids, assembloids, and organoids. Herein, examples of 3D mechanical interfaces are presented, in which thin ribbons of parylene-C form the basis of transparent, highly compliant frameworks that can be reversibly opened and closed to capture, envelop, and mechanically restrain fragile 3D tissues in a gentle, nondestructive manner, for precise measurements of viscoelastic properties using techniques in nanoindentation. Read More

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Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis.

PLoS Pathog 2021 May 13;17(5):e1009532. Epub 2021 May 13.

Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Bacteria inhabit diverse environmental niches and consequently must modulate their metabolism to adapt to stress. The nucleotide second messengers guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (collectively referred to as (p)ppGpp) are essential for survival during nutrient starvation. (p)ppGpp is synthesized by the RelA-SpoT homologue (RSH) protein family and coordinates the control of cellular metabolism through its combined effect on over 50 proteins. Read More

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Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and meta-analysis.

PLoS One 2021 13;16(5):e0251642. Epub 2021 May 13.

Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Perú.

Aims: The objective of this systematic review and meta-analysis is to estimate the prevalence and incidence of diabetic peripheral neuropathy (DPN) in Latin America and the Caribbean (LAC).

Materials And Methods: We searched MEDLINE, SCOPUS, Web of Science, EMBASE and LILACS databases of published observational studies in LAC up to December 2020. Meta-analyses of proportions were performed using random-effects models using Stata Program 15. Read More

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Does blood type affect the COVID-19 infection pattern?

PLoS One 2021 13;16(5):e0251535. Epub 2021 May 13.

Department of Physics, Sapienza University, Rome, Italy.

Among the many aspects that characterize the COVID-19 pandemic, two seem particularly challenging to understand: i) the great geographical differences in the degree of virus contagiousness and lethality that were found in the different phases of the epidemic progression, and, ii) the potential role of the infected people's blood type in both the virus infectivity and the progression of the disease. A recent hypothesis could shed some light on both aspects. Specifically, it has been proposed that, in the subject-to-subject transfer, SARS-CoV-2 conserves on its capsid the erythrocytes' antigens of the source subject. Read More

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Prediction of direct carbon emissions of Chinese provinces using artificial neural networks.

Hui Jin

PLoS One 2021 13;16(5):e0236685. Epub 2021 May 13.

School of Economics, Shanghai University of Finance and Economics, Shanghai, China.

Closely connected to human carbon emissions, global climate change is affecting regional economic and social development, natural ecological environment, food security, water supply, and many other social aspects. In a word, climate change has become a vital issue of general concern in the current society. In this study, the carbon emission data of Chinese provinces in 1999-2019 are collected and analyzed, so as to identify the carbon emission of direct consumption per 10,000 residents in each province (including each municipal city and autonomous region) and the entire nation based on population data. Read More

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Primary health care and social isolation against COVID-19 in Northeastern Brazil: Ecological time-series study.

PLoS One 2021 13;16(5):e0250493. Epub 2021 May 13.

Public Health Program, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Background: Brazil is witnessing a massive increase of corona virus disease (COVID-19). Its peculiar primary health care (PHC) system faces a burden due to the contagion occurring in the community environment. Then, the aim is to estimate the effect of the coverage of primary health care and social isolation on the evolution of confirmed cases and deaths by COVID-19, controlling sociodemographic, economic and health system aspects. Read More

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Reverse Remodeling With Left Ventricular Assist Devices.

Circ Res 2021 May 13;128(10):1594-1612. Epub 2021 May 13.

Cardiovascular Research Foundation, New York, NY (D.B.).

This review provides a comprehensive overview of the past 25+ years of research into the development of left ventricular assist device (LVAD) to improve clinical outcomes in patients with severe end-stage heart failure and basic insights gained into the biology of heart failure gleaned from studies of hearts and myocardium of patients undergoing LVAD support. Clinical aspects of contemporary LVAD therapy, including evolving device technology, overall mortality, and complications, are reviewed. We explain the hemodynamic effects of LVAD support and how these lead to ventricular unloading. Read More

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Providing input into all aspects of urology nursing care.

Alaina Howard

Br J Nurs 2021 May;30(9):S27

Urology Nurse Practitioner, Royal Cornwall Hospitals NHS Trust.

, Urology Nurse Practitioner, Royal Cornwall Hospitals NHS Trust (alaina.howard@nhs.net) was runner-up in the Urology Nurse of the Year category in the BJN Awards 2021. Read More

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Gender-contingent effects of leadership on loneliness.

Wei Jee Ong

J Appl Psychol 2021 May 13. Epub 2021 May 13.

Department of Management and Organization, National University of Singapore.

This article builds from role congruity theory to develop and test a theoretical model about the gender-contingent experiences of loneliness for individuals taking on leadership roles. Across three complementary studies using diverse methods, occupying a leader role was associated with greater loneliness for women, but not for men. This effect was mediated by authenticity such that women experienced less authenticity when they occupied leader roles, but men did not. Read More

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Atomic-Scale Imaging of Interfacial Water under 3D Nanoscale Confinement.

Nano Lett 2021 May 13. Epub 2021 May 13.

Instituto de Ciencia de Materiales de Madrid, CSIC, c/Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain.

Capillary condensation of water from vapor is an everyday phenomenon which has a wide range of scientific and technological implications. Many aspects of capillary condensation are not well understood such as the structure of interfacial water, the existence of distinct properties of confined water, or the validity of the Kelvin equation at nanoscale. We note the absence of high-spatial resolution images inside a meniscus. Read More

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Inactivation of the CB receptor accelerated the neuropathological deterioration in TDP-43 transgenic mice, a model of amyotrophic lateral sclerosis.

Brain Pathol 2021 May 13:e12972. Epub 2021 May 13.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense, Madrid, Spain.

The activation of the cannabinoid receptor type-2 (CB ) afforded neuroprotection in amyotrophic lateral sclerosis (ALS) models. The objective of this study was to further investigate the relevance of the CB receptor through investigating the consequences of its inactivation. TDP-43(A315T) transgenic mice were crossed with CB receptor knock-out mice to generate double mutants. Read More

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Considerations in Oncoplastic Surgery.

Adv Exp Med Biol 2021 ;1187:525-544

National Cancer Center, Goyang-si, South Korea.

The development of oncoplastic surgery (OPS) is one of the greatest achievements for the treatment of breast cancer. OPS combines oncological resection with plastic surgery techniques in a single procedure to allow the excision of tumors without compromising cosmetic outcome. It allows better aesthetic-functional outcomes and consequently an improvement of the psychological aspects of patients with breast cancer. Read More

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January 2021

Patient-Derived Xenograft Models in Breast Cancer Research.

Adv Exp Med Biol 2021 ;1187:283-301

Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.

Patient-derived xenograft (PDX) model can be used as a platform to study the individual patient's sensitivity to targeted agents as well as its ability to guide our understanding in various aspects of tumor biology including the tumor's clonal evolution and interaction with microenvironment. In this chapter, we review the history of PDX models in various tumor types. Additionally, we highlight the key studies that suggested potential value of PDX models in cancer treatment. Read More

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January 2021

Fear conditioning and stimulus generalization in association with age in children and adolescents.

Eur Child Adolesc Psychiatry 2021 May 13. Epub 2021 May 13.

Center of Mental Health, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.

The aim of the study was to investigate age-related differences in fear learning and generalization in healthy children and adolescents (n = 133), aged 8-17 years, using an aversive discriminative fear conditioning and generalization paradigm adapted from Lau et al. (2008). In the current task, participants underwent 24 trials of discriminative conditioning of two female faces with neutral facial expressions, with (CS+) or without (CS-) a 95-dB loud female scream, presented simultaneously with a fearful facial expression (US). Read More

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A National Comparative Investigation of Twins With Congenital Heart Defects for Neurodevelopmental Outcomes and Quality of Life (Same Same, but Different?): Protocol for a Prospective Observational Study.

JMIR Res Protoc 2021 May 13;10(5):e26404. Epub 2021 May 13.

Department of Congenital Heart Defects and Pediatric Cardiology, German Heart Center of Munich, Munich, Germany.

Background: Due to the increased survival rates of patients with congenital heart defects (CHD), associated disorders are an increasing focus of research. Existing studies figured out an association between CHD and its treatment, and neurodevelopmental outcomes including motor competence impairments. All these studies, however, compared their test results with reference values or results of healthy control groups. Read More

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