40,214 results match your criteria aspartate alanine


The effects of heat stress exposure on free amino acid concentrations within the plasma and the brain of heat-exposed chicks: A systematic review and meta-analysis.

J Therm Biol 2021 Apr 11;97:102872. Epub 2021 Feb 11.

Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

This study was conducted in order to investigate the effects of heat stress exposure on the concentrations of amino acids within the plasma and the brain of chicks. Methodology: Five electronic databases including; PubMed, Scopus, Web of Science, Embase and ProQuest were reviewed to find relative literature published until the March 8, 2019. A total of eight relative studies and 194 chicks were analyzed. Read More

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Glomus intraradices causes differential changes in amino acid and starch concentrations of in vitro strawberry subjected to water stress.

New Phytol 2000 Oct;148(1):177-186

1 Centre de Recherche en Horticulture, CRH, Envirotron, Université Laval, Ste-Foy, Québec, G1K 7P4, Canada.

The effect of colonization of tissue-cultured strawberry (Fragaria×ananassa Duch. cv. Kent) plantlets in vitro by the arbuscular mycorrhizal fungus (AMF) Glomus intraradices on plantlet response to poly(ethylene glycol) (PEG)-8000-induced water stress was investigated. Read More

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October 2000

Swietenine potentiates the antihyperglycemic and antioxidant activity of Metformin in Streptozotocin induced diabetic rats.

Biomed Pharmacother 2021 Apr 13;139:111576. Epub 2021 Apr 13.

Pharmaceutical Chemistry Department, School of Pharmacy, International Medical University, 126 Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia; Centre of Excellence for Bioactive Molecules and Drug Delivery, Institute for Research, Development & Innovation (IRDI), International Medical University, 126 Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia. Electronic address:

Diabetes mellitus or type-2 diabetes, commonly referred as diabetes, is a metabolic disorder that results in high blood sugar level. Despite the availability of several antidiabetic drugs in the market, they still do not adequately regulate blood sugar levels. Thus, in general people prefer to use herbal supplements/medicines along with antidiabetic drugs to control blood sugar levels. Read More

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Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.

PLoS One 2021 16;16(4):e0249346. Epub 2021 Apr 16.

Department of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.

Background: Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).

Objective: To describe the clinical characteristics of patients with ARDS-COVID-19.

Materials And Methods: This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. Read More

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Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial.

Adv Exp Med Biol 2021 ;1308:109-117

Department of Gynecology and Obstetrics, Iran University of Medical Sciences, Tehran, Iran.

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility, for which the insulin sensitizer metformin has been used therapeutically. It has been shown that curcumin also exhibits insulin-sensitizing properties. Given that metformin acts as an ovulation inducing agent and both curcumin and metformin can reduce insulin resistance, the aim of the current study was to evaluate the effect of metformin with and without curcumin nanomicelles in the treatment of women with polycystic ovary syndrome. Read More

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January 2021

Alteration of cofactor specificity of the acrylyl-CoA reductase from Escherichia coli.

Biotechnol Lett 2021 Apr 16. Epub 2021 Apr 16.

Laboratory of Methylotrophy, Federal Research Center, "Pushchino Scientific Center for Biological Research, Russian Academy of Sciences" IBPM RAS, Pushchino, Moscow Region, Russia, 142290.

Objectives: Alteration of the cofactor specificity of acrylyl-CoA reductase (AcuI) catalyzing the NAD(P)H-dependent reduction of acrylyl-CoA to propionyl-CoA is often desirable for designing of artificial metabolic pathways of various appointments.

Results: Several variants of AcuIs from Escherichia coli K-12 with multiple amino acid substitutions to alter the cofactor preference were obtained by site directed mutagenesis and the modified enzymes as His-tagged proteins were characterized. The simultaneous substitutions of arginine-180, arginine-198 and serine-178 residues by alanine in the enzyme pocket sequence as well as other amino acid changes decreased both NADPH- and NADH-dependent activities in comparison to the wild-type enzyme. Read More

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Ergostatrien-3β-ol (EK100) from Attenuates Oxidative Stress, Inflammation, and Liver Injury and .

Prev Nutr Food Sci 2021 Mar;26(1):58-66

Institute of Food Science and Technology, Taipei 106, Taiwan.

Hepatic ischemia/reperfusion (IR) injury is a complication that occurs during liver surgery, whereby hepatic tissue is injured by oxygen deficiency during ischemia, then further damaged by a cascade of inflammatory and oxidative insults when blood is resupplied during reperfusion. is an indigenous fungus in Taiwan and an esteemed Chinese herbal medicine with various bioactivities. This study examined the effect of ergostatrien-3β-ol (EK100), an active compound found in both the fruiting body and mycelia of , on IR injury pathologies in rats and cell models of oxidative and inflammatory stress. Read More

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Effects of obesity and 10 weeks metformin treatment on liver steatosis.

Biomed Rep 2021 Jun 30;14(6):49. Epub 2021 Mar 30.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in adolescents and adults, and the risk of developing NAFLD increases with obesity. In the present study, it was shown that obesity increased fatty liver (steatosis) using an obese Zucker rat model. Metformin is an oral anti-hyperglycemic agent approved by the FDA for treatment of type 2 diabetes in adults and children >10 years of age. Read More

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Mahuang Decoction Antagonizes Acute Liver Failure via Modulating Tricarboxylic Acid Cycle and Amino Acids Metabolism.

Front Pharmacol 2021 29;12:599180. Epub 2021 Mar 29.

Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.

Acute liver failure (ALF) is a serious clinical disorder with high fatality rates. Mahuang decoction (MHD), a well-known traditional Chinese medicine, has multiple pharmacological effects, such as anti-inflammation, anti-allergy, anti-asthma, and anti-hyperglycemia. In this study, we investigated the protective effect of MHD against ALF. Read More

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Neem Leaf ( A. Juss) Ethanolic Extract on the Liver and Kidney Function of Rats.

ScientificWorldJournal 2021 30;2021:7970424. Epub 2021 Mar 30.

Laboratory of Pathology, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.

Neem ( A. Juss) is one of the tropical plants found in Indonesia that has been used to prevent and treat various diseases. This study aimed to investigate the effect of the ethanol extract of neem leaves on the concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in male rats. Read More

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Comparative physiological and full-length transcriptome analyses reveal the molecular mechanism of melatonin-mediated salt tolerance in okra (Abelmoschus esculentus L.).

BMC Plant Biol 2021 Apr 15;21(1):180. Epub 2021 Apr 15.

Institute of Horticulture, Zhejiang Academy of Agriculture Science, Hangzhou, 310021, Zhejiang, China.

Background: Melatonin, a multifunctional signal molecule, has been reported to play crucial roles in growth and development and stress responses in various plant species. Okra (Abelmoschus esculentus L.) is a food crop with extremely high values of nutrition and healthcare. Read More

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Isomerization of Asp is essential for assembly of amyloid-like fibrils of αA-crystallin-derived peptide.

PLoS One 2021 15;16(4):e0250277. Epub 2021 Apr 15.

Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, Japan.

Post-translational modifications are often detected in age-related diseases associated with protein misfolding such as cataracts from aged lenses. One of the major post-translational modifications is the isomerization of aspartate residues (L-isoAsp), which could be non-enzymatically and spontaneously occurring in proteins, resulting in various effects on the structure and function of proteins including short peptides. We have reported that the structure and function of an αA66-80 peptide, corresponding to the 66-80 (66SDRDKFVIFLDVKHF80) fragment of human lens αA-crystallin, was dramatically altered by the isomerization of aspartate residue (Asp) at position 76. Read More

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Food restriction reduces hepatic alterations associated with experimental periodontitis.

J Periodontol 2021 Apr 15. Epub 2021 Apr 15.

Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of the Parnaiba Delta (UFDPar), Parnaíba, PI, Brazil.

Background: Periodontitis is a chronic inflammatory and multifactorial disease that affects the periodontal structures and can cause alterations in the hepatic tissue. The aim of the present study was to evaluate whether a diet with food restriction can decrease oral and liver alterations associated with ligature-induced periodontitis.

Methods: Twenty-four female Wistar rats were used in this study, randomized into three groups (n = 8 for each group): control (regular food); periodontitis (regular food + periodontitis induced with ligatures) and food restriction (diet with food restriction and periodontitis induction). Read More

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Improving the reproductive, immunity and health status of rabbit does using honey bee venom.

J Anim Physiol Anim Nutr (Berl) 2021 Apr 15. Epub 2021 Apr 15.

Department of Poultry Production, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, Egypt.

The aim of the present study was to investigate the long-term effect of using bee venom (BV) on the reproductive performance, immune, and health status of rabbit does and its effect on their litters. Sixty mature does, from Spanish V-line rabbit stock, were randomly assigned to four homogeneous groups with 15 does each. The 1 , 2 and 3 groups were injected twice weekly under the neck skin with 0. Read More

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Relationship between plasma 12,13-diHOME level and nonalcoholic fatty liver disease in patients with type 2 diabetes and obesity.

Minerva Endocrinol (Torino) 2021 Apr 15. Epub 2021 Apr 15.

Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China -

Objective: 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) was one of the newly found lipokines. The goal of this study was to investigate whether the 12,13-diHOME was associated with related metabolic markers of nonalcoholic fatty liver disease (NAFLD) in a Chinese population with type 2 diabetes (T2DM) and obesity.

Methods: This cross-sectional study enrolled 202 subjects with T2DM. Read More

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Adverse Effects of Ligation of an Aberrant Left Hepatic Artery Arising from the Left Gastric Artery during Radical Gastrectomy for Gastric Cancer: a Propensity Score Matching Analysis.

J Gastric Cancer 2021 Mar 24;21(1):74-83. Epub 2021 Mar 24.

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Purpose: No consensus exists on whether to preserve or ligate an aberrant left hepatic artery (ALHA), which is the most commonly encountered hepatic arterial variation during gastric surgery. Therefore, we aimed to evaluate the clinical effects of ALHA ligation by analyzing the perioperative outcomes.

Materials And Methods: We retrospectively reviewed the data of 5,310 patients who underwent subtotal/total gastrectomy for gastric cancer. Read More

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The Efficacy of Seed on Liver Enzymes in Nonalcoholic Fatty Liver Disease: A Randomized Double-Blind Clinical Trial.

Evid Based Complement Alternat Med 2021 27;2021:6693887. Epub 2021 Mar 27.

Department of Internal Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: This study aims to evaluate the effects of () seed on liver enzymes and ultrasound patterns in nonalcoholic fatty liver disease (NAFLD).

Design: In this randomized double-blind placebo-controlled clinical trial, 74 patients with NAFLD were administered either 2 g or placebo twice daily for 12 weeks. All patients were advised to follow the recommendations for daily exercise and diet modification. Read More

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Evaluation of different almond () extracts against oxidative stress induced by cyclosporine in brain and liver of rats.

J Complement Integr Med 2021 Apr 12. Epub 2021 Apr 12.

Department of Chemical Sciences, Joseph Ayo Babalola University, Ikeji Arakeji, Osun State, Nigeria.

Objectives: This study was designed to evaluate the ameliorative effect of almond () leaf (ALE) and stem bark (ABE) extracts on the enzyme activities and oxidative stress markers in the brain and liver tissues of cyclosporine-A (CsA) stressed male albino rats.

Methods: Eighty-eight adult male rats weighing between 200 and 220 g were randomly distributed to into 11 groups (n=8) and different doses (100 and 200 mg/kg bwt.) of ALE and ABE were administered through oral gavages to the normal rats and 50 mg/kg/bwt/day CsA-stressed, while normal control rats was given a saline solution (p. Read More

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Clinical Case Report: Dissociation of Clinical Course of Coexisting Autoimmune Hepatitis and Graves Disease.

AACE Clin Case Rep 2021 Jan-Feb;7(1):36-39. Epub 2020 Dec 28.

Division of Endocrinology, Diabetes, and Metabolism, Emory University, Atlanta, Georgia.

Objective: Concurrent autoimmune disorders, including autoimmune hepatitis (AIH), with Graves disease have been reported. Glucocorticoids can simultaneously lower thyroid hormone levels and treat AIH. Recurrence of hyperthyroidism is associated with recurrence of hepatitis. Read More

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December 2020

Mechanism of scar formation following Roux-en-Y choledochojejunostomy in a novel rat model of obstructive jaundice.

Ann Transl Med 2021 Mar;9(6):456

Department of Hepatobiliary and Pancreaticosplenic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: The present study aimed to analyze the scar formation mechanism following Roux-en-Y choledochojejunostomy (CJS) in a novel rat model of obstructive jaundice.

Methods: The biliary obstruction model of Sprague-Dawley (SD) rats was established in advance, and 24 rats were randomly divided into 4 groups (control group, 1-day ligation group, 3-day ligation group, and 5-day ligation group). Changes in postoperative weight, common bile duct diameter, and laboratory indexes were analyzed to determine the best operation time. Read More

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Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways.

Med Sci Monit 2021 Apr 14;27:e929438. Epub 2021 Apr 14.

The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland).

BACKGROUND Hepatic stellate cells (HSCs) play a vital role in hepatic fibrogenesis. Our recent clinical study indicated that the Zi Qi decoction, a Traditional Chinese Medicine formula, exhibited good efficacy in alleviating liver fibrosis, but the underlying mechanism remains elusive. MATERIAL AND METHODS Rats repeatedly injected with CCl₄ and cells stimulated with lipopolysaccharide were used as in vivo and in vitro models for liver fibrosis, respectively. Read More

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Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome.

J Transl Med 2021 Apr 13;19(1):148. Epub 2021 Apr 13.

Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning, China.

Background: Time-restricted feeding (TRF) is a form of intermittent fasting, which is beneficial for weight loss and cardiometabolic health. Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine and metabolic diseases affecting women of childbearing age. It is associated with an increased prevalence of metabolic syndrome, cardiovascular diseases and type 2 diabetes. Read More

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Acute toxicity studies and protective effects of bark extract in streptozotocin-induced diabetic rats.

Drug Chem Toxicol 2021 Apr 13:1-11. Epub 2021 Apr 13.

Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, India.

The medicinal properties of () bark have been reported for their clinical importance for many diseases including diabetes. However, there is no clear evidence so far regarding dose selection for its hepato- and nephroprotective effect in diabetic condition. Hence, the present study aims at evaluating antioxidant activity, the acute toxicity, and dose fixation of bark for their effective medicinal values in streptozotocin (STZ)-induced rats. Read More

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Reproductive performance, expression of TRAP6 and TGF-β4 genes in utero-vaginal junction mucosa, and indicators of liver function in female Chukar partridge (Alectoris chukar) breeders fed with fish oil and calcitriol during the egg-laying period.

Theriogenology 2021 Mar 30;168:50-58. Epub 2021 Mar 30.

Department of Animal Science, Sari Agricultural Science and Natural Resources University, Sari, 48177- 36781, Iran.

Reproductive attributes, expression of TRAP6 and TGF-β mRNA in the mucosa of the utero-vaginal junction (UVJ) of oviduct, and liver function were evaluated in Chukar partridge (Alectoris chukar) breeders subjected to long-term oral administration of fish oil (FO) and/or calcitriol (CT). A total of forty-eight 1.5-year-old laying Chukar partridges and 16 age-matched males (female:male ratio of 3:1) were randomly allocated to four groups (4 replicates of 3 female birds and one male bird each). Read More

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De Ritis Ratio as a Significant Prognostic Factor in Patients with Sepsis: A Retrospective Analysis.

J Surg Res 2021 Apr 10;264:375-385. Epub 2021 Apr 10.

Department of General Surgery, First Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China. Electronic address:

Purpose: This study was performed to investigate the relationship between the aspartate transaminase and/or alanine transaminase ratio (DRR) and long-term mortality of patients diagnosed with sepsis or septic shock.

Materials And Methods: We conducted a retrospective study among adult septic patients who were admitted to the surgical intensive care unit (ICU) of the Chinese People's Liberation Army (PLA) General Hospital from January 2014 to December 2018. Baseline characteristics were compared between survivors and non survivors. Read More

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Meta-analysis of the effect of SGLT2 inhibitors on hepatic fibrosis in patients with T2DM complicated with NAFLD.

Hepatol Res 2021 Apr 13. Epub 2021 Apr 13.

Graduate School of Hebei Medical University, Shijiazhuang, China.

Objective: This study aimed to analyze the effects of SGLT2 inhibitors on the indexes of liver fibrosis in patients with T2DM complicated with NAFLD, and also to observe the effects on liver enzymes and liver fat.

Material And Methods: This meta-analysis was performed using RevMan 5.3 statistical software. Read More

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Role of dietary selenium in alleviating bisphenol A toxicity of liver albino rats: Histological, ultrastructural, and biomarker assessments.

J Food Biochem 2021 Apr 13:e13725. Epub 2021 Apr 13.

Pathology Department, College of Medicine, King Khalid University, Abha, Saudi Arabia.

Bisphenol A (BPA) is used as a plasticizer in polycarbonate plastics. It has been used in consumer products and epoxy resins for decades as protective coatings and linings for food and beverage bottles. This can trigger human reactions to BPA which interferes with estrogen receptors. Read More

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Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study.

Med Sci Monit 2021 Apr 13;27:e930176. Epub 2021 Apr 13.

Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China (mainland).

BACKGROUND Intrahepatic cholestasis of pregnancy (ICP) is a condition specific to pregnancy, leading to increased fetal morbidity and mortality. Nitric oxide synthase (iNOS) may be a factor regulating the vasodilation of blood vessels, which are relevant to ischemic-hypoxic conditions. We aimed to explore the potential relationship between iNOS and ICP. Read More

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Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis.

Lipids Health Dis 2021 Apr 12;20(1):31. Epub 2021 Apr 12.

Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.

Background: Hyperhomocysteinemia (HHcy) is associated with various health problems, but less is known about the gender differences in risk factors for high plasma homocysteine (Hcy) levels.

Methods: In this study, a retrospective study was carried out on 14,911 participants (7838 males and 7073 females) aged 16-102 years who underwent routine checkups between January 2012 and December 2017 in the Health Management Department of Xuanwu Hospital, China. Anthropometric measurements, including body mass index (BMI) and waist-to-hip ratio, were collected. Read More

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Porous Se@SiO2 nanospheres attenuate cerulein-induced acute pancreatitis in mice via downregulation of oxidative stress.

J Dig Dis 2021 Apr 12. Epub 2021 Apr 12.

Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Objective: Acute pancreatitis (AP) is a common digestive tract disease caused by gall stone obstruction, alcoholism and other factors. Pancreatitis may develop into severe pancreatitis, which has a relatively high mortality rate. Thus, effective methods for treating it need to be developed. Read More

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