4,721 results match your criteria asd 20005±12


Gait kinematic alterations in subjects with adult spinal deformity and their radiological determinants.

Gait Posture 2021 Jun 4;88:203-209. Epub 2021 Jun 4.

Faculty of Medicine, University of Saint-Joseph in Beirut, Lebanon; Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers ParisTech, Paris, France. Electronic address:

Background: Adults with spinal deformity (ASD) are known to have postural malalignment affecting their quality of life. Classical evaluation and follow-up are usually based on full-body static radiographs and health related quality of life questionnaires. Despite being an essential daily life activity, formal gait assessment lacks in clinical practice. Read More

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Comparison of the early cardiac electromechanical remodeling following transcatheter and surgical secundum atrial septal defect closure in adults.

Egypt Heart J 2021 Jun 10;73(1):53. Epub 2021 Jun 10.

Cardiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: Secundum atrial septal defect (ASD) closure leads to electrical and mechanical remodeling that occurs early after shunt disappearance. The relationship between electromechanical remodeling using electrocardiogram (ECG) and cardiac magnetic resonance (CMR) after percutaneous and surgical closure has not yet been recorded in prospective studies.

Objective: We thought to study right atrium (RA) and right ventricle (RV) changes by CMR 3 months after transcatheter and surgical closure and their comparison with electrical remodeling by ECG. Read More

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Microbiota and Microglia Interactions in ASD.

Front Immunol 2021 25;12:676255. Epub 2021 May 25.

Department of Physiology and Pharmacology, Snyder Institute of Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Autism spectrum disorders (ASD) are serious, highly variable neurodevelopmental disorders, commonly characterized by the manifestation of specific behavioral abnormalities, such as stereotypic behaviors and deficits in social skills, including communication. Although the neurobiological basis for ASD has attracted attention in recent decades, the role of microglial cells, which are the main resident myeloid cell population in the brain, is still controversial and underexplored. Microglia play several fundamental roles in orchestrating brain development and homeostasis. Read More

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Aberrant dynamics of cognitive control and motor circuits predict distinct restricted and repetitive behaviors in children with autism.

Nat Commun 2021 06 10;12(1):3537. Epub 2021 Jun 10.

Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.

Restricted and repetitive behaviors (RRBs) are a defining clinical feature of autism spectrum disorders (ASD). RRBs are highly heterogeneous with variable expression of circumscribed interests (CI), insistence of sameness (IS) and repetitive motor actions (RM), which are major impediments to effective functioning in individuals with ASD; yet, the neurobiological basis of CI, IS and RM is unknown. Here we evaluate a unified functional brain circuit model of RRBs and test the hypothesis that CI and IS are associated with aberrant cognitive control circuit dynamics, whereas RM is associated with aberrant motor circuit dynamics. Read More

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"There's nothing here": Perspectives from rural parents promoting safe active recreation for children living with autism spectrum disorders.

Res Dev Disabil 2021 Jun 7;115:103998. Epub 2021 Jun 7.

University of British Columbia, Okanagan, 3333 University Way, Kelowna, BC, V1V 1V7, Canada; School of Nursing, University of British Columbia, Okanagan, Canada.

Background: Children with autism spectrum disorder (ASD) and their families experience challenges and barriers at multiple levels that influence their activity participation. The purpose of this study was to develop understanding about factors influencing how families can promote safe, active recreation for their children 3-12 years living with ASD across rural settings and how supports for these families can be enhanced.

Methods: This qualitative study used an interpretive descriptive approach. Read More

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Early concerns in parents of infants at risk for autism.

Dev Med Child Neurol 2021 Jun 9. Epub 2021 Jun 9.

Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA, USA.

Aim: To examine parental concerns about children at increased familial risk (i.e. high risk) of developing autism spectrum disorder (ASD) in early infancy. Read More

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Genetic and morphological estimates of androgen exposure predict social deficits in multiple neurodevelopmental disorder cohorts.

Mol Autism 2021 Jun 9;12(1):43. Epub 2021 Jun 9.

Department of Psychiatry, University of Iowa, Iowa City, USA.

Background: Neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) display a strong male bias. Androgen exposure is profoundly increased in typical male development, but it also varies within the sexes, and previous work has sought to connect morphological proxies of androgen exposure, including digit ratio and facial morphology, to neurodevelopmental outcomes. The results of these studies have been mixed, and the relationships between androgen exposure and behavior remain unclear. Read More

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Pivotal Response Treatment with and without robot-assistance for children with autism: a randomized controlled trial.

Eur Child Adolesc Psychiatry 2021 Jun 3. Epub 2021 Jun 3.

Karakter Child and Adolescent Psychiatry University Centre, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.

Pivotal response treatment (PRT) is a promising intervention focused on improving social communication skills in children with autism spectrum disorder (ASD). Since robots potentially appeal to children with ASD and may contribute to their motivation for social interaction, this exploratory randomized controlled trial (RCT) was conducted comparing PRT (PRT and robot-assisted PRT) with treatment-as-usual (TAU). Seventy-three children (PRT: n = 25; PRT + robot: n = 25; TAU: n = 23) with ASD, aged 3-8 years were assessed at baseline, after 10 and 20 weeks of intervention, and at 3-month follow-up. Read More

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Theory of Mind and Moral Decision-Making in the Context of Autism Spectrum Disorder.

J Autism Dev Disord 2021 Jun 8. Epub 2021 Jun 8.

ACSENT Laboratory, Department of Psychology, Faculty of Humanities, University of Cape Town, Cape Town, South Africa.

Social impairment in Autism Spectrum Disorder (ASD) has been linked to Theory of Mind (ToM) deficits. However, little research has investigated the relationship between ToM and moral decision-making in children with ASD. This study compared moral decision-making and ToM between aggregate-matched ASD and neurotypical boys (n = 38 per group; aged 6-12). Read More

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[Visual fixation patterns during basic facial emotion recognition and its correlation with social impairment among children with high-functioning autism spectrum disorder].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):484-488

Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

To explore the visual fixation patterns during facial emotion recognition and the association between fixation duration percentage (FDP) of eye region with social impairment among high-functioning autism spectrum disorders (HFASD). Children were recruited from the Child and Adolescent Behavior Research Center of Sun Yat-sen University, Guangzhou, between July and December 2019 for case control study. A total of 42 children with HFASD and 23 age-and gender-matched typical development (TD) children were enrolled. Read More

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Do referral factors predict a probable Autism Spectrum Disorder diagnosis? A DBPNet Study.

Acad Pediatr 2021 Jun 4. Epub 2021 Jun 4.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Objective: To determine the proportion of children referred to academic medical centers with concerns about Autism Spectrum Disorders (ASD) who received a probable ASD diagnosis, identify factors predicting ASD diagnosis and describe the children with ASD concerns who were not found to have autism.

Methods: 55 Developmental-Behavioral Pediatricians (DBP) at 12 academic sites in the DBPNet research network recorded data on ≤15 consecutive new patients. They coded presumed diagnoses after their first visit with the child. Read More

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The Alteration of Salivary Immunoglobulin A in Autism Spectrum Disorders.

Front Psychiatry 2021 21;12:669193. Epub 2021 May 21.

Department of Orthodontics, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School and Hospital of Stomatology, Tongji University, Shanghai, China.

Autism spectrum disorders (ASD) are neurodevelopmental disorders with changes in the gut and oral microbiota. Based on the intimate relationship between the oral microbiota and oral mucosal immunity, this study aimed to investigate changes in salivary immunoglobulin A (IgA) level in ASD and the underlying mechanism for any such changes. We recruited 36 children diagnosed with ASD and 35 normally developing children and measured their salivary IgA content using enzyme-linked immunosorbent assay (ELISA). Read More

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Urine Nitric Oxide Is Lower in Parents of Autistic Children.

Front Psychiatry 2021 21;12:607191. Epub 2021 May 21.

National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, China.

Parents raising children with autism spectrum disorder (ASD) usually carry on their daily life under tremendous stress, but limited empirical research has been devoted to this population. It is known that parents' health status directly impacts therapeutic outcome of ASD children. As an important regulator in cardiovascular, nervous and immune systems, nitric oxide (NO) levels haven't been reported in parents of ASD children yet. Read More

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Psychometric properties of the Cambridge-Mindreading Face-Voice Battery for Children in children with ASD.

Autism Res 2021 Jun 4. Epub 2021 Jun 4.

Institute for Autism Research, Canisius College, Buffalo, New York, USA.

This study examined the psychometric characteristics of the Cambridge-Mindreading Face-Voice Battery for Children (CAM-C) for a sample of 333 children, ages 6-12 years with ASD (with no intellectual disability). Internal consistency was very good for the Total score (0.81 for both Faces and Voices) and respectable for the Complex emotions score (0. Read More

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Bilingualism and language in children with autistic spectrum disorder: a systematic review.

Neurologia 2021 Jun 1. Epub 2021 Jun 1.

Facultad de Psicología, Universidad de Granada, Granada, España.

Introduction: Communication and language skills are among the most severely affected domains in individuals with autistic spectrum disorder (ASD). When a child diagnosed with ASD lives in a bilingual environment, the parents often express concerns about whether their child should learn both languages simultaneously, turning to specialists for advice. Despite the lack of evidence of any negative effect, some professionals disagree on this subject. Read More

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Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity.

Mol Autism 2021 Jun 4;12(1):41. Epub 2021 Jun 4.

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

Background: Autism spectrum disorder (ASD) has a strong genetic etiology. Germline mutation in the tumor suppressor gene PTEN is one of the best described monogenic risk cases for ASD. Animal modeling of cell-specific Pten loss or mutation has provided insight into how disruptions to the function of PTEN affect neurodevelopment, neurobiology, and social behavior. Read More

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Yoga complemented cognitive behavioral therapy on job burnout among teachers of children with autism spectrum disorders.

Medicine (Baltimore) 2021 Jun;100(22):e25801

Department of Educational Foundations, University of Nigeria, Nsukka, Nigeria.

Background/objective: Job burnout is a syndrome of reaction to chronic job-related stress which affects overall health, limits occupational efficacy, and personal accomplishments of employees thereby thwarting organizational outcomes. Burnout symptoms are common among teachers of children with autism spectrum disorders (ASD) and affect the academic progress of the children. This study investigated the effectiveness of Yoga-based cognitive behavioral therapy (Y-CBT) in reducing occupational burnout among teachers of children with autism in Lagos States, Nigeria. Read More

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Improvements in physical functionality in elderly patients with spinal deformity after corrective fusion surgery: a gait analysis.

J Neurosurg Spine 2021 Jun 4:1-8. Epub 2021 Jun 4.

1Department of Orthopaedic Surgery and.

Objective: Extensive corrective fusion surgery was performed on elderly patients with adult spinal deformity (ASD) to improve abnormal posture. Varying improvements in postoperative walking function were expected owing to differences in muscular strength and bone quality between patients in their 40s and those over 75 years of age. The purpose of this study was to compare preoperative and postoperative gait posture and physical functionality in elderly patients with ASD who underwent extensive corrective fusion to the thoracic spine. Read More

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The implementation of reciprocal imitation training in a Part C early intervention setting: A stepped-wedge pragmatic trial.

Autism Res 2021 May 6. Epub 2021 May 6.

Department of Psychology, University of Washington, Seattle, Washington, USA.

Despite the development of several evidence-based Naturalistic Developmental Behavioral Interventions (NDBIs), very few have been adapted for use in community-based settings. This study examines the implementation of Reciprocal Imitation Training (RIT)-an NDBI-by community Early Intervention (EI; IDEA Part C) providers serving toddlers from birth to 3 years. Of the 87 EI providers enrolled from 9 agencies in 4 counties across Washington State, 66 were included in the current sample. Read More

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Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences.

Cereb Cortex 2021 Jun 3. Epub 2021 Jun 3.

Autism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario M4G 1R8, Canada.

Social communication differences are seen in autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), but the brain mechanisms contributing to these differences remain largely unknown. To address this gap, we used a data-driven and diagnosis-agnostic approach to discover brain correlates of social communication differences in ASD, ADHD, and OCD, and subgroups of individuals who share similar patterns of brain-behavior associations. A machine learning pipeline (regression clustering) was used to discover the pattern of association between structural brain measures (volume, surface area, and cortical thickness) and social communication abilities. Read More

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Automatic Classification of Adult Males With and Without Autism Spectrum Disorder by Non-contact Measurement of Autonomic Nervous System Activation.

Front Psychiatry 2021 17;12:625978. Epub 2021 May 17.

Graduate School of Engineering, Chiba University, Chiba, Japan.

People with autism spectrum disorder (ASD) exhibit atypicality in various domains of behavior. Previous psychophysiological studies have revealed an atypical pattern of autonomic nervous system (ANS) activation induced by psychosocial stimulation. Thus, it might be feasible to develop a novel assessment tool to evaluate the risk of ASD by measuring ANS activation in response to emotional stimulation. Read More

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Direct and indirect costs and cost-driving factors in adults with tuberous sclerosis complex: a multicenter cohort study and a review of the literature.

Orphanet J Rare Dis 2021 Jun 2;16(1):250. Epub 2021 Jun 2.

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Goethe-University Frankfurt, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

Background: Tuberous sclerosis complex (TSC) is a monogenetic, multisystem disorder characterized by benign growths due to TSC1 or TSC2 mutations. This German multicenter study estimated the costs and related cost drivers associated with organ manifestations in adults with TSC.

Methods: A validated, three-month, retrospective questionnaire assessed the sociodemographic and clinical characteristics, organ manifestations, direct, indirect, out-of-pocket (OOP), and nursing care-level costs among adult individuals with TSC throughout Germany from a societal perspective (costing year: 2019). Read More

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The association of adverse life events and parental mental health with emotional and behavioral outcomes in young adults with autism spectrum disorder.

Autism Res 2021 Jun 2. Epub 2021 Jun 2.

Department of Child and Adolescent Psychiatry, King's College London, Institute of Psychiatry, Psychology & Neuroscience, and South London and Maudsley Foundation Trust, London, UK.

People with autism spectrum disorder (ASD) are at increased risk of developing co-occurring mental health difficulties across the lifespan. Exposure to adverse life events and parental mental health difficulties are known risk factors for developing a range of mental health difficulties. This study investigates the association of adverse life events, parental stress and mental health with emotional and behavioral problems in young adults with ASD. Read More

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Gastrointestinal symptoms and sensory abnormalities associated with behavioral problems in children with neurodevelopmental disorders.

Autism Res 2021 Jun 2. Epub 2021 Jun 2.

Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan.

Behavioral problems directly affect the quality of life of caregivers and children with autism spectrum disorder (ASD) and/or attention-deficit/hyperactivity disorder (ADHD), and is known to be associated with clinical factors such as gastrointestinal (GI) symptoms, sensory abnormalities, intellectual abilities, and use of medication. However, previous studies have not considered these relationships comprehensively. We conducted a cross-sectional study of 6-12-year-old children with diagnoses of ASD and/or ADHD at two hospitals in Japan. Read More

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Family-Based Genome-Wide Association Study of Autism Spectrum Disorder in Middle Eastern Families.

Genes (Basel) 2021 May 18;12(5). Epub 2021 May 18.

College of Health and Life Sciences, Hamad Bin Khalifa University, Doha 34110, Qatar.

Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by abnormalities in language and social communication with substantial clinical heterogeneity. Genetic factors play an important role in ASD with heritability estimated between 70% to 80%. Genome-wide association studies (GWAS) have identified multiple loci associated with ASD. Read More

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Equivalent Behavioral Facilitation to Tactile Cues in Children with Autism Spectrum Disorder.

Brain Sci 2021 May 13;11(5). Epub 2021 May 13.

Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN 47907, USA.

The alerting network, a subcomponent of attention, enables humans to respond to novel information. Children with ASD have shown equivalent alerting in response to visual and/or auditory stimuli compared to typically developing (TD) children. However, it is unclear whether children with ASD and TD show equivalent alerting to tactile stimuli. Read More

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Effects of Mini-Basketball Training Program on Social Communication Impairment and Executive Control Network in Preschool Children with Autism Spectrum Disorder.

Int J Environ Res Public Health 2021 May 12;18(10). Epub 2021 May 12.

College of Physical Education, Yangzhou University, Yangzhou 225127, China.

This study evaluated the effect of a 12-week mini-basketball training program (MBTP) on social communication (SC) and the executive control network (ECN) in preschool children with autism spectrum disorders (ASD). We finally assigned 30 preschool children with ASD to an experiment group ( = 15, 12 males, 3 females) or a control group ( = 15, 13 males, 2 females). The experiment group participated in a 12-week MBTP (40-min sessions per day, 5 days a week), while the control group only received the institutional routine behavioral rehabilitation intervention. Read More

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Genetics and Epigenetics of One-Carbon Metabolism Pathway in Autism Spectrum Disorder: A Sex-Specific Brain Epigenome?

Genes (Basel) 2021 May 20;12(5). Epub 2021 May 20.

University Center for Studies on Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition affecting behavior and communication, presenting with extremely different clinical phenotypes and features. ASD etiology is composite and multifaceted with several causes and risk factors responsible for different individual disease pathophysiological processes and clinical phenotypes. From a genetic and epigenetic side, several candidate genes have been reported as potentially linked to ASD, which can be detected in about 10-25% of patients. Read More

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Instruments to Assess Physical Activity in Primary Education Students with Autism Spectrum Disorder: A Systematic Review.

Int J Environ Res Public Health 2021 May 5;18(9). Epub 2021 May 5.

Faculty of Education, Pontifical University of Salamanca, 37007 Salamanca, Spain.

The scientific evidence supports that physical inactivity in childhood is a reality throughout the world which generates important consequences in the global development of children. Young people with Autism Spectrum Disorder (ASD), due to the characteristics of the disorder they suffer, constitute a group at risk. Therefore, assessing the levels of physical activity (PA) in this group is fundamental for subsequent decision making and implementation of PA promotion programmes. Read More

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Use of rhBMP-2 for adult spinal deformity surgery: patterns of usage and changes over the past decade.

Neurosurg Focus 2021 Jun;50(6):E4

7Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York.

Objective: Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been shown to increase fusion rates; however, cost, limited FDA approval, and possible complications impact its use. Decisions regarding rhBMP-2 use and changes over time have not been well defined. In this study, the authors aimed to assess changes in rhBMP-2 use for adult spinal deformity (ASD) surgery over the past decade. Read More

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