173,665 results match your criteria ascending aorta


Sambucus nigra: A traditional medicine effective in reducing inflammation in mice.

J Ethnopharmacol 2021 Oct 11:114736. Epub 2021 Oct 11.

Postgraduate Program in Pharmaceutical Science, Universidade Do Vale Do Itajaí, Itajaí, Santa Catarina, Brazil. Electronic address:

Ethnopharmacological Relevance: Sambucus nigra L. is a plant of European origin and popularly known as elder, elderberry, black elder, European elder, European elderberry, and European black elderberry, being described in pharmacopoeia of several countries. Its flowers and berries have been used in folk medicine to treat feverish conditions, coughing, nasal congestion, and influenza besides its popular use as anti-inflammatory, analgesic, and diuretic agent. Read More

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October 2021

Investigations into the Potential of using of Open Source CFD to analyze the Differences in Hemodynamic Parameters for Aortic Dissections (Healthy vs. Stanford Type A and B).

Ann Vasc Surg 2021 Oct 11. Epub 2021 Oct 11.

Asahikawa Medical University, Asahikawa, Japan.

Objective: The objective of this study was to develop a method to evaluate the effects of an aortic dissection on hemodynamic parameters by conducting a comparison with that of a healthy (non-dissected) aorta. Opensource software will be implemented, no proprietary software/application will be used to ensure accessorily and repeatability, in all the data analysis and processing. CT images of aortic dissection are used for the model geometry segmentation. Read More

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October 2021

Degeneration and Regeneration of Smooth Muscle Cells in Two Different Abdominal Aortic Aneurysm Models in Rabbits: SMCs Change in Rabbit AAA.

Ann Vasc Surg 2021 Oct 11. Epub 2021 Oct 11.

Department of Interventional Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Aims: We aimed to investigate the formation and self-healing process of rabbit abdominal aortic aneurysm (AAA) by focus on the degeneration and regeneration of smooth muscle cells (SMCs) in elastase-induced AAA model and enlarging AAA model in rabbits.

Methods: Sixty rabbits were equally divided into two aneurysm groups (Group A and Group B). Rabbits received a 10-minute incubation of elastase in Group A (10 units/μl) and Group B (1 unit/μl). Read More

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October 2021

Circulating soluble receptor of advanced glycation end product is associated with bicuspid aortic aneurysm progression via NF-κB pathway.

Interact Cardiovasc Thorac Surg 2021 Oct 14. Epub 2021 Oct 14.

Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Objectives: Patients with bicuspid aortic valve (BAV) have a high risk of aortic dilation and adverse vascular events. Previous studies had reported soluble receptor for advanced glycation end products (sRAGE) to compete with receptor of advanced glycation end products (RAGE) for ligand binding and inhibit the activation of nuclear-factor kappa-B (NF-κB) pathway and matrix metalloproteinases (MMP) transcription. Thus, sRAGE serum levels may contribute to the clinical diagnosis and monitoring of ascending aorta aneurysm in patients with BAV. Read More

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October 2021

Ethanolic extract of improves vasoreactivity by modulation of eNOS expression and oxidative stress in spontaneously hypertensive rats.

Clin Exp Hypertens 2021 Oct 14:1-9. Epub 2021 Oct 14.

Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, India.

Background: Endothelial dysfunction is related to the reduced bioavailability of nitric oxide (NO) and plays a significant role in developing hypertension. The intake of a diet rich in antioxidants decreases the threat of hypertension. possesses antioxidant, anti-inflammatory, and hypocholesterolemic activities. Read More

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October 2021

Quantifying image quality in chest computed tomography angiography: Evaluation of different contrast-to-noise ratio measurement methods.

Acta Radiol 2021 Oct 14:2841851211041813. Epub 2021 Oct 14.

Institute of Radiology, 30246Kantonsspital Baden, Baden, Switzerland.

Background: Contrast-to-noise ratio is used to objectively evaluate image quality in chest computed tomography angiography (CTA). Different authors define and measure contrast-to-noise ratio using different methods.

Purpose: To summarize and evaluate the different contrast-to-noise ratio calculation formulas in the current literature. Read More

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October 2021

Abdominal aortic calcification: from ancient friend to modern foe.

Eur J Prev Cardiol 2021 Oct;28(12):1386-1391

Department of Radiology, University Medical Center Utrecht, the Netherlands.

Background: Abdominal aortic calcifications were already ubiquitous in ancient populations from all continents. Although nowadays generally considered as an innocent end stage of stabilised atherosclerotic plaques, increasing evidence suggests that arterial calcifications contribute to cardiovascular risk. In this review we address abdominal aortic calcification from an evolutionary perspective and review the literature on histology, prevalence, risk factors, clinical outcomes and pharmacological interventions of abdominal aortic calcification. Read More

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October 2021

Deciphering the Role of microRNAs in Large-Artery Stiffness Associated With Aging: Focus on miR-181b.

Front Physiol 2021 27;12:747789. Epub 2021 Sep 27.

Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, ML, United States.

Large artery stiffness (LAS) is a major, independent risk factor underlying cardiovascular disease that increases with aging. The emergence of microRNA signaling as a key regulator of vascular structure and function has stimulated interest in assessing its role in the pathophysiology of LAS. Identification of several microRNAs that display age-associated changes in expression in aorta has focused attention on defining their molecular targets and deciphering their role in age-associated arterial stiffening. Read More

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September 2021

ImageTBAD: A 3D Computed Tomography Angiography Image Dataset for Automatic Segmentation of Type-B Aortic Dissection.

Front Physiol 2021 27;12:732711. Epub 2021 Sep 27.

Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Type-B Aortic Dissection (TBAD) is one of the most serious cardiovascular events characterized by a growing yearly incidence, and the severity of disease prognosis. Currently, computed tomography angiography (CTA) has been widely adopted for the diagnosis and prognosis of TBAD. Accurate segmentation of true lumen (TL), false lumen (FL), and false lumen thrombus (FLT) in CTA are crucial for the precise quantification of anatomical features. Read More

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September 2021

Giant Cell Arteritis as an Uncommon Cause of Chronic Cough: A Case Report.

Am J Case Rep 2021 Oct 14;22:e932945. Epub 2021 Oct 14.

Department of Pulmonary Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

BACKGROUND Chronic cough is a common medical concern. Giant cell arteritis (GCA) is an uncommon cause of chronic cough and is not usually suspected since symptoms can be non-specific. We present a case of chronic cough due to GCA in which symptoms were subtle but imaging was remarkable and clearly disclosed the diagnosis. Read More

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October 2021

Ovariectomy Causes Degeneration of Perivascular Adipose Tissue.

J Oleo Sci 2021 Oct 12. Epub 2021 Oct 12.

Department of Applied Biological Chemistry, Kindai University.

Women are more resistant than men to the development of vascular diseases. However, menopause is a factor leading to deterioration of female vascular integrity, and it is reported that the risk of vascular diseases such as atherosclerosis and abdominal aortic aneurysm is increased in postmenopausal women. Although it is suggested that perivascular adipose tissue (PVAT) is deeply involved in the increased risk of vascular disease development, the effect of menopause on PVAT integrity is unknown. Read More

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October 2021

Hydrogen sulfide prevents arterial medial calcification in rats with diabetic nephropathy.

BMC Cardiovasc Disord 2021 Oct 13;21(1):495. Epub 2021 Oct 13.

Department of Physiology, Nanjing Medical University, 101 Longmian Road, Nanjing, 211166, Jiangsu, China.

Background: Arterial medial calcification (AMC) is associated with a high incidence of cardiovascular risk in patients with type 2 diabetes and chronic kidney disease. Here, we tested whether hydrogen sulfide (HS) can prevent AMC in rats with diabetic nephropathy (DN).

Methods: DN was induced by a single injection of streptozotocin and high-fat diet (45% kcal as fat) containing 0. Read More

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October 2021

Complex Regional Pain Syndrome with Aortic Distress after Thoracic Endovascular Aortic Repair and False Lumen Exclusion with "Candy Plug" Technique.

Aorta (Stamford) 2021 Oct 13. Epub 2021 Oct 13.

Department of Vascular Surgery, Vita-Salute San Raffaele University, Milan, Italy.

A 41-year-old male presented for pain treated with oxycodone. A zone-2 thoracic endovascular aortic repair with distal PETTICOAT (provisional extension to induce complete attachment) for complicated Type-IIIb aortic dissection was performed 18 months before. Repeated hospitalizations did not show any issues to justify the recurrent pain. Read More

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October 2021

Systematic review and meta-analysis of outcomes following endovascular and open repair for infective native aortic aneurysms.

Ann Vasc Surg 2021 Oct 10. Epub 2021 Oct 10.

Department of Vascular Surgery, West China Hospital.

Objective: The aim of our systematic review and meta-analysis was to demonstrate the clinical outcomes of open surgical repair (OSR) and endovascular aneurysm repair (EVAR) for infective native aortic aneurysms (INAAs).

Methods: MEDLINE, Embase, and Cochrane Databases were searched for articles reporting OSR and/or EVAR repair of INAA. The methodological quality of included studies was assessed by the Newcastle-Ottawa scale and Moga-Score. Read More

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October 2021

Application of the VORTEC Technique in Creating a Proximal Inflow Conduit in the Circumferentially-Calcified or "Lead-Pipe" Aorta.

Ann Vasc Surg 2021 Oct 10. Epub 2021 Oct 10.

Riverside Community Hospital, 4445 Magnolia Ave., RIVERSIDE, CALIFORNIA, 92501; University of California, Riverside School of Medicine, 900 University Ave., RIVERSIDE, CALIFORNIA, 92521.

A heavily calcified or "lead-pipe" aorta can present many challenges to any surgeon. There is higher risk of vessel wall rupture or disruption, distal embolization, and prolonged ischemia time of visceral organs due to longer clamp times. Hybrid revascularization techniques, which were originally described in visceral revascularization during complex aortic procedures, can be potentially utilized for lower extremity bypasses. Read More

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October 2021

Progression and Regression of Abdominal Aortic Aneurysms in Mice.

Curr Med Sci 2021 Oct 13. Epub 2021 Oct 13.

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Objective: Abdominal aortic aneurysm (AAA) is a significant medical problem with a high mortality rate. Nevertheless, the underlying mechanism for the progression and regression of AAA is unknown.

Methods: Experimental model of AAA was first created by porcine pancreatic elastase incubation around the infrarenal aorta of C57BL/6 mice. Read More

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October 2021

TEG6s Platelet Mapping assay for the estimation of plasma fibrinogen concentration during cardiovascular surgery: a single-center prospective observational study.

J Anesth 2021 Oct 13. Epub 2021 Oct 13.

Department of Anesthesiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Purpose: The Activator F (ActF) test on the TEG6s Platelet Mapping assay system is a means of quantifying blood viscoelasticity caused by fibrin network formation, triggered by reptilase and factor XIII, while platelets are inhibited. This unique methodology enables the measurement of blood viscoelasticity, even in highly heparinized blood. Here, we investigated whether fibrinogen concentration could be estimated using the ActF test in blood samples obtained during cardiopulmonary bypass (CPB) and after CPB in patients undergoing cardiovascular surgery. Read More

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October 2021

First experiences with a new balloon-expandable Myval transcatheter aortic valve: a preliminary study.

Herz 2021 Oct 13. Epub 2021 Oct 13.

Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Department of Cardiology, University of Health Sciences, Trabzon, Turkey.

Background: In the present article, we present our first experiences with a new type of balloon-expandable Myval valve (Meril Life Sciences, Gujarat, India).

Materials And Methods: A total of 25 consecutive patients who underwent transcatheter aortic valve implantation (TAVI) from June 2020 to November 2020 were included in the study.

Results: The mean age of the study population was 83 (75-87) years; 17 (68%) were female, and 20 (80%) had hypertension. Read More

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October 2021

Hypothermic Fibrillatory Arrest During Coronary Artery Bypass Grafting in a Man With Calcified Aorta and Ventricular Fibrillation.

Tex Heart Inst J 2021 Sep;48(4)

Surgical and Perioperative Careline, Department of Veterans Affairs, Los Angeles, California.

A 67-year-old man undergoing coronary artery bypass grafting had aortic calcification that prohibited aortic cross-clamping. When ventricular fibrillation developed during surgery, we instituted hypothermic fibrillatory arrest to avoid aortic cross-clamping. In addition to our patient's case, we discuss the advantages and disadvantages of using hypothermic fibrillatory arrest during cardiac surgery. Read More

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September 2021

A unique case of extrarenal calyces and associated vascular variations in an adult female cadaver.

Folia Morphol (Warsz) 2021 Oct 13. Epub 2021 Oct 13.

Center for Anatomical Science and Education, Department of Surgery, Saint Louis University School of Medicine, Saint Louis, MO, USA.

The following urogenital and vascular anomalies were observed in the left kidney of an 81-year-old female cadaver during routine dissection: three extrarenal calyces; an accessory renal artery originating directly from the abdominal aorta; and a circumaortic renal vein. The typical renal anatomical structures were identified, from anterior to posterior, as the renal vein, renal artery, and ureter appearing near the hilum of the left kidney. After closer examination, three extrarenal calyces were observed exiting from the hilum of the left kidney to form the pelvis, then narrowed and became the ureter which descended 21. Read More

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October 2021

Speckle-Tracking Global Longitudinal and Regional Strain Analysis in Neonates with Coarctation of Aorta: A Case-Control Study.

J Clin Med 2021 Oct 2;10(19). Epub 2021 Oct 2.

Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, Romania.

Our objectives are to compare speckle-tracking peak global longitudinal (pGLS) and regional strain values in neonates with coarctation of aorta (CoA) and control groups. Echocardiographic parameters measured by speckle-tracking were studied in a retrospective single-center study. A comparison of pGLS and segmental deformation between neonates with CoA and control group was performed using a three-way mixed ANOVA model. Read More

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October 2021

Safety, Feasibility, and Impact of Enalapril on Cardiorespiratory Physiology and Health in Preterm Infants with Systemic Hypertension and Left Ventricular Diastolic Dysfunction.

J Clin Med 2021 Sep 29;10(19). Epub 2021 Sep 29.

Division of Neonatology, Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Neonatal hypertension has been increasingly recognized in premature infants with bronchopulmonary dysplasia (BPD); of note, a sub-population of these infants may have impaired left ventricular (LV) diastolic function, warranting timely treatment to minimize long term repercussions. In this case series, enalapril, an angiotensin-converting enzyme (ACE) inhibitor, was started in neonates with systemic hypertension and echocardiography signs of LV diastolic dysfunction. A total of 11 patients were included with birth weight of 785 ± 239 grams and gestational age of 25. Read More

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September 2021

CNPase, a 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production.

Int J Mol Sci 2021 Oct 6;22(19). Epub 2021 Oct 6.

Post-Doctoral Innovation Base, Jinan University Affiliation, Yuanzhi Health Technology Co., Ltd., Hengqin New District, Zhuhai, Guangdong 51900, China.

Heart failure is the end-stage of all cardiovascular diseases with a ~25% 5-year survival rate, and insufficient mitochondrial energy production to meet myocardial demand is the hallmark of heart failure. Mitochondrial components involved in the regulation of ATP production remain to be fully elucidated. Recently, roles of 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNPase) in the pathophysiological processes of heart diseases have emerged, implicated by evidence that mitochondrial CNPase proteins are associated with mitochondrial integrity under metabolic stress. Read More

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October 2021

β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models.

Int J Mol Sci 2021 Sep 29;22(19). Epub 2021 Sep 29.

EMAN Research and Testing Laboratory, School of Pharmacy, Universiti Sains Malaysia, Gelugor 11800, Penang, Malaysia.

Beta-Caryophyllene (BCP), a naturally occurring sesquiterpene abundantly found in cloves, hops, and cannabis, is the active candidate of a relatively new group of vascular-inhibiting compounds that aim to block existing tumor blood vessels. Previously, we have reported the anti-cancer properties of BCP by utilizing a series of in-vitro anti-tumor-related assays using human colorectal carcinoma cells. The present study aimed to investigate the effects of BCP on in-vitro, ex-vivo, and in-vivo models of anti-angiogenic assays and evaluate its anti-cancer activity in xenograft tumor (both ectopic and orthotopic) mice models of human colorectal cancer. Read More

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September 2021

Persistence of Lipoproteins and Cholesterol Alterations after Sepsis: Implication for Atherosclerosis Progression.

Int J Mol Sci 2021 Sep 29;22(19). Epub 2021 Sep 29.

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.

(1) Background: Sepsis is one of the most common critical care illnesses with increasing survivorship. The quality of life in sepsis survivors is adversely affected by several co-morbidities, including increased incidence of dementia, stroke, cardiac disease and at least temporary deterioration in cognitive dysfunction. One of the potential explanations for their progression is the persistence of lipid profile abnormalities induced during acute sepsis into recovery, resulting in acceleration of atherosclerosis. Read More

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September 2021

Atherosclerotic Renal Artery Stenosis: A Review.

Aorta (Stamford) 2021 Oct 12. Epub 2021 Oct 12.

Department of Vascular and Transplant Surgery, National Hospital of Colombo, Sri Lanka.

Renal artery stenosis (RAS) is associated with hypertension and renal impairment. Atherosclerosis is the leading etiologic factor which accounts for >90% of the cases. Those with atherosclerotic RAS (ARAS) tend to have concomitant atherosclerosis in other vascular beds, so they are at a high risk of adverse coronary and cerebrovascular events. Read More

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October 2021

Modified Technique for Retrograde Cerebral Perfusion during Hemiarch Aortic Replacement.

Aorta (Stamford) 2021 Oct 12. Epub 2021 Oct 12.

Division of Cardiovascular and Thoracic Surgery, Missouri Baptist Medical Center, BJC Healthcare, St. Louis, Missouri.

Background:  Uncertainty remains regarding the optimal method of brain protection for procedures that require repair or replacement of the aortic arch. We examined the early outcomes of a technique for brain protection in patients undergoing partial aortic arch (hemiarch) replacement that involves deep hypothermic circulatory arrest (DHCA) and retrograde cerebral perfusion (RCP) of cold blood from the superior vena cava toward the end of the arrest interval.

Methods:  During a recent 15-year interval, 520 patients underwent elective or urgent/emergent ascending aortic and hemiarch replacement as an isolated (47 patients) or combined (473 patients) procedure employing DHCA (mean nasopharyngeal temperature at circulatory arrest, 17. Read More

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October 2021

A High-Echoic Layer Surrounding the Heart Suggesting Cardiac Tamponade by Clotting.

Aorta (Stamford) 2021 Oct 12. Epub 2021 Oct 12.

Department of Acute Critical Care Medicine, Juntendo Shizuoka Hospital, Izunokuni City, Shizuoka Prefecture, Japan.

A 16-year-old boy experienced a sudden loss of consciousness. On arrival, he was in cardiac arrest. An ultrasound study revealed a high-echoic layer surrounding the heart. Read More

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October 2021