51,153 results match your criteria article doi

Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice.

Epilepsy Res 2021 May 27;175:106677. Epub 2021 May 27.

Mercer University, College of Pharmacy, Department of Pharmaceutical Sciences, 3001 Mercer University Drive, Atlanta, GA, 30341, USA. Electronic address:

Recent preclinical and clinical studies suggest that lorcaserin, a preferential serotonin 2C receptor (5-HTR) agonist that was approved for the treatment of obesity, possesses antiepileptic properties. Here, we tested whether lorcaserin (1, 3, 5.6, 10 mg/kg) is prophylactic against audiogenic seizures (AGSs) in juvenile Fmr1 knockout mice, a mouse model of fragile X syndrome (FXS). Read More

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Effects of Mediterranean Diet on plasma metabolites and their relationship with insulin resistance and gut microbiota composition in a crossover randomized clinical trial.

Clin Nutr 2021 Apr 27;40(6):3798-3806. Epub 2021 Apr 27.

Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Rovira i Virgili (URV), Reus, Spain; Institute of Health Pere Virgili, IISPV, University Hospital Sant Joan, Reus, Spain; Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background & Aims: The Mediterranean Diet (MedDiet) may decrease the cardiometabolic risk through modulation of metabolic pathways. Furthermore, the interplay between MedDiet, metabolites and microbial metabolism may improve our understanding on the metabolic effects of this diet. We aimed to evaluate the effect of the MedDiet compared to nuts supplementation on circulating metabolites and their relationship with cardiometabolic health. Read More

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Correction: Measurement of Digital Literacy Among Older Adults: Systematic Review.

J Med Internet Res 2021 Jun 15;23(6):e30828. Epub 2021 Jun 15.

Mo-Im Kim Nursing Research Institute, College of Nursing, Yonsei University, Seoul, Republic of Korea.

[This corrects the article DOI: 10.2196/26145.]. Read More

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First report of causing root and crown rot on maize in Italy.

Plant Dis 2021 Jun 15. Epub 2021 Jun 15.


Maize (Zea mays L.) is a cereal crop of great economic importance in Italy; production is currently of 62,587,469 t, with an area that covers 628,801 ha, concentrated in northern Italy (ISTAT 2020). Fusarium species are associated with root and crown rot causing failures in crop establishment under high soil moisture. Read More

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A Leep1 into migration and macropinocytosis.

J Cell Biol 2021 Jul 15;220(7). Epub 2021 Jun 15.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.

Actin organization underpins conserved functions at the leading edge of cells. In this issue, Yang et al. (2021. Read More

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Herbal medicine for irritable bowel syndrome: An overview of systematic reviews protocol.

Medicine (Baltimore) 2021 Jun;100(24):e26364

Department of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong, Dongnam-ro 892, Gangdong gu.

Background: Irritable bowel syndrome (IBS) is a common disorder characterized by the recurrence of abdominal pain and changes in bowel habits. Owing to the limitations of conventional treatments, patients with IBS are often dissatisfied with the effect of treatment and have a poor quality of life. Herbal medicines (HMs) are frequently used for the treatment of IBS. Read More

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Clinical assessment of prophylactic chemotherapy in treating with hydatidiform mole: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26341

Department of Obstetrics and Gynecology, the First People's Hospital of Nantong, Nantong, Jiangsu, China.

Background: Hydatidiform mole (HM) is more common as molar pregnancy. It is a disease classified under the category of gestational trophoblastic diseases, which could metastasize after originating in the placenta. A majority of females suffering from molar pregnancies are curable by evacuating retained products of conception and the patient's fertility is preserved. Read More

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Evaluation of efficacy and safety of combined rosuvastatin and atorvastatin in treating with coronary heart disease: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26340

Department of Hematology, the Affiliated Hospital of Qinghai University, Xining, Qinghai.

Background: Globally, coronary heart disease (CHD) is a primary cause of morbidity leading to disabilities and mortality. Modern clinical practice adopts several pharmacological methods to treat CHD. Angina pectoris refers to sever chest pain due to CHD, it has a profound impact on the wellbeing of patients. Read More

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Long noncoding RNA taurine-up regulated gene 1 for the prognosis of osteosarcoma: A protocol for meta-analysis and bioinformatics analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26182

Department of Orthopedics and Soft Surgery, Gansu Cancer Hospital, Lanzhou, Gansu Province, China.

Background: In recent years, a variety of long noncoding RNA (lncRNA) has been confirmed to be involved in the initiation and progression of osteosarcoma. Taurine-up regulated gene 1 (TUG1) plays an important role in the formation, invasion, and metastasis of osteosarcoma. Therefore, perhaps TUG1 is a potential biomarker for the prognosis of patients suffering from osteosarcoma. Read More

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Cold Spells and Cause-Specific Mortality in 47 Japanese Prefectures: A Systematic Evaluation.

Environ Health Perspect 2021 Jun 15;129(6):67001. Epub 2021 Jun 15.

Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: Many studies have investigated the devastating health effects of heat waves, but less is known about health risks related to cold spells, despite evidence that extreme cold may contribute to a larger proportion of deaths.

Objectives: We aimed to systematically investigate the association between cold spells and mortality in Japan.

Methods: Daily data for weather conditions and 12 common causes of death during the 1972-2015 cold seasons (November-March) were obtained from 47 Japanese prefectures. Read More

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Rapid diagnostic testing for antimicrobial stewardship: Utility in Asia Pacific.

Infect Control Hosp Epidemiol 2021 Jun 15:1-5. Epub 2021 Jun 15.

Clinical Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Rapid diagnostic testing (RDT) can provide prompt, accurate identification of infectious organisms and be a key component of antimicrobial stewardship (AMS) programs. However, their use is less widespread in Asia Pacific than western countries. Cost can be prohibitive, particularly in less resource-replete settings. Read More

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Synthesis of L-[5-11C]Leucine and L-alfa-[5-11C]Methylleucine via Pd0-mediated 11C-Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging.

ChemMedChem 2021 Jun 14. Epub 2021 Jun 14.

RIKEN Kobe Institute, Center for Biosystems Dynamics Research, 6-7-3 Minatojima-minamimachi, Chuo-ku, 650-0047, Kobe, JAPAN.

The efficient synthesis of L-[5-11C]leucine and L-alfa-[5-11C]methylleucine has been investigated using a continuous two-step sequence of rapid reactions consisting of Pd0-mediated 11C-methylation and microfluidic hydrogenation. The synthesis of L-[5-11C]leucine and L-alfa-[5-11C]methylleucine was accomplished within 40 min with a decay-corrected radiochemical yield of 15-38% based on [11C]CH3I, radiochemical purity of 95-99%, and chemical purity of 95-99%. The Pd impurities in the injectable solution measured using inductively coupled plasma mass spectrometry met the international criteria for human use. Read More

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Cost-effectiveness of trifluridine/tipiracil against nivolumab for heavily pretreated metastatic gastric cancer in Japan.

Jpn J Clin Oncol 2021 Jun 14. Epub 2021 Jun 14.

Department of Experimental Therapeutics, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

Objective: Nivolumab and trifluridine/tipiracil have significantly improved the overall survival of patients with heavily pretreated metastatic gastric cancer in different placebo-controlled phase III trials. Accordingly, nivolumab and trifluridine/tipiracil have been approved and recommended for patients with heavily pretreated metastatic gastric cancer in Japan. The aim of this study was to assess the cost-effectiveness of trifluridine/tipiracil against nivolumab. Read More

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Correction to: Well‑Being Reduces COVID‑19 Anxiety: A Three‑Wave Longitudinal Study in China.

J Happiness Stud 2021 Jun 9. Epub 2021 Jun 9.

Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education (Beijing Normal University), Faculty of Psychology, Beijing Normal University, Beijing, China.

[This corrects the article DOI: 10.1007/s10902-021-00385-2.]. Read More

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Mood symptoms Associated with CADASIL Syndrome: A Case Report.

CNS Spectr 2021 Apr;26(2):144


Objective: To discuss the psychiatric symptoms that are associated with CADASIL syndrome Abstract Cerebral:Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare type of hereditary disease involving the small cerebral vessels. The clinical symptoms are various and include recurrent ischemic strokes, migraine with aura, seizures with epilepsy, psychiatric problems such as mood disturbances, and progressive cognitive decline leading to dementia. This disease needs awareness amongst the psychiatrists even though it is discussed much more in neurology literature. Read More

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Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial.

Crit Care 2021 06 14;25(1):209. Epub 2021 Jun 14.

Department of Surgical Sciences, Section of Anaesthesiology and Intensive Care Medicine, Uppsala University, Entrance 78, 1 floor, 751 85, Uppsala, Sweden.

Background: The effect of awake prone positioning on intubation rates is not established. The aim of this trial was to investigate if a protocol for awake prone positioning reduces the rate of endotracheal intubation compared with standard care among patients with moderate to severe hypoxemic respiratory failure due to COVID-19.

Methods: We conducted a multicenter randomized clinical trial. Read More

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Soft but Not Too Soft-How a Rigid Tube Expands without Breaking.

mBio 2021 Jun 15:e0050121. Epub 2021 Jun 15.

Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.

Fungi grow by apical extension of their hyphae. The continuous growth requires constant delivery of vesicles, which fuse with the membrane and secrete cell wall biosynthesis enzymes. The growth mechanism requires the fungal cytoskeleton and turgor pressure. Read More

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Bacterial Metal Resistance: Coping with Copper without Cooperativity?

mBio 2021 Jun 15:e0065321. Epub 2021 Jun 15.

Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

In Escherichia coli and other Gram-negative bacteria, tripartite efflux pumps (TEPs) span the entire cell envelope and serve to remove noxious molecules from the cell. CusBCA is a TEP responsible for copper and silver detoxification in E. coli powered by the resistance-nodulation-cell division (RND) transporter, CusA. Read More

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Correction: One-pot syntheses of irida-polycyclic aromatic hydrocarbons.

Chem Sci 2019 Dec 19;11(3):896. Epub 2019 Dec 19.

Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University Wuhan 430079 P. R. China

[This corrects the article DOI: 10.1039/C9SC03914G.]. Read More

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December 2019

Generation of High-Quality Pharmacokinetic Data from Parallel Tail Vein Dosing and Bleeding in Non-cannulated Rats.

J Pharm Sci 2021 Jun 11. Epub 2021 Jun 11.

DMPK, Research and Early Development, Oncology R&D, AstraZeneca, Boston, US. Electronic address:

It is common practice to use cannulated rats for pharmacokinetic (PK) in-life studies as it yields high quality PK parameter estimation. While offering many benefits, cannulation requires surgery, post-surgical care, and cannula maintenance. As an alternative approach, the strategy of dosing and bleeding rats via the tail vein in a single experiment is technically feasible and theoretically offers many benefits. Read More

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Correction: Ionotropic Receptor-dependent cool cells control the transition of temperature preference in Drosophila larvae.


PLoS Genet 2021 Jun 14;17(6):e1009631. Epub 2021 Jun 14.

[This corrects the article DOI: 10.1371/journal.pgen. Read More

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Correction: Palladium-catalysed 5- allylic (hetero)arylation.

Chem Sci 2020 Aug 14;11(33):9026-9027. Epub 2020 Aug 14.

Organic Synthesis and Catalysis Lab, Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali Sector 81, Manauli PO, S. A. S. Nagar Punjab 140306 India

[This corrects the article DOI: 10.1039/D0SC01932A.]. Read More

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Obes Sci Pract 2021 Jun 2;7(3):353-354. Epub 2021 Jun 2.

[This corrects the article DOI: 10.1111/OSP4508.]. Read More

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Correction: Direct synthesis of the organic and Ge free Al containing BOG zeolite (ITQ-47) and its application for transformation of biomass derived molecules.

Chem Sci 2020 Nov 5;11(44):12221. Epub 2020 Nov 5.

Instituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas Avenida de los Naranjos s/n 46022 Valencia Spain

[This corrects the article DOI: 10.1039/D0SC04044D.]. Read More

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November 2020

Corrigendum to "Impact of Diabetic Ketoacidosis on Thyroid Function in Patients with Diabetes Mellitus".

Int J Endocrinol 2021 26;2021:9832382. Epub 2021 May 26.

Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050017, China.

[This corrects the article DOI: 10.1155/2021/2421091.]. Read More

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