984,642 results match your criteria article critical


Ozone for SARS-CoV-2 inactivation on surfaces and in liquid cell culture media.

J Hazard Mater 2022 Jan 10;428:128251. Epub 2022 Jan 10.

College of Engineering, Bay Campus, Swansea University, Swansea SA1 8EN, United Kingdom.

This study evaluated the inactivation of SARS-CoV-2, the virus responsible for COVID-19, by ozone using virus grown in cell culture media either dried on surfaces (plastic, glass, stainless steel, copper, and coupons of ambulance seat and floor) or suspended in liquid. Treatment in liquid reduced SARS-CoV-2 at a rate of 0.92 ± 0. Read More

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January 2022

Critical measurement issues in the assessment of social media influence on body image.

Body Image 2022 Jan 12;40:225-236. Epub 2022 Jan 12.

School of Psychology, Deakin University, 1 Gheringhap Street, Geelong, Victoria, Australia; Centre for Social and Early Emotional Development, School of Psychology, Deakin University, Burwood, Australia.

Progress towards understanding how social media impacts body image hinges on the use of appropriate measurement tools and methodologies. This review provides an overview of common (qualitative, self-report survey, lab-based experiments) and emerging (momentary assessment, computational) methodological approaches to the exploration of the impact of social media on body image. The potential of these methodologies is detailed, with examples illustrating current use as well as opportunities for expansion. Read More

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January 2022

The effect of gap duration on the perception of fluent versus disfluent speech.

J Fluency Disord 2022 Jan 7;71:105896. Epub 2022 Jan 7.

Department of Communicative Sciences and Disorders, New York University, 665 Broadway, 9th Floor, New York, NY, 10012, United States.

Purpose: Gap duration contributes to the perception of utterances as fluent or disfluent, but few studies have systematically investigated the impact of gap duration on fluency judgments. The purposes of this study were to determine how gaps impact disfluency perception, and how listener background and experience impact these judgments.

Methods: Sixty participants (20 adults who stutter [AWS], 20 speech-language pathologists [SLPs], and 20 naïve listeners) listened to four tokens of the utterance, "Buy Bobby a puppy," produced at typical speech rates. Read More

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January 2022

Multiphoton microfabrication and micropatternining (MMM)-based screening of multiplex cell niche factors for phenotype maintenance - Bovine nucleus pulposus cell as an example.

Biomaterials 2022 Jan 6;281:121367. Epub 2022 Jan 6.

Tissue Engineering Laboratory, Biomedical Engineering Programme, Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong. Electronic address:

Upon monolayer cultures on flat and rigid plastic dishes, many cells de-differentiate and lose their native phenotype. Technologies able to identify and reconstitute the cell niche factors that best maintain the physiological cellular phenotype in cultures are critical. We have developed a multiphoton microfabrication and micropatterning (MMM) technology, a robust 3D micro-printing platform capable to fabricate protein microstructures and micropatterns with quantitative, spatial and independent control of the mechanical, topological and extracellular matrix properties. Read More

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January 2022

Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection.

Virology 2021 Dec 24;567:77-86. Epub 2021 Dec 24.

Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, 98101, USA; Department of Pediatrics, Division of Hematology and Oncology, University of Washington, Seattle, WA, 98195, USA. Electronic address:

Type-I interferon (IFN-I) signals exert a critical role in disease progression during viral infections. However, the immunomodulatory mechanisms by which IFN-I dictates disease outcomes remain to be fully defined. Here we report that IFN-I signals mediate thymic atrophy in viral infections, with more severe and prolonged loss of thymic output and unique kinetics and subtypes of IFN-α/β expression in chronic infection compared to acute infection. Read More

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December 2021

Computational characterization of transducer recognition of β2 adrenergic receptor.

Biochem Biophys Res Commun 2022 Jan 7;592:67-73. Epub 2022 Jan 7.

State Key Laboratory of Drug Research and Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou, 310024, China. Electronic address:

As an important drug target, β2 adrenergic receptor (B2AR) regulates many physiological processes, including cardiac function, airway tone and metabolic functions. The selective coupling between B2AR and specific transducers is critical for the physiological action of the receptor. However, the molecular mechanism by which B2AR recognizes different transducers remains elusive. Read More

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January 2022

Commonly expressed key transcriptomic profiles of sepsis in the human circulation and brain via integrated analysis.

Int Immunopharmacol 2022 Jan 12;104:108518. Epub 2022 Jan 12.

Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410013, PR China. Electronic address:

Background: Sepsis is the leading cause of death in intensive care units and is characterized by multiple organ failure, including dysfuction of the immune system and brain. This study aims to determine the differential effect of sepsis on specific circulating immune cell subsets compared with brain transcriptome and identify the genes co-expressed by them, so as to identify key genes and regulatory factors involved in the pathogenesis of sepsis induced brain injury and identify novel therapeutic targets.

Methods: The GSE133822 and GSE135838 datasets were obtained from the Gene Expression Omnibus (GEO) database and utilized for bioinformatics analyses. Read More

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January 2022

Harnessing self-assembling peptide nanofibers toprime robust tumor-specific CD8 T cell responses in mice.

Int Immunopharmacol 2022 Jan 12;104:108522. Epub 2022 Jan 12.

The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University Of Medical Sciences, Bushehr, Iran. Electronic address:

Induction of tumor-specific CD8 + T cell responses is known as a major challenge for cancer vaccine development; here we presented a strategy to improve peptide nanofibers-mounted antitumor immune responses. To this end, peptide nanofibers bearing class I (Kb)-restricted epitope (Epi-Nano) were formulated with polyethylene imine backbone (Epi-Nano-PEI), and characterized using morphological and physicochemicalcharacterizationtechniques. Nanofibers were studied in terms of their uptake by antigen-presenting cells (APCs), antigen cross-presentation capacity, and cytotoxic activity. Read More

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January 2022

Factors contributing to level and type of child welfare involvement following prenatal substance exposure: A scoping review.

Child Abuse Negl 2022 Jan 12;125:105484. Epub 2022 Jan 12.

Department of Health Behavior, University of North Carolina at Chapel Hill Gillings School of Global Public Health, 135 Dauer Dr., Chapel Hill, NC 27599, USA. Electronic address:

Background: An understanding of factors contributing to variation in child welfare outcomes in cases of prenatal substance exposure (PSE) can help identify gaps in research and practice and guide state and agency policy.

Objective: To summarize the evidence base and identify critical gaps in the literature, we conducted a scoping review regarding individual- and institutional-level factors associated with child welfare decision-marking across the service continuum and caregivers' perceptions of child welfare involvement in cases of PSE.

Participants And Setting: The sample included peer-reviewed studies based in the United States. Read More

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January 2022

Mycoplasma synoviae dihydrolipoamide dehydrogenase is an immunogenic fibronectin/plasminogen binding protein and a putative adhesin.

Vet Microbiol 2021 Dec 31;265:109328. Epub 2021 Dec 31.

Shanghai Veterinary Research Institute, the Chinese Academy of Agricultural Sciences (CAAS), 518 Ziyue Road, Shanghai, 200241, PR China. Electronic address:

Mycoplasma synoviae (M. synoviae) is an important avian pathogen that causes arthritis and airsacculitis in young chickens and turkeys. Infection by M. Read More

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December 2021

Quantifying ventilator unloading in CPAP ventilation.

Comput Biol Med 2022 Jan 10;142:105225. Epub 2022 Jan 10.

Department of Intensive Care, Christchurch Hospital, Christchurch, New Zealand.

Background: The intrinsic (muscular) patient effort driving inspiration in non-invasive ventilation modes, such as continuous positive airway pressure (CPAP) therapy, has not been identified from non-invasive data. Current CPAP settings are based on clinical judgment and assessment of symptoms of respiratory distress. Non-optimal settings, including too much positive end expiratory pressure (PEEP) can cause unintended lung injury and ventilator unloading, where patient effort drops and the CPAP device enables too much work being imposed on the injured lung. Read More

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January 2022

Distribution of chronic cough phenotypes in the general population: A cross-sectional analysis of the LEAD cohort in Austria.

Respir Med 2021 Dec 30;192:106726. Epub 2021 Dec 30.

Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Sigmund Freud University, Faculty of Medicine, Vienna, Austria.

Rationale: Recent guidelines consider chronic cough to be a unique clinical entity with different phenotypes. We aimed to investigate them in a general population and to describe prevalence, distribution, and characteristics of these phenotypes within the Austrian general population.

Methods: From the LEAD study, a longitudinal observational population-based cohort, data from questionnaires and spirometry of 10,057 adult participants was analysed. Read More

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December 2021

Retrosigmoid Vestibular Neurectomy for Meniere's Disease: a technical note.

World Neurosurg 2022 Jan 12. Epub 2022 Jan 12.

Department of Neurosurgery - Emory University, Atlanta, Georgia, United States of America. Electronic address:

Background And Objective: Meniere's disease (MD) is an idiopathic peripheral pathology involving the acoustic apparatus. One of the most critical challenges in managing MD is intractable vertigo. In this context, the retrosigmoid vestibular neurectomy (RVN) has been described as a safe and effective technique to manage this symptom when resistant to first- and second-line treatments. Read More

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January 2022

Changing Who Has a Seat and Voice at the Table: How the Academic Pediatric Association is Responding to Systemic Racism.

Acad Pediatr 2022 Jan 12. Epub 2022 Jan 12.

Professor of Pediatrics, Department of Pediatrics, Division of Hospital Medicine and Division of General Pediatrics and Adolescent Medicine, University of North Carolina School of Medicine, Campus Box 7593, Chapel Hill, NC, 27599.

The Academic Pediatrics Association (APA) has taken multiple steps over the last two years to incorporate the lenses of anti-racism and social justice into our mission and work. In this commentary, we discuss the creation and work of the Anti-Racism and Diversity Task Force, which was charged by the APA's Board of Directors with identifying strategies to promote anti-racism and advance the diversity, equity and inclusion agenda. Read More

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January 2022

The RppC-AvrRppC NLR-effector Interaction Mediates the Resistance to Southern Corn Rust in Maize.

Mol Plant 2022 Jan 12. Epub 2022 Jan 12.

Center of Biotechnology, Beijing Lantron Seed, Zhengzhou 450001, China.

Southern corn rust (SCR), caused by the fungal pathogen Puccinia polysora, is a major threat to maize production worldwide. Efficient breeding and deployment of resistant hybrids are key to the durable control of SCR. Here, we report molecular cloning and characterization of RppC, encoding an NLR-type immune receptor that is responsible for a major SCR resistance QTL. Read More

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January 2022

Response Inhibition and Predicting Response to Pharmacological and Cognitive Behavioral Therapy Treatments for Major Depressive Disorder: A CAN-BIND Study.

Biol Psychiatry Cogn Neurosci Neuroimaging 2022 Jan 12. Epub 2022 Jan 12.

eBrain Lab, Simon Fraser University, Surrey, British Columbia; University of Toronto, Toronto, Ontario, Canada; Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Electronic address:

Background: Major Depressive Disorder (MDD) is associated with various cognitive impairments, including response inhibition. Deficits in response inhibition may also underlie poor antidepressant treatment response. Recent studies revealed that the neurobiological correlates of response inhibition can predict response to pharmacological treatments. Read More

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January 2022

Grouper USP12 exerts antiviral activity against nodavirus infection.

Fish Shellfish Immunol 2022 Jan 12. Epub 2022 Jan 12.

University Joint Laboratory of Guangdong Province, Hong Kong and Macao Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

The ubiquitin-specific proteases (USPs) have attracted particular attention due to their multiple functions in different biological processes. USP12, a member of the USP family, has been demonstrated to exert critical roles in diverse cellular processes, including cell death, cancer and antiviral immunity. Here, we cloned a USP12 homolog from orange spotted grouper (Epinephelus coioides, E. Read More

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January 2022

Cellular and Molecular Mechanisms Implicated in the Dual Role of ROR2 in Cancer.

Crit Rev Oncol Hematol 2022 Jan 12:103595. Epub 2022 Jan 12.

Centro de Estudios Biomédicos, Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Buenos Aires, 1405, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, 1425, Argentina. Electronic address:

ROR1 and ROR2 are Wnt receptors that are critical for β-catenin-independent Wnt pathways and were have been linked to processes driving tumor progression, such as cell proliferation, survival, invasion, and therapy resistance. Both receptors have garnered interest as potential therapeutic targets since they are largely absent in adult tissue, are overexpressed in several cancers, and, as members of the receptor tyrosine kinase family, are easier to target than all other components of the pathway. Unlike ROR1 which always promotes tumorigenesis, ROR2 has a very complex role in cancer acting either to promote or inhibit tumor progression in different tumor types. Read More

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January 2022

An updated systematic review and meta-analysis of the effect of statins on asymmetric dimethylarginine.

Nitric Oxide 2022 Jan 12. Epub 2022 Jan 12.

Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia; Department of Clinical Pharmacology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, Australia. Electronic address:

Objectives: We conducted an updated systematic review and meta-analysis of the effect of statins on serum or plasma concentrations of the endogenous inhibitor of endothelial nitric oxide synthase, asymmetric N,N-dimethyl-l-arginine (ADMA).

Methods: A systematic literature search was conducted in the electronic databases PubMed, Web of Science, and Scopus, from inception to July 2021. Risk of bias and certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist for analytical studies and GRADE, respectively. Read More

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January 2022

The interplay between Sleep and Gut Microbiota.

Brain Res Bull 2022 Jan 12. Epub 2022 Jan 12.

Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Sleep is a universal physiological need in all species and is essential for the maintenance and recovery of various physiological functions of the body. In late years, the gut microbiota (GM), a vast and extraordinarily complex ecosystem located in human gastrointestinal tract that oversees an array of critical bodily functions, has become a popular focus among researchers. Accumulated evidences in this field have revealed that it exerts important roles in the regulation of some biological characteristics, especially metabolic, immunological and neurobehavioral functions. Read More

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January 2022

Combination of molecular docking and liver transcription sequencing analysis for the evaluation of salt-processed psoraleae fructus-induced hepatotoxicity in ovariectomized mice.

J Ethnopharmacol 2022 Jan 12:114955. Epub 2022 Jan 12.

Jiangsu Key Laboratory of Chinese Medicine Processing, Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China. Electronic address:

Ethnopharmacological Relevance: Salt-processed Psoraleae fructus (SPF) is widely used as a phytoestrogen-like agent in the treatment of osteoporosis. However, SPF-associated hepatotoxicity is a known health hazard. Cholestasis is often associated with SPF-induced hepatotoxicity. Read More

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January 2022

Mussel-inspired tannic acid/polyethyleneimine assembling positively-charged membranes with excellent cation permselectivity.

Sci Total Environ 2022 Jan 12:153051. Epub 2022 Jan 12.

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China; Key Laboratory of Materials Processing and Mold (Zhengzhou University), Ministry of Education, National Engineering Research Center for Advanced Polymer Processing Technology, Department of Chemical Engineering, Zhengzhou University, Zhengzhou 450002, China.. Electronic address:

The extraction of valuable target ions through monovalent cation exchange membranes (MCEMs) has been increasingly attracting in modern energy and environmental fields. However, the separation performance of MCEMs in terms of the permselectivity and cation fluxes, is typically restricted by membrane architecture and applied materials. Recently, mussel-inspired surface modification methods have been deployed in new membrane fabrications with special surface characteristics and functions. Read More

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January 2022

Trauma and stressor-related disorders among health care workers during COVID-19 pandemic and the role of the gender: A prospective longitudinal survey.

J Affect Disord 2022 Jan 12. Epub 2022 Jan 12.

Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain; Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain; Spanish Network for Research in Mental Health (CIBERSAM), Madrid, Spain; Department of Psychiatry, University of Seville, Seville, Spain.

Introduction: Health-care Workers (HCW) are facing a critical situation caused by Coronavirus Disease 2019 (COVID-19) which could impact on their mental health status. In addition, HCW women have been identified as a group at high-risk of developing psychological distress, although no previous longitudinal studies have explored this issue in a sample of HCW.

Aims: The main aim of the study was to observe the temporal pattern of the stress reactions among HCW as well as to explore its potential predictors of poor outcome. Read More

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January 2022

Acute respiratory deterioration in rheumatoid arthritis-associated interstitial lung disease: a single-center study.

Chest 2022 Jan 12. Epub 2022 Jan 12.

Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. Electronic address:

Background: Interstitial lung disease (ILD) is associated with increased morbidity and mortality in rheumatoid arthritis (RA). Moreover, acute exacerbation (AE) is a devastating complication of RA-ILD. However, there is little data on AE in RA-ILD. Read More

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January 2022

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.

Cell 2021 Dec 28. Epub 2021 Dec 28.

Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Center for Infection Research (HZI), Würzburg, Germany.

Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, and it remains unclear whether T cells contribute to disease pathology. Here, we combined single-cell transcriptomics and single-cell proteomics with mechanistic studies to assess pathogenic T cell functions and inducing signals. We identified highly activated CD16 T cells with increased cytotoxic functions in severe COVID-19. Read More

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December 2021

Confronting legacies of underrepresentation in clinical trials: The case for greater diversity in research.

Neuron 2022 Jan 11. Epub 2022 Jan 11.

Department of Health, Society, and Behavior, Program in Public Health, Henry and Susan Samueli College of Health Sciences, University of California, Irvine, Irvine, CA, USA; Department of Neurology, School of Medicine, Henry and Susan Samueli College of Health Sciences, University of California, Irvine, Irvine, CA, USA. Electronic address:

Involvement of women and racial/ethnic minorities is critical to the scientific, economic, and ethical value of clinical trials. Despite legal precedents, diversity and inclusion in trials have been suboptimal. I present strategies to help investigators increase representation. Read More

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January 2022

Clinical factors associated with lower health scores in COVID-19 related persistent olfactory dysfunction.

Int Forum Allergy Rhinol 2022 Jan 15. Epub 2022 Jan 15.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego, San Diego, CA.

Background: Patients suffering from persistent COVID-19 olfactory dysfunction (OD) commonly report parosmia. Understanding the impact of COVID-19 OD and parosmia is critical to prioritizing research and interventions. This study investigates the impact of parosmia and other clinical and disease characteristics on health state utility values (HUVs) for those with persistent COVID-19 OD. Read More

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January 2022

Mitigation of portal fibrosis and cholestatic liver disease in ANKS6-deficient livers by macrophage depletion.

FASEB J 2022 Feb;36(2):e22157

Division of Nephrology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Congenital hepatic fibrosis (CHF) is a developmental liver disease that is caused by mutations in genes that encode ciliary proteins and is characterized by bile duct dysplasia and portal fibrosis. Recent work has demonstrated that mutations in ANKS6 can cause CHF due to its role in bile duct development. Here, we report a novel ANKS6 mutation, which was identified in an infant presenting with neonatal jaundice due to underlying biliary abnormalities and liver fibrosis. Read More

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February 2022

Quality by design-assisted development of a capillary electrophoresis method for the enantiomeric purity determination of tenofovir.

Electrophoresis 2022 Jan 15. Epub 2022 Jan 15.

Friedrich Schiller University, Department of Pharmaceutical/Medicinal Chemistry, Philosophenweg 14, Jena, 07743, Germany.

A capillary electrophoresis method was developed and validated for the assessment of the chiral purity of the drug tenofovir applying a quality by design approach. Following selection of a quaternary ammonium β-cyclodextrin as chiral selector, a fractional factorial resolution V+ design was employed for identification of the critical process parameters, while a central composite design served for method optimization. The final method used a 40/50. Read More

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January 2022

"From the World of Falsehood to the World of Truth": Recovery and reflexivity in Clubs of Families with Alcohol-related Problems in Crete.

J Community Psychol 2022 Jan 15. Epub 2022 Jan 15.

Department of Psychology, Addiction Psychology Laboratory, University of Crete, Rethymnon, Crete, Greece.

The potential for a critical realist community psychology in the Greek context is not yet apparent. In this article, we present the results of a qualitative study that adheres to critical realism and community psychology principles. The study's focus is the lives of members of the 12 Clubs of Families with Alcohol-related Problems (CFAP) that operate on Crete. Read More

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January 2022