30,484,691 results match your criteria article

A multi-laboratory assessment of congenital thrombophilia assays performed on the ACL Top 50 family for harmonisation of thrombophilia testing in a large laboratory network.

Clin Chem Lab Med 2021 Jun 14. Epub 2021 Jun 14.

Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology, Westmead Hospital, Westmead, NSW, Australia.

Objectives: Thrombophilia testing is commonly performed within hemostasis laboratories, and the ACL TOP 50 family of instruments represent a new 'single platform' of hemostasis instrumentation. The study objective was to evaluate these instruments and manufacturer reagents for utility of congenital thrombophilia assays.

Methods: Comparative evaluations of various congenital thrombophilia assays (protein C [PC], protein S [PS], antithrombin [AT], activated protein C resistance [APCR]) using newly installed ACL TOPs 550 and 750 as well as comparative assessments with existing, predominantly STAGO, instrumentation and reagents. Read More

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SARS-CoV-2 in pregnancy and possible transfer of immunity: assessment of peripartal maternal and neonatal antibody levels and a longitudinal follow-up.

J Perinat Med 2021 Jun 11. Epub 2021 Jun 11.

University Department of Obstetrics and Gynecology at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.

Objectives: In the current Severe Acute Respiratory Distress Coronavirus 2 (SARS-CoV-2) pandemic there is still great uncertainty about the effects of an infection in pregnancy especially regarding a possible fetal transmission of antibodies to SARS-CoV-2 and the longevity of this immunity.

Methods: Sixteen women who were infected with SARS-CoV-2 during pregnancy and their offspring were included. The antibody response to SARS-CoV-2 was measured in mother and umbilical cord blood peripartum and in a follow-up examination 6-11 weeks after birth. Read More

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Ethical challenges in management of critically ill pregnant patients with coronavirus disease 2019 (COVID-19).

J Perinat Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, Lenox Hill Hospital - Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA.

Despite the overwhelming number of coronavirus disease 2019 (COVID-19) cases worldwide, data regarding the optimal clinical guidance in pregnant patients is not uniform or well established. As a result, clinical decisions to optimize maternal and fetal benefit, particularly in patients with critical COVID-19 in the early preterm period, continue to be a challenge for obstetricians. There is often uncertainty in clinical judgment about fetal monitoring, timing of delivery, and mode of delivery because of the challenge in balancing maternal and fetal interests in reducing morbidity and mortality. Read More

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Pre-sleep cognitive arousal exacerbates sleep disturbance in chronic pain: an exploratory daily diary and actigraphy study.

Scand J Pain 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychological Medicine, The University of Auckland, Auckland, New Zealand.

Objectives: Insomnia is commonly comorbid with chronic pain, and typically leads to worse outcomes. Two factors that could contribute to a cycle of pain and sleeplessness are pre-sleep cognitive arousal (repetitive thought processes) and low mood. This study aimed to examine how pain, sleep disturbance, mood, and pre-sleep cognitive arousal inter-relate, to determine whether low mood or pre-sleep cognitive arousal contribute to a vicious cycle of pain and insomnia. Read More

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Newborns at risk of Covid-19 - lessons from the last year.

J Perinat Med 2021 Jun 11. Epub 2021 Jun 11.

Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

After more than 1 year of the SARS-CoV-2 pandemic, a great deal of knowledge on how this virus affects pregnant women, the fetus and the newborn has accumulated. The gap between different guidelines how to handle newborn infants during this pandemic has been minimized, and the American Academy of Pediatrics (AAP)'s recommendations are now more in accordance with those of the World Health Organization (WHO). In this article we summarize present knowledge regarding transmission from mother to the fetus/newborn. Read More

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The molecular mechanism underlying pathogenicity inhibition by sanguinarine in Magnaporthe oryzae.

Pest Manag Sci 2021 Jun 11. Epub 2021 Jun 11.

Fuzhou Institute of Oceanography, Minjiang University, Fuzhou, 350108, China.

Background: Sanguinarine (SAN) is a benzophenanthridine alkaloid that broadly targets a range of pathways in mammalian and fungal cells. In this study we set to explore the molecular mechanism how sanguinarine inhibits fungal development and pathogenicity of Magnaporthe oryzae with the hope that sanguinarine will bolster the development of anti-blast agents.

Results: We found that the fungus exhibited a significant reduction in the vegetative growth and hyphal melanization while the spores produced long germ tubes on the artificial hydrophobic surface characteristic of a defect in thigmotropic sensing when exposed to 4 μM, 8 μM and 0. Read More

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Neonatal Lymphopenia Screening Is Important For Early Diagnosis of Severe Combined Immunodeficiency.

Am J Perinatol 2021 Jun 11. Epub 2021 Jun 11.

Division of Hematology and Oncology, Immunology, Department of Pediatrics, Erciyes University, School of Medicine, Kayseri, Turkey.

Objective:  T-cell receptor excision circles are expensive for neonatal severe combined immunodeficiency screening in developing countries. We aimed to detect immunodeficiencies presenting with lymphopenia to enable screening in the general population and to improve awareness regarding lymphopenia among clinicians.

Study Design:  This study was conducted prospectively. Read More

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The interaction effect between comorbidity and venous thromboembolism on mortality rates after venous thromboembolism: A 5-year cohort study.

Thromb Haemost 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Background: Comorbidity influences venous thromboembolism (VTE) mortality, but it is unknown whether this is due to comorbidity alone or whether biological interaction exists.

Objectives: We examined whether comorbidity and VTE interact to increase VTE mortality beyond their individual effects.

Methods: This register-based 5-year cohort study included all VTE patients ≥18 years during 2000-2016, and an age-, sex-, and comorbidity-matched comparison cohort of individuals without VTE. Read More

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[Validity of the "Structured Inventory of Malingered Symptomatology" [SIMS] in the Assessment of Healthy Individuals and Patients with Psychiatric Disorders Outside the Forensic Context].

Fortschr Neurol Psychiatr 2021 Jun 11. Epub 2021 Jun 11.

Forensische Psychiatrie, Zentralinstitut für Seelische Gesundheit, Mannheim, Germany.

Objective: Assessment of the rate of false-positive results of the Structured Inventory of Malingered Symptomatology (SIMS) in healthy controls and authentic patients outside the forensic or rehabilitative context.

Methods: Beyond the SIMS scores, further variables (PANSS, Hamilton scale, MMSE) were obtained. SIMS scores of healthy individuals were compared with the SIMS scores of the different groups of patients. Read More

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Cancer-Associated Splanchnic Vein Thrombosis.

Semin Thromb Hemost 2021 Jun 11. Epub 2021 Jun 11.

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Splanchnic vein thrombosis (SVT), which includes portal, mesenteric, and splenic vein thrombosis and the Budd-Chiari syndrome, is an infrequent manifestation of venous thromboembolism (VTE). Like typical site VTE, SVT is also frequently associated with cancer, particularly intra-abdominal solid malignancies and myeloproliferative neoplasms (MPNs). The clinical presentation of SVT is nonspecific. Read More

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Circulating MicroRNA Responses to Postprandial Lipemia with or without Prior Exercise.

Int J Sports Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Kinesiology, University of Maryland School of Public Health, College Park, United States.

Repeated exposure to a high-fat meal triggers inflammation and oxidative stress, contributing to the onset of cardiometabolic diseases. Regular exercise prevents cardiometabolic diseases and a prior bout of acute endurance exercise can counteract the detrimental cardiovascular effects of a subsequent high-fat meal. Circulating microRNAs (ci-miRs) are potential mediators of these vascular effects through regulation of gene expression at the posttranscriptional level. Read More

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Grannemann JJ, Roper A. Aufenthalte in großen Höhen nach COVID-19-Infektion – neue Aspekte der höhenmedizinischen Beratung. Pneumologie 2021, 75: 214–220.

Pneumologie 2021 Jun 11;75(6):474-476. Epub 2021 Jun 11.

Klinik für Innere Medizin V - Pneumologie, Allergologie und Intensivmedizin, Universitätskliniken des Saarlandes, Homburg/Saar.

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[Pulmonary Rehabilitation in Patients with Chronic Obstructive Airway Diseases].

Pneumologie 2021 Jun 11;75(6):457-473. Epub 2021 Jun 11.

Pulmonary rehabilitation of asthma and COPD patients can improve their physical performance and quality of life, maintain participation in social and professional life and actively promote self-help. In addition, the resources for acute medical treatment can be spared. In case of COPD, rehabilitation directly after exacerbation can also improve the poor survival prognosis and reduce the risk of emergency hospital readmission. Read More

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[Early Pulmonary Rehabilitation after Long Term Mechanical Ventilation].

Pneumologie 2021 Jun 11;75(6):432-438. Epub 2021 Jun 11.

Fachkrankenhaus Kloster Grafschaft GmbH, Abteilung Pneumologie I.

Background:  The term early rehabilitation is defined as a rehabilitation that begins in the early phase after acute illness and is statutory positioned in § 39SGB V. Aim of this investigation is to describe the quality of outcome of pulmonary early rehabilitation.

Method:  Prospective census of functional parameters, status of ventilation and discharge-disposition in a specialized unit for early pulmonary rehabilitation over a period of one year. Read More

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[Modern Treatment Options for Postoperative Chylothorax: a Systematic Review].

Pneumologie 2021 Jun 11;75(6):439-446. Epub 2021 Jun 11.

Klinik für Thoraxchirurgie, Regiomed Kliniken GmbH, Sonneberg/Coburg.

Background:  Chylothorax is a multifactorial complication, usually caused by surgery or traumatic injury, and more rarely by malignant disease. Because of the lack of prospective, randomised trials, the evidence-based treatment rests upon personal experience, but ideally taking into account retrospective analysis.

Material And Methods:  The aim of this review is to provide a comprehensive overview of the currently available modern treatment options. Read More

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Use of a Transarticular Calcaneo-Tibial Locking Plate for Temporary Immobilization of the Tarsocrural Joint following Surgical Repair of Common Calcaneal Tendon Rupture in Eight Dogs.

Vet Comp Orthop Traumatol 2021 Jun 11. Epub 2021 Jun 11.

Dipartimento di Scienze Veterinarie, Università di Torino, Grugliasco (To), Italy.

Objective:  The purpose of this clinical communication is to report the management of common calcaneal tendon rupture in dogs using a transarticular calcaneo-tibial locking plate as a method of temporary immobilization of the tarsocrural joint to support primary repair of the common calcaneal tendon.

Study Design:  Dogs presented with partial or complete common calcaneal tendon rupture treated with primary tendon repair supported by the transarticular calcaneo-tibial locking plate technique from July 2016 to December 2019 were included. The tarsus was placed at a standing angle of 150 degrees and the pre-contoured Fixin locking 'L' or 'T' plate was medially applied with two locking screws inserted in the calcaneus and two screws inserted in the distal tibia. Read More

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COVID-19 und die epidemiologische Triade.

Manfred Wildner

Gesundheitswesen 2021 Jun 11;83(6):416-418. Epub 2021 Jun 11.

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Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain.

Sleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. Read More

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Protection of Beta Boswellic Acid against Streptozotocin-induced Alzheimer's Model by Reduction of Tau Phosphorylation Level and Enhancement of Reelin Expression.

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

Laboratory of Neuro-organic Chemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.

Alzheimer's disease is a growing general health concern with huge implications for individuals and society. Beta boswellic acid, a major compound of the plant, has long been used for the treatment of various inflammatory diseases. The exact mechanism of beta boswellic acid action in Alzheimer's disease pathogenesis remains unclear. Read More

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Herbacetin Broadly Blocks the Activities of CYP450s by Different Inhibitory Mechanisms.

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Herbacetin is a bioactive flavanol compound that has various pharmacological effects. However, the pharmacokinetic characteristics have not been thoroughly investigated. Previously, we screened a natural compound library and identified herbacetin as a potent CYP blocker. Read More

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Support for Regulatory Assessment of Percutaneous Absorption of Retronecine-type Pyrrolizidine Alkaloids through Human Skin.

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

Procter & Gamble Technical Centres Ltd, Reading, UK.

1,2-unsaturated pyrrolizidine alkaloids are found naturally in , well known as comfrey, which has a longstanding use for the topical treatment of painful muscle and joint complaints. Pyrrolizidine alkaloids (PA) are a relevant concern for the safety assessment due to their liver genotoxicity profile, and close attention is paid during manufacturing to minimizing their levels. Current regulatory risk assessment approaches include setting limits that derive from toxicity data coming from the oral route of exposure. Read More

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Arteriovenous Fistula Formation After Transradial Coronary Intervention.

Tex Heart Inst J 2021 Jun;48(2)

Department of Cardiology, Michigan State University, East Lansing, Michigan.

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Ultralow lattice thermal conductivity and dramatically enhanced thermoelectric properties of monolayer InSe induced by an external electric field.

Phys Chem Chem Phys 2021 Jun 12. Epub 2021 Jun 12.

Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, School of Energy and Power Engineering, Dalian University of Technology, Dalian 116024, China.

With the ability to alter the inherent interatomic electrostatic interactions, modulating external electric field strength is a promising approach to tune the phonon transport behavior and enhance the thermoelectric performance of two-dimensional (2D) materials. Here, by applying an electric field (Ez = 0.1 V Å-1), it is predicted that an ultralow value of the lattice thermal conductivity (0. Read More

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h-FBN assisted negative ion paper spray for the sensitive detection of small molecules.

Chem Commun (Camb) 2021 Jun 12. Epub 2021 Jun 12.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, People's Republic of China.

Negative ion mode paper spray mass spectrometry (PS-MS) suffers from intense background noise and unstable MS signal. For the first time, we reported fluorinated boron nitride nanosheet (h-FBN) assisted negative ion PS-MS for the detection of a series of molecules. We demonstrated that the introduction of h-FBN can greatly improve the detection sensitivity and signal stability in the negative ion mode. Read More

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Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance.

J Mater Chem B 2021 Jun 12. Epub 2021 Jun 12.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Platinum drugs are commonly used in cancer therapy, but their therapeutic outcomes have been significantly compromised by the drug resistance of cancer cells. To this end, intensive efforts have been made to develop nanoparticle-based drug delivery systems for platinum drugs, due to their multifunctionality in delivering drugs, in modulating the tumor microenvironment, and in integrating additional genes, proteins, and small molecules to overcome chemoresistance in cancers. To facilitate the clinical application of these promising nanoparticle-based platinum drug delivery systems, this paper summarizes the common mechanisms for chemoresistance towards platinum drugs, the advantages of nanoparticles in drug delivery, and recent strategies of nanoparticle-based platinum drug delivery. Read More

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Instrumentational implementation for parallelized nanopore electrochemical measurements.

Analyst 2021 Jun 12. Epub 2021 Jun 12.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 210023, Nanjing, China.

Nanopore electrochemistry, as one of the promising tools for single molecule sensing, has proved its capability in DNA sequencing and protein analysis. To achieve a high resolution for obtaining molecular information, the nanopore electrochemical technique not only urgently requires an appropriate nanopore sensing interface with atomic resolution but also requires advanced instrumentation and its related data processing methods. In order to reveal the fundamental biological process and process the point-of-care diagnosis, it is necessary to use a nanopore sensing instrument with a high amperometric and temporal resolution as well as high throughput. Read More

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Inhibition of the Ras/ERK1/2 pathway contributes to the protective effect of ginsenoside Re against intimal hyperplasia.

Food Funct 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Neointimal hyperplasia is the major cause of carotid stenosis after vascular injury, which restricts the long-term efficacy of endovascular treatment and endarterectomy in preventing stenosis. Ginsenoside Re (Re) is a major active ingredient of ginseng having multifaceted pharmacological effects on the cardiovascular system, and is a potential treatment for restenosis. In this study, we demonstrated that Re treatment significantly inhibited vascular injury-induced neointimal thickening, reduced the intimal area and intima/media (I/M) ratio, increased the lumen area, and inhibited pro-inflammatory cytokines. Read More

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Tetrahydrocurcumin alleviates allergic airway inflammation in asthmatic mice by modulating the gut microbiota.

Food Funct 2021 Jun 12. Epub 2021 Jun 12.

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University (Guangzhou Campus), Guangzhou, China. and Guangdong Engineering Technology Research Center of Nutrition Translation, Guangzhou, China.

Dietary factors can reshape the gut microbiota and consequently affect disease progression. We previously reported that tetrahydrocurcumin (THC), the major active metabolite of curcumin (Cur), could ameliorate allergic inflammation in asthmatic mice. Herein, we aimed to investigate whether THC or Cur exerts anti-inflammatory effects on allergic asthma via modulating gut microbiota. Read More

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Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.

N S Kron L A Fieber

PLoS One 2021 11;16(6):e0252647. Epub 2021 Jun 11.

Department of Marine Biology and Ecology, Rosenstiel School of Marine and Atmospheric Science, University of Miami, Miami, FL, United States of America.

Aging of the nervous system is typified by depressed metabolism, compromised proteostasis, and increased inflammation that results in cognitive impairment. Differential expression analysis is a popular technique for exploring the molecular underpinnings of neural aging, but technical drawbacks of the methodology often obscure larger expression patterns. Co-expression analysis offers a robust alternative that allows for identification of networks of genes and their putative central regulators. Read More

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Nurses Do Not Need an Order to Assess the Patient.

J Neurosci Nurs 2021 Jun 10. Epub 2021 Jun 10.

Questions or comments about this article may be directed to DaiWai M. Olson, PhD RN CCRN FNCS, at D.M.O. is a Professor, Department of Neurology, UT Southwestern Medical Center, Dallas, TX. Molly M. McNett.

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