323,278 results match your criteria artery disease


Development and validation of a RPLC-MS/MS method for the quantification of ceramides in human serum.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 3;1175:122734. Epub 2021 May 3.

Biomic_AUTh, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, B1.4, 10th Km Thessaloniki-Thermi Rd, P.O. Box 8318, 57001 Thessaloniki, Greece; Laboratory of Forensic Medicine & Toxicology, School of Medicine, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece. Electronic address:

Ceramides are key-role lipids involved in numerous central cellular processes. A plethora of studies have demonstrated that the levels of ceramides in blood circulation are related to different disease states, such as type 2 diabetes, cardiovascular diseases, ovarian cancer, multiple sclerosis and others. Herein, a RPLC-MS/MS method for the rapid quantification of ceramides Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1) in human blood serum was developed and validated. Read More

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Prevalence and associated risk factors of coronary artery disease in patients with a zero coronary calcium score.

Clin Imaging 2021 May 10;77:207-212. Epub 2021 May 10.

Department of Radiology, Faculty of Medicine, Gazi University, Emniyet, Mevlana Blv. No:29, 06560 Yenimahalle, Ankara, Türkiye.

Purpose: A zero coronary calcium score (CCS) is not able to provide a definite exclusion for coronary artery disease (CAD). The goal of this study was to determine the prevalence and associated cardiovascular risk factors of CAD in patients with zero CCS.

Methods: Six hundred thirteen patients with zero CCS referred to coronary calcium score analysis (CCSA) and coronary computed tomography angiography (CCTA) with suspicion of CAD were included. Read More

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Automated detection of coronary artery disease, myocardial infarction and congestive heart failure using GaborCNN model with ECG signals.

Comput Biol Med 2021 May 7;134:104457. Epub 2021 May 7.

School of Engineering, Ngee Ann Polytechnic, Singapore; Biomedical Engineering, School of Social Science and Technology, Singapore University of Social Sciences, Singapore; International Research Organization for Advanced Science and Technology (IROAST), Kumamoto University, Kumamoto, Japan; Department Bioinformatics and Medical Engineering, Asia University, Taiwan; School of Management and Enterprise, University of Southern Queensland, Australia. Electronic address:

Cardiovascular diseases (CVDs) are main causes of death globally with coronary artery disease (CAD) being the most important. Timely diagnosis and treatment of CAD is crucial to reduce the incidence of CAD complications like myocardial infarction (MI) and ischemia-induced congestive heart failure (CHF). Electrocardiogram (ECG) signals are most commonly employed as the diagnostic screening tool to detect CAD. Read More

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Age, Gender, and Laterality of Retinal Vascular Occlusion: A Retrospective Study from the IRIS® Registry.

Ophthalmol Retina 2021 May 12. Epub 2021 May 12.

Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

Purpose: Retinal vascular occlusion is a leading cause of profound irreversible visual loss, but the understanding of the disease is insufficient. We systematically investigated the age, gender, and laterality at the onset of retinal artery occlusion (RAO) and retinal vein occlusion (RVO) in the IRIS® Registry (Intelligent Research in Sight).

Design: A retrospective registry cohort. Read More

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Effectiveness and Tolerability of the Single-Pill Combination of Bisoprolol and Perindopril in Patients with Arterial Hypertension and Stable Coronary Artery Disease in Daily Clinical Practice: The STYLE Study.

Adv Ther 2021 May 15. Epub 2021 May 15.

Department of Angiology, National Medical Research Center of Cardiology of the Ministry of Health of Russia, Moscow, Russia.

Introduction: Combination antihypertensive therapy is required by most patients to achieve guideline-recommended blood pressure (BP) goals. This study assessed the effectiveness and tolerability of bisoprolol/perindopril (Bis/Per) single-pill combination (SPC) in Russian patients with hypertension and coronary artery disease (CAD) treated in routine clinical practice.

Methods: STYLE (NCT03730116) was an open-label, uncontrolled, prospective observational study conducted in patients who were already receiving Bis/Per SPC, switched to SPC from Bis or Per monotherapy, or switched from a free combination of Bis and Per. Read More

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Coronary artery disease and its impact on the pulsatile brain: A functional NIRS study.

Hum Brain Mapp 2021 May 15. Epub 2021 May 15.

Research Center, University Institute of Geriatrics of Montreal, Montreal, Quebec, Canada.

Recent studies have reported that optical indices of cerebral pulsatility are associated with cerebrovascular health in older adults. Such indices, including cerebral pulse amplitude and the pulse relaxation function (PRF), have been previously applied to quantify global and regional cerebral pulsatility. The aim of the present study was to determine whether these indices are modulated by cardiovascular status and whether they differ between individuals with low or high cardiovascular risk factors (LCVRF and HCVRF) and coronary artery disease (CAD). Read More

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Nurse-led counseling for coronary artery disease patients: A one-year follow-up study.

Nurs Health Sci 2021 May 14. Epub 2021 May 14.

Director of Nursing Excellence, Central Finland Health Care District, Keskussairaalantie 19, Jyvaskyla, Finland.

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Ramadan fasting: recommendations for patients with cardiovascular disease.

Heart 2021 May 14. Epub 2021 May 14.

Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, UK

Ramadan fasting is observed by most of the 1.8 billion Muslims around the world. It lasts for 1 month per the lunar calendar year and is the abstention from any food and drink from dawn to sunset. Read More

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Evaluation of socio-economic insecurity in peripheral artery disease patients.

J Med Vasc 2021 May 18;46(3):108-113. Epub 2021 Mar 18.

Department of Vascular Medicine, Grenoble-Alpes University Hospital, Grenoble, France; University Grenoble-Alpes, CNRS/TIMC-IMAG UMR 5525/Themas, Grenoble, France. Electronic address:

The social and economic environment has become a major determinant of cardiovascular health. The objective of our study was to assess socio-economic insecurity in patients with symptomatic PAD. The PRECAR study was a non-interventional prospective cohort study. Read More

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From CASS to ischemia: Almost 40 years of blindness in stable coronary artery disease.

Authors:
Joseph Emmerich

J Med Vasc 2021 May 18;46(3):105-107. Epub 2021 Mar 18.

Department of vascular medicine, Paris Saint-Joseph Hospital Group, University of Paris, INSERM CRESS UMR 1153, 185 rue Raymond Losserand, 75674 Paris Cedex 14, France. Electronic address:

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Stroke affects intestinal immune cell trafficking to the central nervous system.

Brain Behav Immun 2021 May 11. Epub 2021 May 11.

Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY. Electronic address:

Stroke is an acute neurological disease with a strong inflammatory component that can be regulated by the intestinal microbiota and intestinal immune cells. Although stroke has been shown to alter immune cell populations in the gut, the dynamics of cell trafficking have not been elucidated. To study the trafficking of gut-derived immune cells after stroke, we used mice expressing the photoconvertible protein Kikume Green-Red, which turns form green to red when exposed to violet light. Read More

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Kidney Transplant List Status and Outcomes in the ISCHEMIA-CKD Trial.

J Am Coll Cardiol 2021 May 4. Epub 2021 May 4.

NYU Grossman School of Medicine, New York, NY, USA.

Background: Patients with chronic kidney disease (CKD) and coronary artery disease frequently undergo preemptive revascularization before kidney transplant listing.

Objectives: In this post-hoc analysis from ISCHEMIA-CKD, we compared outcomes of patients not listed versus those listed according to management strategy.

Methods: In ISCHEMIA-CKD (n=777), 194 patients (25%) with chronic coronary syndromes and at least moderate ischemia were listed for transplant. Read More

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A Novel Fenestrating Device, "Quick Fenestrater," for Reconstructing Supra-aortic Arteries In Situ during Thoracic Endovascular Aortic Repair.

Can J Cardiol 2021 May 11. Epub 2021 May 11.

Department of Vascular and Endovascular Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200001, China. Electronic address:

Background: In situ fenestration (ISF) is an effective approach for reconstructing supra-aortic branches during thoracic endovascular aortic repair (TEVAR). A dedicated device is needed for ISF.

Methods: The "Quick Fenestrater" (QF) underwent in vitro, animal-based, and initial clinical testing. Read More

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Microvascular Disease and Cardiovascular Outcomes in Type 2 Diabetes: The Look AHEAD Study.

Diabetes Res Clin Pract 2021 May 11:108859. Epub 2021 May 11.

Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA; Welch Prevention Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Aim: To evaluate the associations of microvascular disease (MVD) with incident cardiovascular disease (CVD) in individuals with type 2 diabetes.

Methods: A total of 4098 participants with type 2 diabetes and without CVD were assessed for MVD (diabetic kidney disease, retinopathy or neuropathy) in the Look AHEAD (Action for Health in Diabetes) study. Cox models were used to generate hazard ratios (HRs) for: (1) CVD composite (myocardial infarction, stroke, hospitalization for angina and/or death from cardiovascular causes), (2) coronary artery disease (CAD), (3) stroke, and (4) CVD-related deaths. Read More

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Atherogenic Index of Plasma, Triglyceride-Glucose Index and Monocyte-to-Lymphocyte Ratio for Predicting Subclinical Coronary Artery Disease.

Am J Med Sci 2021 May 11. Epub 2021 May 11.

Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, HeBei, China. Electronic address:

Background: The atherogenic index of plasma (AIP), triglyceride-glucose (TyG) index, and monocyte-to-lymphocyte ratio (MLR) are strongly associated with atherogenesis of the coronary artery. This study aimed to investigate the association of the AIP, TyG index, and MLR with subclinical coronary artery disease (CAD) and evaluate their ability to predict subclinical CAD.

Methods: A total of 697 asymptomatic patients were enrolled in this study and assigned to the subclinical CAD group (n=332) and control group (n=365). Read More

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Statin but not Aspirin Treatment is Associated with Reduced Cardiovascular Risk in Patients with Diabetes without Obstructive Coronary Artery Disease.

Eur Heart J Cardiovasc Pharmacother 2021 May 14. Epub 2021 May 14.

Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens, Boulevard 99, Aarhus N, 8200, Denmark.

Aims: Patients with diabetes and no obstructive coronary artery disease (CAD) as assessed by coronary angiography (CAG) are frequently treated with aspirin and statins. We examined the effectiveness of aspirin and statin treatment on cardiovascular and bleeding incidence in patients with diabetes and absent obstructive CAD.

Methods And Results: The study included patients with diabetes and absent obstructive CAD as assessed by CAG from 2003 to 2016 in Western Denmark. Read More

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Recipient vessel selection for multiple free flap transfers in head and neck reconstruction at different periods.

Microsurgery 2021 May 14. Epub 2021 May 14.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China.

Background: Treatment decisions can be challenging in patients undergoing multiple oropharyngeal microsurgical reconstructions at different periods by various causes. We, retrospectively, reviewed patients with at least three consecutive free flap reconstructions to determine the optimal strategy for selecting recipient vessels.

Methods: Then, 36 patients (33 men and 3 women) who underwent at least 3 microsurgical reconstructions with a total of 51 free flap transfers for head and neck defects were included in this report. Read More

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The Association between Multi-Vessel Coronary Artery Disease and High On-Aspirin Platelet Reactivity.

Cardiovasc Drugs Ther 2021 May 14. Epub 2021 May 14.

Department of Cardiology, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, and "Sackler" Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background: Multi-vessel coronary artery disease (MV-CAD) is correlated with worse clinical outcomes compared with single-vessel CAD (SV-CAD). The aim of this study was to evaluate the association between MV-CAD and high on-aspirin platelet reactivity (HAPR) in patients with stable CAD treated with aspirin.

Methods: The current study is an analysis of prospectively enrolled randomly selected patients with known stable CAD, who were taking aspirin (75-100 mg qd) regularly for at least one month, and had undergone coronary angiography at least 3 months prior to the enrollment to the study. Read More

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Chronic Oral Anticoagulation and Clinical Outcome in Hospitalized COVID-19 Patients.

Cardiovasc Drugs Ther 2021 May 14. Epub 2021 May 14.

Division of Cardiology, "Bolognini" Hospital, ASST Bergamo Est, Seriate, BG, Italy.

Purpose: The clinical course of COVID-19 may be complicated by acute respiratory distress syndrome (ARDS) and thromboembolic events, which are associated with high risk of mortality. Although previous studies reported a lower rate of death in patients treated with heparin, the potential benefit of chronic oral anticoagulation therapy (OAT) remains unknown. We aimed to investigate the association between OAT with the risk of ARDS and mortality in hospitalized patients with COVID-19. Read More

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Low risk patients with acute atrial fibrillation and elevated high-sensitivity troponin do not have increased incidence of pathological stress tests.

Scand Cardiovasc J 2021 May 14:1-5. Epub 2021 May 14.

Department of Clinical Sciences, Lund University, Lund, Sweden.

Objectives: Many patients with atrial fibrillation (AF) or atrial flutter (AFL) and rapid ventricular response (RVR) have elevated high-sensitivity troponin T (hsTnT) values. Elevated hsTnT is an independent risk marker for cardiovascular events and mortality. The aim was to examine if AF/AFL patients with RVR and elevated hsTnT have an increased incidence of pathological cardiac stress tests, indicating need of further evaluation for coronary artery disease (CAD). Read More

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Involvement of chronic inflammation via monocyte chemoattractant protein-1 in uraemic cardiomyopathy: a human biopsy study.

ESC Heart Fail 2021 May 14. Epub 2021 May 14.

Department of Cardiovascular Medicine, Nara Medical University, Kashihara, Nara, Japan.

Aims: Patients undergoing dialysis, even those without coronary artery disease or valvular abnormalities, sometimes present with reduced heart function, which resembles dilated cardiomyopathy (DCM). This condition is known as uraemic cardiomyopathy (UCM). The mechanisms of UCM development are not fully understood. Read More

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Current patterns of beta-blocker prescription in cardiac amyloidosis: an Italian nationwide survey.

ESC Heart Fail 2021 May 14. Epub 2021 May 14.

Department of Internal Medicine, University of Genova, Viale Benedetto XV, 10, Genova, 16132, Italy.

Aims: The use of beta-blocker therapy in cardiac amyloidosis (CA) is debated. We aimed at describing patterns of beta-blocker prescription through a nationwide survey.

Methods And Results: From 11 referral centres, we retrospectively collected data of CA patients with a first evaluation after 2016 (n = 642). Read More

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Cell-specific epigenetic changes in atherosclerosis.

Clin Sci (Lond) 2021 May;135(9):1165-1187

Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia.

Atherosclerosis is a disease of large and medium arteries that can lead to life-threatening cerebrovascular and cardiovascular consequences such as heart failure and stroke and is a major contributor to cardiovascular-related mortality worldwide. Atherosclerosis development is a complex process that involves specific structural, functional and transcriptional changes in different vascular cell populations at different stages of the disease. The application of single-cell RNA sequencing (scRNA-seq) analysis has discovered not only disease-related cell-specific transcriptomic profiles but also novel subpopulations of cells once thought as homogenous cell populations. Read More

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Evaluation of Growth Differentiation Factor-15 in Patients with or without Coronary Artery Disease.

Acta Biomed 2021 May 12;92(2):e2021051. Epub 2021 May 12.

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Growth-differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor-beta cytokine superfamily expressed in human atherosclerotic plaque macrophages. In this study, we sought to compare GDF-15 between patients with coronary artery disease and control group.

Methods: In this cross-sectional study, 176 subjects were enrolled, consisted of 88 coronary artery disease patients (CAD group) and 88 non-CAD participants (control group. Read More

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GCN2 Regulates ATF3-p38 MAPK Signaling Transduction in Pulmonary Veno-Occlusive Disease.

J Cardiovasc Pharmacol Ther 2021 May 14:10742484211015535. Epub 2021 May 14.

Department of Cell Biology, State Key Laboratory of Medical Molecular Biology, 12501Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Pulmonary veno-occlusive disease (PVOD) is a fatal disease of pulmonary vascular lesions leading to right heart failure. Heritable PVOD (hPVOD) is related to biallelic mutation of (encoding GCN2), but its molecular mechanism remains unclear. In this study, we aimed to investigate the pathogenesis of PVOD and to find potential drug targets for PVOD. Read More

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The association of proBNPage with manifestations of age-related cardiovascular, physical, and psychological impairment in community-dwelling older adults.

Geroscience 2021 May 13. Epub 2021 May 13.

Department of Medical and Surgical Sciences, University of Bologna, Via Albertoni, 15 40138, Bologna, Italy.

NT-proB-type natriuretic peptide (NT-proBNP) serum concentration can be transformed by simple formulas into proBNPage, a surrogate of biological age strongly associated with chronological age, all-cause mortality, and disease count. This cross-sectional study aimed to assess whether proBNPage is also associated with other manifestations of the aging process in comparison with other variables. The study included 1117 noninstitutionalized older adults (73. Read More

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Chronic obstructive pulmonary disease is associated with worse outcomes in ischemic colitis: a nationwide retrospective study.

Int J Colorectal Dis 2021 May 13. Epub 2021 May 13.

Department of Gastroenterology and Hepatology, MercyOne Des Moines Medical Center, Des Moines, IA, USA.

Background: Ischemic colitis (IC) occurs when the blood supply of the large intestine becomes compromised. Several cardiovascular conditions, such as coronary artery disease, congestive heart failure, and atrial fibrillation, are well-established risk factors for the development of IC. The effects of pulmonary conditions, namely chronic obstructive pulmonary disease (COPD), on IC have not been well studied. Read More

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Gender Differences in the Association of Insomnia Symptoms and Coronary Artery Calcification in the Multi-Ethnic Study of Atherosclerosis.

Sleep 2021 May 14. Epub 2021 May 14.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA.

Study Objectives: To quantify the gender-specific associations between insomnia symptoms and subclinical atherosclerosis, measured by coronary artery calcium (CAC) scores, which has strong predictive value for incident cardiovascular disease.

Methods: We analyzed data from 1,429 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Participants completed standardized questionnaires and underwent polysomnography (PSG) and 7-day actigraphy. Read More

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Large HDL combined with inflammatory factors as superior predictors for coronary artery disease than small HDL.

Ann Transl Med 2021 Apr;9(8):672

Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background: This study investigated whether combinations of high-density lipoprotein (HDL) subfractions and inflammatory markers would add value to coronary artery disease (CAD) prediction.

Methods: Non-CAD subjects (n=245) were stratified into low/moderate/high-Framingham risk (L/M/H-FR) groups and 180 CAD patients were enrolled. Levels of HDL-C, HDL, HDL, monocyte chemoattractant protein-1 (MCP-1), and high-sensitivity C-reactive protein (hsCRP) were measured. Read More

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Homocysteine alters vasoreactivity of human internal mammary artery by affecting the K channel family.

Ann Transl Med 2021 Apr;9(8):625

Center for Basic Medical Research & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Background: Hyperhomocysteinemia is an independent risk factor for atherosclerotic heart disease. We previously demonstrated that disruption of calcium-activated potassium (K) channel activity is involved in homocysteine-induced dilatory dysfunction of porcine coronary arteries. Recently we reported that the K channel family, including large-, intermediate-, and small-conductance K (BK, IK, and SK) subtypes, are abundantly expressed in human internal mammary artery (IMA). Read More

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