Prenat Diagn 2020 06 20;40(7):813-824. Epub 2020 Apr 20.
Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, District of Columbia, USA.
Objective: To establish whether fetal cerebral vasoreactivity (CVR ), following maternal hyperoxia, is predicted by fetal cerebral and uteroplacental Doppler pulsatility indices (PI) at baseline, fetal pulmonary vasoreactivity to oxygen (PVR ), gestational age (GA), or sex.
Methods: Pulsatility index of middle (MCA), anterior (ACA), posterior cerebral (PCA), umbilical (UA), uterine (UtA), and branch of the pulmonary arteries (PA) were obtained, by ultrasound, before (baseline), during (hyperoxia) and after 15 minutes of maternal administration of 8 L/min of 100% oxygen, through a non-rebreathing face mask, in normal singleton pregnancies within 20 to 38 weeks' gestation. CVR was defined as changes greater than zero in z score of PI of the cerebral arteries from baseline to hyperoxia. Read More