22,082 results match your criteria arterial carbon


Hyperpolarized C MR Spectroscopy Depicts in Vivo Effect of Exercise on Pyruvate Metabolism in Human Skeletal Muscle.

Radiology 2021 Jun 22:204500. Epub 2021 Jun 22.

From the Advanced Imaging Research Center (J.M.P., C.E.H., J.M., J.C., J.R., J.L., G.D.R., A.C., C.R.M.), Department of Radiology (J.M.P., A.C., C.R.M.), Department of Neurology and Neurotherapeutics (R.G.H.), and Department of Internal Medicine (C.R.M.), University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8568; Department of Electrical and Computer Engineering, University of Texas at Dallas, Dallas, Tex (J.M.P.); Department of Diagnostic Imaging and Radiology, Developing Brain Institute, Children's National Hospital, Washington, DC (Z.Z.); Department of Pediatrics and Radiology, George Washington University, Washington, DC (Z.Z.); GE Healthcare, Dallas, Tex (G.D.R.); Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, Calif (T.J.); and Veterans Affairs North Texas Healthcare System, Dallas, Tex (C.R.M.).

Background Pyruvate dehydrogenase (PDH) and lactate dehydrogenase are essential for adenosine triphosphate production in skeletal muscle. At the onset of exercise, oxidation of glucose and glycogen is quickly enabled by dephosphorylation of PDH. However, direct measurement of PDH flux in exercising human muscle is daunting, and the net effect of covalent modification and other control mechanisms on PDH flux has not been assessed. Read More

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Safety and efficacy evaluation of the automatic stepwise recruitment manoeuvre in the neonatal population: An in-vivo interventional study.

Paediatr Anaesth 2021 Jun 21. Epub 2021 Jun 21.

President of the Spanish Society of Anaesthesia, Intensive Care and Pain. Chairman of Anaesthesia, Critical Care and Pain Department. Hospital Universitario Puerta de Hierro en Majadahonda, Spain.

Background: A new software has recently been incorporated in almost all new anaesthesia machines to enable automatic lung recruitment manoeuvres. To date, no studies have assessed the safety and efficacy of these automatic software programs in the neonatal population.

Aims: We aimed to evaluate the safety and efficacy of the lung recruitment manoeuvre performed using the automatic stepwise recruitment manoeuvre software of the FLOW-i 4. Read More

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Comprehensive nursing intervention combined with early activityactivity applied in ventilator-associated pneumonia and its influence on blood gas index.

Am J Transl Res 2021 15;13(5):5647-5652. Epub 2021 May 15.

Department of Respiratory and Critical Care Medicine, Weifang People's Hospital Weifang 261000, Shandong Province, China.

Objective: To study the application effect of comprehensive nursing combined with early activityactivity in patients with ventilator-associated pneumonia (VAP) and its influence on blood gas indexes of patients.

Methods: 100 patients with VAP admitted to our hospital from February 2018 to November 2019 were randomly selected and divided into control group and experimental group, with 50 patients in each group. Patients in the control group received routine nursing intervention with early activity, and patients in the experimental group received comprehensive nursing intervention with early activity. Read More

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Early rehabilitation nursing in ICU promotes rehabilitation of patients with respiratory failure treated with invasive mechanical ventilation.

Am J Transl Res 2021 15;13(5):5232-5239. Epub 2021 May 15.

Intensive Care Unit, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University Changzhou 213000, Jiangsu Province, China.

Objective: This paper aimed at exploring the application value of early rehabilitation nursing (ERN) in intensive care unit (ICU) for nursing patients with respiratory failure (RF) treated with invasive mechanical ventilation (IMV).

Methods: Admitted to the ICU of our hospital from January 2019 to June 2020, 172 RF patients that was treated with IMV were selected as the research objects. Those in the general group (n=80) received routine nursing in ICU, whereas those in the recovery group (n=92) received ERN on the basis of the general group. Read More

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Efficacy comparison of high-frequency oscillatory ventilation with continuous nasal positive airway pressure in neonatal respiratory distress syndrome treatment.

Am J Transl Res 2021 15;13(5):5137-5146. Epub 2021 May 15.

Department of Neonatology, The Affiliated Fuzhou Children Hospital of Fujian Medical University Fuzhou 350001, Fujian, China.

Objectives: To compare the treatment efficacy of high-frequency oscillatory ventilation (HFOV) with nasal continuous positive airway pressure (NCPAP) in the treatment of neonatal respiratory distress syndrome (NRDS) and its effect on the expression of high-mobility group protein B1 (HMGB1).

Methods: A total of 180 infants with NRDS admitted to our hospital were included and randomly assigned into the HFOV group (receiving conventional therapy and HFOV), the NCPAP group (receiving conventional therapy and NCPAP), and the conventional group (receiving conventional therapy). Qi and blood indicators, heart rate, respiratory frequency, PCO, and PaO were observed and recorded before and after treatment, together with complications after treatment. Read More

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Aerosol inhalation of ambroxol hydrochloride combined with terbutaline can promote recovery of children with severe pneumonia.

Am J Transl Res 2021 15;13(5):5019-5026. Epub 2021 May 15.

Department of Pediatrics, Linyi Central Hospital Linyi 276400, Shandong Province, China.

Objective: This research aimed to investigate the clinical efficacy of aerosol inhalation of ambroxol hydrochloride combined with terbutaline on children with severe pneumonia, and to evaluate its influence on their immune function and inflammatory level.

Methods: Totally 113 severe pneumonia children were included. Thereinto, 55 children in the control group (CG) were treated with terbutaline aerosol inhalation, while 58 in the research group (RG) were given ambroxol hydrochloride on the basis of the CG. Read More

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Efficacy of budesonide in the prevention and treatment of bronchopulmonary dysplasia in premature infants and its effect on pulmonary function.

Am J Transl Res 2021 15;13(5):4949-4958. Epub 2021 May 15.

Department of Neonatology, Qinghai Red Cross Hospital Xining, Qinghai Province, China.

Objective: This study was designed to explore the efficacy of budesonide (BUD) in preventing and treating bronchopulmonary dysplasia (BPD) in premature infants and its effect on pulmonary function.

Methods: A total of 94 premature infants with BPD who were born in our hospital were selected as the research subjects and divided into the control group (47 cases) for routine treatment and the research group (47 cases) for BUD therapy on the basis of routine treatment according to the random number table method. The incidence of BPD and the time of oxygen inhalation, ventilator ventilation, extubation and hospitalization were recorded in the two groups. Read More

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Sarcoidosis associated pulmonary hypertension: an update.

Curr Opin Pulm Med 2021 Jun 11. Epub 2021 Jun 11.

National Pulmonary Hypertension Service, Royal Brompton Hospital National Lung and Heart Institute, Imperial College London, London, UK.

Purpose Of Review: Sarcoidosis associated pulmonary hypertension (SAPH) is a well-recognised complication, associated with a seven-fold increase in mortality. This comprehensive review will summarise these recent developments and proposes the use of a phenotype-based management approach in SAPH.

Recent Findings: Recent registry-based studies have highlighted the adverse outcomes associated with SAPH and shown that reduced 6-min walk distance and diffusion capacity for carbon monoxide are predictive of poor prognosis. Read More

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[Effect of obstructive sleep apnea on cardiopulmonary function in patients with chronic obstructive pulmonary disease].

Zhonghua Yi Xue Za Zhi 2021 Jun;101(22):1665-1670

Department of Respiratory and Critical Medicine, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

To study the characteristics of cardiopulmonary function in patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) overlapping syndrome (OS). A total of 149 COPD patients, who were on stable treatment, were enrolled from the Second Affiliated Hospital of Soochow University from December 2017 to December 2019. The patients were divided into the OS group (=56) and the COPD only group (=93) according to their apnea hypopnea index (AHI) measured by the Apnealink device. Read More

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Vasodilation by carbon dioxide and sodium nitroglycerin reduces compliance of the cerebral arteries in humans.

Exp Physiol 2021 Jun 11. Epub 2021 Jun 11.

School of Kinesiology, University of Western Ontario, London, ON, Canada.

New Findings: What is the central question of this study? Vascular compliance importantly contributes to the regulation of cerebral perfusion and complex mechanisms are known to influence compliance of a vascular bed. While vasodilation mediates changes in vascular resistance, it remains unknown whether it may also affect compliance, particularly in the cerebral vasculature. What is the main finding and its importance? The present findings demonstrate that cerebral vasodilation, elicited by hypercapnia and sodium nitroglycerin administration, reduced cerebrovascular compliance by approximately 26% from baseline. Read More

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Trial of aerosolised surfactant for preterm infants with respiratory distress syndrome.

Arch Dis Child Fetal Neonatal Ed 2021 Jun 10. Epub 2021 Jun 10.

Neonatology, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA

Objective: To evaluate the safety of an aerosolised surfactant, SF-RI 1, administered via nasal continuous positive airway pressure (nCPAP) and a prototype breath synchronisation device (AeroFact), to preterm infants with respiratory distress syndrome (RDS).

Design: Multicentre, open-label, dose-escalation study with historical controls.

Setting: Newborn intensive care units at Mater Mothers' Hospital, Brisbane, and Royal Hospital for Women, Sydney, Australia. Read More

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Comparison of high-flow nasal oxygen cannula therapy versus a standard oxygen face mask in patients with hypostatic pneumonia.

J Int Med Res 2021 Jun;49(6):3000605211022279

Department of Respiratory and Critical Care Medicine, Harrison International Peace Hospital Affiliated to Hebei Medical University, Hengshui, China.

Objective: We assessed the clinical effects of high-flow nasal cannula (HFNC) oxygen therapy and a standard oxygen atomizer mask on the respiratory tract in patients with hypostatic pneumonia.

Methods: We included patients with hypostatic pneumonia in this retrospective cohort study. Patients were provided continuous airway humidification by continuous oxygen atomization using either an HFNC or standard oxygen mask. Read More

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CORM-2 inhibits intracerebral hemorrhage-mediated inflammation.

Neurol Res 2021 Jun 10:1-8. Epub 2021 Jun 10.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

: Low-dose of carbon monoxide delivered by CO-releasing molecule-2 (CORM-2) had been confirmed having anti-inflammatory efficacy in some inflammatory diseases. Herein, we assessed the usefulness of CORM-2 in correcting intracerebral hemorrhage (ICH)-mediated inflammation.: Healthy male Sprague Dawley (SD) rats randomly entered into four groups: sham-ICH, ICH, ICH+CORM-2, and ICH+ inactive carbon monoxide releasing molecule 2 (iCORM-2). Read More

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A systematic review and meta-analysis of effect evaluation of traditional Chinese medicine in treating acute respiratory distress syndrome.

Ann Palliat Med 2021 May;10(5):5520-5532

Department of Respiratory Medicine, Yichang Hospital of Traditional Chinese Medicine, Yichang, China; College of Traditional Chinese Medicine, China Three Gorges University, Yichang, China; College of Medical Science, China Three Gorges University, Yichang, China.

Background: It was to systematically evaluate the effects of traditional Chinese medicine (TCM) in the treatment of acute respiratory distress syndrome (ARDS), and provide a theoretical basis for the clinical treatment of ARDS.

Methods: English databases of PubMed, Embase, Medline, Spring, Cochrane Library, and Web of Science were searched, and the randomized controlled trial literatures on the treatment of ARDS patients with TCM published from January 1, 2001 to December 31, 2020 were screened. Then, Cochrane Handbook 5. Read More

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Alterations in arterial CO rather than pH affect the kinetics of neurovascular coupling in humans.

J Physiol 2021 Jun 9. Epub 2021 Jun 9.

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, V1V 1V7, Canada.

Key Points: We investigated the influence of arterial PCO (PaCO ) with and without acute experimental metabolic alkalosis on neurovascular coupling (NVC). We assessed stepwise iso-oxic alterations in PaCO prior to and following intravenous sodium bicarbonate (NaHCO ) to acutely elevate arterial pH and bicarbonate ([HCO ]). The NVC response was not altered following NaHCO between stepwise PaCO stages; therefore, NVC is acutely mediated by PaCO rather than the prevailing arterial [H ]/pH. Read More

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Effects of 45° prone position ventilation in the treatment of acute respiratory distress syndrome: A protocol for a randomized controlled trial study.

Medicine (Baltimore) 2021 May;100(19):e25897

Guangzhou Panyu Central Hospital.

Background: Acute respiratory distress syndrome (ARDS) is an increasingly common acute respiratory failure that seriously threaten people's health. ARDS has a case fatality rate of up to 40%. ARDS is a serious threat to the life safety of patients and the quality of life, causing a huge economic burden to individuals, families and society. Read More

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Elevated Arterial-Central Venous Carbon Dioxide Partial Pressure Difference Indicates Poor Prognosis in the Early Postoperative Period of Open Heart Surgery in Infants with Congenital Heart Disease.

Pediatr Cardiol 2021 Jun 9. Epub 2021 Jun 9.

Cardiac Intensive Care Unit, Department of Cardiovascular and Thoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.

Background: Elevated arterial-central venous carbon dioxide partial pressure difference (AVCO) may be an important marker to predict tissue and organ hypoperfusion in adults. We analyzed the hemodynamic data of infants with congenital heart disease who underwent corrective repair with cardiopulmonary bypass (CPB) to identify whether AVCO has clinical significance in early postoperative tissue hypoperfusion, occurrence of complications, and clinical outcomes.

Methods: Infants with clinical conditions of hypoperfusion, without volume responsiveness and with ineffective initial treatment, within 3 h of cardiac surgery were enrolled in this study. Read More

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Differential regional cerebral blood flow reactivity to alterations in end-tidal gases in healthy volunteers.

Can J Anaesth 2021 Jun 8. Epub 2021 Jun 8.

Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.

Purpose: Anesthesia is associated with alterations in end-tidal (ET) respiratory gases from the awake state. These alterations result in marked vasoactive changes in regional cerebral blood flow (rCBF). Altered regional cerebrovascular reactivity (rCVR) is linked to neurologic dysfunction. Read More

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Effect of oral gabapentin premedication on hemodynamic parameters and postoperative pain in patients of laparoscopic cholecystectomy: A randomized double-blind controlled study.

J Anaesthesiol Clin Pharmacol 2021 Jan-Mar;37(1):67-72. Epub 2021 Apr 10.

Department of Surgery, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India.

Background And Aims: Carbon dioxide (CO) pneumoperitoneum created during laparoscopic cholecystectomy causes adverse hemodynamic changes such as rise in arterial pressure. The aim of this study was to assess the effect of oral gabapentin premedication on hemodynamic parameters in addition to postoperative nausea and vomiting (PONV) and pain in patients of laparoscopic cholecystectomy conducted under general anesthesia.

Material And Methods: Randomly selected 60 American Society of Anesthesiologists (ASA) class I patients scheduled for laparoscopic cholecystectomy were premedicated with either gabapentin 1200 mg (Group GB) or placebo (Group PL) 2 h prior to induction of anesthesia. Read More

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Intraoperative Monitoring of the Obese Patient Undergoing Surgery: A Narrative Review.

Adv Ther 2021 Jun 5. Epub 2021 Jun 5.

University of Campania "Luigi Vanvitelli", Naples, Italy.

With the increasing prevalence of obesity in the population, anaesthetists must confidently manage both the pathophysiological and technical challenges presented in bariatric and non-bariatric surgery. The intraoperative period represents an important opportunity to optimise and mitigate risk. However, there is little formal guidance on what intraoperative monitoring techniques should be used in this population. Read More

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The Ability of Carbon Dioxide-Derived Indices to Predict Adverse Outcome After Cardiac Surgery.

J Cardiothorac Vasc Anesth 2021 May 3. Epub 2021 May 3.

Department Anesthesiology and Intensive Care Medicine, Habib Bourguiba University Hospital, Sfax, Tunisia.

Objective: The objective of this study was to assess whether the central venous-to-arterial carbon dioxide partial-pressure difference (ΔPCO) and the ratio of the ΔPCO to the arterial-venous difference in oxygen content (ΔPCO/Ca-vO) predict postoperative complications (PC) after cardiac surgery.

Design: Prospective, observational, noninterventional study.

Participants: The study comprised 60 patients undergoing cardiac surgery with cardiopulmonary bypass. Read More

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New models for donor-recipient matching in lung transplantations.

PLoS One 2021 4;16(6):e0252148. Epub 2021 Jun 4.

Department of Computer Science and Numerical Analysis, Universidad de Córdoba, Córdoba, Spain.

Objective: One of the main problems of lung transplantation is the shortage of organs as well as reduced survival rates. In the absence of an international standardized model for lung donor-recipient allocation, we set out to develop such a model based on the characteristics of past experiences with lung donors and recipients with the aim of improving the outcomes of the entire transplantation process.

Methods: This was a retrospective analysis of 404 lung transplants carried out at the Reina Sofía University Hospital (Córdoba, Spain) over 23 years. Read More

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Differential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular function.

Sci Rep 2021 Jun 3;11(1):11808. Epub 2021 Jun 3.

2nd Cardiology Department, Attikon Hospital, National and Kapodistrian University of Athens, Rimini 1, Haidari, 12462, Athens, Greece.

We compared the effects of Heat-not-Burn cigarette (HNBC) to those of tobacco cigarette (Tcig), on myocardial, coronary and arterial function as well as on oxidative stress and platelet activation in 75 smokers. In the acute study, 50 smokers were randomised into smoking a single Tcig or a HNBC and after 60 min were crossed-over to the alternate smoking. For chronic phase, 50 smokers were switched to HNBC and were compared with an external group of 25 Tcig smokers before and after 1 month. Read More

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Therapeutic hypercapnia for prevention of secondary ischemia after severe subarachnoid hemorrhage: physiological responses to continuous hypercapnia.

Sci Rep 2021 Jun 3;11(1):11715. Epub 2021 Jun 3.

Department of Neurosurgery, University Hospital Wuerzburg, Josef-Schneider-Strasse 11, 97080, Wuerzburg, Germany.

Temporary hypercapnia has been shown to increase cerebral blood flow (CBF) and might be used as a therapeutical tool in patients with severe subarachnoid hemorrhage (SAH). It was the aim of this study was to investigate the optimum duration of hypercapnia. This point is assumed to be the time at which buffer systems become active, cause an adaptation to changes of the arterial partial pressure of carbon dioxide (PaCO) and annihilate a possible therapeutic effect. Read More

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Effects of sedative psychotropic drugs combined with oxycodone on respiratory depression in the rat.

Clin Transl Sci 2021 Jun 3. Epub 2021 Jun 3.

Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

Following a decision to require label warnings for concurrent use of opioids and benzodiazepines and increased risk of respiratory depression and death, the US Food and Drug Administratioin (FDA) recognized that other sedative psychotropic drugs may be substituted for benzodiazepines and be used concurrently with opioids. In some cases, data on the ability of these alternatives to depress respiration alone or in conjunction with an opioid are lacking. A nonclinical in vivo model was developed that could detect worsening respiratory depression when a benzodiazepine (diazepam) was used in combination with an opioid (oxycodone) compared to the opioid alone based on an increased arterial partial pressure of carbon dioxide (pCO ). Read More

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Pathophysiological profile of awake and anesthetized pigs following systemic exposure to the highly lethal ricin toxin.

Clin Toxicol (Phila) 2021 Jun 3:1-7. Epub 2021 Jun 3.

Division of Medicinal Chemistry, Israel Institute for Biological Research, Ness Ziona, Israel.

Ricin, a plant-derived toxin originating from the seeds of (castor bean plant), is one of the most lethal toxins known. To date, no in-depth study of systemic exposure to ricin in a standardized large animal model has been reported. This study details for the first time the pathophysiological hemodynamic profile following systemic/intramuscular exposure to the ricin toxin in a porcine model by comprehensive cardiorespiratory monitoring of awake and anesthetized pigs. Read More

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Effect of hemoglobin content on cerebral oxygen saturation during surgery for scoliosis in pediatric patients.

BMC Anesthesiol 2021 Jun 1;21(1):165. Epub 2021 Jun 1.

Department of Transfusion Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Background: Although regional cerebral oxygen saturation (rScO) monitoring has been widely used in clinical practice, the relationship between hemoglobin (dHB) content and rScO is incompletely understood. The aim of this study was to analyze the effect of hemoglobin content on rScO in pediatric patients undergoing general anesthesia for correction of scoliosis.

Methods: Ninety-two pediatric patients aged 3 to 14 years undergoing scoliosis correction surgery were enrolled. Read More

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Connective Tissue Disease-Associated Pulmonary Arterial Hypertension in Southern Taiwan: A Single-Center 10-Year Longitudinal Observation Cohort.

Healthcare (Basel) 2021 May 20;9(5). Epub 2021 May 20.

Division of Rheumatology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.

: Pulmonary arterial hypertension (PAH) is a life-threatening disease with different etiologies and outcomes. We aimed to explore differences in clinical features and outcomes of idiopathic PAH (iPAH) and connective tissue disease-related PAH (CTD-PAH) in Taiwanese patients and determine risk factors for mortality. : We retrospectively reviewed the medical records of patients with right-sided heart catheterization-diagnosed PAH between January 2005 and December 2015. Read More

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New risk model is able to identify patients with a low risk of progression in systemic sclerosis.

RMD Open 2021 May;7(2)

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To develop a prediction model to guide annual assessment of systemic sclerosis (SSc) patients tailored in accordance to disease activity.

Methods: A machine learning approach was used to develop a model that can identify patients without disease progression. SSc patients included in the prospective Leiden SSc cohort and fulfilling the ACR/EULAR 2013 criteria were included. Read More

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[The predictive value of central venous-arterial CO difference/arterial-central venous O difference ratio for progressive organ dysfunction in patients with septic shock after resuscitation].

Authors:
C Yu W J Fan M Shao

Zhonghua Nei Ke Za Zhi 2021 Jun;60(6):533-538

Department of Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230000, China.

To study the predictive value of central venous-arterial CO difference (Pv-aCO)/arterial-central venous O difference (Ca-vO) ratio for progressive organ dysfunction in patients with septic shock after resuscitation. Septic shock patients receiving resuscitation in ICU were retrospectively enrolled from July 2018 to June 2019 at the First Affiliated Hospital Anhui Medical University. Hemodynamic and laboratory data were collected. Read More

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