113 results match your criteria arrest unsuspected


Cardiac arrest following unsuspected self-poisoning with doxylamine.

Ther Drug Monit 2022 Jan 11. Epub 2022 Jan 11.

Clinical Toxicology Unit, Clinical Analysis Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Intensive Care Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Intensive Care Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Intensive Care Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Cardiology Department. Hospital Universitari Son Llàtzer. Department of Medicine, Faculty of Medicine, University of the Balearic Islands. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Institute of Legal Medicine of the Balearic Islands. Ministry of Justice. Department of Medicine, Faculty of Medicine, University of the Balearic Islands. Palma de Mallorca, Spain. Institute of Legal Medicine of the Balearic Islands. Ministry of Justice. Department of Medicine, Faculty of Medicine, University of the Balearic Islands. Palma de Mallorca, Spain.

View Article and Full-Text PDF
January 2022

Plasticity of the human preimplantation embryo: developmental dogmas, variations on themes and self-correction.

Hum Reprod Update 2021 Aug;27(5):848-865

CARE Fertility Group, Northampton, UK.

Background: IVF for the treatment of infertility offers unique opportunities to observe human preimplantation development. Progress in time-lapse technology (TLT) and preimplantation genetic testing (PGT) has greatly expanded our knowledge of developmental patterns leading to a healthy pregnancy or developmental failure. These technologies have also revealed unsuspected plastic properties of the preimplantation embryo, at macromolecular, cellular and multicellular levels. Read More

View Article and Full-Text PDF

Myocarditis Presenting as Sudden Death in Infants and Children: A Single Centre Analysis by ESGFOR Study Group.

Pediatr Dev Pathol 2021 Jul-Aug;24(4):327-336. Epub 2021 Apr 19.

Histopathology Department, Sheffield Children's NHS FT, Sheffield, UK.

Background: Acute myocarditis is an inflammatory disease of the heart mostly diagnosed in young people, which can present as sudden death. The etiology includes infectious agents (mostly viruses), systemic diseases and toxins. We aim to characterize infants and children with myocarditis at post-mortem presenting as sudden deaths. Read More

View Article and Full-Text PDF
December 2021

Sudden death in the young adult: a Tunisian autopsy-based series.

BMC Public Health 2020 Dec 17;20(1):1915. Epub 2020 Dec 17.

Department of Forensic Medicine, Fattouma Bourguiba Teaching Hospital, 5000, Monastir, Tunisia.

Background: We aim to study the profile, and pathological characteristics of sudden death in young in purpose of recommendations for prevention.

Methods: We performed a retrospective cohort study using autopsy data from the Department of Forensic Medicine of Monastir (Tunisia). A review of all autopsies performed for 28 years was done (August 1990 to December 2018). Read More

View Article and Full-Text PDF
December 2020

Calibration between trigger and color: Neutralization of a genetically encoded coulombic switch and dynamic arrest precisely tune reflectin assembly.

J Biol Chem 2019 11 26;294(45):16804-16815. Epub 2019 Sep 26.

Department of Molecular, Cellular and Developmental Biology and the Institute for Collaborative Biotechnologies, University of California, Santa Barbara, California 93106-5100

Reflectin proteins are widely distributed in reflective structures in cephalopods. However, only in loliginid squids are they and the subwavelength photonic structures they control dynamically tunable, driving changes in skin color for camouflage and communication. The reflectins are block copolymers with repeated canonical domains interspersed with cationic linkers. Read More

View Article and Full-Text PDF
November 2019

Neonatal Death Caused by Interrupted Aortic Arch Associated With 22q11.2 Deletion Syndrome: An Autopsy Case Report.

Am J Forensic Med Pathol 2019 Jun;40(2):178-182

From the *Section of Legal Medicine, Department of Social Medicine, Faculty of Medicine, University of Miyazaki; and †Radiology Division and ‡Division of Clinical Genetics, Faculty of Medicine, University of Miyazaki Hospital, Miyazaki; and §Division of Genomic Medicine, Kanazawa Medical University, Ishikawa, Japan.

A case of clinically unsuspected fatal interrupted aortic arch (IAA) is described. A 17-day-old Japanese girl unexpectedly entered respiratory arrest at home. On autopsy, the heart was hypertrophic, with no apparent connection between the ascending and descending aortas. Read More

View Article and Full-Text PDF

40 Years of Research Put p53 in Translation.

Cancers (Basel) 2018 May 21;10(5). Epub 2018 May 21.

Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008 Lyon, France.

Since its discovery in 1979, p53 has shown multiple facets. Initially the tumor suppressor p53 protein was considered as a stress sensor able to maintain the genome integrity by regulating transcription of genes involved in cell cycle arrest, apoptosis and DNA repair. However, it rapidly came into light that p53 regulates gene expression to control a wider range of biological processes allowing rapid cell adaptation to environmental context. Read More

View Article and Full-Text PDF

Endocannabinoids in Caenorhabditis elegans are essential for the mobilization of cholesterol from internal reserves.

Sci Rep 2018 04 23;8(1):6398. Epub 2018 Apr 23.

Laboratorio de Fisiología Microbiana, Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, 2000, Rosario, Argentina.

Proper cholesterol transport is crucial for the functionality of cells. In C. elegans, certain cholesterol derivatives called dafachronic acids (DAs) govern the entry into diapause. Read More

View Article and Full-Text PDF

Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence.

Cell Death Dis 2018 02 15;9(3):259. Epub 2018 Feb 15.

Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, 69373, Lyon, France.

Cellular senescence response is (i) activated by numerous stresses, (ii) is characterized by a stable proliferation arrest, and (iii) by a set of specific features. Timely regulated senescence is thought to be beneficial, whereas chronic senescence such as during normal or premature aging is deleterious as it favors most, if not all, age-related diseases. In this study, using in-house or publicly available microarray analyses of transcriptomes of senescent cells, as well as analyses of the level of expression of several DNA repair genes by RT-qPCR and immunoblot, we show that repression of DNA repair gene expression is associated with cellular senescence. Read More

View Article and Full-Text PDF
February 2018

The Growth arrest specific 1 (Gas1) gene is transcriptionally regulated by NeuroD1 via two distal E-boxes.

Exp Cell Res 2018 02 1;363(2):332-341. Epub 2018 Feb 1.

Departamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del IPN, 07360 Ciudad de México, México. Electronic address:

Growth arrest specific 1 (GAS1) is a signaling mediator for the development of the central nervous system that works as a co-receptor for sonic hedgehog (SHH) to induce the amplification of neural progenitors during the patterning of the mammalian neural tube and establishing granular cells in the cerebellum. Recently, we confirmed that Gas1 is also expressed by neural progenitors of the developing cortex and the dentate gyrus of the hippocampus. The presence of GAS1 in progenitor stages indicates that one of its principal roles is the maintenance of these cells during neurogenic events. Read More

View Article and Full-Text PDF
February 2018

Bedside Identification of Massive Pulmonary Embolism with Point-of-Care Transesophageal Echocardiography.

J Emerg Med 2017 Nov;53(5):722-725

Department of Emergency Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Background: Pulmonary embolism can be difficult to diagnose, particularly in those who are hemodynamically unstable and cannot be imaged to confirm the diagnosis. Echocardiography can allow for rapid assessment of patients in shock, but requires adequate transthoracic windows to obtain clinically useful information. Emergency physician-performed transesophageal echocardiography (TEE) may be a useful tool when transthoracic echocardiography fails. Read More

View Article and Full-Text PDF
November 2017

Unsuspected Critical Illness Among Emergency Department Patients Presenting for Acute Alcohol Intoxication.

Ann Emerg Med 2018 03 24;71(3):279-288. Epub 2017 Aug 24.

Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN.

Study Objective: Emergency department (ED) visits for acute alcohol intoxication are common, but this population is at risk for decompensation and occult critical illness. The purpose of this study is to describe the incidence and predictors of unsuspected critical illness among patients with acute alcohol intoxication.

Methods: This was a retrospective observational study of ED patients from 2011 to 2016 with acute alcohol intoxication. Read More

View Article and Full-Text PDF

Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells.

Oncogene 2017 03 17;36(13):1849-1861. Epub 2016 Oct 17.

Department of Clinical Chemistry and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

BRAF inhibitor (BRAFi) therapy for melanoma patients harboring the V600E mutation is initially highly effective, but almost all patients relapse within a few months. Understanding the molecular mechanisms underpinning BRAFi-based therapy is therefore an important issue. Here we identified a previously unsuspected mechanism of BRAFi resistance driven by elevated Hedgehog (Hh) pathway activation that is observed in a cohort of melanoma patients after vemurafenib treatment. Read More

View Article and Full-Text PDF

Unexpected macrophage-independent dyserythropoiesis in Gaucher disease.

Haematologica 2016 12 28;101(12):1489-1498. Epub 2016 Jul 28.

Université Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge, Laboratoire d'Excellence GR-Ex, Paris

Gaucher disease is a rare inherited disease caused by a deficiency in glucocerebrosidase leading to lipid accumulation in cells of mononuclear-macrophage lineage known as Gaucher cells. Visceral enlargement, bone involvement, mild anemia and thrombocytopenia are the major manifestations of Gaucher disease. We have previously demonstrated that the red blood cells from patients exhibit abnormal properties, which indicates a new role in Gaucher disease pathophysiology. Read More

View Article and Full-Text PDF
December 2016

An Unsuspected Tooth: Spontaneous Tooth Aspiration Leading to Cardiac Arrest.

Am J Med Sci 2016 Apr 8;351(4):426. Epub 2016 Feb 8.

Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

View Article and Full-Text PDF

Comparison of the Frequency of Sudden Cardiovascular Deaths in Young Competitive Athletes Versus Nonathletes: Should We Really Screen Only Athletes?

Am J Cardiol 2016 Apr 1;117(8):1339-41. Epub 2016 Feb 1.

Jesse E. Edwards Registry of Cardiovascular Disease, Nasseff Heart Center, St. Paul, Minnesota.

The issue of sudden death in young athletes and consideration for the most practical and optimal strategy to identify those genetic and/or congenital heart diseases responsible for these tragic events continues to be debated. However, proponents of broad-based and mandatory national preparticipation screening, including with 12-lead electrocardiograms have confined the focus to a relatively small segment of the youthful population who choose to engage in competitive athletic programs at the high school, college, and elite-professional level. Therefore, lost in this discussion of preparticipation screening of athletes is that the larger population of young people not involved in competitive sports (and, therefore, a priori are excluded from systematic screening) who nevertheless may die suddenly of the same cardiovascular diseases as athletes. Read More

View Article and Full-Text PDF

Historical Perspectives on Sudden Deaths in Young Athletes With Evolution over 35 Years.

Authors:
Barry J Maron

Am J Cardiol 2015 Nov 14;116(9):1461-8. Epub 2015 Aug 14.

Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota. Electronic address:

Sudden death in young competitive athletes has become a highly visible and substantial issue within cardiovascular medicine of interest both to the general public and to the practicing community. At this time, it is instructive to revisit the evolution of this clinical problem over the past 35 years starting with introduction into the public and medical consciousness by the unexpected sudden deaths of 2 college basketball players within 8 weeks of each other in 1976, 1 with Marfan syndrome and the other with hypertrophic cardiomyopathy. Subsequently, over the next years, a number of elite athletes died suddenly, raising public visibility and awareness of these tragic events: Len Bias, "Pistol" Pete Maravich, Hank Gathers, Reggie Lewis, Kori Stringer, Jason Collier, and Thomas Herrion. Read More

View Article and Full-Text PDF
November 2015

Sudden Cardiac Death in a Young Man with Migraine-associated Arrhythmia.

J Forensic Sci 2015 11 7;60(6):1633-6. Epub 2015 Aug 7.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Avenue, MSC-908, Charleston, SC, 29425.

A 31-year-old man with migraine-induced syncope and bradycardia with subsequent pacemaker implantation died unexpectedly. Clinically unsuspected cardiac anomalies were found at autopsy including myocardial bridging of the left anterior descending artery and shelf-like coronary artery ostia. Nortriptyline was identified by toxicologic analysis. Read More

View Article and Full-Text PDF
November 2015

Genetics of sudden cardiac death.

Curr Cardiol Rep 2015 Jul;17(7):606

Department of Internal Medicine (Cardiology Division), American University of Beirut Medical Center, Beirut, Lebanon,

Sudden cardiac death (SCD) is defined by the World Health Organization (WHO) as death within 1 h of symptom onset (witnessed) or within 24 h of being observed alive and symptom free (unwitnessed). It affects more than 3 million people annually worldwide and affects approximately 1/1000 people each year in the USA. Familial studies of syndromes with Mendelian inheritance, candidate genes analyses, and genome-wide association studies (GWAS) have helped our understanding of the genetics of SCD. Read More

View Article and Full-Text PDF

Ethics of preparticipation cardiovascular screening for athletes.

Nat Rev Cardiol 2015 Jun 24;12(6):375-8. Epub 2015 Feb 24.

Division of Medical Ethics, NYU Langone Medical Center, 455 1st Avenue, New York, NY 10016, USA.

Preparticipation screening for unsuspected cardiovascular disease is a controversial topic in the medical and lay communities. Much attention has been directed towards young competitive athletes, particularly the proposed strategy of incorporating 12-lead electrocardiograms into the screening process, even on a national or worldwide basis. However, sudden deaths of young athletes owing to genetic or congenital heart diseases have a low incidence in the general population. Read More

View Article and Full-Text PDF

Symptom recovery in virus-infected plants: Revisiting the role of RNA silencing mechanisms.

Virology 2015 May 9;479-480:167-79. Epub 2015 Feb 9.

Department of Botany, University of British Columbia, 3529-6270 University Boulevard, Vancouver, BC, Canada V6T 1Z4; Pacific Agri-Food Research Centre, Agriculture and Agri-Food Canada, 4200 Highway 97, Summerland, BC, Canada V0H 1Z0. Electronic address:

The natural outcome of some plant-virus interactions is symptom recovery, which is characterized by the emergence of asymptomatic leaves following a systemic symptomatic infection. Symptom recovery is generally accompanied with reduced virus titers and sequence-specific resistance to secondary infection and has been linked with the induction of antiviral RNA silencing. Recent studies have revealed an unsuspected diversity of silencing mechanisms associated with symptom recovery in various host-virus interactions, including degradation or translation repression of viral RNAs and in the case of DNA viruses, transcriptional arrest of viral minichromosomes. Read More

View Article and Full-Text PDF

An autopsy study of sudden cardiac death in persons aged 1-40 years in Brescia (Italy).

J Cardiovasc Med (Hagerstown) 2016 Jun;17(6):446-53

Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Section of Public Health and Human Sciences, Forensic Medicine Unit, University of Brescia, Brescia, Italy.

Introduction: Sudden cardiac death (SCD), above all when occurring in young people, remains a major clinical problem. We have analysed the clinical and post mortem findings of patients who were evaluated for SCD.

Methods And Results: We have analysed 54 cases of SCD which occurred in patients aged below 40 years during the period 1993-2012 and were studied at the Institute of Forensic Medicine of Brescia. Read More

View Article and Full-Text PDF

Gas1 is a receptor for sonic hedgehog to repel enteric axons.

Proc Natl Acad Sci U S A 2015 Jan 22;112(1):E73-80. Epub 2014 Dec 22.

Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21218; and

The myenteric plexus of the enteric nervous system controls the movement of smooth muscles in the gastrointestinal system. They extend their axons between two peripheral smooth muscle layers to form a tubular meshwork arborizing the gut wall. How a tubular axonal meshwork becomes established without invading centrally toward the gut epithelium has not been addressed. Read More

View Article and Full-Text PDF
January 2015

The PCNA binding domain of Rad2p plays a role in mutagenesis by modulating the cell cycle in response to DNA damage.

DNA Repair (Amst) 2014 Apr 18;16:1-10. Epub 2014 Feb 18.

Department of Pharmacology, College of Medicine, Inha University, Incheon 400-712, Republic of Korea. Electronic address:

The xeroderma pigmentosum group G (XPG) gene, encoding an essential element in nucleotide excision repair (NER), has a proliferating cell nuclear antigen-binding domain (PCNA-BD) at its C-terminal region. However, the role of this domain is controversial because its presence does not affect NER. Using yeast RAD2, a homolog of human XPG, we show that Rad2p interacts with PCNA through its PCNA-BD and the PCNA-BD of Rad2p plays a role in UV-induced mutagenesis. Read More

View Article and Full-Text PDF

RPA provides checkpoint-independent cell cycle arrest and prevents recombination at uncapped telomeres of Saccharomyces cerevisiae.

DNA Repair (Amst) 2013 Mar 9;12(3):212-26. Epub 2013 Jan 9.

UMR CNRS 5239, Ecole Normale Supérieure de Lyon, IFR128 BioSciences Gerland, 69364 Lyon, France.

Replication Protein A (RPA) is an evolutionary conserved essential complex with single-stranded DNA binding properties that has been implicated in numerous DNA transactions. At damaged telomeres, Saccharomyces cerevisiae RPA recruits the Mec1-Ddc2 module of the DNA damage checkpoint network, its only known function in DNA damage signaling. Here, we describe rfa1 mutants (rfa1-1, rfa1-9, rfa1-10, rfa1-11 and rfa1-12) that are proficient in this checkpoint but nevertheless exhibit deregulation of cell cycle control upon telomere uncapping induced by the cdc13-1 mutation. Read More

View Article and Full-Text PDF

Staging a recovery from mitotic arrest: Unusual ways of Cdk1.

Bioarchitecture 2012 Feb;2(2):33-37

Institute of Molecular and Cell Biology; Proteos, Singapore.

Checkpoint controls, the surveillance pathways that impose "an order of execution" on the major cell cycle events, are critical to the maintenance of genome stability. When cells fail to execute a cellular event or do so erroneously due to misregulation or exposure to genotoxic stresses, these evolutionarily conserved regulatory circuits prevent passage to the subsequent event, thus bringing the cell cycle to a halt. Once the checkpoint stimulus is removed, cells recover from the arrest and eventually resume cell cycle progression. Read More

View Article and Full-Text PDF
February 2012

Ribonuclease E modulation of the bacterial SOS response.

PLoS One 2012 8;7(6):e38426. Epub 2012 Jun 8.

Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America.

Plants, animals, bacteria, and Archaea all have evolved mechanisms to cope with environmental or cellular stress. Bacterial cells respond to the stress of DNA damage by activation of the SOS response, the canonical RecA/LexA-dependent signal transduction pathway that transcriptionally derepresses a multiplicity of genes-leading to transient arrest of cell division and initiation of DNA repair. Here we report the previously unsuspected role of E. Read More

View Article and Full-Text PDF
December 2012

Restricting sports for athletes with heart disease: are we saving lives, avoiding lawsuits, or just promoting obesity and sedentary living?

Pediatr Cardiol 2012 Mar 11;33(3):407-16. Epub 2012 Feb 11.

Division of Cardiology, Department of Medicine, UCLA Cardiac Arrhythmia Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Sudden cardiac death in young competitive athletes is tragic and usually due to unsuspected cardiovascular disease. Screening programs for athletes remain debatable, and restriction of athletes from sports can have physical, emotional, and legal ramifications. In this article, we review the epidemiology of the more common inherited arrhythmias and congenital heart diseases that are of concern in a newly diagnosed athlete. Read More

View Article and Full-Text PDF

Prevalence and spectrum diseases predisposing to sudden cardiac death: are they the same for both the athlete and the nonathlete?

Pediatr Cardiol 2012 Mar;33(3):379-86

Division of Pediatric Cardiology, Children’s Hospital of Orange County, University of California at Irvine, 455 S Main Street, Orange, CA 92868, USA.

Sudden cardiac death (SCD) is a rare but devastating event among young people. The precise scale of the event remains undefined. This uncommon but catastrophic event usually is proved to be the consequence of varied unsuspected congenital or acquired cardiovascular diseases. Read More

View Article and Full-Text PDF

Utility of cardiovascular magnetic resonance in identifying substrate for malignant ventricular arrhythmias.

Circ Cardiovasc Imaging 2012 Jan 28;5(1):12-20. Epub 2011 Oct 28.

Division of Cardiology, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

Background: Sudden cardiac death (SCD) and sustained monomorphic ventricular tachycardia (SMVT) are frequently associated with prior or acute myocardial injury. Cardiovascular magnetic resonance (CMR) provides morphological, functional, and tissue characterization in a single setting. We sought to evaluate the diagnostic yield of CMR-based imaging versus non-CMR-based imaging in patients with resuscitated SCD or SMVT. Read More

View Article and Full-Text PDF
January 2012