16,144 results match your criteria argentina associated

Prognostic value of masked uncontrolled apparent resistant hypertension detected through home blood pressure monitoring.

J Hypertens 2021 Jun 14. Epub 2021 Jun 14.

Hypertension Section, Internal Medicine Department, Hospital Italiano de Buenos Aires Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB), UE de triple dependencia CONICET- Instituto Universitario del Hospital Italiano (IUHI)- Hospital Italiano (HIBA), Buenos Aires, Argentina.

Objective: Resistant hypertension carries a poor prognosis and current guidelines recommend the exclusion of the white-coat phenomenon for proper diagnosis. However, guidelines do not focus on patients treated with at least three drugs whose blood pressure (BP) is controlled at the office but elevated out of it. We aimed at determining whether this masked uncontrolled apparent resistant hypertension (MUCRH) detected through home blood pressure monitoring (HBPM) has prognostic value for fatal and nonfatal events in these hypertensive patients. Read More

View Article and Full-Text PDF

Management of factor XI deficiency in oncological liver and colorectal surgery by therapeutic plasma exchange: A case report.

Transfus Apher Sci 2021 May 31:103176. Epub 2021 May 31.

Transfusion Medicine Deparment, Hospital Italiano de Buenos Aires, Argentina.

Introduction: Factor XI (FXI) deficiency is a rare congenital hemostatic disorder associated with increased bleeding tendency in trauma, surgery or when other hemostatic defects are present. Perioperative hemostatic management of a patient with a severe FXI deficiency undergoing major oncological liver and colorectal surgery with therapeutic plasma exchange (TPE) with fresh frozen plasma (FFP) is reported.

Case Description: A 54-year-old male with severe FXI deficiency was scheduled for resection of synchronous rectal cancer and multiple liver metastases. Read More

View Article and Full-Text PDF

Clinical Pharmacology of Hyperammonemia by Sodium Valproate and Carbamazepine in People Living with HIV.

CNS Spectr 2021 Apr;26(2):143

Argentine Society of Neuropsychopharmacology, Buenos Aires City, Buenos Aires, Argentina.

Introduction: Hyperammonaemia (HA) is observed in decompensated liver disease. The picture of hyperammonemic encephalopathy in non-cirrhotic patients was reported mostly associated with valproic acid. There are few reports of hyperammonemia in people living with human immunodeficiency virus (PLHIV) and they are associated with other comorbidities and few with antiretrovirals (HAART), but not as adverse drug reactions associated with psychotropic drugs associated with the virus. Read More

View Article and Full-Text PDF

A numerical study of the statistics of roughness parameters for fluctuating interfaces.

J Phys Condens Matter 2021 Jun 14. Epub 2021 Jun 14.

Physics of complex systems (PCSL), Ecole Polytechnique Federale de Lausanne, Route Cantonale, Lausanne, VD, 1015, SWITZERLAND.

Self-affine rough interfaces are ubiquitous in experimental systems, and display characteristic scaling properties as a signature of the nature of disorder in their supporting medium, i.e. of the statistical features of its heterogeneities. Read More

View Article and Full-Text PDF

Exploring the ecological and evolutionary relationships between Rickettsia and hard ticks in the Neotropical region.

Ticks Tick Borne Dis 2021 Jun 4;12(5):101754. Epub 2021 Jun 4.

Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária. São Paulo, SP, 05508-270, Brazil.

This study addresses a meta-analysis of the distribution of Rickettsia spp. in the Neotropical region, as well as their associations with ticks and vertebrates. A total of 219 published reports on Rickettsia in ticks in the target region were compiled, providing 599 records of 31 species of Rickettsia recorded in 50 species of Ixodidae. Read More

View Article and Full-Text PDF

First body of evidence suggesting a role of a tankyrase-binding motif (TBM) of vinculin (VCL) in epithelial cells.

PeerJ 2021 27;9:e11442. Epub 2021 May 27.

Grupo de Biofisicoquímica, Departamento de Ciencias Biológicas, Centro Universitario Regional Litoral Norte (CENUR), Universidad de la República, Salto, Uruguay.

Background: (AJ) are involved in cancer, infections and neurodegeneration. Still, their composition has not been completely disclosed. Poly(ADP-ribose) polymerases (PARPs) catalyze the synthesis of poly(ADP-ribose) (PAR) as a posttranslational modification. Read More

View Article and Full-Text PDF

Case Report of Novel Genetic Variant in KCNT1 Channel and Pharmacological Treatment With Quinidine. Precision Medicine in Refractory Epilepsy.

Front Pharmacol 2021 28;12:648519. Epub 2021 May 28.

Department of Neurology, Garrahan Hospital, Buenos Aires City, Argentina.

In this work we present a female infant patient with epilepsy of infancy with migrating focal seizures (EIMFS). Although many pharmacological schemes were attempted, she developed an encephalopathy with poor response to antiepileptic drugs and progressive cerebral dysfunction. To present the pharmacological response and therapeutic drug monitoring of a paediatric patient with a severe encephalopathy carrying a genetic variant in KCNT1 gene, whose identification led to include quinidine (QND) in the treatment regimen as an antiepileptic drug. Read More

View Article and Full-Text PDF

Low bleeding and thromboembolic risk with continued dabigatran during cardiovascular interventions: the GLORIA-AF study.

Eur J Intern Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.

Background: Prospective data on nonvitamin-K-antagonist oral anticoagulant (NOAC) management during cardiovascular interventions are limited. We therefore evaluated the safety and effectiveness of uninterrupted dabigatran therapy as well as dabigatran management during atrial fibrillation (AF)-cardioversions, AF-ablations, pacemaker implantations and coronary angiography and/or stenting procedures.

Method: GLORIA-AF is an international registry programme involving patients with newly diagnosed AF. Read More

View Article and Full-Text PDF

A practical guide to estimating the light extinction coefficient with nonlinear models-a case study on maize.

Plant Methods 2021 Jun 12;17(1):60. Epub 2021 Jun 12.

Department of Agronomy, Kansas State University, 1712 Claflin Rd, Manhattan, KS, 66506, USA.

Background: The fraction of intercepted photosynthetically active radiation (fPARi) is typically described with a non-linear function of leaf area index (LAI) and k, the light extinction coefficient. The parameter k is used to make statistical inference, as an input into crop models, and for phenotyping. It may be estimated using a variety of statistical techniques that differ in assumptions, which ultimately influences the numerical value k and associated uncertainty estimates. Read More

View Article and Full-Text PDF

Cardiac Natriuretic Peptide Profiles in Chronic Hypertension by Single or Sequentially Combined Renovascular and DOCA-Salt Treatments.

Front Physiol 2021 25;12:651246. Epub 2021 May 25.

Facultad de Farmacia y Bioquímica, Cátedras de Fisiopatología y Anatomía e Histología, Universidad de Buenos Aires, Buenos Aires, Argentina.

The involvement of natriuretic peptides was studied during the hypertrophic remodeling transition mediated by sequential exposure to chronic hemodynamic overload. We induced hypertension in rats by pressure (renovascular) or volume overload (DOCA-salt) during 6 and 12 weeks of treatment. We also studied the consecutive combination of both models in inverse sequences: RV 6 weeks/DS 6 weeks and DS 6 weeks/RV 6 weeks. Read More

View Article and Full-Text PDF

Updated Review on the Diagnosis and Primary Management of Psychogenic Nonepileptic Seizure Disorders.

Neuropsychiatr Dis Treat 2021 4;17:1825-1838. Epub 2021 Jun 4.

Buenos Aires University, Ramos Mejía Hospital, Epilepsy Center, Buenos Aires, Argentina.

Psychogenic nonepileptic seizures (PNES) are paroxystic and episodic events associated with motor, sensory, mental or autonomic manifestations, which resemble epileptic seizures (ES), but are not caused by epileptogenic activity. PNES affect between 20% and 30% of patients attending at epilepsy centers and constitute a serious mental health problem. PNES are often underdiagnosed, undertreated and mistaken with epilepsy. Read More

View Article and Full-Text PDF

RHBDD2‑WWOX protein interaction during proliferative and differentiated stages in normal and breast cancer cells.

Oncol Rep 2021 Aug 10;46(2). Epub 2021 Jun 10.

Basic and Applied Immunological Research Center, School of Medical Sciences, National University of La Plata, La Plata, Buenos Aires CP1900, Argentina.

Rhomboid pseudoproteases are catalytically inactive members of the rhomboid superfamily that modulate the traffic, turnover and activity of their target proteins. Rhomboid domain containing 2 () is a rhomboid family member overexpressed during mammary gland development and advanced stages of breast cancer. Interactome profiling studies have identified RHBDD2 as a novel binding partner of WW domain‑containing oxidoreductase (WWOX) protein. Read More

View Article and Full-Text PDF

Burnout Syndrome in Cardiology Residents. Impact of the COVID-19 Pandemic on Burnout Syndrome in Cardiology Residents.

Curr Probl Cardiol 2021 May 10:100873. Epub 2021 May 10.

Instituto Cardiovascular de Buenos Aires, CABA, Argentina.

Burnout syndrome (BO) may be increased during periods of high work and emotional stress, as occurred in the 2019 coronavirus disease pandemic (COVID-19). Resident physicians appear to be more exposed due to the higher workload, prolonged exposure and the first contact with patients. To compare the incidence of burnout syndrome before and during the COVID 19 pandemic in cardiology residents. Read More

View Article and Full-Text PDF

An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients.

Crit Care 2021 06 9;25(1):199. Epub 2021 Jun 9.

Critical Care Research Group, The Prince Charles Hospital, Chermside, Australia.

Background: Heterogeneous respiratory system static compliance (C) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous small-case series or studies conducted at a national level.

Methods: We designed a retrospective observational cohort study with rapid data gathering from the international COVID-19 Critical Care Consortium study to comprehensively describe C-calculated as: tidal volume/[airway plateau pressure-positive end-expiratory pressure (PEEP)]-and its association with ventilatory management and outcomes of COVID-19 patients on mechanical ventilation (MV), admitted to intensive care units (ICU) worldwide.

Results: We studied 745 patients from 22 countries, who required admission to the ICU and MV from January 14 to December 31, 2020, and presented at least one value of C within the first seven days of MV. Read More

View Article and Full-Text PDF

Understanding introduction history: Genetic structure and diversity of the edible ectomycorrhizal fungus, , in Patagonia (Argentina).

Mycologia 2021 Jun 9:1-10. Epub 2021 Jun 9.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.

is a common ectomycorrhizal (EM) fungus associated with several species. It is distributed throughout the Northern Hemisphere and has been introduced into South America and New Zealand. We examined the genetic structure and population biology of , which was introduced into Patagonian plantations with species in Argentina. Read More

View Article and Full-Text PDF

Molecular Monitoring of Knockdown Resistance in Head Louse (Phthiraptera: Pediculidae) Populations in Iran.

J Med Entomol 2021 Jun 9. Epub 2021 Jun 9.

Cellular and Molecular Research Center, Research Institute on Cellular and Molecular Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Knockdown resistance (kdr) is a common mechanism of insecticide resistance in head lice to the conventionally used pyrethroid pediculosis and can be the result of various amino acid substitutions within the voltage-sensitive sodium channel (VSSC). In this study, 54 sequences from varied specimens were investigated to monitor well-known resistance mutations and probable new mutations. The Pediculus humanus capitis de Geer specimens were collected from 13 provinces in Iran. Read More

View Article and Full-Text PDF

Characteristics of the treatment received by children with cleft lip and palate in Argentina.

Andes Pediatr 2021 Feb 24;92(1):67-78. Epub 2021 Feb 24.

Red Nacional de Anomalías congénitas, Centro Nacional de Genética Médica, Ministerio de Salud, Buenos Aires, Argentina.

Introduction: Cleft lip and palate (CLP) are congenital abnormalities that affect anatomically and functionally the face and mouth, involving lip (CL), palate (CP), or both (CL/CP).

Objective: to characterize the treatment of children with CLP in public institutions in Argentina.

Patients And Method: Cross sectional study in a random sample of 100 children from the Flap Network. Read More

View Article and Full-Text PDF
February 2021

Urban infestation by Triatoma infestans (Hemiptera: Reduviidae), an overlooked phenomena for Chagas disease in Argentina.

Mem Inst Oswaldo Cruz 2021 2;116:e210056. Epub 2021 Jun 2.

Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Ecología, Genética y Evolución de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina.

Vector-borne transmission of Chagas disease in urban areas of Argentina has been an overlooked phenomena. We conducted the first comprehensive cross-sectional study of domestic infestation with Triatoma infestans and vector infection with Trypanosoma cruzi in a metropolitan area of San Juan, Argentina. Our results document the occurrence of T. Read More

View Article and Full-Text PDF

Mismatch between midline shift and hematoma thickness as a prognostic factor of mortality in patients sustaining acute subdural hematoma.

Trauma Surg Acute Care Open 2021 21;6(1):e000707. Epub 2021 May 21.

Department of Neurology, University of São Paulo, São Paulo, Brazil.

Background: Acute subdural hematoma (ASDH) is a traumatic lesion commonly found secondary to traumatic brain injury. Radiological findings on CT, such as hematoma thickness (HT) and structures midline shift (MLS), have an important prognostic role in this disease. The relationship between HT and MLS has been rarely studied in the literature. Read More

View Article and Full-Text PDF

Intravenous immunoglobulin treatment for mild Guillain-Barré syndrome: an international observational study.

J Neurol Neurosurg Psychiatry 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, Erasmus MC, Rotterdam, The Netherlands

Objective: To compare the disease course in patients with mild Guillain-Barré syndrome (GBS) who were treated with intravenous immunoglobulin (IVIg) or supportive care only.

Methods: We selected patients from the prospective observational International GBS Outcome Study (IGOS) who were able to walk independently at study entry (mild GBS), treated with one IVIg course or supportive care. The primary endpoint was the GBS disability score four weeks after study entry, assessed by multivariable ordinal regression analysis. Read More

View Article and Full-Text PDF

Genetic variation in Neotropical butterflies is associated with sampling scale, species distributions, and historical forest dynamics.

Mol Ecol Resour 2021 Jun 7. Epub 2021 Jun 7.

Museo Argentino de Ciencias Naturales "Bernardino Rivadavia" (MACN-CONICET), Buenos Aires, Argentina.

Prior studies of butterfly diversification in the Neotropics have focused on Amazonia and the tropical Andes, while southern regions of the continent have received little attention. To address the gap in knowledge about the Lepidoptera of temperate South America, we analyzed over 3,000 specimens representing nearly 500 species from Argentina for a segment of the mitochondrial COI gene. Representing 42% of the country's butterfly fauna, collections targeted species from the Atlantic and Andean forests, biodiversity hotspots that were previously connected but are now isolated. Read More

View Article and Full-Text PDF

Laparoscopic Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer in Mutation Carriers.

J Laparoendosc Adv Surg Tech A 2021 Jun 7. Epub 2021 Jun 7.

Department of Surgery and Hospital de Gastroenterología "Dr. Carlos Bonorino Udaondo," Ciudad Autónoma de Buenos Aires, Argentina.

Patients with hereditary diffuse gastric cancer (HDGC) and germline mutations in the E-cadherin gene, , have a very high cumulative lifetime risk of developing diffuse gastric cancer. In these patients, it is formally recommended to perform a prophylactic total gastrectomy (PTG). We analyzed the course of patients with HDGC who have undergone PTG in our institution. Read More

View Article and Full-Text PDF

Prevention of tubulin/aldose reductase association delays the development of pathological complications in diabetic rats.

J Physiol Biochem 2021 Jun 7. Epub 2021 Jun 7.

Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, 5800, Córdoba, CP, Argentina.

In recent studies, we found that compounds derived from phenolic acids (CAFs) prevent the formation of the tubulin/aldose reductase complex and, consequently, may decrease the occurrence or delay the development of secondary pathologies associated with aldose reductase activation in diabetes mellitus. To verify this hypothesis, we determined the effect of CAFs on Na,K-ATPase tubulin-dependent activity in COS cells, ex vivo cataract formation in rat lenses and finally, to evaluate the antidiabetic effect of CAFs, diabetes mellitus was induced in Wistar rats, they were treated with different CAFs and four parameters were determinates: cataract formation, erythrocyte deformability, nephropathy and blood pressure. After confirming that CAFs are able to prevent the association between aldose reductase and tubulin, we found that treatment of diabetic rats with these compounds decreased membrane-associated acetylated tubulin, increased NKA activity, and thus reversed the development of four AR-activated complications of diabetes mellitus determined in this work. Read More

View Article and Full-Text PDF

Increased Cholesteryl Ester Transfer Protein and Lipoprotein-Associated Phospholipase A2 Activities in Children and Adolescents Presenting High Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio.

Indian J Pediatr 2021 Jun 7. Epub 2021 Jun 7.

Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Av. Córdoba 2351, C1120, Buenos Aires, Argentina.

Objective: To explore the association between Triglyceride/High-density lipoprotein cholesterol (TG/HDL-C) index and these enzymes and proteins in a pediatric population.

Methods: Children and adolescents (7-14 y old) were recruited (n = 150) and anthropometric data were registered. Glucose, TG, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), HDL-C plus cholesteryl ester transfer protein (CETP), lipoprotein-associated phospholipase A (Lp-PLA) and paraoxonase 1 (PON1) activities were determined. Read More

View Article and Full-Text PDF

Implementation of an experiential learning strategy to reduce the risk of ventilator-associated pneumonia in critically ill adult patients.

J Intensive Care Soc 2020 Nov 13;21(4):320-326. Epub 2019 Nov 13.

Medical School, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina.

Objective: We evaluated the impact of an experiential learning strategy on both the adherence to the use of bundles and the incidence of ventilator-associated pneumonia in critically ill adult patients.

Methods: Longitudinal, quasi-experimental interrupted time-series study in a tertiary teaching hospital in Buenos Aires, Argentina. Successive measurements were made before and after the intervention was implemented between January 2016 and December 2018. Read More

View Article and Full-Text PDF
November 2020

Epigenetic Changes Associated With Exposure to Glyphosate-Based Herbicides in Mammals.

Front Endocrinol (Lausanne) 2021 21;12:671991. Epub 2021 May 21.

Instituto de Salud y Ambiente del Litoral (ISAL), Universidad Nacional del Litoral (UNL)- Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.

Glyphosate is a phosphonomethyl amino acid derivative present in a number of non-selective and systemic herbicides. During the last years the use of glyphosate-based herbicide (GBH) has been increasing exponentially around the world, including Argentina. This fact added to the detection of glyphosate, and its main metabolite, amino methylphosphonic acid (AMPA), in environmental matrices such as soil, sediments, and food, has generated great concern about its risks for humans, animals, and environment. Read More

View Article and Full-Text PDF

Quantitative analysis of KLF4 and SOX2 expression in oral carcinomas reveals independent association with oral tongue subsite location and histological grade.

Cancer Biomark 2021 May 28. Epub 2021 May 28.

Surgical Pathology Laboratory, Oral Pathology Department, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.

Background: Stemness factors associated with tumorigenesis in different types of cancers have not been specifically studied in oral tongue SCC (OTSSC). Here, we aimed to quantify expression levels and distribution of KLF4 and SOX2, two relevant stemness factors, in oral SCC including OTSCC samples from different subsites.

Methods And Results: We determined KLF4 and SOX2 expression levels by immunostaining 35 biopsies of OSCC. Read More

View Article and Full-Text PDF

Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution.

Aging Cell 2021 Jun 6:e13383. Epub 2021 Jun 6.

Biomedical Signal Interpretation and Computational Simulation group (BSICoS), Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza, Spain.

Aging is the main risk factor for cardiovascular diseases. In humans, cardiac aging remains poorly characterized. Most studies are based on chronological age (CA) and disregard biological age (BA), the actual physiological age (result of the aging rate on the organ structure and function), thus yielding potentially imperfect outcomes. Read More

View Article and Full-Text PDF

Discriminating the biophysical signal from human-induced effects on long-term primary production dynamics. The case of Patagonia.

Glob Chang Biol 2021 Jun 5. Epub 2021 Jun 5.

Departamento de Métodos Cuantitativos y Sistemas de Información, LART IFEVA, Universidad, de Buenos Aires, CONICET, Facultad de Agronomía, Buenos Aires, Argentina.

The temporal trend of aboveground net primary production (ANPP) is frequently used to estimate the human effect on ecosystems. In water-limited ecosystems, like most grazing areas in the world, human effects act upon ANPP in combination with environmental variations. Our main objective was to quantify long-term (1981-2012) changes of ANPP and discriminate the causes of these changes between environmental and human at a subcontinental scale, across vast areas of Patagonia. Read More

View Article and Full-Text PDF

The relationship between 25(OH) vitamin D levels and COVID-19 onset and disease course in Spanish patients.

J Steroid Biochem Mol Biol 2021 Jun 3:105928. Epub 2021 Jun 3.

Department of Internal Medicine, Metabolic Bone Diseases, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD, UAM), Spain.

Objective: Currently, there are no definitive data on the relationship between low levels of vitamin D in the blood and a more severe disease course, in terms of the need for hospital admission, intensive care unit (ICU) stay, and mortality, in patients with coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to study the association between levels of circulating 25-hydroxyvitamin D (25(OH)D) and adverse clinical outcomes linked to SARS-CoV-2 infection. We further aimed to observe the incidence of low, below-average, and normal levels of 25(OH)D in patients hospitalized for COVID-19 between March 12, 2020, and May 20, 2020, and assess whether these values differed between these patients and a normal population. Read More

View Article and Full-Text PDF