25,631 results match your criteria area ulceration

Comparative analysis of effects of various toilet seat cushions on buttock pressure during toileting in persons with spinal cord injury.

J Spinal Cord Med 2021 Jul 22:1-6. Epub 2021 Jul 22.

Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, Japan.

Objectives: To measure buttock pressure during toilet seating in persons with spinal cord injury (SCI).

Design: A case series study.

Setting: Kibikogen Rehabilitation Center for Employment Injuries. Read More

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A radiation ulcer that required partial lung resection and recurred in a small residual area of ectopic calcification.

Int J Surg Case Rep 2021 Jul 17;85:106201. Epub 2021 Jul 17.

Division of Plastic Surgery, Nara Medical University Hospital, 840 Shijocho, Kashihara, Nara 634-8522, Japan.

Introduction And Importance: Surgery for chest radiation ulcers must involve appropriate wide margins, but it is not usually possible to remove all radiation-damaged tissue. Therefore, it is difficult to determine how extensive such surgery should be. There have not been any reports about the recurrence of such ulcers years after surgery. Read More

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Prevalence of lower limb venous disease in surgeons: a case study and results of a survey by the BAOMS Reconstruction Surgical Subspecialty Interest Group.

Br J Oral Maxillofac Surg 2021 Jan 8. Epub 2021 Jan 8.

Leeds Teaching Hospitals, United Kingdom. Electronic address:

We report a case of venous leg ulceration in a reconstructive oral and maxillofacial surgeon. An online survey was created by the British Association of Oral and Maxillofacial Surgeons (BAOMS) Reconstruction Surgical Subspecialty Interest Group (SSIG), primarily to target head and neck surgeons, to investigate the perceived risk and occurrence of venous leg disease. Two respondents had received treatment for lower limb venous disease thus compromising their ability to work, while 13 had symptoms of early venous disease. Read More

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January 2021

Successful combined therapy with Glucantime™ and pentoxifylline for the nasal mucosal lesion recently developed in a leishmaniasis patient having untreated cutaneous lesion for seven decades.

Parasitol Int 2021 Jul 16:102422. Epub 2021 Jul 16.

Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. Electronic address:

Leishmaniasis is a worldwide problem and has been neglected in a wide range of fields, from diagnosis to treatment. This report describes a case of mucosal leishmaniasis, which may developped after seven decades of an inadequately treated cutaneous lesion. A female patient, 79 years old, from the non-endemic area for leishmaniasis in northern Paraná, presenting mucosal lesion in the nose and throat, reported an "angry ulcer" treated inappropriately as a child when she lived in an endemic region of the state of São Paulo. Read More

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Early and Intensive Glycemic Control for Diabetic Foot Ulcer Healing: A Prospective Observational Nested Cohort Study.

Int J Low Extrem Wounds 2021 Jul 19:15347346211033458. Epub 2021 Jul 19.

29751Post Graduate Institute of Medical Education and Research, Chandigarh, India.

We aimed to assess the effect of glycemic control on diabetic foot ulcer (DFU) healing. A prospective nested cohort study was employed of individuals with poorly controlled diabetes (glycated hemoglobin [HbA] >9%) and neuropathic DFU of >2-week duration. All individuals received standard diabetes and ulcer interventions for 12 weeks. Read More

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Management of diabetes-related foot disease in the outpatient setting during the COVID-19 pandemic.

Intern Med J 2021 Jul;51(7):1146-1150

Multidisciplinary Diabetes Foot Unit, Fiona Stanley Hospital, Perth, Western Australia, Australia.

The use of telephone and/or video consultation in routine management of acute diabetes-related foot disease (DFD) before the coronavirus disease 2019 (COVID-19) pandemic at a tertiary hospital is unprecedented. In March 2020, the Diabetes Feet Australia (DFA) released a national guideline to inform DFD management during the COVID-19 pandemic. The present study aimed to describe the adherence to the DFA guideline of managing acute DFD using telephone and/or video consultation at a Western Australian tertiary hospital during this period. Read More

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Oral mucosal lesions and oral symptoms of the SARS-CoV-2 infection.

Minerva Dent Oral Sci 2021 Aug;70(4):161-168

Research Center, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia.

Introduction: SARS-CoV-2 develops well in the oral mucosa because, it is the first contact area with the virus. The oral mucosa is highly expressed with angiotensin-converting enzyme 2 (ACE2) and makes the virus replicated in the epithelial cells and produce both oral lesions and oral symptoms. This review aimed to describe the oral mucosal symptoms and lesions related to SARS-CoV-2-infected patients that have been reported around the world. Read More

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Impact of multiple lymphatic basin drainage in truncal melanoma patients.

J Plast Reconstr Aesthet Surg 2021 Jun 18. Epub 2021 Jun 18.

Internal Medicine Clinic, University Clinical Centre of the Republic of Srpska, 12 Beba bb Street, Banja Luka, Republic of Srpska 78 000, Bosnia and Herzegovina.

Introduction: In many patients with cutaneous melanoma that affects the trunk area, there is lymphatic drainage to multiple basins (MLBD). This study aimed to examine whether MLBD is associated with disease outcomes.

Methods: Lymphatic mapping and sentinel lymph node (SLN) biopsy were performed in 161 patients with truncal melanoma. Read More

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An individual randomised efficacy trial of autologous blood products, leukocyte and platelet-rich fibrin (L-PRF), to promote ulcer healing in leprosy in Nepal: the TABLE trial protocol.

Trials 2021 Jul 15;22(1):453. Epub 2021 Jul 15.

Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Background: Leprosy is curable with multidrug therapy and treatment in the early stages can prevent disability. However, local nerve damage can lead to injury and consequently recurring and disfiguring ulcers. The aim of this study is to evaluate the treatment of leprosy ulcers using an autologous blood product; leukocyte and platelet-rich fibrin (L-PRF) to promote healing. Read More

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Case Report: Systemic Sclerosis After Covid-19 Infection.

Serena Fineschi

Front Immunol 2021;12:686699. Epub 2021 Jun 28.

Department of Public Health and Caring Sciences, Unit of General Practice, Uppsala University, Uppsala, Sweden.

The coronavirus disease (COVID-19) is a respiratory tract infection caused by the new virus SARS-CoV-2. The acute phase of the infection may in certain individuals be followed by another longer phase of disease (long COVID) of unknown etiology probably associated in certain cases with autoimmune activation. It has been shown that COVID-19 can trigger autoantibody production and in genetically predisposed patients may cause the onset or exacerbation of autoimmune diseases. Read More

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Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway.

Stem Cell Res Ther 2021 Jul 13;12(1):392. Epub 2021 Jul 13.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Benha University, Benha, Egypt.

Background: Diabetic foot ulceration is a serious chronic complication of diabetes mellitus characterized by high disability, mortality, and morbidity. Platelet-rich plasma (PRP) has been widely used for diabetic wound healing due to its high content of growth factors. However, its application is limited due to the rapid degradation of growth factors. Read More

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Outcomes of periarterial sympathectomy in patients with digital ischemia.

Vascular 2021 Jul 14:17085381211032854. Epub 2021 Jul 14.

Department of Vascular and Endovascular Surgery, Faculty of Medicine, 68780Mansoura University, Mansoura, Egypt.

Introduction: Digital ischemia with subsequent severe pain and tissue loss is often difficult to treat, with no obvious guidelines or strong evidence in the literature to support a specific treatment modality. Patients who fail medical treatment remain with very limited surgical options due to the difficulty of any intervention in this "no man's land" area of the hand, as described since 1918. Extended distal periarterial sympathectomy is reported as an effective treatment option since the eighties of last century. Read More

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Healing hard-to-heal diabetic foot ulcers: the role of dehydrated amniotic allograft with cross-linked bovine-tendon collagen and glycosaminoglycan matrix.

J Wound Care 2021 Jul;30(Sup7):S47-S53

Department of Podiatry, Mount Sinai, South Nassau, US.

The treatment of diabetic foot ulcers is complex and costly with an increased risk for infection, which may even lead to amputation. This prospective case series aims to assess the effectiveness of a dehydrated amniotic membrane allograft combined with a bilayer dermal matrix for healing complicated foot ulcers in patients with comorbidities. A total of six patients with complicated full-thickness ulcers and comorbidities, such as diabetes and peripheral vascular disease were treated with this technique. Read More

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Punch Grafting for the Management of Hard-to-Heal Diabetic Foot Ulcers: A Prospective Case Series.

Int J Low Extrem Wounds 2021 Jul 13:15347346211031085. Epub 2021 Jul 13.

Diabetic Foot Unit, Clínica Universitaria de Podología, Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.

Punch grafting is an alternative treatment to enhance wound healing which has been associated with promising clinical outcomes in various leg and foot wound types. We aimed to evaluate the clinical outcomes of punch grafting as a treatment for hard-to-heal diabetic foot ulcers (DFUs). Six patients with chronic neuropathic or neuroischemic DFUs with more than 6 months of evolution not responding to conventional treatment were included in a prospective case series between May 2017 and December 2020. Read More

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Cavitary Pneumonia Due to Methicillin-Resistant Staphylococcus aureus in a Non-Immunocompromised Patient After an Endoscopy: A Case Report.

Am J Case Rep 2021 Jul 13;22:e930136. Epub 2021 Jul 13.

School of Medicine, Universidad San Francisco de Quito, Quito, Ecuador.

BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) pneumonia has well-defined characteristics. We present a case of cavitary pneumonia due to MRSA in a patient who had undergone a recent outpatient gastroscopic procedure. CASE REPORT A 32-year-old man presented at the Emergency Department with tonic-clonic seizures of 2 min durations. Read More

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Impact of repeated remote ischemic conditioning on diabetic foot ulcers: A proof-of-concept study.

Wound Repair Regen 2021 Jul 8. Epub 2021 Jul 8.

LifeCuff Technologies, Inc., Philadelphia, Pennsylvania, USA.

Patients with a diabetic foot ulcer (DFU) suffer disabilities and are at increased risk for lower extremity amputation. Current standard of care includes debridement, topical antibiotics, and weight off-loading-still resulting in low rates of healing. Previous small-scale research has indicated that repeated remote ischemic conditioning (rRIC) is a novel modality that delivers significantly higher DFU healing rates. Read More

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Glycopeptides from ameliorate ethanol-induced gastric ulcers anti-inflammation and the miR-9-5p-MEK/ERK signaling pathway.

Food Funct 2021 Jul 8. Epub 2021 Jul 8.

Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin 300457, People's Republic of China.

The aim of this study was to investigate the immunomodulatory effect and mechanism of the glycopeptides from Paecilomyces sinensis (CPS-II) on ethanol induced ulcers in mice. In this study, histopathological evaluation (H&E staining) and the gastric ulcer score, ulcer index, total acid secretion and gastric pH value were used to determine the anti-ulcer activity. The expression levels of interleukin (IL)-6, interleukin (IL)-10 and tumor necrosis factor-α (TNF-α) were detected by ELISA. Read More

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The role of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers: a systematic review with meta-analysis of randomized controlled trials on limb amputation and ulcer healing.

Int Angiol 2021 Jul 8. Epub 2021 Jul 8.

Faculty of Medicine of Porto, Porto, Portugal.

Introduction: Hyperbaric Oxygen Therapy (HBOT) is increasingly being used in the treatment of as diabetic foot ulcers (DFU). However, definitive evidence regarding its beneficial effects is still scarce. The present systematic review aims to analyse the role of HBOT in the prevention of limb amputation along with improvement of ulcer healing in patients with lower limbs DFU. Read More

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Wound Management of Multi-Site Pressure Ulcer at Different Stages in Elderly Patients.

Clin Cosmet Investig Dermatol 2021 29;14:747-751. Epub 2021 Jun 29.

Department of Wound Repair, Hongmei Hospital of Dongguan, Dongguang, Guangdong, 523160, People's Republic of China.

Objective: The present study aims to explore the individualized treatment options for multisite pressure ulcer (PU) at various stages in elderly patients with multiple medical conditions.

Methods: Stages 1 and 2 PU at 146 sites were treated with closed negative pressure suction combined with continuous micro-oxygen perfusion and the local application of foam dressings, silver ion dressings, and moist burn cream. Stages 3 and 4 PU in the sacrococcygeal region were treated with skin or myocutaneous flap transplantation. Read More

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Endoscopic Prediction of Crohn's Disease Postoperative Recurrence.

Inflamm Bowel Dis 2021 Jul 7. Epub 2021 Jul 7.

Department of Gastroenterology, St. Vincent's Hospital and Department of Medicine, The University of Melbourne, Melbourne, Australia.

Background: The presence and severity of endoscopic recurrence after Crohn's disease intestinal resection predicts subsequent disease course. The Rutgeerts postoperative endoscopic recurrence score is unvalidated but has proven prognostically useful in many clinical studies. This study aimed to investigate the association between specific early endoscopic findings and subsequent disease course. Read More

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Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial.

Wound Repair Regen 2021 Jul 7. Epub 2021 Jul 7.

Plastic and Reconstructive Surgery Department, Meir Medical Center, Kfar Saba, Israel.

Chronic wounds are estimated to affect over 6 million people annually in the United States with an estimated annual cost of $25 billion. Debridement represents a key step in their management and is considered a basic necessity to induce the functional process of tissue repair. However, there is an unmet need for an efficient rapid acting non-surgical debridement agent. Read More

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Multidisciplinary Team Effort Results in Better Outcomes in Critically Ill Obstetric Patients Admitted in ICU.

Mymensingh Med J 2021 Jul;30(3):855-859

Dr Mohammad Ashrafuzzaman, Resident Phase B, Critical Care Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh; E-mail:

Management of critically ill obstetric patients is a great challenge for the ICU team. The safety of both mother and fetus are of real concerns. Teamwork is essential for better outcome in obstetric patients in the ICU. Read More

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Stratification of Microvascular Disease Severity in the Foot Using Spatial Frequency Domain Imaging.

J Diabetes Sci Technol 2021 Jul 5:19322968211024666. Epub 2021 Jul 5.

The Division of Vascular Surgery, University of Arizona, Tucson, AZ, USA.

Background: Microvascular disease (MVD) describes systemic changes in the small vessels (~100 um diameter) that impair tissue oxygenation and perfusion. MVD is a common but poorly monitored complication of diabetes. Recent studies have demonstrated that MVD: (i) is an independent risk factor for ulceration and amputation and (ii) increases risk of adverse limb outcomes synergistically with PAD. Read More

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Clinicodemographic pattern and treatment outcome of Behcet's disease cases presenting in a tertiary eye center of Nepal.

Int Ophthalmol 2021 Aug 4;41(8):2861-2868. Epub 2021 Jul 4.

Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal.

Purpose: To know the clinical and demographic pattern, and the outcome of treatment of Behcet's disease (BD) cases in Nepal METHODS: Retrospective series of all the cases of BD who had come over the period of 12 years (Jan 2007-Dec 2015) Tilganga Institute of Ophthalmology.

Result: Twenty-one cases were included, 17 (81%) male and four (19%) female. Mean age was 28. Read More

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Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at RISK (PARISK) study.

Atherosclerosis 2021 Jul 11;329:22-29. Epub 2021 Jun 11.

Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Background And Aims: Lipoprotein(a) is an independent risk factor for cardiovascular disease and recurrent ischemic stroke. Lipoprotein(a) levels are known to be associated with carotid artery stenosis, but the relation of lipoprotein(a) levels to carotid atherosclerotic plaque composition and morphology is less known. We hypothesize that higher lipoprotein(a) levels and lipoprotein(a)-related SNPs are associated with a more vulnerable carotid plaque and that this effect is sex-specific. Read More

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Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial.

Int J Low Extrem Wounds 2021 Jul 2:15347346211020268. Epub 2021 Jul 2.

524788Zealand University Hospital, Køge, Sjælland, Denmark.

. Chronic foot ulcers are a major cause of morbidity in people with diabetes with a lifetime risk of 25%. Treatment is challenging and the recurrence rates of foot ulcers are >50% after 3 years. Read More

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Bilateral foam polidocanol sclerotherapy of great saphenous veins and their tributaries in synchronous procedure.

J Vasc Bras 2021 Jun 16;20:e20200178. Epub 2021 Jun 16.

Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, MG, Brasil.

Background: Chronic venous insufficiency is a highly prevalent disease. Advanced cases have high morbidity.

Objectives: To evaluate the risks and benefits of foam sclerotherapy in patients who underwent bilateral treatment of the great saphenous veins in a single procedure, in selected cases of advanced venous insufficiency. Read More

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Cutaneous Leishmaniasis in Pakistan: a neglected disease needing one health strategy.

BMC Infect Dis 2021 Jun 30;21(1):622. Epub 2021 Jun 30.

Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Background: Cutaneous Leishmaniasis (CL) is a neglected tropical disease, which mainly affects poor communities. It is one of the major vector-borne disease and endemic in Pakistan.

Methods: A case-control study to evaluate potential risk factors of human-CL was conducted in Khewra region, District Jhelum, Pakistan from January-April 2014. Read More

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[Application strategy and clinical effects of paraumbilical perforator flap carrying inferior epigastric vessels for repairing destructive wounds].

Zhonghua Shao Shang Za Zhi 2021 Jun 25;37:1-8. Epub 2021 Jun 25.

Department of Burns, Beijing Jishuitan Hospital, Beijing 100035, China.

To explore the application strategy and clinical effects of paraumbilical perforator flap carrying inferior epigastric vessels for repairing various destructive wounds. The retrospective cohort study method was applied. From January 2015 to December 2020, 28 patients (21 males and 8 females, aged 25 to 66 years) with destructive wounds were admitted to the Beijing Jishuitan Hospital. Read More

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Bacterial cellulose an effective material in the treatment of chronic venous ulcers of the lower limbs.

J Mater Sci Mater Med 2021 Jun 30;32(7):79. Epub 2021 Jun 30.

Department of Angiology and Vascular Surgery, Clinics Hospital, Federal University of Pernambuco, Recife, Pernambuco, Brazil.

Chronic venous ulcers (CVU) of the lower limbs (LL) are common and cause psychological changes and significant social impact, as they make the patient susceptible to pain, absence from work and social bonds. Some materials are suggested as dressings for the treatment of CVU, but they are expensive and are generally not available for use in public health services. To evaluate the efficacy of the treatment for lower limbs (LL) chronic venous ulcer (CVU) using bacterial cellulose (BC), gel and multi-perforated film associated. Read More

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