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Normalization of Peri-Arteriovenous Malformation Hemodynamics Prior to Direct Microsurgery: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurological Surgery, Mayo Clinic, Phoenix, Arizona, USA.

Arteriovenous malformations (AVMs) are highly complex vascular lesions characterized by abnormal connections between arteries and an intervening nidus. Definitive and safe treatment of AVMs may require the combination of multiple treatment modalities to address the various complex features of the AVM.1 Endovascular embolization can be used as an adjuvant to surgery in order to control deep feeders, reduce flow, and address high-risk features such as aneurysms. Read More

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September 2021

Systemic Immune-Inflammation Index Predicts Delayed Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage.

Neurosurgery 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago, Illinois, USA.

Background: Delayed cerebral vasospasm is a feared complication of aneurysmal subarachnoid hemorrhage (SAH).

Objective: To investigate the relationship of systemic inflammation, measured using the systemic immune-inflammation (SII) index, with delayed angiographic or sonographic vasospasm. We hypothesize that early elevations in SII index serve as an independent predictor of vasospasm. Read More

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September 2021

Pulmonary valve reconstruction by allograft replacement of underdeveloped anterior leaflet in case of late combined pulmonary restenosis after early primary repair.

Int J Surg Case Rep 2021 Sep 15;87:106410. Epub 2021 Sep 15.

Center of Cardiac Surgery (OOO), Chelyabinsk, Russian Federation.

Introduction: The native pulmonary valve (PV) reconstruction is an attractive alternative to a replacement but is challenging due to the systematic underdevelopment of the valve structures in congenital heart diseases. The partial replacement of underdeveloped parts of the valve and saving of well-developed may have advantages versus replacing the whole valve in terms of durability and patient outgrowth of the prosthesis.

Case Presentation: This report describes a case of the PV reconstruction by allograft replacement of an underdeveloped anterior leaflet in an adolescent patient who previously corrected pulmonary stenosis during the first year of her life. Read More

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September 2021

Poplar tree (Populus balsamifera L.) as indicator of mercury emission from a point source.

Chemosphere 2021 Sep 11;287(Pt 3):132157. Epub 2021 Sep 11.

National Research Tomsk Polytechnic University, Lenin Ave., 30, Tomsk, 634050, Russia.

The article provides original data on the ecological and geochemical characteristics of the distribution of Hg in the leaves and annual rings of balsam poplar (P. balsamifera L.) in the zone of influence of lithium production (Novosibirsk). Read More

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September 2021

Chemical and biological tracking in decentralized sanitation systems: The case of artificial constructed wetlands.

J Environ Manage 2021 Sep 21;300:113799. Epub 2021 Sep 21.

Institute of Chemical Engineering Sciences, Foundation of Research & Technology Hellas (ICEHT/FORTH), 10 Stadiou St., Platani, 26504, Patras, Greece.

Given that the social and economic sustainability of rural areas is highly based on the protection of natural resources, biodiversity and human health, simple-operated and cost-effective wastewater treatment systems, like artificial constructed wetlands (CWs), are widely proposed for minimizing the environmental and human impact of both water and soil pollution. Considering that the optimization of wastewater treatment processes is vital for the reduction of effluents toxic potential, there is imperative need to establish appropriate management strategies for ensuring CW performance and operational efficiency. To this end, the present study aimed to assess the operational efficiency of a horizontal free water surface CW (HFWS-CW) located in a world heritage area of Western Greece, via a twelve-month duration Toxicity Identification Evaluation (TIE)-like approach, including both chemical and biological tracking tools. Read More

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September 2021

Hazard identification and risk assessment of the organic, inorganic and microbial contaminants in the surface water after the high magnitude of flood event.

Environ Int 2021 Sep 21;157:106851. Epub 2021 Sep 21.

River Engineering and Urban Drainage Research Centre (REDAC), Universiti Sains Malaysia (USM), Engineering Campus, Seri Ampangan, 14300 Nibong Tebal, Penang, Malaysia. Electronic address:

The present work has been oriented to the qualitative and quantitative assessments of the aftermath effects of 2014 flood tragedy on the organic, inorganic and microbial contaminants in the floodwater, with a particular emphasis on their relative health risks and microbial infectious hazards to the flood-affected population, using average daily dose, hazard quotient, hazard index (HI), cancer risk (CR) and quantitative microbial risk assessment. Statistical comparison of the organic and inorganic contents was performed using the paired t-tests, while the predominant socio-demographic profiles and health attributes of the respondents to flood-induced health risks (HI) were verified by the chi-square test and binary logistic regression analysis. Among all, Fe, Cu, Pb, Ni, Zn, Cr, Cd, chlorpyrifos, diazinon, polycyclic aromatic hydrocarbons, estriol, 17α-ethinylestradiol, estrone, β-estradiol and bisphenol A were detected at the study area after flooding. Read More

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September 2021

Predictive value of intraoperative neuromonitoring in brainstem cavernous malformation surgery.

World Neurosurg 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany.

Objective: To evaluate the predictive value of intraoperative neuromonitoring (IONM) in brainstem cavernous malformation (BSCM) surgery.

Methods: Surgically treated BSCM patients were included. All patients received IONM consisting of motor- and somatosensory-evoked potentials (MEP, SSEP). Read More

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September 2021

Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.

Bioorg Med Chem Lett 2021 Sep 21:128376. Epub 2021 Sep 21.

Bristol Myers Squibb Research and Development, 100 Binney St, Cambridge, MA 02142-1096, USA.

We describe our efforts to introduce structural diversity to a previously described triazole-containing N1-carboline series of bromodomain and extra-terminal (BET) inhibitors. N9 carbolines were designed to retain favorable binding interactions that the N1-carbolines possess. A convergent synthetic route enabled modifications to reduce clearance, enhance physicochemical properties, and improve the overall in vitro profile. Read More

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September 2021

Orthogonal Characterization and Pharmacokinetic Studies of Polylactide-Polyethyleneglycol Polymeric Nanoparticles with Different Physicochemical Properties.

Int J Pharm 2021 Sep 21:121120. Epub 2021 Sep 21.

Department of Biopharmaceutics, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan.

To optimize prolonged and sustained delivery of polylactide-block-polyethyleneglycol polymeric nanoparticles (PLA-PEG NPs), in terms of the PLA isomer and molecular weight, we performed orthogonal physicochemical characterization and evaluated the pharmacokinetics of tamoxifen (TAM)-loaded PLA-PEG NPs. DL-lactide- (DL-PEG NP), L-lactide- (L-PEG NPs), and stereocomplex-based (SC-PEG NPs) PLA-PEGs, with two different PLA to PEG ratios (12k-5k and 5k-5k Da) were synthesized, and NPs were prepared by anti-solvent precipitation. Size exclusion chromatography, multi-angle light scattering, dynamic light scattering, and H nuclear magnetic resonance studies revealed that SC-PEG NPs (12k-5k) had a compact structure and the highest PEG density, followed by L-PEG NPs (12k-5k), DL-PEG NPs (12k-5k), and all PLA-PEG NPs (5k-5k). Read More

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September 2021

Inhibition of Piezo1/Ca/calpain Signaling in the Rat Basal Forebrain Reverses Sleep Deprivation-induced Fear Memory Impairments.

Behav Brain Res 2021 Sep 21:113594. Epub 2021 Sep 21.

Department of Anesthesiology, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China. Electronic address:

In this study, we tested the hypothesis that the Piezo1/Ca/calpain pathway of the basal forebrain (BF) modulates impaired fear conditioning caused by sleep deprivation. Adult male Wistar rats were subjected to 6h of total sleep deprivation using the gentle handling protocol. Step-down inhibitory avoidance tests revealed that sleep deprivation induced substantial short- and long-term fear memory impairment in rats, which was accompanied by increased Piezo1 protein expression (P<0. Read More

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September 2021

The impact of daytime napping on athletic performance - a narrative review.

Scand J Med Sci Sports 2021 Sep 24. Epub 2021 Sep 24.

School of Physical Education and Sports Science, National and Kapodistrian University of Athens, Athens, Greece.

Mid-day napping has been recommended as a countermeasure against sleep debt and an effective method for recovery, regardless of nocturnal sleep duration. Herein, we summarize the available evidence regarding the influence of napping on exercise and cognitive performance as well as the effects of napping on athletes' perceptual responses prior to or during exercise. The existing studies investigating the influence of napping on athletic performance have revealed equivocal results. Read More

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September 2021

Noncontrast Cardiac Magnetic Resonance Imaging Predictors of Heart Failure Hospitalization in Heart Failure With Preserved Ejection Fraction.

J Magn Reson Imaging 2021 Sep 24. Epub 2021 Sep 24.

Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

Background: Heart failure patients with preserved ejection fraction (HFpEF) are at increased risk of future hospitalization. Contrast agents are often contra-indicated in HFpEF patients due to the high prevalence of concomitant kidney disease. Therefore, the prognostic value of a noncontrast cardiac magnetic resonance imaging (MRI) for HF-hospitalization is important. Read More

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September 2021

BASDAI cut-off values corresponding to ASDAS cut-off values.

Rheumatology (Oxford) 2021 Sep 24. Epub 2021 Sep 24.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Objective: To determine cut-off values of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) that can discriminate the four disease activity states (inactive disease, moderate disease activity, high disease activity, and very high disease activity), separated by the validated Ankylosing Spondylitis Disease Activity Score (ASDAS) cut-off values (1.3, 2.1, and 3. Read More

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September 2021

Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson's disease patients with dysphagia after repetitive transcranial magnetic stimulation: a case-control study.

Neural Regen Res 2022 May;17(5):1051-1058

Department of Neurological Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China.

Repetitive transcranial magnetic stimulation (rTMS) has been shown to effectively improve impaired swallowing in Parkinson's disease (PD) patients with dysphagia. However, little is known about how rTMS affects the corresponding brain regions in this patient group. In this case-control study, we examined data from 38 PD patients with dysphagia who received treatment at Beijing Rehabilitation Medicine Academy, Capital Medical University. Read More

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Tumor stiffness measured by Shear-wave elastography: association with disease-free survival in women with Early-stage breast cancer.

Br J Radiol 2021 Sep 24:20210584. Epub 2021 Sep 24.

Department of Radiology, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea.

Objective: To determine whether shear-wave elastography (SWE)-measured tumor stiffness is associated with disease-free survival in females with early-stage invasive breast cancer.

Methods: This retrospective study included 202 consecutive females (mean age, 52.9 years; range, 25-84 years) with newly diagnosed T1-two breast cancer who underwent preoperative SWE between April 2015 and January 2016. Read More

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September 2021

miR133b Microinjection during Early Development Targets Transcripts of Cardiomyocyte Ion Channels and Induces Oil-like Cardiotoxicity in Zebrafish () Embryos.

Chem Res Toxicol 2021 Sep 24. Epub 2021 Sep 24.

Department of Environmental Sciences, University of California, Riverside, California 92521, United States.

Previous studies have shown that altered expression of a family of small noncoding RNAs (microRNAs, or miRs) regulates the expression of downstream mRNAs and is associated with diseases and developmental disorders. miR133b is highly expressed in mammalian cardiac and skeletal muscle, and aberrant expression is associated with cardiac disorders and electrophysiological changes in cardiomyocytes. Similarly, cardiac dysfunction has been observed in early life-stage mahi-mahi () exposed to crude oil, a phenotype that has been associated with an upregulation of miR133b as well as subsequent downregulation of a delayed rectifier potassium channel (I) and calcium signaling genes that are important for proper heart development during embryogenesis. Read More

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September 2021

Genomic Analyses Revealed the Genetic Difference and Potential Selection Genes of Growth Traits in Two Duroc Lines.

Front Vet Sci 2021 7;8:725367. Epub 2021 Sep 7.

College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.

Duroc pigs are famous for their high growth rate, feed conversion efficiency, and lean meat percentage. Given that they have been subjected to artificial selection and breeding in multiple countries, various lines with obvious differences in production performance have formed. In this study, we genotyped 3,770 American Duroc (AD) pigs and 2,098 Canadian Duroc (CD) pigs using the GeneSeek Porcine SNP50 Beadchip to dissect the genetic differences and potential selection genes of growth traits in these two Duroc pig lines. Read More

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September 2021

Prevalence and Molecular Characterization of Infection in Feral Cats in Alexandria City, Northern Egypt.

Iran J Parasitol 2021 Apr-Jun;16(2):270-278

Department of Parasitology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

Background: This study was performed to determine the prevalence and to identify precisely spp., which infects feral cats in Alexandria, Egypt based on morphological and molecular approaches.

Methods: This cross-sectional study was carried out on 100 feral cats trapped from different areas of Alexandria during 2018. Read More

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Behavioral and Brain Structural Changes in Kindled Rats Induced by Coriaria Lactone/Pentylenetetrazol.

Front Behav Neurosci 2021 7;15:727872. Epub 2021 Sep 7.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Epilepsy is a common chronic neurological disease that is characterized by spontaneous seizures. It is commonly comorbid with behavioral and mood disorders. No studies have yet examined the behavioral or structural brain changes associated with coriaria lactone (CL)-induced and pentylenetetrazol (PTZ)-induced kindlings. Read More

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September 2021

Vaginal microbiome as a tool for prediction of chorioamnionitis in preterm labor: a pilot study.

Sci Rep 2021 Sep 23;11(1):18971. Epub 2021 Sep 23.

Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

Intra-amniotic infection (IAI) is a major cause of preterm birth with a poor perinatal prognosis. We aimed to determine whether analyzing vaginal microbiota can evaluate the risk of chorioamnionitis (CAM) in preterm labor cases. Vaginal discharge samples were collected from 83 pregnant women admitted for preterm labor. Read More

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September 2021

Novel composite materials of modified roasted date pits using ferrocyanides for the recovery of lithium ions from seawater reverse osmosis brine.

Sci Rep 2021 Sep 23;11(1):18896. Epub 2021 Sep 23.

Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, P.O. Box: 2713, Doha, State of Qatar, Qatar.

In this paper, novel composite materials from modified roasted date pits using ferrocyanides were developed and investigated for the recovery of lithium ions (Li) from seawater reverse osmosis (RO) brine. Two composite materials were prepared from roasted date pits (RDP) as supporting material, namely potassium copper hexacyanoferrate-date pits composite (RDP-FC-Cu), and potassium nickel hexacyanoferrate-date pits composite (RDP-FC-Ni). The physiochemical characterization of the RO brine revealed that it contained a variety of metals and salts such as strontium, zinc, lithium, and sodium chlorides. Read More

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September 2021

Hollow zeolitic imidazolate framework-7 coated stainless steel fiber for solid phase microextraction of volatile biomarkers in headspace gas of breast cancer cell lines.

Anal Chim Acta 2021 Oct 2;1181:338901. Epub 2021 Aug 2.

Key Laboratory of Analytical Science and Technology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, China. Electronic address:

In this work, we reported the preparation of the hollow zeolitic imidazolate framework-7 (ZIF-7) via etching ZIF-7 with tannic acid, and further fabricated the hollow ZIF-7 coated fiber for the solid phase microextraction (SPME) of the five volatile biomarkers (acetone, isopropanol, hexanal, hexanol and decanal) generated from breast cancer cell lines. The hollow structure not only endowed higher extraction performance for the SPME of analytes, but also improved the diffusion rate of the analytes inside the hollow ZIF-7. Under the optimal conditions, the hollow ZIF-7 coated fiber offered high extraction capacity (25-153 mg g) and enhancement factors (EFs, 2023-11250) for the five biomarkers, good linearity (R > 0. Read More

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October 2021

Caught in the middle: a thematic analysis of the experiences of Korean-Canadian caregiver-employees in the greater Toronto and Hamilton area.

BMC Public Health 2021 Sep 23;21(1):1728. Epub 2021 Sep 23.

School of Earth, Environment & Society, McMaster University, Hamilton, ON, Canada.

Background: The objective of this study was to investigate the experiences of caregiver-employees (CEs) from the Korean-Canadian community in the Greater Toronto and Hamilton Area.

Methods: Nine participants were recruited and invited to partake in data collection, which consisted of the completion of a sociodemographic questionnaire as well as a qualitative, semi-structured interview. The interview transcripts were thematically analyzed. Read More

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September 2021

Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children's Study (JECS).

BMC Pediatr 2021 Sep 23;21(1):419. Epub 2021 Sep 23.

Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama City, Toyama, 930-0194, Japan.

Background: The association between delivery mode and subsequent development of diseases is a growing area of research. Cesarean delivery affects the diversity of the microbiota in the infant gut, which may be associated with gastrointestinal disorders, including functional constipation, in infants. In this study, we investigated the association between delivery mode and prevalence of functional constipation in 3-year-old Japanese toddlers. Read More

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September 2021

Physiological and histopathological effects of electroporation pulse on stomach of rats.

BMC Gastroenterol 2021 Sep 23;21(1):351. Epub 2021 Sep 23.

National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Yanta District, Xi'an, 710061, China.

Background: Irreversible electroporation (IRE) is an emerging tissue ablation technique with widespread potential, especially for cancer treatment. Although the safety and efficacy of IRE for gastric tissue ablation have been demonstrated, there is a gap of knowledge regarding the effect of electroporation pulse (EP) on the physiology and histopathology of the stomach. This study applied EP to the stomach of healthy rats and investigated the digestive function, serum marker levels, and gastric tissue structure of EP-treated rats. Read More

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September 2021

A DNA barcode library for mangrove gastropods and crabs of Hong Kong and the Greater Bay Area reveals an unexpected faunal diversity associated with the intertidal forests of Southern China.

BMC Ecol Evol 2021 Sep 23;21(1):180. Epub 2021 Sep 23.

Department of Biology, University of Florence, 50019, Sesto Fiorentino, Italy.

Background: Mangroves are tropical and subtropical intertidal forests colonising sheltered coasts across the world. They host a unique faunal community, dominated by brachyuran crabs and gastropods. These invertebrates strongly contribute to the functionality of the entire forest. Read More

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September 2021

Development of food-origin biochars for the adsorption of selected volatile organic compounds (VOCs) for environmental matrices.

Bioresour Technol 2021 Sep 6;342:125881. Epub 2021 Sep 6.

Department of Chemistry, University of Cyprus, P.O.Box 20537, 1678 Nicosia, Cyprus. Electronic address:

Four novel fruit-derived biochars were developed: pomegranate peels (PB), prickly pear peels (PPB), carob (CB), and locust bean gum (LBGB). The feedstocks were pyrolyzed at 350 and 550 ℃ (under N), respectively, and characterized using Scanning Electron Microscopy (SEM), Elemental Analysis (EA), Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS), Brunauer-Emmett-Teller (B.E. Read More

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September 2021

Premature atrial stimulation accentuates conduction abnormalities in cardiac surgery patients that develop postoperative atrial fibrillation.

J Electrocardiol 2021 Sep 10;69:36-43. Epub 2021 Sep 10.

Nora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah - Health, Salt Lake City, UT 84112, USA; Division of Cardiovascular Medicine, Department of Internal Medicine, The University of Utah - Health, Salt Lake City, UT 84112, USA; Department of Bioengineering, The University of Utah - Health, Salt Lake City, UT 84112, USA; Division of Cardiothoracic Surgery, Department of Surgery, The University of Utah - Health, Salt Lake City, UT 84112, USA. Electronic address:

Background: postoperative atrial fibrillation (POAF) is a common cardiac surgery complication that is associated with increased complications and negative outcomes, but the association between presurgical atrial conduction abnormalities and POAF has not been investigated clinically during premature atrial S1S2 stimulation. This clinical study sought to examine whether intraoperative premature atrial stimulation reveals increased areas of slowed and/or blocked conduction in patients that develop POAF.

Methods: High-density intraoperative epicardial left atrial mapping was conducted in 20 cardiac surgery patients with no prior history of atrial fibrillation (AF). Read More

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September 2021

Evaluation of the hepatotoxicity of the novel GPR40 (FFAR1) agonist CPL207280 in the rat and monkey.

PLoS One 2021 23;16(9):e0257477. Epub 2021 Sep 23.

Gad Consulting Services, Raleigh, North Carolina Area, United States of America.

GPR40 (FFAR1) is a promising target for the managing type 2 diabetes (T2D). The most advanced GPR40 agonist TAK-875 exhibited satisfactory glucose-lowering effects in phase II and III studies. However, the phase III studies of TAK-875 revealed drug-induced liver injury (DILI). Read More

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September 2021

Membrane-binding mechanism of the EEA1 FYVE domain revealed by multi-scale molecular dynamics simulations.

PLoS Comput Biol 2021 Sep 23;17(9):e1008807. Epub 2021 Sep 23.

Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

Early Endosomal Antigen 1 (EEA1) is a key protein in endosomal trafficking and is implicated in both autoimmune and neurological diseases. The C-terminal FYVE domain of EEA1 binds endosomal membranes, which contain phosphatidylinositol-3-phosphate (PI(3)P). Although it is known that FYVE binds PI(3)P specifically, it has not previously been described of how FYVE attaches and binds to endosomal membranes. Read More

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September 2021