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Determination of the Rituximab Binding Site to the CD20 Epitope Using SPOT Synthesis and Surface Plasmon Resonance Analyses.

Anal Chem 2021 Apr 21. Epub 2021 Apr 21.

Université Grenoble-Alpes, CNRS, DCM UMR 5250, 570 rue de la chimie, CS 40700, 38058 Grenoble Cedex 9, France.

Antibodies not only play a major role in clinical diagnostics and biopharmaceutical analysis but also are a class of drugs that are regularly used to treat numerous diseases. The identification of antibody-epitope binding sites is then of great interest to many emerging medical and bioanalytical applications, particularly to design monoclonal antibodies (mAb) mimics taking advantage of amino acid residues involved in the binding. Among relevant antibodies, the monoclonal antibody rituximab has received significant attention as it is exploited to treat several cancers including non-Hodgkin's lymphoma and chronic lymphocytic leukemia, as well as some autoimmune disorders such as rheumatoid arthritis. Read More

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[Training and knowledge on basic life support by civil guards.]

Rev Esp Salud Publica 2021 Apr 21;95. Epub 2021 Apr 21.

Área de Medicina Preventiva y Salud Pública. Departamento de Medicina. Universidad de Oviedo / ISPA. Oviedo. España.

Objective: Civil Guards are deployed throughout Spain and susceptible to being the first responders in out-of-hospital cardiorespiratory arrest. However, their level of training to perform Basic Life Support (BLS) is unknown. The aim of this work was to evaluate the level of knowledge on BLS of Civil Guards, and to explore the association between periodicity of training and knowledge. Read More

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Effect of oil palm biomass cellulosic content on nanopore structure and adsorption capacity of biochar.

Bioresour Technol 2021 Mar 31;332:125070. Epub 2021 Mar 31.

Department of Biological Functions and Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka 808-0196, Japan.

The influence of biomass cellulosic content on biochar nanopore structure and adsorption capacity in aqueous phase was scarcely reported. Commercial cellulose (100% cellulose), oil palm frond (39.5% cellulose), and palm kernel shell (20. Read More

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Brain network mechanisms of visual shape completion.

Neuroimage 2021 Apr 17:118069. Epub 2021 Apr 17.

Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Ave, 07102, USA.

Visual shape completion recovers object shape, size, and number from spatially segregated edges. Despite being extensively investigated, the process's underlying brain regions, networks, and functional connections are still not well understood. To shed light on the topic, we scanned (fMRI) healthy adults during rest and during a task in which they discriminated pac-man configurations that formed or failed to form completed shapes (illusory and fragmented condition, respectively). Read More

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Characteristics and sources of atmospheric pollutants in typical inland cities in arid regions of central Asia: A case study of Urumqi city.

PLoS One 2021 20;16(4):e0249563. Epub 2021 Apr 20.

School of Environmental and Geographical Sciences, Shanghai Normal University, Shanghai, China.

The arid zone of central Asia secluded inland and has the typical features of the atmosphere. Human activities have had a significant impact on the air quality in this region. Urumqi is a key city in the core area of the Silk Road and an important economic center in Northwestern China. Read More

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Experimental investigations into the irregular synthesis of iron(iii) terephthalate metal-organic frameworks MOF-235 and MIL-101.

Dalton Trans 2021 Apr 26;50(14):4976-4985. Epub 2021 Mar 26.

Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.

MOF-235(Fe) and MIL-101(Fe) are two well-studied metal-organic frameworks (MOFs) with dissimilar crystal structures and topologies. Previously reported syntheses of the former show that it has greatly varying surface areas, indicating a lack of phase purity of the products, i.e. Read More

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Shortened tethering filaments stabilize presynaptic vesicles in support of elevated release probability during LTP in rat hippocampus.

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Department of Neuroscience, Center for Learning and Memory, Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712;

Long-term potentiation (LTP) is a cellular mechanism of learning and memory that results in a sustained increase in the probability of vesicular release of neurotransmitter. However, previous work in hippocampal area CA1 of the adult rat revealed that the total number of vesicles per synapse decreases following LTP, seemingly inconsistent with the elevated release probability. Here, electron-microscopic tomography (EMT) was used to assess whether changes in vesicle density or structure of vesicle tethering filaments at the active zone might explain the enhanced release probability following LTP. Read More

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International Consensus Document on Obstructive Sleep Apnea.

Arch Bronconeumol 2021 Mar 24. Epub 2021 Mar 24.

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, España; Unidad Funcional de Sueño, Hospital Universitario Araba, OSI Araba, Vitoria-Gasteiz, Álava, España.

The main aim of this international consensus document on obstructive sleep apnea is to provide guidelines based on a critical analysis of the latest literature to help health professionals make the best decisions in the care of adult patients with this disease. The expert working group was formed primarily of 17 scientific societies and 56 specialists from a wide geographical area (including the participation of 4 international societies), an expert in methodology, and a documentalist from the Iberoamerican Cochrane Center. The document consists of a main section containing the most significant innovations and a series of online manuscripts that report the systematic literature searches performed for each section of the international consensus document. Read More

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The influence of open-top chambers on the growth and development of field bean.

New Phytol 1991 Mar;117(3):439-447

Department of Physiology and Environmental Science, University of Nottingham School of Agriculture, Sutton Bonington, Loughborough, Leics, LE12 5RD, U.K.

In 1988, open-top chambers (OTCs) based on the Raleigh (USA) design were used to investigate the effect of ambient pollutants on field-sown Vicia faba cv, Ticol. This paper reports an aspect of this study in which the effect of the chamber itself on crop growth and development was investigated. Non-filtered chamber (NF OTC) microclimates were typically 0. Read More

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Tansley Review No. 22 What becomes of the transpiration stream?

M J Canny

New Phytol 1990 Mar;114(3):341-368

Department of Biology, Carleton University, Ottawa, Canada K1S 5B6.

Changes of view on the course of the transpiration stream beyond the veins in leaves are followed from the imbibition theory of Sachs, through the (symplastic) endosmotic theory of Pfeffer (which prevailed almost unquestioned until the late 1930s), to Strugger's experiments with fluorescent dye tracers and the epifluorescence microscope. This latter work persuaded many to return to the apoplastic-(wall)-path viewpoint, which, despite early and late criticisms that were never rebutted, is still widely held. Tracer experiments of the same kind are still frequently published without consideration of the evidence that they do not reveal the paths of water movement. Read More

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Ectomycorrhiza formation in Eucalyptus.: IV. Ectomycorrhizas in the sporocarps of the hypogeous fungi Mesophellia and Castorium in Eucalypt forests of Western Australia.

New Phytol 1990 Mar;114(3):449-456

School of Biological Sciences, Murdoch University, Murdoch, Western Australia 6150.

Mesophellia and Castorium are common hypogeous macrofungi in the karri (Eucalyptus diversicolor F. Muell.) and jarrah (Eucalyptus marginata Donn ex Sm. Read More

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Q C B Cronk

New Phytol 1987 Mar;105(3):509-520

Botany School, Downing Street, Cambridge CB2 3EA, UK.

When the endemic plant species of St Helena are ordered according to their increasing taxonomic isolation, their corresponding 'sister groups' show a 'relictual series' of increasing geographical disjunction. This is best explained by progressive extinction and evolution in continental areas rather than by particularly high rates of evolutionary change on the island (i.e. Read More

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New Phytol 1987 Mar;105(3):421-428

Division of Forest Research, CSIRO, Private Bag, P.O. Wembley, Western Australia 6014.

Cortinarius and Hysterangium species are a dominant component of the macrofungi in eucalypt forests of Western Australia, and their hyphae occupy 10 % of the soil surface area. Anatomical studies of jarrah (Eucalyptus marginata Donn ex Sm.) and karri (E. Read More

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Bit-Related Lesions in Event Horses After a Cross-Country Test.

Front Vet Sci 2021 31;8:651160. Epub 2021 Mar 31.

Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

Bit-related oral lesions are common and may impair horse welfare. The aim of this study was to investigate the prevalence of oral lesions and their risk factors in a sample of Finnish event horses. The rostral part of the oral cavity (the bit area) of 208 event horses (127 warmbloods, 52 coldbloods, and 29 ponies) was examined in a voluntary inspection after the last competition phase, i. Read More

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Correlation between craniovertebral angle in the sagittal plane and angles and indices measured in the frontal plane at the moment of inducing forward head posture.

Work 2021 Apr 11. Epub 2021 Apr 11.

Rehabilitation Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Forward head posture (FHP) is the most common malposition in the head and neck area. With the growing use of digital devices, the prevalence of FHP may be expected to increase dramatically. Thus far, FHP has been evaluated only in the sagittal plane. Read More

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Comparison of clinical features on admission between coronavirus disease 2019 and influenza a among children: a retrospective study in China.

BMC Infect Dis 2021 Apr 17;21(1):365. Epub 2021 Apr 17.

Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.

Background: Coronavirus disease 2019 (COVID-19) share similar symptoms with influenza A (IA), but it is more worthwhile to understand the disparities of the two infections regarding their clinical characteristics on admission.

Methods: A total of 71 age-matched pediatric IA and COVID-19 patient pairs were formed and their clinical data on admission were compared.

Results: Fever, cough, nasal congestion and nausea/vomiting were the most common symptoms on admission for both infections but occurred less often in COVID-19. Read More

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Nanostructured micro particles as a low-cost and sustainable catalyst in the recycling of PET fiber waste by the glycolysis method.

Waste Manag 2021 Apr 13;126:559-566. Epub 2021 Apr 13.

Department of Industrial and Materials Science, Chalmers University of Technology, Göteborg SE-41296, Sweden.

Magnetic Mg-Al-O@FeO micro particles were synthesized by coating nanosized Mg-Al double oxides onto FeO micro particles. The formed hierarchical structure gave Mg-Al-O@FeO micro particles a high active surface area, which enabled these micro particles to work efficiently as a catalyst in the glycolysis of poly(ethylene terephthalate) (PET). The bis(hydroxyethyl) terephthalate (BHET) yield reached above 80 mol% in the presence of 0. Read More

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A g-CN self-templated preparation of N-doped carbon nanosheets@Co-CoO/Carbon nanotubes as high-rate lithium-ion batteries' anode materials.

J Colloid Interface Sci 2021 Apr 5;597:1-8. Epub 2021 Apr 5.

Key Laboratory of Functional Small Organic Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China. Electronic address:

A novel N-doped graphene-like carbon nanosheets (CNs) and carbon nanotubes (CNTs)-encapsulated Co-CoO nanoparticles (NPs) (CN@Co-CoO/CNTs) were synthesized successfully by a simple hydrothermal and annealing method with graphite carbon nitride (g-CN) as self-template. By annealing Co/g-CN under N atmosphere, g-CN was transformed into CN/CNTs, and Co was reduced into CoNPs which were embedded in CNs. Further annealing in air, a shell of CoO was formed around CoNPs. Read More

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The effects of reducing the root length by apicoectomy on dental pulp revascularization following tooth replantation in mice.

Dent Traumatol 2021 Apr 16. Epub 2021 Apr 16.

Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background/aim: Root length is a critical factor for dental pulp regeneration following tooth replantation. The aim of this study was to analyze the effects of reducing the root length by apicoectomy on the pulp healing process using a model for tooth replantation.

Material And Methods: After extraction of the upper first molars (M1) of 3-week-old mice, the roots from the experimental group (EG) were shortened to half to two-thirds of their length before replantation, whereas in the control group (CG) the extracted teeth were immediately repositioned into their alveolar sockets. Read More

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Enhancement of X-ray-Excited Red Luminescence of Chromium-Doped Zinc Gallate via Ultrasmall Silicon Carbide Nanocrystals.

Chem Mater 2021 Apr 18;33(7):2457-2465. Epub 2021 Mar 18.

Wigner Research Centre for Physics, Institute for Solid State Physics and Optics, P.O. Box 49, Budapest H-1525, Hungary.

X-ray-activated near-infrared luminescent nanoparticles are considered as new alternative optical probes due to being free of autofluorescence, while both their excitation and emission possess a high penetration efficacy . Herein, we report silicon carbide quantum dot sensitization of trivalent chromium-doped zinc gallate nanoparticles with enhanced near-infrared emission upon X-ray and UV-vis light excitation. We have found that a ZnGaO shell is formed around the SiC nanoparticles during seeded hydrothermal growth, and SiC increases the emission efficiency up to 1 order of magnitude due to band alignment that channels the excited electrons to the chromium ion. Read More

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Priority Intervention Targets Identified Using an In-Depth Sampling HIV Molecular Network in a Non-Subtype B Epidemics Area.

Front Cell Infect Microbiol 2021 29;11:642903. Epub 2021 Mar 29.

NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.

Molecular network analysis based on the genetic similarity of HIV-1 is increasingly used to guide targeted interventions. Nevertheless, there is a lack of experience regarding molecular network inferences and targeted interventions in combination with epidemiological information in areas with diverse epidemic strains of HIV-1.We collected 2,173 sequences covering 84% of the total newly diagnosed HIV-1 infections in Shenyang city, Northeast China, between 2016 and 2018. Read More

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Clusteroluminescence from Cluster Excitons in Small Heterocyclics Free of Aromatic Rings.

Adv Sci (Weinh) 2021 Apr 11;8(7):2004299. Epub 2021 Feb 11.

Department of Chemistry The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong 999077 China.

The study of nonconventional luminescence is important for revealing the luminescence of natural systems and has gradually drawn the attention of researchers in recent years. However, the underlying mechanism is still inexplicable. Herein, the luminescence behavior of two series of simple, heteroatom-containing small molecules without aromatic rings, i. Read More

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Nanotwinning and tensile behavior in cold-welded high-entropy-alloy nanowires.

Nanotechnology 2021 Apr 14. Epub 2021 Apr 14.

Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 4648603, JAPAN.

Since the fabrication technique for high-entropy alloy (HEA) nanowires/nanopillars is still at its infancy, neither experimental nor modeling efforts on their cold-welding performance have been reported. Based on insights accumulated in our previous experiments and simulations regarding cold-welded metallic nanowires, in this study, the cold-welding performance of HEA nanowires is probed by atomistic simulations. Among different materials, our simulations reveal that multiple twinned structures are formed in CoCrMnFeNi samples, but not in CoCrCuFeNi or Ni samples. Read More

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Spatialization of breeding values of Brangus animals associated with climatic, physical, and socio-economic factors.

Trop Anim Health Prod 2021 Apr 14;53(2):260. Epub 2021 Apr 14.

Departamento de Zootecnia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

This study was realized to analyze the combinations of climatic, physical, and socio-economic variables on distribution of breeding values for performance characteristics and scrotal circumference of Brangus cattle. Records of 84,703 Brangus animals, born from 2000 to 2010 distributed in 65 farms in Brazil were used. The characteristics analyzed were average daily gain from birth to weaning and from weaning to yearling (WW and YW), visual scores of conformations (WC and YC), muscle score (WM and YM), precocity score (WP and YS), and size score (WS and YS) at weaning and yearling and scrotal circumference (SC) at yearling. Read More

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A SnO Quantum Dots Embedded Carbon Nanocage Network with Ultrahigh Li Storage Capacity.

ACS Nano 2021 Apr 14. Epub 2021 Apr 14.

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Linggong Road 2, Ganjingzi District, Dalian 116024, P. R. China.

Tin-based materials with high specific capacity have been studied as high-performance anodes for energy storage devices. Herein, a SnO ( = 0, 1, 2) quantum dots@carbon hybrid is designed and prepared by a binary oxide-induced surface-targeted coating of ZIF-8 followed by pyrolysis approach, in which SnO quantum dots (under 5 nm) are dispersed uniformly throughout the nitrogen-containing carbon nanocage. Each nanocage is cross-linked to form a highly conductive framework. Read More

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The Effect of Intra-articular versus Intravenous Injection of Mesenchymal Stem Cells on Experimentally-Induced Knee Joint Osteoarthritis.

J Microsc Ultrastruct 2021 Jan-Mar;9(1):31-38. Epub 2020 May 20.

Department of Histology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Background: Osteoarthritis (OA) is a chronic degenerative debilitating disease, primarily affects joints, particularly weight-bearing areas. The surface layer of the articular cartilage breaks down and wears away leading to rubbing of bones, pain, swelling, and joint stiffness.

Aim And Objectives: This study investigates the possible therapeutic effects of intra-articular versus intravenous injection of umbilical cord blood mesenchymal stem cells (UCB-MSCs) against mono-iodoacetate-induced OA of the knee joints in male albino rats, using histological and immunohistochemical techniques. Read More

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Biocompatibility of NeoMTA Plus® versus MTA Angelus as delayed furcation perforation repair materials in a dog model.

BMC Oral Health 2021 Apr 13;21(1):192. Epub 2021 Apr 13.

Department of Endodontic, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

Background: The biocompatibility of NeoMTA Plus® (Avlon BioMed Inc., Bradenton, Fl) as a furcal perforation repair material is not fully understood. This study compares the biocompatibility of Mineral Trioxide Aggregate (MTA Angelus) and NeoMTA Plus® as delayed furcation perforation repair materials. Read More

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An affinity prediction approach for the ligand of E3 ligase Cbl-b and an insight into substrate binding pattern.

Bioorg Med Chem 2021 Apr 2;38:116130. Epub 2021 Apr 2.

State Key Laboratory of Natural Medicines, and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Protein-protein interactions (PPIs) are essentially fundamental to all cellular processes, so that developing small molecule inhibitors of PPIs have great significance despite representing a huge challenge. Studying PPIs with the help of peptide motifs could obtain the structural information and reference significance to reduce the difficulty in the development of small molecules. Computational methods are powerful tools to characterize peptide-protein interactions, especially molecular dynamics simulation and binding free energy calculation. Read More

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gen. nov., sp. nov., a novel marine bacterium isolated from a bacterial consortium that degrades polyethylene terephthalate.

Int J Syst Evol Microbiol 2021 Apr;71(4)

Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources of China, State Key Laboratory Breeding Base of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Xiamen 361005, PR China.

A novel Gram-stain-negative, aerobic, gliding, rod-shaped and carotenoid-pigmented bacterium, designated A20-9, was isolated from a microbial consortium of polyethylene terephthalate enriched from a deep-sea sediment sample from the Western Pacific. Growth was observed at salinities of 1-8 %, at pH 6.5-8 and at temperatures of 10-40 °C. Read More

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Development of biodegradable webs of PLA/PCL blends prepared via electrospinning: Morphological, chemical, and thermal characterization.

J Biomed Mater Res B Appl Biomater 2021 Apr 13. Epub 2021 Apr 13.

Textile Engineering Department, Istanbul Technical University, Istanbul, Turkey.

Biodegradable polymers have a mean role to mimic native tissues and allow cells to penetrate, grow, and proliferate with their advanced features in tissue engineering applications. The physiological, chemical, mechanical, and biological qualities of the surfaces, which are presented from biodegradable polymers, affect the final properties of the scaffolds. In this study, it is aimed to produce fibrous webs by electrospinning method for tissue engineering applications using two different biopolymers, polylactic acid (PLA) and polycaprolactone (PCL). Read More

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