21,824 results match your criteria ards patients


ECMO induces early alterations in coagulation and fibrinolysis profiles in COVID-19 patients with acute respiratory distress syndrome.

Thromb Haemost 2021 Jun 15. Epub 2021 Jun 15.

Department of haematology, Assistance Publique - Hopitaux de Paris, Paris, France.

Hemostatic changes induced by extracorporeal membrane oxygenation (ECMO) support have been yet poorly documented in COVID-19 patients who have a baseline complex hypercoagulable state. In this prospective monocentric study of patients with severe acute respiratory distress syndrome (ARDS) rescued by ECMO, we performed longitudinal measurements of coagulation and fibrinolysis markers throughout the course of ECMO support in 20 COVID-19 and 10 non-COVID-19 patients. Blood was sampled before and then 24 hours, 7 and 14 days after ECMO implantation. Read More

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The immunological response among COVID-19 patients with acute respiratory distress syndrome.

J Infect Public Health 2021 May 26;14(7):954-959. Epub 2021 May 26.

Faculty Member at King Saud Abdul-Aziz University for Health Sciences, Riyadh, Saudi Arabia; Department of Rehabilitation Science, School of Health Profession, University of Alabama at Birmingham, Birmingham, AL, United States; King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia. Electronic address:

Coronavirus disease 2019 (COVID-19) often results in pneumonia and can lead to acute respiratory distress syndrome (ARDS). ARDS is one of the most significant causes of death in patients with COVID-19. The development of a "cytokine storm" in patients with COVID-19 causes progression to ARDS. Read More

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Phenotypic spectrum and mechanism analysis of Schaff Yang syndrome: A case report on new mutation of MAGEL2 gene.

Medicine (Baltimore) 2021 Jun;100(24):e26309

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University.

Rationale: The Schaaf-Yang syndrome (SYS) is an autosomal dominant multi-system genetic disease caused by melanoma antigen L2 (MAGEL2) gene mutations imprinted by mothers and expressed by fathers on the 15q11-15q13 chromosomes in the critical region of Prader-Willi. MAGEL2 is a single exon gene and one of the protein-coding genes of the Prader-Willi domain. MAGEL2 is a matrilineal imprinted gene (i. Read More

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Type 1 inflammatory endotype relates to low compliance, lung fibrosis, and severe complications in COVID-19.

Cytokine 2021 Jun 7:155618. Epub 2021 Jun 7.

Kobe City Medical Centre General Hospital, 2-1-1, Minamimachi, Minatojima, Chuo Ward, Kobe, Japan.

Background: Coronavirus disease 2019 (COVID-19) is an acute respiratory disease; approximately 5% of patients developing severe COVID-19. It is known that cytokine release is associated with disease severity, but the relationship between the different clinical phenotypes and inflammatory endotypes is not well understood.

Objective: This study investigated the association between inflammatory biomarker-based endotypes and severe COVID-19 phenotypes. Read More

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Serum uric acid, disease severity and outcomes in COVID-19.

Crit Care 2021 06 14;25(1):212. Epub 2021 Jun 14.

Division of Nephrology, Cliniques universitaires Saint-Luc, 1200, Brussels, Belgium.

Background: The severity of coronavirus disease 2019 (COVID-19) is highly variable between individuals, ranging from asymptomatic infection to critical disease with acute respiratory distress syndrome requiring mechanical ventilation. Such variability stresses the need for novel biomarkers associated with disease outcome. As SARS-CoV-2 infection causes a kidney proximal tubule dysfunction with urinary loss of uric acid, we hypothesized that low serum levels of uric acid (hypouricemia) may be associated with severity and outcome of COVID-19. Read More

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Short-term effects of synchronized vs. non-synchronized NIPPV in preterm infants: study protocol for an unmasked randomized crossover trial.

Trials 2021 Jun 14;22(1):392. Epub 2021 Jun 14.

Neonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.

Background: Non-invasive ventilation (NIV) has been recommended as the best respiratory support for preterm infants with respiratory distress syndrome (RDS). However, the best NIV technique to be used as first intention in RDS management has not yet been established. Nasal intermittent positive pressure ventilation (NIPPV) may be synchronized (SNIPPV) or non-synchronized to the infant's breathing efforts. Read More

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Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis.

Crit Care 2021 06 14;25(1):211. Epub 2021 Jun 14.

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Background: There are several reports of extracorporeal membrane oxygenation (ECMO) use in patients with coronavirus disease 2019 (COVID-19) who develop severe acute respiratory distress syndrome (ARDS). We conducted a systematic review and meta-analysis to guide clinical decision-making and future research.

Methods: We searched MEDLINE, Embase, Cochrane and Scopus databases from 1 December 2019 to 10 January 2021 for observational studies or randomised clinical trials examining ECMO in adults with COVID-19 ARDS. Read More

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Extracorporeal Blood Purification in Moderate and Severe COVID-19 Patients: A Prospective Cohort Study.

Blood Purif 2021 Jun 14:1-10. Epub 2021 Jun 14.

Zan Mitrev Clinic, Skopje, North Macedonia.

Introduction: Coronavirus disease 2019 (COVID-19) is characterized by hyperinflammation and coagulopathy. Severe cases often develop respiratory distress, requiring mechanical ventilation and with critical cases progressing to acute respiratory distress syndrome. Control of hyperinflammation has been proposed as a possible therapeutic avenue for COVID-19; extracorporeal blood purification (EBP) modalities offer an attractive mean to ameliorate maladaptive inflammation. Read More

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Subcutaneous emphysema and spontaneous pneumomediastinum in non-intubated COVID-19 patient: Presenting unusual case report.

Int J Surg Case Rep 2021 Jun 10;84:106071. Epub 2021 Jun 10.

Department of Critical Care Nursing, College of Nursing, Urmia University of Medical Science, Iran. Electronic address:

Introduction And Importance: In non-intubated COVID-19 patients, subcutaneous emphysema and spontaneous pneumomediastinum (SPM) remain rarely, with incidence rates of 3.0 and 1.2 per 100,000, respectively; nevertheless, the occurrence of these conditions in COVID-19 patients is unclear. Read More

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Driving Pressure-Guided Individualized Positive End-Expiratory Pressure in Abdominal Surgery: A Randomized Controlled Trial.

Anesth Analg 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Anesthesiology and Critical Care Medicine, Xinhua Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: The optimal positive end-expiratory pressure (PEEP) to prevent postoperative pulmonary complications (PPCs) remains unclear. Recent evidence showed that driving pressure was closely related to PPCs. In this study, we tested the hypothesis that an individualized PEEP guided by minimum driving pressure during abdominal surgery would reduce the incidence of PPCs. Read More

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Postprandial Hypotension in the Intensive Care Unit Due To Portal Hypertension and Coronavirus Disease 2019: A Case Report.

A A Pract 2021 Jun 14;15(6):e01485. Epub 2021 Jun 14.

Anesthesiology, University of Wisconsin Hospitals and Clinics, Madison, Wisconsin.

A 49-year-old man with cirrhosis and portal hypertension was admitted for acute respiratory distress syndrome secondary to coronavirus disease 2019 (COVID-19) pneumonia. His course was complicated by postprandial hypotension (PPH)-episodic hemodynamic collapse that occurred minutes after enteral administration of medications or fluids. Octreotide, which reduces splanchnic pooling and can treat PPH, successfully prevented ongoing events. Read More

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Analysis of the Efficacy and Mechanism of Action of Xuebijing Injection on ARDS Using Meta-Analysis and Network Pharmacology.

Biomed Res Int 2021 22;2021:8824059. Epub 2021 May 22.

Immunology Research Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Objective: Acute respiratory distress syndrome (ARDS) is defined as the acute onset of noncardiogenic edema and subsequent gas-exchange impairment due to a severe inflammatory process known as cytokine storm. Xuebijing injection (hereinafter referred to as Xuebijing) is a patent drug that was used to treat ARDS or severe pneumonia (SP) in China. However, its efficacy and mechanism of actions remain unclear. Read More

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Early vs. Late Onset Cardiac Injury and Mortality in Hospitalized COVID-19 Patients in Wuhan.

Front Cardiovasc Med 2021 28;8:645587. Epub 2021 May 28.

Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Increasing evidence points to cardiac injury (CI) as a common coronavirus disease 2019 (COVID-19) related complication. The characteristics of early CI (occurred within 72 h of admission) and late CI (occurred after 72 h of admission) and its association with mortality in COVID-19 patients is unknown. This retrospective study analyzed patients confirmed with COVID-19 in Union Hospital (Wuhan, China) from Jan 29th to Mar 15th, 2020. Read More

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Heat Shock Protein-70 Levels Are Associated With a State of Oxidative Damage in the Development of Bronchopulmonary Dysplasia.

Front Pediatr 2021 26;9:616452. Epub 2021 May 26.

Department of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan.

Heat shock protein-70 (Hsp-70) exhibits cytoprotective effects against oxidative stress-induced airway injury. This study aimed to examine Hsp-70 and 8-hydroxy-2'-deoxyguanosine (8-OHdG) from tracheal aspirates (TA) in very low-birth weight (VLBW) preterm infants to predict the development of bronchopulmonary dysplasia (BPD). This birth cohort study enrolled 109 VLBW preterm infants, including 32 infants who developed BPD. Read More

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Sex-Disaggregated Data on Clinical Characteristics and Outcomes of Hospitalized Patients With COVID-19: A Retrospective Study.

Front Cell Infect Microbiol 2021 26;11:680422. Epub 2021 May 26.

Department of Nuclear medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Sex and gender are crucial variables in coronavirus disease 2019 (COVID-19). We sought to provide information on differences in clinical characteristics and outcomes between male and female patients and to explore the effect of estrogen in disease outcomes in patients with COVID-19.

Method: In this retrospective, multi-center study, we included all confirmed cases of COVID-19 admitted to four hospitals in Hubei province, China from Dec 31, 2019 to Mar 31, 2020. Read More

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Worsening of gas exchange parameters at high FiO in COVID-19: misleading or informative?

Multidiscip Respir Med 2021 Jan 25;16(1):759. Epub 2021 May 25.

Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo.

Background: In COVID-19, higher than expected level of intrapulmonary shunt has been described, in association with a discrepancy between the initial relatively preserved lung mechanics and the hypoxia severity. This study aim was to measure the shunt fraction and variations of PaO/FiO ratio and oxygen alveolar-arterial gradient (A-a O) at different FiO.

Methods: Shunt was measured by a non-invasive system during spontaneous breathing in 12 patients hospitalized at COVID-19 Semi-Intensive Care Unit of Papa Giovanni XXIII Hospital, Bergamo, Italy, between October 22 and November 23, 2020. Read More

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January 2021

Prognostic Value of the Red Cell Distribution Width in Patients with Sepsis-Induced Acute Respiratory Distress Syndrome: A Retrospective Cohort Study.

Dis Markers 2021 2;2021:5543822. Epub 2021 Jun 2.

Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China.

Objective: The prognostic value of the red cell distribution width (RDW) in patients with sepsis-induced acute respiratory distress syndrome (ARDS) is still elusive. This study is aimed at determining whether RDW is a prognostic indicator of sepsis-induced ARDS.

Methods: This retrospective cohort study included 1161 patients with sepsis-induced ARDS. Read More

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Clinical Characteristics and Early Interventional Responses in Patients with Severe COVID-19 Pneumonia.

Comput Math Methods Med 2021 31;2021:6676987. Epub 2021 May 31.

Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Taizhou, China.

Progressive acute respiratory distress syndrome (ARDS) is the most lethal cause in patients with severe COVID-19 pneumonia due to uncontrolled inflammatory reaction, for which we found that early intervention of combined treatment with methylprednisolone and human immunoglobulin is a highly effective therapy to improve the prognosis of COVID-19-induced pneumonia patients. . Herein, we have demonstrated the clinical manifestations, laboratory, and radiological characteristics of patients with severe Coronavirus Disease-2019 (COVID-19) pneumonia, as well as measures to ensure early diagnosis and intervention for improving clinical outcomes of COVID-19 patients. Read More

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Transcriptional Start Site Coverage Analysis in Plasma Cell-Free DNA Reveals Disease Severity and Tissue Specificity of COVID-19 Patients.

Front Genet 2021 28;12:663098. Epub 2021 May 28.

BGI-Shenzhen, Shenzhen, China.

Symptoms of coronavirus disease 2019 (COVID-19) range from asymptomatic to severe pneumonia and death. A deep understanding of the variation of biological characteristics in severe COVID-19 patients is crucial for the detection of individuals at high risk of critical condition for the clinical management of the disease. Herein, by profiling the gene expression spectrum deduced from DNA coverage in regions surrounding transcriptional start site in plasma cell-free DNA (cfDNA) of COVID-19 patients, we deciphered the altered biological processes in the severe cases and demonstrated the feasibility of cfDNA in measuring the COVID-19 progression. Read More

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Accuracy of the Radiographic Assessment of Lung Edema Score for the Diagnosis of ARDS.

Front Physiol 2021 26;12:672823. Epub 2021 May 26.

Department of Intensive Care, Academic Medical Center, Amsterdam, Netherlands.

Bilateral opacities on chest radiographs are part of the Berlin Definition for Acute Respiratory Distress Syndrome (ARDS) but have poor interobserver reliability. The "Radiographic Assessment of Lung Edema" (RALE) score was recently proposed for evaluation of the extent and density of alveolar opacities on chest radiographs of ARDS patients. The current study determined the accuracy of the RALE score for the diagnosis and the prognosis of ARDS. Read More

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Low-dose radiotherapy for COVID 19: A radioimmunological perspective.

J Cancer Res Ther 2021 Apr-Jun;17(2):295-302

Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi; Department of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, Jhajjar, Haryana, India.

The world is fighting the onslaught of COVID 19 for the last 10 months, ever since the first case was reported in December 2019 in Wuhan, China. Now, it has spread to over 200 countries. COVID 19-associated respiratory syndrome is causing a lot of mortality and morbidity. Read More

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Mortality of right ventricular dysfunction in patients with acute respiratory distress syndrome subjected to lung protective ventilation: A systematic review and meta-analysis.

Heart Lung 2021 Jun 9;50(5):730-735. Epub 2021 Jun 9.

Department of ICU, Shaanxi Provincial People's Hospital, Xi'an, China.

Background: The impact of right ventricular dysfunction(RVD) on the prognosis of acute respiratory distress syndrome(ARDS) patients is controversial.

Objectives: The objectives of this systematic review and meta-analysis was to investigate whether RVD or pulmonary vascular dysfunction are associated with increased mortality in patients with ARDS.

Methods: We searched Pubmed, Embase, Cochrane Library, Wanfang Data, CNKI, and the WHO Clinical Trial Registry for studies of RVD or pulmonary vascular dysfunction in patients with ARDS. Read More

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Comparison of fixed dose versus train-of-four titration of cisatracurium in acute respiratory distress syndrome.

J Crit Care 2021 May 25;65:86-90. Epub 2021 May 25.

University of Kentucky HealthCare, Department of Pharmacy Services, United States of America; University of Kentucky College of Pharmacy, Department of Pharmacy Practice and Science, United States of America. Electronic address:

Purpose: To compare the ventilatory and clinical outcomes associated with a fixed-dose cisatracurium infusion versus a titrated infusion strategy in patients with Acute Respiratory Distress Syndrome (ARDS).

Materials And Methods: Single-center, retrospective, cohort study in a medical ICU of a tertiary care academic medical center. Adult patients ≥18 years old with a continuous infusion of cisatracurium for ≥12 h for treatment of ARDS were included. Read More

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Autoimmunity and COVID-19 - The microbiotal connection.

Autoimmun Rev 2021 Jun 9:102865. Epub 2021 Jun 9.

Department of Medicine C, Wolfson Medical Center, Holon, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background And Aims: The novel SARS-CoV-2 has been rattling the world since its outbreak in December 2019, leading to the COVID-19 pandemic. The learning curve of this new virus has been steep, with a global scientific community desperate to learn how the virus is transmitted, how it replicates, what cause such a wide spectrum of disease manifestations, causing none or few symptoms in some. Others are burdened by an intense immune response that resembles the cytokine storm syndrome (CSS), which leads to severe disease manifestations, often complicated by fatal acute respiratory distress syndrome and death. Read More

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7-ketocholesterol: effects on viral infections and hypothetical contribution in COVID-19.

J Steroid Biochem Mol Biol 2021 Jun 9:105939. Epub 2021 Jun 9.

University Bourgogne Franche-Comté, Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA 7270 / Inserm, 21000 Dijon, France. Electronic address:

7-ketocholesterol, which is one of the earliest cholesterol oxidization products identified, is essentially formed by the auto-oxidation of cholesterol. In the body, 7-ketocholesterol is both provided by food and produced endogenously. This pro-oxidant and pro-inflammatory molecule, which can activate apoptosis and autophagy at high concentrations, is an abundant component of oxidized Low Density Lipoproteins. Read More

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The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID-19 viruses.

IUBMB Life 2021 Jun 12. Epub 2021 Jun 12.

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The kidney is one of the main targets attacked by viruses in patients with a coronavirus infection. Until now, SARS-CoV-2 has been identified as the seventh member of the coronavirus family capable of infecting humans. In the past two decades, humankind has experienced outbreaks triggered by two other extremely infective members of the coronavirus family; the MERS-CoV and the SARS-CoV. Read More

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Use of aspirin in reduction of mortality of COVID-19 patients: A metanalysis.

Int J Clin Pract 2021 Jun 12:e14515. Epub 2021 Jun 12.

Department of Pharmacology and Clinical research, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), New Delhi-110017, India.

COVID-19 infection affecting every one of us from the last year and continue to affecting. Emerging reports have indicated thrombo-embolism in serious cases of COVID-19. The aspirin is useful to reduce mortality of serious patients with acute respiratory distress syndrome without COVID-19. Read More

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Etiology, incidence, and outcomes of patient-ventilator asynchrony in critically-ill patients undergoing invasive mechanical ventilation.

Sci Rep 2021 Jun 11;11(1):12390. Epub 2021 Jun 11.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN, 55902, USA.

Patient-ventilator asynchrony (PVA) is commonly encountered during mechanical ventilation of critically ill patients. Estimates of PVA incidence vary widely. Type, risk factors, and consequences of PVA remain unclear. Read More

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