1,873 results match your criteria aqueous hexane


Extracts of Euphorbia nivulia Buch.-Ham. showed both phytotoxic and insecticidal capacities against Lemna minor L. and Oxycarenus hyalinipennis Costa.

PLoS One 2021 30;16(4):e0250118. Epub 2021 Apr 30.

Department of Biotechnology, College of Sciences, Taif University, Taif, Saudi Arabia.

Many phytochemicals can affect the growth and development of plants and insects which can be used as biological control agents. In this study, different concentrations of crude, hexane, chloroform, butanol, and aqueous extracts of Euphorbia nivulia Buch.-Ham. Read More

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Evaluation of Antiulcer Activity of Hydro-Methanol Extract and Solvent Fractions of the Stem Bark of (Moraceae) on Rodent Models.

Biomed Res Int 2021 9;2021:6685395. Epub 2021 Apr 9.

Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: The stem bark of is used by Ethiopian traditional healers and the community for the treatment of peptic ulcer disease. Thus, the current study was aimed at evaluating the antiulcer effect of hydro-methanol extract and solvent fractions of .

Methods: The stem bark of was collected and shed dried. Read More

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Isolation, Structure Elucidation and In Silico Prediction of Potential Drug-Like Flavonoids from Targeted towards Functionally Important Proteins of Drug-Resistant Bad Bugs.

Molecules 2021 Apr 2;26(7). Epub 2021 Apr 2.

Basic Science Department, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.

Admittedly, the disastrous emergence of drug resistance in prokaryotic and eukaryotic human pathogens has created an urgent need to develop novel chemotherapeutic agents. is a source of traditional medicine with cooling, laxative, and anthelmintic effects. The objective of the current research was to analyze the biological potential of and to isolate and characterize the chemical constituents of the plant. Read More

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In vitro antimicrobial activity of plant fractions against major respiratory pathogens.

Pak J Pharm Sci 2020 Nov;33(6):2557-2565

Barrett Hodgson University, Karachi, Pakistan.

From the ancient times, the use of plants is considered as a cure for many diseases and now, they are being used as a new resource for producing agents that could act as alternative to antibiotics. Current work was carried to investigate the antimicrobial potential of 42 different aqueous plant extracts and oils against Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa. In vitro antimicrobial activity of different concentrations (1. Read More

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November 2020

Evaluation of effect of Acacia jacquemontii Benth. on blood pressure in normotensive and fructose induced hypertensive sprague dawley rats: An ethnopharmacological approach.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2341-2345

College of Pharmacy, Jouf University, Aljouf, Sakaka, 2014, Saudi Arabia.

Acacia jacquemontii Benth. is used traditionally to treat hypertension but no scientific literature supports this claim. So, this study was aimed at validating this claim. Read More

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September 2020

Phytochemical, antimicrobial and time-kill kinetics potentials of Euphorbia nivulia Buch.-Ham.: A Cholistan desert medicinal plant.

Pak J Pharm Sci 2020 Sep;33(5(Special)):2461-2469

Department of Pharmacognosy, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.

Euphorbia nivulia a locally occurring plant species possesses antiseptic, analgesic and anti-inflammatory properties and is ethnopharmacologically used in various ailments like skin, ear disorders, boils, and worm infestation. Preliminary phytochemical screening showed presence of flavonoids, polyphenolics, glycosides, alkaloids, tannins and triterpenoids in (70% aqueous-ethanolic) Euphorbia nivulia crude extract (En cr) and its four fractions, i.e. Read More

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September 2020

Development of ultrasound-assisted centrifugal extraction combined with two countercurrent chromatography systems for the simultaneous extraction and isolation of phytochemicals.

J Sep Sci 2021 Apr 1. Epub 2021 Apr 1.

Central Laboratory, Changchun Normal University, Changchun, P. R. China.

We proposed a method for the extraction of medicinal herbs, called ultrasound-assisted centrifugal extraction, and an online solvent concentration method. These techniques were coupled with two countercurrent chromatography systems and applied to the continuous extraction and online isolation of chemical constituents from Inonotus obliquus. Raw plants were extracted using a two-phase petroleum-ethanol-water (2. Read More

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Momordica charantia L. Induces Non-Apoptotic Cell Death in Human MDA-MB-436 Breast and A549 Lung Cancer Cells by Disrupting Energy Metabolism and Exacerbating Reactive Oxygen Species' Generation.

J Ethnopharmacol 2021 Mar 19:114036. Epub 2021 Mar 19.

Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria. Electronic address:

Ethnopharmacological Relevance: Bitter melon, Momordica charantia L. (MC), is an ethnomedicinal plant cultivated in different climes. It's cytotoxic effect on several cancer cell lines has been evaluated. Read More

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Phytochemicals of Periploca aphylla Dcne. ameliorated streptozotocin-induced diabetes in rat.

Environ Health Prev Med 2021 Mar 22;26(1):38. Epub 2021 Mar 22.

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

Background: Periploca aphylla is used by local population and indigenous medicine practitioners as stomachic, tonic, antitumor, antiulcer, and for treatment of inflammatory disorders. The aim of this study was to evaluate antidiabetic effect of the extract of P. aphylla and to investigate antioxidant and hypolipidemic activity in streptozotocin (STZ)-induced diabetic rats. Read More

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Development of ultrasound-assisted mixture extraction and online extraction solution concentration coupled with countercurrent chromatography for the preparation of pure phytochemicals from Phellinus vaninii.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 6;1171:122619. Epub 2021 Mar 6.

Guelph Research and Development Center, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, Ontario N1G 5C9, Canada.

Herein, ultrasound-assisted mixture extraction (UAME) and online extraction solution concentration (OESC) were conducted to extract products from crops and plants. These techniques were coupled with parallel countercurrent chromatography (PCCC) and applied for continuous extraction and online isolation of chemical constituents from Phellinus vaninii. The UAME instrument comprises extraction and solution separation chambers. Read More

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Anti-parasitic activity of Annona muricata L. leaf ethanolic extract and its fractions against Toxoplasma gondii in vitro and in vivo.

J Ethnopharmacol 2021 Jun 12;273:114019. Epub 2021 Mar 12.

Laboratory of Immunopathology, Institute of Biomedical Sciences, Federal University of Uberlândia, Av. Pará 1720, Uberlândia, CEP 38400902, MG, Brazil. Electronic address:

Ethnopharmacological Relevance: Sulfadiazine and pyrimethamine are the two drugs used as part of the standard therapy for toxoplasmosis, however; they may cause adverse side effects and fail to prevent relapse in many patients, rendering infected individuals at risk of reactivation upon becoming immunocompromised. Extracts from various parts of Annona muricata have been widely used medicinally for the management, control and/or treatment of several human diseases, acting against parasites that cause diseases in humans.

Aim Of The Study: This study was performed to investigate the action of the ethanolic extract of A. Read More

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Extractive removal of micro and trace nitrofen, 2, 4-dichlorophenol and p-nitrotrophenol from water/soil by humic acid ester ether.

Environ Technol 2021 Mar 3:1-12. Epub 2021 Mar 3.

College of Chemistry and Material Science, Sichuan Normal University, Chengdu, People's Republic of China.

The amphiphilic humic acid ester ether (HAEE), as a kind of solid-phase extractant with characteristics of easy separation and hydrophilic-hydrophobic amphiphilic property, was prepared and used to extract micro or trace nitrofen, 2,4-dichlorophenol and p-nitrotrophenol (NIPs) from water and soil. Degradation of NIPs and extractant regeneration were carried out by simple photocatalysis. The adsorption equilibrium of the mono- or three mixed NIPs by HAEE in aqueous could be quickly reached within 20 min. Read More

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Phytochemical profiling of bioactive compounds, anti-inflammatory and analgesic potentials of Habenaria digitata Lindl.: Molecular docking based synergistic effect of the identified compounds.

J Ethnopharmacol 2021 Jun 27;273:113976. Epub 2021 Feb 27.

Department of Medicinal Chemistry, School of Pharmacy, Najran University, Saudi Arabia.

Ethnopharmacological Relevance: Members of Orchidaceae family has a long history in herbal and Chinese medicines. Members of this family are most commonly famous in the management of inflammation and analgesia in folk medicine. Habenaria digitata, an unexplored specie of Orchidaceae is found in North areas of Pakistan and is used by the local population for the management of analgesia and inflammation. Read More

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Cardioprotective Effect of Crude Extract and Solvent Fractions of Leaves on Cyclophosphamide-Induced Myocardial Injury in Rats.

J Exp Pharmacol 2021 16;13:147-160. Epub 2021 Feb 16.

Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia.

Background: Globally, cardiovascular diseases (CVDs) are becoming the major cause of death. is one of endogenous plant which treats a wide range of disease conditions including heart diseases. However, there is limited information on safety and efficacy of the plant. Read More

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February 2021

Dataset describing biodegradation of individual polychlorinated biphenyl congeners (PCBs) by LB400 in presence and absence of sediment slurry.

Data Brief 2021 Apr 30;35:106821. Epub 2021 Jan 30.

Department of Civil & Environmental Engineering, 4105 Seamans Center for the Engineering Arts & Sciences, University of Iowa, Iowa City, IA 52245, United States.

This dataset describes the biodegradation of polychlorinated biphenyl (PCB) congeners by LB400 in absence and presence of PCB-contaminated sediment slurry, over time [1]. In absence of sediment, PCBs were extracted from aqueous bioreactors by liquid-liquid extraction (LLE) with hexane. In presence of sediment, the extraction method used was a modification of U. Read More

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Antimalarial Activity of Methanolic Extracts and Solvent Fractions of Leaves in Infected Mice.

J Exp Pharmacol 2021 5;13:69-89. Epub 2021 Feb 5.

Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Malaria is an infectious disease-causing mortality and morbidity in children and adults. Our study planned to measure the antimalarial activity of extract in vivo assays against in Swiss albino mice.

Methods: was inoculated to healthy mice and methanolic crude extract and solvent fractions of at 100, 200, and 400mg/kg/day were administered. Read More

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February 2021

Effect of Caralluma tuberculata on regulation of carbohydrate metabolizing genes in alloxan-induced rats.

J Ethnopharmacol 2021 May 7;271:113897. Epub 2021 Feb 7.

Department of Immunology, University of Health Sciences, Lahore, Pakistan. Electronic address:

Ethnopharmacological Relevance: Caralluma tuberculata (C. tuberculata) has traditionally been used in Pakistan and other parts of the world as a folk treatment for diabetes mellitus. A few studies indicated its antihyperglycemic effect, however, the mystery remained unfolded as how did it modify the pathophysiological condition. Read More

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Controlling the growth of a SiO coating on hydrophobic CsPbBr nanocrystals towards aqueous transfer and high luminescence.

Nanoscale 2021 Feb 10;13(6):3860-3867. Epub 2021 Feb 10.

School of Material Science & Engineering, University of Jinan, No. 336, Nanxinzhuangxi Rd, Jinan, 250022, P. R. China.

Silica coating can effectively solve the stability issue of lead halide perovskite nanomaterials. However, it is difficult to achieve aqueous SiO coating on hydrophobic CsPbBr nanocrystals (NCs). In this paper, the hydrolysis process of tetramethoxysilane was controlled to get a homogeneous SiO coating or a NC/SiO Janus structure. Read More

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February 2021

HO-Induced Hydrophobic Interactions in MS-Guided Counter-Current Chromatography Separation of Anti-Cancer Mollugin from .

Molecules 2021 Feb 2;26(3). Epub 2021 Feb 2.

Research Center of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.

Counter-current chromatography (CCC) is a unique liquid-liquid partition chromatography and largely relies on the partition interactions of solutes and solvents in two-phase solvents. Usually, the two-phase solvents used in CCC include a lipophilic organic phase and a hydrophilic aqueous phase. Although a large number of partition interactions have been found and used in the CCC separations, there are few studies that address the role of water on solvents and solutes in the two-phase partition. Read More

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February 2021

Effect of solvent-solvent partition on antioxidant activity and GC-MS profile of Loes. leaves extract and fractions.

Nat Prod Res 2021 Feb 4:1-5. Epub 2021 Feb 4.

Centro de Investigaciones Biotecnológicas del Ecuador, ESPOL Polytechnic University, Escuela Superior Politécnica del Litoral, ESPOL, Guayaquil, Ecuador.

The use of guayusa ( Loes.) leaves as functional food has increase recently. This work discusses the antioxidant activity and volatile compounds of guayusa leaves extract and fractions. Read More

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February 2021

Two species of inhibits the progression of cervical cancer cells SiHa by means of autophagic cell death induction.

3 Biotech 2021 Feb 11;11(2):52. Epub 2021 Jan 11.

Department of Botany, Centre of Advanced Studies, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019 West Bengal India.

Edible green algal seaweeds, namely and constitute a significant repository of popular herbal medicines in the Traditional Chinese Medicinal system. The present study aimed to assess the anticancer potential of these algal members and its mode of action in cervical cancer cells SiHa. The algal samples primarily extracted in methanol was fractionated into hexane, chloroform, and aqueous algal fractions, which inhibited the proliferation of SiHa cells in a dose-dependent manner, with the algal chloroform fractions harbouring the lowest IC dose of 141. Read More

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February 2021

Skin-Related Properties and Constituents from the Aerial Parts Extract of .

Oxid Med Cell Longev 2020 19;2020:6627752. Epub 2020 Dec 19.

Natural Products Research Team, Biocenter, Gyeonggido Business and Science Accelerator, Suwon 16229, Republic of Korea.

In the course of screening for cosmetic ingredients by measuring antioxidant and antiwrinkle and whitening and anti-inflammatory activities, skin-related activity was tested using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, elastase inhibition, tyrosinase inhibition, and nitric oxide assay. Several Polygonaseae extracts were found to show potent activity. The results showed that the methanolic extract has the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ABTS radical scavenging activities (IC 61. Read More

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December 2020

Colorimetric sensing of chloride in sweat based on fluorescence wavelength shift via halide exchange of CsPbBr perovskite nanocrystals.

Mikrochim Acta 2021 Jan 2;188(1). Epub 2021 Jan 2.

State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 361005, People's Republic of China.

Considering the high importance of the rapid detection of chloride ion (Cl) in sweat for the diagnosis of fibrotic cysts, we have investigated the heterogeneous halide exchange between CsPbBr perovskite nanocrystals (PNCs) in n-hexane and Cl in aqueous solution. The results show that CsPbBr PNCs could achieve fast halide exchange with Cl in the aqueous phase under magnetic stirring at pH = 1, accompanied by a significant wavelength blue shift and vivid fluorescence color changes from green to blue. Therefore, a fluorescence wavelength shift-based colorimetric sensing of Cl based on the halide exchange of CsPbBr PNCs has been developed to realize the rapid detection of Cl in sweat. Read More

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January 2021

Preparative separation of high-purity trans- and cis-ferulic acid from wheat bran by pH-zone-refining counter-current chromatography.

J Chromatogr A 2021 Jan 2;1636:461772. Epub 2020 Dec 2.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China. Electronic address:

Ferulic acid stereoisomers are the most abundant phenolic acids in cereal bran. However, it is challenging to separate them because of the similar structures and properties. In this study, a preparative separation method of ferulic acid stereoisomers from the crude extract of wheat bran was successfully developed. Read More

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January 2021

Treating Hyperglycemia From M. Bieb: - α-Glucosidase, Antioxidant, Antidiabetic and Molecular Docking-Based Approaches.

Front Chem 2020 26;8:558641. Epub 2020 Nov 26.

Department of Biotechnology, Faculty of Biological Sciences, University of Malakand, Chakdara, Pakistan.

Natural-based drugs are believed to be safe, effective and economical. Based on the medicinal importance of the genus Eryngium and unexplored nature of , we have evaluated its antidiabetic and antioxidant potentials. Both and assays have been carried out for antidiabetic assays. Read More

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November 2020

Endothelium-independent vasorelaxant effect of Asphodelus tenuifolius Cav. via inhibition of myosin light chain kinase activity in the porcine coronary artery.

J Ethnopharmacol 2021 Apr 14;269:113693. Epub 2020 Dec 14.

Pharmacology Research Group, School of Life Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom. Electronic address:

Ethnopharmacological Relevance: Asphodelus tenuifolius Cav. (Asphodelaceae), a wild, terrestrial, annual stemless herb, is widely used in traditional medicine for the treatment of hypertension, diabetes, atherosclerosis and circulatory problems. A previous research study from our laboratory revealed that A. Read More

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Tiliacora racemosa leaves induce oxidative stress mediated DNA damage leading to G2/M phase arrest and apoptosis in cervical cancer cells SiHa.

J Ethnopharmacol 2021 Apr 10;269:113686. Epub 2020 Dec 10.

Cell Biology Laboratory, Department of Botany, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, India. Electronic address:

Ethnopharmacological Relevance: The Menispermaceae plant Tiliacora racemosa is immensely popular in Indian traditional Ayurvedic medicine as "Krishnavetra" for its remarkable anti-cancerous property, and is commonly used by tribal population for the treatment of skin infections, snake bites and filariasis.

Aim Of The Study: This present study intends to identify the modus operandi behind the cytotoxic activity of Tiliacora racemosa leaves in cervical cancer cells SiHa. Focus has been instilled in the ability of the plant extract to target multiple signaling pathways leading to cell cycle arrest and cell death in SiHa cells, followed by a pharmacological characterization to identify the bioactive principle. Read More

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Enantioseparation of ondansetron by countercurrent chromatography using sulfobutyl ether-β-cyclodextrin as chiral selector.

J Sep Sci 2021 Feb 18;44(4):922-930. Epub 2021 Jan 18.

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.

Ondansetron, a highly selective 5-hydroxytryptamine 3 receptor antagonist, was successfully enantioseparated by recycling countercurrent chromatography using sulfobutyl ether-β-cyclodextrin as chiral selector. Important factors for the enantioseparation were optimized, including different organic solvent, type of substituted β-cyclodextrin, pH of aqueous phase, concentration of chiral selector, and separation temperature. A biphasic solvent system composed of n-hexane: n-butyl acetate: 0. Read More

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February 2021

Selective, rapid and simultaneous determination of ergosterol and ergocalciferol in mushrooms by UPLC-Q-TOF-MS.

J Pharm Biomed Anal 2021 Feb 6;194:113748. Epub 2020 Nov 6.

Department of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, c/Prof. García González, s/n. 41012, Seville, Spain.

An ultra-performance liquid chromatography coupled to atmospheric pressure chemical ionization-quadrupole time-of-flight mass spectrometry method has been optimized and validated for the determination of ergosterol and ergocalciferol in mushroom samples, using cholecalciferol as surrogate standard. The separation was carried out with a Synergi Hydro-RP column (100 mm x 3.00 mm i. Read More

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February 2021

and computational studies of the antioxidant and anti-diabetic properties of .

J Biomol Struct Dyn 2020 Dec 4:1-15. Epub 2020 Dec 4.

Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa.

The leaves, stem and root bark of were sequentially extracted with solvents of increasing polarity to yield the hexane, ethyl acetate, ethanol and aqueous extracts. analysis revealed the ability of the extracts to scavenge 1,1-diphenyl-2-picryl-hydrazyl (DPPH), nitric oxide (NO) and hydroxyl radical. They also inhibited the activities of -glucosidase, -amylase and lipase enzymes. Read More

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December 2020