640 results match your criteria approach sarcopenia

[Diagnostic and therapeutic approach to sarcopenia].

Z Gerontol Geriatr 2021 Sep 20. Epub 2021 Sep 20.

Medizinische Klinik IV, Schwerpunkt Geriatrie, LMU Klinikum München, Ziemssenstr. 1, 80336, München, Deutschland.

Sarcopenia describes a generalized loss of muscle power, mass and function. It is marked by an impaired quality of life and an increased mortality rate. The SARC‑F questionnaire was developed as a screening tool to identify patients at risk of impairment in primary care. Read More

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September 2021

Musculoskeletal Changes Across the Lifespan: Nutrition and the Life-Course Approach to Prevention.

Front Med (Lausanne) 2021 31;8:697954. Epub 2021 Aug 31.

Department of Clinical and Community Sciences, University of Milan, Milan, Italy.

Aging is characterized by the progressive decline of muscle mass and function, the so-called sarcopenia. Also bone loss is widespread among older people. Sarcopenia and osteopenia/osteoporosis are associated with several adverse outcomes including falls, risk of fractures, functional decline, frailty, and mortality. Read More

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Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.

J Cachexia Sarcopenia Muscle 2021 Sep 15. Epub 2021 Sep 15.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass index (BMI) and lung function. We tested the hypothesis genetic variation is associated with weight loss in COPD using a genome-wide association study approach. Read More

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September 2021

Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration.

Bone Res 2021 Sep 10;9(1):41. Epub 2021 Sep 10.

Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA.

Emerging insights into cellular senescence highlight the relevance of senescence in musculoskeletal disorders, which represent the leading global cause of disability. Cellular senescence was initially described by Hayflick et al. in 1961 as an irreversible nondividing state in in vitro cell culture studies. Read More

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September 2021

Cognitive Function, Sarcopenia, and Inflammation are strongly associated with Frailty: a Framingham cohort study.

Am J Med 2021 Aug 28. Epub 2021 Aug 28.

Division of Gastroenterology and Hepatology, University of Michigan. Electronic address:

Background: Frailty is an important contributor to morbidity and mortality in chronic liver disease. Understanding the contributors to frailty has the potential to identify individuals at risk for frailty and may potentially provide targets for frailty-modifying interventions. We evaluated the relationship between cognitive function, inflammation, and sarcopenia and frailty. Read More

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Nomogram for Predicting Bone Development State of Female Children and Adolescents-A Fast Screening Approach Based on Pubes Stages for Growth and Development.

Front Pediatr 2021 12;9:694958. Epub 2021 Aug 12.

Department of Physical Education, Shanghai University of Medicine and Health Sciences, Shanghai, China.

To develop a nomogram for predicting bone development state (BDS) of female children and adolescents in a large scale. Four hundred forty-seven female students were designated as the training cohort to develop the predictive model, whereas 196 female students were used as the validation cohort to verify the established model. Bone age, height, body mass, body fat percentage, and secondary sexual characteristics were recorded, and BDS was determined with the chronological age and bone age. Read More

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Low urine pH is a risk factor for low muscle mass: A new way to predict sarcopenia.

Geriatr Gerontol Int 2021 Aug 28. Epub 2021 Aug 28.

Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan.

Aims: Sarcopenia, one of the primary diseases of the older adult population, is a condition characterized by loss of skeletal muscle mass, strength and functionality. Due to its considerable economic impact, preventive interventions for sarcopenia play an important role in the older adult population. Urine includes many indicators of physiology and pathophysiology. Read More

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Diagnostic criteria for cancer cachexia: reduced food intake and inflammation predict weight loss and survival in an international, multi-cohort analysis.

J Cachexia Sarcopenia Muscle 2021 Aug 27. Epub 2021 Aug 27.

Clinical Nutrition and Gastroenterology Unit, Institut de recherche en Cancérologie de Montpellier (IRCM) Inserm U1194, Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.

Background: Cancer-associated weight loss (WL) associates with increased mortality. International consensus suggests that WL is driven by a variable combination of reduced food intake and/or altered metabolism, the latter often represented by the inflammatory biomarker C-reactive protein (CRP). We aggregated data from Canadian and European research studies to evaluate the associations of reduced food intake and CRP with cancer-associated WL (primary endpoint) and overall survival (OS, secondary endpoint). Read More

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Muscular abnormalities in liver cirrhosis.

Andrej Hari

World J Gastroenterol 2021 Aug;27(29):4862-4878

Department of Gastroenterology and Hepatology, General Hospital Celje, Celje 3000, Savinjska, Slovenia.

Sarcopenia is becoming a well-established player in evaluating patients with chronic liver disease. Data regarding its clinical significance and consequences in the course of liver disease have been growing; many of the data support the idea that it impacts decompensation event frequency, prolonged hospitalization, and mortality, as well as providing the possibility to better prioritize patients on lists awaiting liver transplantation. When assessing the whole clinical scope of the field, which includes malnutrition and frailty, as well as the complete spectrum of muscle mass, strength, and function, it becomes clear that a well-founded approach in everyday clinical practice is essential. Read More

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Nutritional Supplements and Neuroprotective Diets and Their Potential Clinical Significance in Post-Stroke Rehabilitation.

Nutrients 2021 Aug 5;13(8). Epub 2021 Aug 5.

Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 93-113 Lodz, Poland.

Nutrition and rehabilitation are crucial in post-stroke recovery, especially in the elderly. Since stroke is the leading cause of long-term disability, there is a need to promote special, individually tailored nutrition strategies targeting older patients with low motor ability. Chronic stroke survivors have higher risk of developing nutrition-related chronic diseases, such as sarcopenia, anemia, type 2 diabetes mellitus and osteoporosis. Read More

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The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

Lancet Respir Med 2021 Aug 17. Epub 2021 Aug 17.

Population Health Science Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle, UK. Electronic address:

Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. Read More

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Approach to Obesity in the Older Population.

J Clin Endocrinol Metab 2021 Aug;106(9):2788-2805

The Sagol Center for Epigenetics of Aging and Metabolism, Tel Aviv-Sourasky Medical Center, Tel Aviv 6423906, Israel.

Until recently, weight loss in older obese people was feared because of ensuing muscle loss and frailty. Facing overall increasing longevity, high rates of obesity in older individuals (age ≥ 65 years) and a growing recognition of the health and functional cost of the number of obesity years, abetted by evidence that intentional weight loss in older obese people is safe, this approach is gradually, but not unanimously, being replaced by more active principles. Lifestyle interventions that include reduced but sufficient energy intake, age-adequate protein and micronutrient intake, coupled with aerobic and resistance exercise tailored to personal limitations, can induce weight loss with improvement in frailty indices. Read More

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Acute sarcopenia changes following hospitalization: influence of pre-admission care dependency level.

Age Ageing 2021 Aug 9. Epub 2021 Aug 9.

Department of Geriatrics, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent, Belgium.

Introduction: Hospitalization is associated with acute changes in sarcopenia status in older people, but the influencing factors are not fully understood. Pre-admission care dependency level as a risk factor has not yet been investigated.

Objective: Evaluate if pre-admission care dependency level is an independent predictor of sarcopenia changes following hospitalization. Read More

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Weight Loss Strategies and the Risk of Skeletal Muscle Mass Loss.

Nutrients 2021 Jul 20;13(7). Epub 2021 Jul 20.

Faculty of Medicine, University of Freiburg, 79117 Freiburg, Germany.

With energy intake restriction and exercise remaining the key diet and lifestyle approaches to weight loss, this is not without potential negative implications for body composition, metabolic health, and quality and quantity of life. Ideally, weight loss should be derived almost exclusively from the fat mass compartment as this is the main driver of metabolic disease, however, several studies have shown that there is an accompanying loss of tissue from the fat-free compartment, especially skeletal muscle. Population groups including post-menopausal women, the elderly, those with metabolic disease and athletes may be particularly at risk of skeletal muscle loss when following a weight management programme. Read More

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A Sarcopenia Detection System Using an RGB-D Camera and an Ultrasound Probe: Eye-in-Hand Approach.

Biosensors (Basel) 2021 Jul 16;11(7). Epub 2021 Jul 16.

Department of Biomedical Engineering, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Skeletal muscle mass deficiency and quality degradation constitute sarcopenia for elderly people. Sarcopenia can result in musculoskeletal damage and accompany various metabolic problems, which make early sarcopenia diagnosis important. Various modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), have been developed for screening sarcopenia. Read More

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Sarcopenia in patients following stroke: an overlooked problem.

Int J Rehabil Res 2021 Sep;44(3):269-275

Division of Geriatrics, Department of Internal Medicine.

Our aim was to investigate the prevalence of sarcopenia in stroke patients, the relationship between sarcopenia detected with different low muscle mass (LMM) adjustment methods, and between stroke-related parameters. Eighty-one patients with chronic stroke who underwent inpatient rehabilitation were included. Spasticity was evaluated by modified Ashworth scale, Brunnstrom staging approach was used for motor function evaluation, physical independence was evaluated using Barthel Index, quality-of-life was evaluated by EQ-5D-3L, and the Cumulative Illness Rating Scale was used to measure multimorbidity. Read More

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September 2021

Changes in Body Composition, Muscle Strength, and Fat Distribution Following Kidney Transplantation.

Am J Kidney Dis 2021 Aug 2. Epub 2021 Aug 2.

Department of Medicine, Stanford University School of Medicine, Stanford, CA; Departments of Pediatrics, Stanford University School of Medicine, Stanford, CA.

Rationale And Objective: Low muscle mass relative to fat mass (relative sarcopenia) has been associated with mortality and disability but has not been examined following transplantation. We studied how measures of body composition change after receipt of a kidney allograft.

Study Design: Prospective longitudinal cohort study. Read More

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Vitamin D supplementation and risk of falling: outcomes from the randomized, placebo-controlled D-Health Trial.

J Cachexia Sarcopenia Muscle 2021 Aug 1. Epub 2021 Aug 1.

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Background: Falls cause considerable morbidity and mortality in older people. It is unclear how vitamin D supplementation affects falls risk, particularly when taken at high doses. We sought to determine whether monthly high-dose vitamin D supplementation reduces risk and incidence of falls. Read More

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Post-COVID-19 acute sarcopenia: physiopathology and management.

Aging Clin Exp Res 2021 Jul 30. Epub 2021 Jul 30.

Department of Internal Medicine, Geriatrics Section, University of Palermo, Palermo, Italy.

In this review, we discuss the pathophysiologic and management aspects of acute sarcopenia in relation to SARS-CoV-2 infection. COVID-19 is as a multi-organ infectious disease characterized by a severe inflammatory and highly catabolic status, influencing the deep changes in the body build, especially the amount, structure, and function of skeletal muscles which would amount to acutely developed sarcopenia. Acute sarcopenia may largely impact patients' in-hospital prognosis as well as the vulnerability to the post-COVID-19 functional and physical deterioration. Read More

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Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor.

Endocrinol Metab (Seoul) 2021 Aug 30;36(4):865-874. Epub 2021 Jul 30.

Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Despite clinical evidence indicating poor muscle health in subjects with primary aldosteronism (PA), it is still unclear whether the role of aldosterone in muscle metabolism is direct or mediated indirectly via factors, such as electrolyte imbalance or impaired glucose uptake. As one approach to clarify this issue, we investigated the effect of aldosterone on in vitro myogenesis and the potential mechanism explaining it.

Methods: Myogenesis was induced in mouse C2C12 myoblasts with 2% horse serum. Read More

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Optimising protein intake in older people to maintain their musculo- skeletal health.

Nurs Stand 2021 Jul 26. Epub 2021 Jul 26.

Life Sciences Department, University of Roehampton, London, England.

The concept of healthy ageing has become a significant aspect of the public health approach to older people's well-being. Physiological changes that occur with ageing, such as a lack of mobility and sarcopenia (an age-related decline in muscle mass and strength), have the potential to negatively affect older people's quality of life and musculoskeletal health, often contributing to falls and fractures. Protein intake is a crucial element in maintaining optimal health in older people, and is important in delaying sarcopenia. Read More

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Binge-eating disorder is associated with an unfavorable body mass composition in patients with non-alcoholic fatty liver disease.

Int J Eat Disord 2021 Jul 17. Epub 2021 Jul 17.

Section of Endocrinology and Metabolic Medicine, St Mary's Hospital, Imperial College NHS Trust, London, UK.

The interaction between eating disorders and non-alcoholic fatty liver disease (NAFLD) remains unexplored, especially with regards to binge-eating disorder (BED). Our team conducted a service evaluation project in order to assess risk factors for the presence of BED among patients with NAFLD and the impact of BED on body mass composition. The overall prevalence of patients screening positive to BED Screener-7 (BEDS-7) was 28. Read More

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Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice.

J Physiol 2021 Sep 4;599(17):4045-4063. Epub 2021 Aug 4.

Département des sciences de l'activité physique, Faculté des Sciences, UQAM, Québec, Canada.

Key Points: The maintenance of mitochondrial integrity is critical for skeletal muscle health. Mitochondrial dynamics play key roles in mitochondrial quality control; however, the exact role that mitochondrial fission plays in the muscle ageing process remains unclear. Here we report that both Drp1 knockdown and Drp1 overexpression late in life in mice is detrimental to skeletal muscle function and mitochondrial health. Read More

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September 2021

Artificial intelligence to assess body composition on routine abdominal CT scans and predict mortality in pancreatic cancer- A recipe for your local application.

Eur J Radiol 2021 Sep 24;142:109834. Epub 2021 Jun 24.

MIT Computer Science & Artificial Intelligence Laboratory, 32 Vassar St, Cambridge, MA 02139, United States; Center for Evidence Based Imaging, Department of Radiology, Brigham and Women's Hospital, 20 Kent Street, Brookline, MA 02445, United States. Electronic address:

Background: Body composition is associated with mortality; however its routine assessment is too time-consuming.

Purpose: To demonstrate the value of artificial intelligence (AI) to extract body composition measures from routine studies, we aimed to develop a fully automated AI approach to measure fat and muscles masses, to validate its clinical discriminatory value, and to provide the code, training data and workflow solutions to facilitate its integration into local practice.

Methods: We developed a neural network that quantified the tissue components at the L3 vertebral body level using data from the Liver Tumor Challenge (LiTS) and a pancreatic cancer cohort. Read More

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September 2021

Low-dose MDCT: evaluation of the impact of systematic tube current reduction and sparse sampling on quantitative paraspinal muscle assessment.

Quant Imaging Med Surg 2021 Jul;11(7):3042-3050

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Wasting disease entities like cachexia or sarcopenia are associated with a decreasing muscle mass and changing muscle composition. For valid and reliable disease detection and monitoring diagnostic techniques offering quantitative musculature assessment are needed. Multi-detector computed tomography (MDCT) is a broadly available imaging modality allowing for muscle composition analysis. Read More

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Molecular and Neural Mechanism of Dysphagia Due to Cancer.

Int J Mol Sci 2021 Jun 29;22(13). Epub 2021 Jun 29.

Department of Rehabilitation Medicine, Toho University Graduate School of Medicine, Tokyo 143-8541, Japan.

Cancer is one of the most common causes of death worldwide. Along with the advances in diagnostic technology achieved through industry-academia partnerships, the survival rate of cancer patients has improved dramatically through treatments that include surgery, radiation therapy, and pharmacotherapy. This has increased the population of cancer "survivors" and made cancer survivorship an important part of life for patients. Read More

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Uremic Toxins and Frailty in Patients with Chronic Kidney Disease: A Molecular Insight.

Int J Mol Sci 2021 Jun 10;22(12). Epub 2021 Jun 10.

Nephrology Division, Department of Internal Medicine, National Defense Medical Center, Taipei 11490, Taiwan.

The accumulation of uremic toxins (UTs) is a prototypical manifestation of uremic milieu that follows renal function decline (chronic kidney disease, CKD). Frailty as a potential outcome-relevant indicator is also prevalent in CKD. The intertwined relationship between uremic toxins, including small/large solutes (phosphate, asymmetric dimethylarginine) and protein-bound ones like indoxyl sulfate (IS) and -cresyl sulfate (pCS), and frailty pathogenesis has been documented recently. Read More

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Utilisation of Post-Activation Performance Enhancement in Elderly Adults.

J Clin Med 2021 Jun 4;10(11). Epub 2021 Jun 4.

Institute of Sport Sciences, Jerzy Kukuczka Academy of Physical Education in Katowice, 40-065 Katowice, Poland.

With age, many physiological changes occur in the human body, leading to a decline in biological functions, and those related to the locomotor system are some of the most visible. Hence, there is a particular need to provide simple and safe exercises for the comprehensive development of physical fitness among elderly adults. The latest recommendations for the elderly suggest that the main goal of training should be to increase muscle power. Read More

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What you need to know about falls.

Br J Hosp Med (Lond) 2021 Jun 22;82(6):1-8. Epub 2021 Jun 22.

Department of Ageing and Health, Guy's and St Thomas NHS Foundation Trust, London, UK.

Falls are a common presenting complaint, particularly in older patients, and are associated with significant morbidity. Inpatient falls also have financial implications for healthcare systems, including litigation costs. This article provides an approach to assessing a patient presenting with a fall, encompassing the cause and consequence of the event. Read More

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Pathophysiology and mechanisms of primary sarcopenia (Review).

Int J Mol Med 2021 Aug 29;48(2). Epub 2021 Jun 29.

The Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569‑8686, Japan.

Aging causes skeletal muscle atrophy, and myofiber loss can be a critical component of this process. In 1989, Rosenberg emphasized the importance of the loss of skeletal muscle mass that occurs with aging and coined the term 'sarcopenia'. Since then, sarcopenia has attracted considerable attention due to the aging population in developed countries. Read More

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