76,330 results match your criteria approach mortality


Diagnostic approach to sleep disordered-breathing among patients with grade III obesity.

Sleep Med 2021 Mar 29;82:18-22. Epub 2021 Mar 29.

AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Service de Pathologies Du Sommeil (Département R3S), F-75013 Paris, France; Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.

Sleep apnea test (SAT) is a cost-effective approach to evaluate subjects without associated comorbidities suspected for obstructive sleep apnea (OSA), a disorder particularly common in obese subjects. The association of obesity with awake hypercapnia (carbon dioxide arterial pressure, PaCO ≥45 mmHg) defines the obesity-hypoventilation syndrome (OHS), which in turn results in increased morbidity and mortality compared to simple OSA. Isolated hypoventilation during sleep in obese patients (obesity-related sleep hypoventilation, ORSH) is now considered as an early stage of OHS. Read More

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Convalescent plasma therapy in COVID-19 critically ill patients during advanced phases of clinical trials and their preliminary results.

Einstein (Sao Paulo) 2021 19;19:eRW6186. Epub 2021 Apr 19.

Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

The objective of this study was to highlight the global scientific effort to fight the SARS-CoV-2, addressing the preliminary results of passive immunization through convalescent plasma. We performed a search at the major databases of interventional clinical trial protocols about the transfusion of convalescent plasma in patients with COVID-19, as well as, published articles (n≥25), using the following search strategy: [(COVID-19 OR SARS-CoV-2 OR nCoV-2019) AND (Convalescent plasma OR Plasma exchange) AND (Treatment OR Therapy)]. A total of 24 interventional clinical trial protocols (advanced in phases II-III, III, and IV) were included in this review, as well as three studies that had enough outcomes to evaluate the efficacy of convalescent plasma therapy for patients with COVID-19. Read More

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Clinical utility of hepatitis C virus core antigen (HCVcAg) assay to identify active HCV infection in hemodialysis and renal transplant patients.

PLoS One 2021 22;16(4):e0250263. Epub 2021 Apr 22.

Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, India.

Background: The prevalence of HCV infection is high and it is a major cause of liver-related morbidity and mortality in hemodialysis and renal transplant patients. Diagnosis of hepatitis C virus (HCV) infection requires both HCV antibody screening and confirmatory nucleic acid testing (NAT). Hepatitis C virus core antigen (HCVcAg) is a reliable direct viral marker to identify active HCV infection. Read More

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Forecasting ocean acidification impacts on kelp forest ecosystems.

PLoS One 2021 22;16(4):e0236218. Epub 2021 Apr 22.

Institute of the Environment and Sustainability, University of California Los Angeles, Los Angeles, California, United States of America.

Ocean acidification is one the biggest threats to marine ecosystems worldwide, but its ecosystem wide responses are still poorly understood. This study integrates field and experimental data into a mass balance food web model of a temperate coastal ecosystem to determine the impacts of specific OA forcing mechanisms as well as how they interact with one another. Specifically, we forced a food web model of a kelp forest ecosystem near its southern distribution limit in the California large marine ecosystem to a 0. Read More

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Prognostic value of myocardial perfusion scintigraphy in asymptomatic patients with diabetes mellitus at high cardiovascular risk: 5-year follow-up of the prospective multicenter BARDOT trial.

Eur J Nucl Med Mol Imaging 2021 Apr 21. Epub 2021 Apr 21.

Cardiovascular Research Institute Basel, Basel, Switzerland.

Background: The Basel Asymptomatic High-Risk Diabetics' Outcome Trial (BARDOT) demonstrated that asymptomatic diabetic patients with an abnormal myocardial perfusion scintigraphy (MPS) were at increased risk of major adverse cardiovascular events (MACEs) at 2-year follow-up. It remains unclear whether this finding holds true even for a longer follow-up.

Methods: Four hundred patients with type 2 diabetes, neither history nor symptoms of coronary artery disease (CAD), were evaluated clinically and with MPS. Read More

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Therapeutic Implications of NLRP3-Mediated Inflammation in Coronary Artery Disease.

Cardiol Rev 2021 Mar 2. Epub 2021 Mar 2.

From the Departments of Medicine at Temple University Hospital, Philadelphia, PA New York Medical College/Westchester Medical Center, Valhalla, NY 10595.

Atherosclerosis is considered a chronic, inflammatory disease responsible for more than 15% of all global deaths, secondary to its complications of myocardial infarction, vascular disease, and stroke. Current treatment regimens consist of lipid-lowering pharmaceuticals, control of risk factors, and prevention of plaque rupture and thrombosis with anti-platelet agents. However, a significant burden on society remains due to the morbidity and mortality of coronary artery disease (CAD) despite our best practices. Read More

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Catalytic Support for Improving Clinical Care in Special Newborn Care Units (SNCU) Through Composite SNCU Quality of Care Index (SQCI).

Indian Pediatr 2021 Apr;58(4):338-344

Ministry of Health and Family Welfare, Government of India; New Delhi, India.

Objective: To develop a composite index that serves as a proxy marker of quality of clinical service and pilot test its use in 11 special neonatal care units (SNCUs) across two states in India.

Design: Secondary data from SNCU webportal.

Setting: Special new-born care units in Rajasthan and Orissa. Read More

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Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents.

Sci Transl Med 2021 Apr;13(590)

Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, M5G 0A4, Canada.

Fetal lung underdevelopment, also known as pulmonary hypoplasia, is characterized by decreased lung growth and maturation. The most common birth defect found in babies with pulmonary hypoplasia is congenital diaphragmatic hernia (CDH). Despite research and clinical advances, babies with CDH still have high morbidity and mortality rates, which are directly related to the severity of lung underdevelopment. Read More

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Promoting physical health among people with enduring mental illness: a qualitative study of healthcare providers' perspectives.

BMJ Open 2021 Apr 21;11(4):e044855. Epub 2021 Apr 21.

Research Centre, Irish College of General Practitioners, Dublin, Ireland.

Background: People with enduring mental illness (EMI) have higher morbidity and mortality from chronic diseases than the general population, and this results in a significantly reduced relative life expectancy-accounted for primarily by physical illness. This gap may be partly influenced by the reduced likelihood of access to and uptake of regular physical health screening.

Aim: To establish Irish service providers' perspectives regarding the care of the physical health of people with EMI in an effort to inform future service developments aimed at improving the physical health of people with EMI. Read More

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Thematic research clusters in very old populations (≥ 80 years): a bibliometric approach.

BMC Geriatr 2021 04 21;21(1):266. Epub 2021 Apr 21.

Department of Internal Medicine, General University Hospital of Alicante-ISABIAL, Alicante, Spain.

Background: Population aging will be one of humanity's major challenges in the decades to come. In addition to focusing on the pathologies causing the greatest mortality and morbidity in this population, such as dementia, health research in elderly people must consider a myriad of other interlinked factors, such as geriatric syndromes, social aspects, and factors related to preserving quality of life and promoting healthy aging. This study aims to identify the main subject areas attracting research attention with regard to very old (≥ 80 years) populations. Read More

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A Comparison of Contemporary Clinical Outcomes Following Femoro-Popliteal Plain Balloon Angioplasty and Bypass Surgery for Chronic Limb Threatening Ischemia.

Vasc Endovascular Surg 2021 Apr 22:15385744211004656. Epub 2021 Apr 22.

Department of Vascular Surgery, University Hospitals Birmingham NHS Foundation Trust, University of Birmingham, Birmingham, England.

Introduction: Despite the BASIL-1 trial concluding that bypass surgery (BS) was superior to plain balloon angioplasty (PBA) in terms of longer-term amputation free (AFS) and overall survival (OS), CLTI patients are increasingly offered an endovascular-first revascularization strategy. This study investigates whether the results of BASIL-1 are still relevant to current practice by comparing femoro-popliteal (FP) BS with PBA in a series of CLTI patients treated in our unit 10 years after BASIL-1 (1999-2004).

Methods: We retrospectively analyzed prospectively gathered hospital data pertaining to 279 patients undergoing primary FP BS or PBA for CLTI in the period 2009 to 2014. Read More

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Wnt/β-catenin Antagonists: Exploring New Avenues to Trigger Old Drugs in Alleviating Glioblastoma Multiforme.

Curr Mol Pharmacol 2021 Apr 19. Epub 2021 Apr 19.

Central Inter-Disciplinary Research Facility, School of Biological Sciences, Sri Balaji Vidyapeeth (Deemed to-be University), Puducherry, India.

Background: Glioblastoma multiforme is one of the most heterogenous primary brain tumor with high mortality. Nevertheless, of the current therapeutic approaches, survival rate remains poor with 12 to 15 months following preliminary diagnosis, this warrants the need for effective treatment modality. Wnt/β-catenin pathway is presumably the most noteworthy pathway up-regulated in almost 80% GBM cases contributing to tumor-initiation, progression and survival. Read More

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The Role of Relaparoscopy in the Management of Early Bariatric Surgery Complications and 30-Day Outcome: a Tertiary Centre Experience.

Obes Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of Surgery, Luton and Dunstable University Hospital, Luton, UK.

The laparoscopic approach for dealing with bariatric complications has become the gold standard of modern practice. The aim of this study is to assess the role of relaparoscopy as a diagnostic and therapeutic approach towards managing complications and improving 30-day outcome.

Materials And Methods: A retrospective review of a prospectively maintained database was conducted in a tertiary bariatric unit. Read More

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Barriers and facilitators in the implementation of bio-psychosocial care at the primary healthcare level in South Kivu, Democratic Republic of Congo.

Afr J Prim Health Care Fam Med 2021 Apr 20;13(1):e1-e10. Epub 2021 Apr 20.

École Régionale de Santé Publique (ERSP), Faculté de Médecine, Université Catholique de Bukavu, Bukavu, The Democratic Republic of Congo; and, Institute of Health and Society (IRSS), Ecole de Santé Publique, Université Catholique de Louvain, Brussels.

Background: In the Democratic Republic of Congo (DRC), healthcare services are still focused on disease control and mortality reduction in specific groups. The need to broaden the scope from biomedical criteria to bio-psychosocial (BPS) dimensions has been increasingly recognized.

Aim: The objective of this study was to identify the barriers and facilitators to providing healthcare at the health centre (HC) level to enable BPS care. Read More

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Transvaginal Evisceration of the Small Bowel More Than 15 Years After Abdominal Hysterectomy and Vaginal Surgery.

Cureus 2021 Mar 17;13(3):e13955. Epub 2021 Mar 17.

Obstetrics and Gynaecology, Russells Hall Hospital, The Dudley Group NHS Foundation Trust, Dudley, GBR.

Transvaginal evisceration of the intra-abdominal organs is a rare emergency event. In this paper, we discuss the case of a 97-year-old female who presented to the emergency department due to abdominal pain and a large prolapse with visible extrusion of the small bowel per vagina. Past surgical history was significant for a total abdominal hysterectomy and surgical repair for pelvic organ prolapse; both performed more than 15 years prior to the patient's current presentation. Read More

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Solitary late spinal metastasis from apocrine salivary duct carcinoma: Case report.

Surg Neurol Int 2021 30;12:122. Epub 2021 Mar 30.

Department of Neuroscience, Neurosurgery Unit, Città Della Scienza e Della Salute, Italy.

Background: The salivary duct carcinomas (SDCs) are rare, high-grade neoplasms involving major salivary glands. Parotid is the most frequently involved gland (85%). Apocrine phenotype (histological presence of decapitation secretions) and androgen reception expression define SDC. Read More

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Impact of Body Mass Index and Initial Respiratory Support on Pediatric Subjects in Acute Respiratory Failure.

Respir Care 2021 Apr 20. Epub 2021 Apr 20.

Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

Background: It is unknown how the initial choice of respiratory support by pediatric ICU providers contributes to outcomes of nonintubated obese children with respiratory failure. We hypothesized that body mass index and the type of initial respiratory support applied are associated with poor clinical outcomes in patients who carry respiratory failure-associated diagnoses.

Methods: This is a retrospective analysis of de-identified patient data obtained from the Virtual PICU System database (2009-2018). Read More

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Cardiovascular risk factors and autonomic indices in relation to fatal and non-fatal coronary events.

Open Heart 2021 Apr;8(1)

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Objective: Mortality caused by coronary artery disease has markedly decreased in recent years. However, a substantial proportion of patients suffering a coronary event (CE) die within the first day, most of them out of hospital. We aimed to investigate how established cardiovascular (CV) risk factors and CV autonomic indices associate with fatal versus non-fatal CEs in the population. Read More

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Consensus on thromboprophylaxis in gynecological surgery

Rev Colomb Obstet Ginecol 2021 03 30;72(1):53-68. Epub 2021 Mar 30.

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Objective: To draw a synthesis of the available evidence regarding interventions for the prevention of venous thromboembolic events during the perioperative care of women with benign gynecological pathology, with the aim of reducing the associated morbidity and mortality. Materials and methods: The development group included healthcare professionals, decision-makers and one patient representative. All the participants stated their disclosures. Read More

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Fibrinolysis in Acute and Chronic Cardiovascular Disease.

Semin Thromb Hemost 2021 Apr 20. Epub 2021 Apr 20.

Department of Metabolic Medicine, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom.

The formation of an obstructive thrombus within an artery remains a major cause of mortality and morbidity worldwide. Despite effective inhibition of platelet function by modern antiplatelet therapies, these agents fail to fully eliminate atherothrombotic risk. This may well be related to extensive vascular disease, beyond the protective abilities of the treatment agents used. Read More

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Preventing sepsis; how can artificial intelligence inform the clinical decision-making process? A systematic review.

Int J Med Inform 2021 Apr 10;150:104457. Epub 2021 Apr 10.

School of Pharmacy, Newcastle University, King George VI Building, Newcastle upon Tyne, NE1 7RU, UK. Electronic address:

Background And Objectives: Sepsis is a life-threatening condition that is associated with increased mortality. Artificial intelligence tools can inform clinical decision making by flagging patients at risk of developing infection and subsequent sepsis. This systematic review aims to identify the optimal set of predictors used to train machine learning algorithms to predict the likelihood of an infection and subsequent sepsis. Read More

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CUDC-101 enhances the chemosensitivity of gemcitabine-treated lymphoma cells.

Leuk Res 2021 Mar 31;106:106575. Epub 2021 Mar 31.

Department of Hematology, Yanbian University Hospital, Jilin, Yanji, 133000, China; Research center of Yanbian University Hospital, Jilin, Yanji, 133000, China. Electronic address:

Background: The metastasis and recurrence of Non-Hodgkin's lymphoma (NHL) is a major cause of morbidity and mortality. Recent work suggests that drugs capable of targeting epigenetic regulatory mechanisms may be well suited to the treatment of such disease progression.

Methods: This study was thus designed to evaluate the ability of the novel histone deacetylase (HDAC) inhibitor CUDC-101 to synergize with gemcitabine in order to kill human HUT78 and Pfeiffer NHL cells. Read More

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5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.

Aging (Albany NY) 2021 Apr 20;13. Epub 2021 Apr 20.

Department of Neurosurgery, Chongqing Emergency Center, Chongqing University Center Hospital, School of medicine, Chongqing University, Chongqing, China.

Early brain injury (EBI) is a major contributor to the high mortality and morbidity after subarachnoid hemorrhage (SAH). Inflammatory responses and neuronal apoptosis are important causes of EBI. Because 5- lipoxygenase (5-LOX) is known to be involved various central nervous system diseases, we investigated the effects of 5-LOX inhibition during EBI after SAH. Read More

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Primary percutaneous coronary intervention in patients aged 85 years or older: a retrospective analysis of outcomes.

J R Coll Physicians Edinb 2021 Mar;51(1):13-18

Department of Cardiology, University Hospital Monklands, Airdrie, UK.

Background: Primary percutaneous coronary intervention (PPCI) is the first-line treatment for acute ST-elevation myocardial infarction (STEMI). Evidence of benefit from PPCI in the elderly is sparse. Our aim was to evaluate survival outcomes in patients aged ≥85 years who undergo PPCI for STEMI. Read More

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Long-term Outcome of Microscopic Transsphenoidal Surgery for Prolactinomas as an Alternative to Dopamine Agonists.

J Korean Med Sci 2021 Apr 19;36(15):e97. Epub 2021 Apr 19.

Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.

Background: Although long-term dopamine agonist (DA) therapy is recommended as a first-line treatment for prolactinoma, some patients may prefer surgical treatment because of the potential adverse effects of long-term medication, or the desire to become pregnant. This study aimed to determine whether surgical treatment of prolactinomas could be an alternative to DA therapy.

Methods: In this retrospective study, 96 consecutive patients (74 female, 22 male) underwent primary pituitary surgery without long-term DA treatment for prolactinomas at a single institution from 1990 to 2010. Read More

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Update on Pediatric Tracheostomy: Indications, Technique, Education, and Decannulation.

Curr Otorhinolaryngol Rep 2021 Apr 15:1-12. Epub 2021 Apr 15.

Department of Otolaryngology, Head and Neck Surgery, University of Arkansas for Medical Sciences, 1 Children's Way, Little Rock, AR 72202 USA.

Purpose Of Review: Tracheostomy in a child demands critical pre-operative evaluation, deliberate family education, competent surgical technique, and multidisciplinary post-operative care. The goals of pediatric tracheostomy are to establish a safe airway, optimize ventilation, and expedite discharge. Herein we provide an update regarding timing, surgical technique, complications, and decannulation, focusing on a longitudinal approach to pediatric tracheostomy care. Read More

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Transplant-associated thrombotic microangiopathy: theoretical considerations and a practical approach to an unrefined diagnosis.

Bone Marrow Transplant 2021 Apr 19. Epub 2021 Apr 19.

Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.

Transplant-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized complication of hematopoietic stem cell transplant (HSCT) with high morbidity and mortality. The triad of endothelial cell activation, complement dysregulation, and microvascular hemolytic anemia has the potential to cause end organ dysfunction, multiple organ dysfunction syndrome and death, but clinical features mimic other disorders following HSCT, delaying diagnosis. Recent advances have implicated complement as a major contributor and the therapeutic potential of complement inhibition has been explored. Read More

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Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm.

Br J Gen Pract 2020 Dec 9. Epub 2020 Dec 9.

Division of Primary Care, University of Nottingham, Nottingham.

Background: Diagnosis of prostate cancer at an early stage can potentially identify tumours when intervention may improve treatment options and survival.

Aim: To develop and validate an equation to predict absolute risk of prostate cancer in asymptomatic men with prostate specific antigen (PSA) tests in primary care.

Design And Setting: Cohort study using data from English general practices, held in the QResearch database. Read More

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December 2020

Intentional internal drainage tube method for nonlocalized persistent pancreatic leakage: a case report.

BMC Surg 2021 Apr 19;21(1):198. Epub 2021 Apr 19.

Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, 2-1-1, Amakubo, Tsukuba-shi, 305-8575, Ibaraki, Japan.

Background: Persistent pancreatic leakage (PL) due to disconnected pancreatic duct syndrome (DPDS) is associated with severe morbidity and mortality and it usually treated with internal drainage. However, in cases without localized fistula formation, internal drainage is challenging to perform. We report an original one-stage surgical approach for nonlocalized persistent PL, namely, the "intentional internal drainage tube method". Read More

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