20,161 results match your criteria approach indicates


Physician's perspective regarding asthma guided self-management: directives or guidance?

J Asthma 2021 Apr 20:1-6. Epub 2021 Apr 20.

Clinical Research and Knowledge Transfer Unit on Childhood Asthma, Research Centre, CHU Sainte-Justine, Montreal, Quebec, Canada.

Introduction: Asthma guided self-management enhances patients' control of their condition under the guidance of the treating physician. The aim of the present study was to understand how physicians perceive, endorse, uptake, and support asthma guided self-management.

Methods: We conducted a secondary supplementary analysis of data originally collected as part of a multicenter collective case study in which physicians treating patients with asthma were interviewed. Read More

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Relationship between Hydrogen-Bonding Motifs and the 1b Splitting in the X-ray Emission Spectrum of Liquid Water.

J Phys Chem Lett 2021 Apr 20:3996-4002. Epub 2021 Apr 20.

San Diego Supercomputer Center, University of California, San Diego, La Jolla, California 92093, United States.

The split of the 1b peak observed in the X-ray emission (XE) spectrum of liquid water has been the focus of intense research. Although several hypotheses have been proposed to explain the origin of this split, a consensus has not yet been reached. Here, we introduce a novel theoretical/computation approach which, combining path-integral molecular dynamics simulations with the MB-pol model and time-dependent density functional theory calculations, predicts the 1b splitting in liquid water and not in crystalline ice, in agreement with the experimental observations. Read More

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Epidemiological Profile of Meningitis following Pentavalent Vaccination in Iran: Impact of Vaccine Introduction.

J Epidemiol Glob Health 2021 Apr 3. Epub 2021 Apr 3.

Center for Communicable Diseases Control, Ministry of Health & Medical Education, Tehran, Iran.

Ensuring the effectiveness of the (DTwP-Hib-HepB) vaccine in reducing meningitis is an essential approach in evaluating the effectiveness of the vaccine. The study aimed to address the epidemiology of meningitis following pentavalent vaccination in Iran. Data on meningitis patients from 21st March 2011 to 21st July 2018 were extracted from the National Notifiable Diseases Surveillance System. Read More

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Genomic and proteomic profiles of biofilms on microplastics are decoupled from artificial surface properties.

Environ Microbiol 2021 Apr 19. Epub 2021 Apr 19.

University of Greifswald, Institute of Pharmacy, Greifswald, Germany.

Microplastics in marine ecosystems are colonized by diverse prokaryotic and eukaryotic communities. How these communities and their functional profiles are shaped by the artificial surfaces remains broadly unknown. In order to close this knowledge gap, we set up an in situ experiment with pellets of the polyolefin polymer polyethylene (PE), the aromatic hydrocarbon polymer polystyrene (PS), and wooden beads along a coastal to estuarine gradient in the Baltic Sea, Germany. Read More

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Computational and infrared spectroscopic investigations of N-substituted carbazoles.

Phys Chem Chem Phys 2021 Apr 25;23(14):8426-8438. Epub 2021 Mar 25.

Natural Resources Canada, CanmetENERGY Devon, 1 Oil Patch Drive, Devon, Alberta T9G 1A8, Canada.

The carbazole moiety is a commonly identified structural motif in the high-molecular-weight components of petroleum, known as asphaltenes. Detailed characterization of carbazoles is important for understanding the structure of asphaltenes and addressing challenges in the areas of heavy oil recovery, transportation, upgrading, and oil spills, arising from asphaltene properties and composition. In this work we study carbazole and the four N-substituted carbazoles 9-methylcarbazole, 9-ethylcarbazole, 9-vinylcarbazole and 9-phenylcarbazole. Read More

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Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality.

Nat Commun 2021 Apr 19;12(1):2321. Epub 2021 Apr 19.

Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Bactericidal antibiotics kill bacteria by perturbing various cellular targets and processes. Disruption of the primary antibiotic-binding partner induces a cascade of molecular events, leading to overproduction of reactive metabolic by-products. It remains unclear, however, how these molecular events contribute to bacterial cell death. Read More

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DeepGRAI (Deep Gray Rating via Artificial Intelligence): Fast, feasible, and clinically relevant thalamic atrophy measurement on clinical quality T2-FLAIR MRI in multiple sclerosis.

Neuroimage Clin 2021 Mar 29;30:102652. Epub 2021 Mar 29.

Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Background: Thalamic volume loss is a key marker of neurodegeneration in multiple sclerosis (MS). T2-FLAIR MRI is a common denominator in clinical routine MS imaging, but current methods for thalamic volumetry are not applicable to it.

Objective: To develop and validate a robust algorithm to measure thalamic volume using clinical routine T2-FLAIR MRI. Read More

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Recyclable Luminescence Sensor for Dinotefuran in Water by Stable Cadmium-Organic Framework.

Anal Chem 2021 Apr 19. Epub 2021 Apr 19.

Department of Chemistry, Key Laboratory of Advanced Energy Material Chemistry, MOE, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.

Due to the widespread use of dinotefuran around the world, its impact on food and environmental safety has aroused great concern, and the establishment of a rapid and convenient approach for dinotefuran detection is necessary but challenging. Herein, we synthesized a unique three-dimensional framework {[(CH)NH][Cd(BCP)]·10HO·3.5DMF} (). Read More

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Videoconference fatigue? Exploring changes in fatigue after videoconference meetings during COVID-19.

J Appl Psychol 2021 Mar;106(3):330-344

Strome College of Business, Old Dominion University.

In response to the Coronavirus disease 2019 (COVID-19) global health pandemic, many employees transitioned to remote work, which included remote meetings. With this sudden shift, workers and the media began discussing videoconference fatigue, a potentially new phenomenon of feeling tired and exhausted attributed to a videoconference. In the present study, we examine the nature of videoconference fatigue, when this phenomenon occurs, and what videoconference characteristics are associated with fatigue using a mixed-methods approach. Read More

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Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer.

Curr Res Struct Biol 2020 30;2:116-129. Epub 2020 Jun 30.

Center for Advanced Biotechnology and Medicine, And Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, 08854, USA.

The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding aptamer contained 2'-O-methyl modifications and a seven base-pair GC-rich tract and the structure of the RT-aptamer complex revealed specific contacts between RT and the template strand of the aptamer. Similar to all crystal structures of RT bound to nucleic acid template-primers, the aptamer bound RT with a bend in the duplex DNA. Read More

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Attitudes Toward Asylum Policy in a Divided Europe: Diverging Contexts, Diverging Attitudes?

Front Sociol 2020 21;5:35. Epub 2020 May 21.

Department of Sociology, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, Netherlands.

The large inflow of asylum-seekers in recent years has heralded a diversification in adopted asylum policies across European societies. Although a growing body of research has addressed these versatile approaches and their implications for the European integration project, insight into the social basis of these restrictive or open asylum policies remains underdeveloped. Hence, the current study provides detailed insight into public preferences for asylum policies and offers a new understanding of how these attitudes are affected by diverging socio-economic realities across Europe. Read More

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Rights-Based Training Enhancing Engagement of Health Providers With Communities, Cape Metropole, South Africa.

Front Sociol 2019 30;4:35. Epub 2019 Apr 30.

Health and Human Rights Programme, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.

Community participation, the central principle of the primary health care approach, is widely accepted in the governance of health systems. Health Committees (HCs) are community-based structures that can enable communities to participate in the governance of primary health care. Previous research done in the Cape Town Metropole, South Africa, reports that HCs' potential can, however, be limited by a lack of local health providers' (HPs) understanding of HC roles and functions as well as lack of engagement with HCs. Read More

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Development and Evaluation of a Digital Health Intervention for Substance Use Reduction in Young Refugees With Problematic Use of Alcohol and/or Cannabis-Study Protocol for a Single-Armed Feasibility Trial.

Front Public Health 2021 31;9:557431. Epub 2021 Mar 31.

German Institute on Addiction and Prevention Research (DISuP), Catholic University of Applied Sciences of North Rhine-Westphalia, Cologne, Germany.

Refugee populations are at substantial risk of developing substance use disorder (SUD) and other mental health disorders. At the same time, refugee populations face numerous barriers to accessing mental health services. Digital interventions can address some of these issues, as emerging evidence indicates that digital interventions offer an effective, low-cost alternative with high accessibility and similar efficacy as standard SUD prevention programs. Read More

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General Characteristics of Microbubble-Adenovirus Vectors Carrying Genes.

Cell Mol Bioeng 2021 Apr 30;14(2):201-208. Epub 2020 Nov 30.

Department of Echocardiography, First Affiliated Hospital of Xinjiang Medical University, Urmuqi, 830011 China.

Introduction: Transferring genes safely, targeting cells and achieving efficient transfection are urgent problems in gene therapy that need to be solved. Combining microbubbles (MBs) and viruses to construct double vectors has become a promising approach for gene delivery. Understanding the characteristic performance of MBs that carry genes is key to promoting effective gene transfer. Read More

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Cultural Adaptation of Community Informant Tool for Detection of Maternal Depression in Rural Pakistan.

Front Psychiatry 2021 1;12:598857. Epub 2021 Apr 1.

Human Development Research Foundation, Islamabad, Pakistan.

Evidence indicates that mental health issues like depression, epilepsy, and substance misuse can be detected with reasonable accuracy in resource-poor settings. The Community Informant Detection Tool (CIDT) is one such approach used for detecting mental health problems, including depression. We adapted this community informant approach for detecting maternal depression in Pakistan. Read More

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Evaluating lower computational burden approaches for calibration of large environmental models.

Ground Water 2021 Apr 18. Epub 2021 Apr 18.

Watermark Numerical Computing, Brisbane, Queensland, Australia.

Realistic environmental models used for decision making typically require a highly parameterized approach. Calibration of such models is computationally intensive because widely used parameter estimation approaches require individual forward runs for each parameter adjusted. These runs construct a parameter-to-observation sensitivity, or Jacobian, matrix used to develop candidate parameter upgrades. Read More

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Endowing 2,6-bis-triazolyl-pyridine of poor extraction with superior efficiency for actinide/lanthanide separation at high acidity by anchoring to a macrocyclic scaffold.

J Hazard Mater 2021 Mar 26;416:125745. Epub 2021 Mar 26.

Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, College of Chemistry, Sichuan University, Chengdu 610064, China. Electronic address:

Exploring nitrogen-containing extractants for recovering hazardous minor actinides that are workable in solutions of high acidity has been a challenge in nuclear waste treatment. Herein, we report our findings that 2,6-bis-triazolyl-pyridine (PyTri), which is ineffective as a hydrophobic ligand for minor actinide separation, turns into an excellent extractant that exhibits unexpectedly high efficiency and selectivity (SF = 172, 1 M HNO) when attaching to pillar[5]arene platform. Surprisingly, the distribution ratio of Am(III) (D) is 4300 times higher than that of the acyclic PyTri ligand. Read More

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Cometabolic degradation of 1,4-dioxane by a tetrahydrofuran-growing Arthrobacter sp. WN18.

Ecotoxicol Environ Saf 2021 Apr 15;217:112206. Epub 2021 Apr 15.

Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ 07102, United States. Electronic address:

1,4-Dioxane (dioxane), an emerging groundwater contaminant, is frequently detected in landfill leachates with its structural analog, tetrahydrofuran (THF). Along with undesirable leakage of landfill leachates, dioxane and THF inevitably percolate into groundwater leading to a broader region of contamination. Cometabolic bioremediation is an effective approach to manage commingled THF and dioxane pollution. Read More

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Epigenetic effects of insecticides on early differentiation of mouse embryonic stem cells.

Toxicol In Vitro 2021 Apr 15:105174. Epub 2021 Apr 15.

Center for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan; Department of Environmental Health and Preventive Medicine, Yokohama University of Pharmacy, 601 Matanocho, Totsuka, Yokohama 245-0066, Japan. Electronic address:

Increasing evidence indicates that many insecticides produce significant epigenetic changes during embryogenesis, leading to developmental toxicities. However, the effects of insecticides on DNA methylation status during early development have not been well studied. We developed a novel nuclear phenotypic approach using mouse embryonic stem cells harboring enhanced green fluorescent protein fused with methyl CpG-binding protein to evaluate global DNA methylation changes via high-content imaging analysis. Read More

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[Role of B vitamins, thiamine, pyridoxine, and cyanocobalamin in back pain and other musculoskeletal conditions: a narrative review].

Semergen 2021 Apr 14. Epub 2021 Apr 14.

Grupo de Trabajo Aparato Locomotor Semergen. Gerencia de Atención Primaria de Burgos, Castilla y León, España. Electronic address:

Low back pain, as well as other musculoskeletal disorders (neck pain, osteoarthritis, etc.), are a very frequent cause of consultation both in primary care and in other hospital specialties and are usually associated with high functional and work disability. Acute low back pain can present different nociceptive, neuropathic and nonciplastic components, which leads to consider it as a mixed type pain. Read More

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Public health implications of vaping in the USA: the smoking and vaping simulation model.

Popul Health Metr 2021 Apr 17;19(1):19. Epub 2021 Apr 17.

Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.

Background: Nicotine vaping products (NVPs) are increasingly popular worldwide. They may provide public health benefits if used as a substitute for smoking, but may create public health harms if used as a gateway to smoking or to discourage smoking cessation. This paper presents the Smoking and Vaping Model (SAVM), a user-friendly model which estimates the public health implications of NVPs in the USA. Read More

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Subalpine dwarf shrubs differ in vulnerability to xylem cavitation: an innovative staining approach enables new insights.

Physiol Plant 2021 Apr 18. Epub 2021 Apr 18.

Department of Botany, University of Innsbruck, Innsbruck, Austria.

Dwarf shrubs are a key functional group of the high elevation vegetation belt. Despite their ecological relevance and high sensitivity to environmental changes, the hydraulic adaptations and species-specific variations in drought tolerance within this growth form are mostly unknown. Here, we assess the xylem vulnerability to cavitation of important character species of the Alpine dwarf shrub heaths in Central Europe. Read More

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Physalin B attenuates liver fibrosis via suppressing LAP2α-HDAC1 mediated deacetylation of GLI1 and hepatic stellate cell activation.

Br J Pharmacol 2021 Apr 17. Epub 2021 Apr 17.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.

Background And Purpose: Liver fibrosis is one of the leading causes of morbidity and mortality worldwide of which no acceptable therapy exists. Accumulating evidence supports that glioma-associated oncogene homologue 1 (GLI1) is a potentially important therapeutic target for liver fibrosis. This study investigates the antifibrotic activities and potential mechanisms of Physalin B (PB), a natural Solanaceae compound. Read More

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Enhancing CO utilization by a physical absorption-based technique in microalgae culture.

Bioprocess Biosyst Eng 2021 Apr 16. Epub 2021 Apr 16.

Joint International Research Laboratory of Agriculture & Agri-Product Safety, Yangzhou University, Yangzhou, 225009, People's Republic of China.

Carbon dioxide supplementation is significant for cell growth in autotrophic cultures of microalgae. However, the CO utilization efficiency is quite low in most processes. Aimed at this problem, six kinds of physical absorption enhancers were investigated to enhance the biological carbon sequestration of microalgae. Read More

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Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial.

Lancet Oncol 2021 Apr 13. Epub 2021 Apr 13.

Hôpital Nord Franche-Comté, Montbéliard, France; University Hospital of Besançon, Besançon, France.

Background: Treatment of locally advanced rectal cancer with chemoradiotherapy, surgery, and adjuvant chemotherapy controls local disease, but distant metastases remain common. We aimed to assess whether administering neoadjuvant chemotherapy before preoperative chemoradiotherapy could reduce the risk of distant recurrences.

Methods: We did a phase 3, open-label, multicentre, randomised trial at 35 hospitals in France. Read More

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Electrical resistivity methods to characterize the moisture content in Brazilian sanitary landfill.

Environ Monit Assess 2021 Apr 16;193(5):277. Epub 2021 Apr 16.

Universidad Regional Amazonica Ikiam , Tena, Ecuador.

The moisture content of the municipal solid waste (MSW) is a physical characteristic that plays a fundamental role in the stability and settlement of landfills. However, this physical index is difficult to monitor within the mass of landfilled MSW because it undergoes great variation due, mainly, to the heterogeneity and biodegradation of the waste. Brazilian MSW generally has a large amount of organic matter, that when biodegraded, generates a considerable volume of gases and fluids, aggravated by climatic conditions, such as high rainfall and temperatures. Read More

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Photobiomodulation Therapy Ameliorates Glutamatergic Dysfunction in Mice with Chronic Unpredictable Mild Stress-Induced Depression.

Oxid Med Cell Longev 2021 29;2021:6678276. Epub 2021 Mar 29.

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.

Accumulating evidence indicates that dysfunction of the glutamatergic neurotransmission has been widely involved in the pathophysiology and treatment of depression. Photobiomodulation therapy (PBMT) has been demonstrated to regulate neuronal function both and . Herein, we aim to investigate whether the antidepressant phenotype of PBMT is associated with the improvement of glutamatergic dysfunction and to explore the mechanisms involved. Read More

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A three-shell supramolecular complex enables the symmetry-mismatched chemo- and regioselective bis-functionalization of C.

Nat Chem 2021 Apr 15. Epub 2021 Apr 15.

Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.

Molecular Russian dolls (matryoshkas) have proven useful for testing the limits of preparative supramolecular chemistry but applications of these architectures to problems in other fields are elusive. Here we report a three-shell, matryoshka-like complex-in which C sits inside a cycloparaphenylene nanohoop, which in turn is encapsulated inside a self-assembled nanocapsule-that can be used to address a long-standing challenge in fullerene chemistry, namely the selective formation of a particular fullerene bis-adduct. Spectroscopic evidence indicates that the ternary complex is sufficiently stable in solution for the two outer shells to affect the addition chemistry of the fullerene guest. Read More

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Enhancing Human-Centered Design With Youth-Led Participatory Action Research Approaches for Adolescent Sexual and Reproductive Health Programming.

Health Promot Pract 2021 Apr 15:15248399211003544. Epub 2021 Apr 15.

California State University, Sacramento, CA, USA.

Existing participatory research approaches have failed to identify innovative methods that overcome the persistent barriers to adolescent sexual and reproductive health service demand and access. Increasingly, programmers have turned to human-centered design (HCD), a problem-solving process that centers the needs, perspectives, and experiences of people, when developing solutions to complex SRH challenges. This article describes the application of a youth-engaged version of HCD as part of Adolescents 360, a transdisciplinary initiative to increase 15- to 19-year-old girls' use of modern contraception in Nigeria, Ethiopia, and Tanzania. Read More

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Estrogen profile- and pharmacogenetics-based lamotrigine dosing regimen optimization: recommendations for pregnant women with epilepsy.

Pharmacol Res 2021 Apr 12:105610. Epub 2021 Apr 12.

Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address:

During pregnancy, various physiological changes occur that can alter the pharmacokinetics of antiepileptic drugs, such as lamotrigine (LTG). Anticipating the change in LTG dose required to achieve a pre-pregnancy target concentration is challenging. This study aimed to develop a refined population pharmacokinetic (PopPK) model of LTG in pregnant women with epilepsy (WWE) to identify factors explaining the variability in pharmacokinetics and to establish a model-informed individualized dosing regimen. Read More

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