1,458,976 results match your criteria approach


Regression analysis of arbitrarily censored survival data under the proportional odds model.

Stat Med 2021 Apr 21. Epub 2021 Apr 21.

Department of Statistics, University of South Carolina, Columbia, South Carolina, USA.

Arbitrarily censored data are referred to as the survival data that contain a mixture of exactly observed, left-censored, interval-censored, and right-censored observations. Existing research work on regression analysis on arbitrarily censored data is relatively sparse and mainly focused on the proportional hazards model and the accelerated failure time model. This article studies the proportional odds (PO) model and proposes a novel estimation approach through an expectation-maximization (EM) algorithm for analyzing such data. Read More

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[40 Years Interdisciplinary Transplant Center at the University Medical Center Schleswig-Holstein, Campus Lübeck - Team Spirit at its Best].

Zentralbl Chir 2021 Apr 21. Epub 2021 Apr 21.

Klinik für Chirurgie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Deutschland.

In transplantation medicine, recent decades have seen an increase in the number of interdisciplinary organ centres that can guarantee optimal care before, during and after the transplantation of solid organs. Since the foundation of our centre 40 years ago, the interdisciplinary approach between transplant surgery and nephrology has been practised at the Lübeck site, allowing a centre specialising in kidney transplantation to develop. In addition to the medical-technical aspects, an organisational and structural-infrastructural centre could be built up, which became a model for interdisciplinary transplantation centres. Read More

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[Treatment of a Patient with a Pronounced Cytokine Storm in Severe COVID-19 Pneumonia using a Hemoadsorption in Combination with the Administration of tocilizumab].

Pneumologie 2021 Apr 21. Epub 2021 Apr 21.

Klinikum Würzburg Mitte gGmbH, Standort Missioklinik, Medizinische Klinik mit Schwerpunkt Pneumologie & Beatmungsmedizin.

Despite growing experience due to increasing patient numbers, the intensive care treatment of patients with severe COVID-19 pneumonia continues to be a particular challenge in individual cases, which may also therefore legitimize individualized therapeutic attempts. In this context, the so-called hyperinflammation syndrome characterized by a cytokine storm accompanied by a massive increase in inflammatory markers such as interleukin(IL)-6, represents such a situation. This case report describes the therapeutic approach of using the IL-6-specific antibody tocilizumab in combination with hemoadsorption therapy (CytoSorb) in a 58-year-old male patient with severe COVID-19 pneumonia. Read More

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Ambient Assisted Living: Identifying New Challenges and Needs for Digital Technologies and Service Innovation.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

On behalf of the Swedish interest organizations for Elderly, Stockholm, Sweden. Member of SeniorNet and Active Seniors non-profit organizations.

Background: The ambient assisted living (AAL) market is rapidly becoming fundamental to the delivery of health and social care services for the elderly. Worldwide many different steps have been taken to increase the engagement of older adults with these technologies. Much of this work has focused on the development of novel digital services that increase wellbeing or tackle social challenges. Read More

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Enhancing Safety During a Pandemic Using Virtual Care Remote Monitoring Technologies and UML Modeling.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Division of Clinical Informatics, Harvard School of Medicine, Harvard University, United States of America.

Objectives: This paper describes a methodology for gathering requirements and early design of remote monitoring technology (RMT) for enhancing patient safety during pandemics using virtual care technologies. As pandemics such as COrona VIrus Disease (COVID-19) progress there is an increasing need for effective virtual care and RMT to support patient care while they are at home.

Methods: The authors describe their work in conducting literature reviews by searching PubMed. Read More

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Drawing Reproducible Conclusions from Observational Clinical Data with OHDSI.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Observational Health Data Sciences and Informatics, New York, New York, USA.

Objective: The current observational research literature shows extensive publication bias and contradiction. The Observational Health Data Sciences and Informatics (OHDSI) initiative seeks to improve research reproducibility through open science.

Methods: OHDSI has created an international federated data source of electronic health records and administrative claims that covers nearly 10% of the world's population. Read More

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An in vitro air-liquid interface inhalation platform for petroleum substances and constituents.

ALTEX 2021 Apr 20. Epub 2021 Apr 20.

VITO NV (Flemish Institute for Technological Research), Unit HEALTH, Mol, Belgium.

The goal is to optimize and show the validity of an in vitro method for inhalation testing of petroleum substances and its constituents at the air-liquid interface (ALI). The approach is demonstrated in a pilot study with ethylbenzene (EB), a mono-constituent petroleum substance using a human alveolar epithelial cell line model. This included the development and validation of a generation facility to obtain EB vapors and the optimization of an exposure system for a negative control (clean air, CA), positive control (nitrogen dioxide), and EB vapors. Read More

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Assessing Evidence-Based Practice Knowledge: An Innovative Approach by a Nursing Research Council.

J Nurs Adm 2021 May;51(5):279-286

Author Affiliations: Program Manager for Nursing Research and WOC Nursing Services (Dr Maydick-Youngberg), Research Manager for Nursing (Ms Gabbe), RN Instructor, Nursing Education (Ms Simmons), Director of Nursing Education and Professional Development, CPM Site Coordinator (Ms Quimson), Senior Director, Nursing Professional Practice & Clinical Informatics (Ms Meyerson), Vice President of Patient Care Services and Nursing (Ms Manley-Cullen), NYU Langone Hospital-Brooklyn; and Data Analyst-Research Coordinator, Center for Innovations in the Advancement of Care (CIAC) (Mr Smith); and Director, Outcomes Research & Program Evaluation, Director, CIAC (Dr Rosenfeld), NYU Langone Health, New York.

Objective: The aim of this study was to describe the structure and processes implemented by nursing research councils to conduct a nurse-led research study at an urban community teaching hospital.

Background: We assessed nurses' knowledge, skills, and attitudes toward evidence-based practice (EBP) to inform development plans.

Methods: This is an institutional review board-approved single-site cross-sectional anonymous online survey (Evidence-Based Practice Questionnaire [EBPQ]) emailed to 850 participants. Read More

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An Integrative Review of Organizational Factors Influencing Successful Large-Scale Changes in Healthcare.

J Nurs Adm 2021 May;51(5):264-270

Author Affiliations: Doctoral Student and Part-Time Faculty Lecturer (Ms Castiglione) and Associate Professor (Dr Lavoie-Tremblay), Ingram School of Nursing, McGill University, Montréal, Québec, Canada.

Objective: The aim of this study was to review organizational factors influencing successful large-scale change (LSC) in healthcare.

Background: LSC is necessary to achieve sustained and meaningful healthcare improvement. However, organizational readiness needs to be considered to promote successful LSC. Read More

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Telemedicine for adult congenital heart disease patients during the first wave of COVID-19 era: a single center experience.

J Cardiovasc Med (Hagerstown) 2021 Apr 20. Epub 2021 Apr 20.

Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University of the Sacred Heart Department of Pediatric Cardiology and Cardiac Surgery - Bambino Gesù Hospital, Rome, Italy.

Aim: To summarize our experience on the implementation of a telemedicine service dedicated to adult congenital heart disease (ACHD) patients during the lockdown for the first wave of COVID-19.

Methods: This is a prospective study enrolling all ACHD patients who answered a questionnaire dedicated telematic cardiovascular examination.

Results: A total of 289 patients were enrolled, 133 (47%) were male, 25 (9%) were affected by a genetic syndrome. Read More

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Prevalence and predictors of persistent sinus rhythm after elective electrical cardioversion for atrial fibrillation.

J Cardiovasc Med (Hagerstown) 2021 Apr 20. Epub 2021 Apr 20.

Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Trieste, Italy.

Aims: To evaluate the prevalence and predictors of persistent sinus rhythm in a recent cohort of unselected patients undergoing electrical cardioversion for atrial fibrillation.

Methods: We enrolled all consecutive patients undergoing elective electrical cardioversion for atrial fibrillation between January 2017 and December 2018. We analysed baseline clinical and echocardiographic data as well as pharmacological antiarrhythmic therapy. Read More

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Evaluation of the Use of Diverse Mental Health Simulation in Nursing Students' Learning Experience: An International Multisite Study.

Nurse Educ 2021 Mar 30. Epub 2021 Mar 30.

Clinical Assistant Professor (Dr Ozkara San), NYU Rory Meyers College of Nursing, New York; and Associate Professor (Dr Dikec) and Assistant Professor (Dr Ata), Department of Psychiatric Nursing, and Professor (Dr Sendir), Department of Fundamental Nursing, Hamidiye Faculty of Nursing, University of Health Sciences, Istanbul, Turkey.

Background: Simulated patients (SPs) in mental health nursing education provide a unique approach to assist student development in complex assessment skills.

Purpose: The purpose of this international multisite study was to evaluate the use of two diverse mental health SP simulation scenarios on nursing students' satisfaction and self-confidence in learning to care for patients with mental health disorders in the United States (n = 70) and Turkey (n = 90).

Methods: A multisite cross-sectional study design was used. Read More

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Sustaining a Concept-Based Curriculum: Beyond the Launch.

Nurse Educ 2021 Apr 12. Epub 2021 Apr 12.

Author Affiliations: Clinical Professor (Dr Solheim), Clinical Associate Professor (Dr Muehrer), and Interim Associate Dean for Academic Affairs (Dr Pinekenstein), School of Nursing, and Academic Planner (Ms Mittelstadt), Academic Planning and Institutional Research, University of Wisconsin-Madison; and Dean and Professor (Dr Willis), Trudy Busch Valentine School of Nursing, Saint Louis University, Missouri.

Background: Many schools of nursing are transitioning to a concept-based curriculum (CBC) to better prepare students to practice across complex practice settings.

Problem: Current literature focused on transitioning to a CBC lacks discussion on how to sustain a CBC once it is implemented.

Approach: In this article, the authors emphasize the importance of intentionally sustaining a dynamic CBC and provide strategies to accomplish this aspect of the curriculum trajectory. Read More

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Myeloid-Derived Suppressor Cells (MDSCs) and The Immunoinflammatory Response To Injury (Mini Review).

Shock 2021 Apr 13. Epub 2021 Apr 13.

Dell Medical School, University of Texas, Austin TX Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, TX.

Abstract: Myeloid-derived suppressor cells (MDSCs) are a heterogenous population of immature myeloid cells hallmarked by their potent immunosuppressive function in a vast array of pathologic conditions. MDSCs have recently been shown to exhibit marked expansion in acute inflammatory states including traumatic injury, burn, and sepsis. Although MDSCs have been well characterized in cancer, there are significant gaps in our knowledge of their functionality in trauma and sepsis, and their clinical significance remains unclear. Read More

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European Guidelines for Obesity Management in Adults with a Very Low-Calorie Ketogenic Diet: A Systematic Review and Meta-Analysis.

Obes Facts 2021 Apr 21:1-24. Epub 2021 Apr 21.

Dipartimento di Medicina, Università degli Studi di Padova, Padova, Italy.

Background: The very low-calorie ketogenic diet (VLCKD) has been recently proposed as an appealing nutritional strategy for obesity management. The VLCKD is characterized by a low carbohydrate content (<50 g/day), 1-1.5 g of protein/kg of ideal body weight, 15-30 g of fat/day, and a daily intake of about 500-800 calories. Read More

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A motion correction approach for oral and maxillofacial cone-beam CT imaging.

Phys Med Biol 2021 Apr 21. Epub 2021 Apr 21.

KU Leuven, Leuven, Flanders, BELGIUM.

Patient movement affects image quality in oral and maxillofacial cone-beam CT imaging. While many efforts are made to minimize the possibility of motion during a scan, relatively little attention has been given to motion correction after the acquisition. We propose a novel method which can improve the image quality after an oral and maxillofacial scan. Read More

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Reducing Metal/Graphene Contact Resistance via N, N-Dimethylacetamide-Assisted Clean Fabrication Process.

Nanotechnology 2021 Apr 21. Epub 2021 Apr 21.

Institute of Microelectronics Chinese Academy of Sciences, Beijing, CHINA.

Contact resistance (R) is of great importance for radio frequency (RF) applications of graphene, especially graphene field effect transistors (FETs) with short channel. FETs and transmission line model (TLM) test structures based on chemical vapor deposition grown graphene are fabricated. The effects of employing traditional lithography solvent (Acetone) and strong solvents for photo resist, such as N, N-Dimethylacetamide (ZDMAC) and N-Methyl pyrrolidone (NMP), are systematically investigated. Read More

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A CNN identified by reinforcement learning-based optimization framework for EEG-based state evaluation.

J Neural Eng 2021 Apr 21. Epub 2021 Apr 21.

School of Electrical and Information Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, Tianjin, 300072, CHINA.

Objective: Electroencephalogram (EEG) data, as a kind of complex time-series, is one of the most widely-used information measurements for evaluating human psychophysiological states. Recently, numerous works applied deep learning techniques, especially the convolutional neural network (CNN), into EEG-based research. The design of the hyper-parameters of the CNN model has a great influence on the performance of the model. Read More

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Gas-solid Interfacial Charge Transfer in Volatile Organic Compound Detection by CuCrONanoparticles.

Nanotechnology 2021 Apr 21. Epub 2021 Apr 21.

Key Laboratory of Advanced Display and System Applications of Ministry of Education, Shanghai University, Shanghai, 200444, CHINA.

Nanostructured metal oxide semiconductors have received great attention used as the chemiresistive layer of gas sensor to detect the volatile organic compound recently. Among these, p-type semiconductors have many advantages, such as temperature/humidity stability and compositional versatility; however, the study of sensing mechanism is still insufficient, which hampers their practical applications. In this work, the p-type delafossite CuCrOnanoparticles were synthesized, characterized, and tested for gas sensing, followed by the first principles calculations to simulate the generation of chemiresistive signal. Read More

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Optimising use of 4D-CT phase information for radiomics analysis in lung cancer patients treated with stereotactic body radiotherapy.

Phys Med Biol 2021 Apr 21. Epub 2021 Apr 21.

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., The University of Manchester, Manchester, Manchester, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Purpose: 4D-CT is routine imaging for lung cancer patients treated with stereotactic body radiotherapy. No studies have investigated optimal 4D phase selection for radiomics. We aim to determine how phase data should be used to identify prognostic biomarkers for distant failure, and test whether stability assessment is required. Read More

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Multi-parameter optimization of attenuation data for characterizing grain size distributions and application to bimodal microstructures.

Ultrasonics 2021 Apr 18;115:106425. Epub 2021 Apr 18.

Université Paris-Saclay, CentraleSupélec, CNRS, Laboratoire de Mécanique des Sols, Structures et Matériaux, 91190 Gif-sur-Yvette, France.

In this paper, the effect on the ultrasonic attenuation of the grain size heterogeneity in polycrystals is analyzed. First, new analytical developments allowing the extension of the unified theory of Stanke and Kino to general grain size distributions are presented. It is then shown that one can additively decompose the attenuation coefficient provided that groups of grains are defined. Read More

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'A sleeping volcano that could erupt sooner or later'. Lived experiences of women with multiple sclerosis during childbearing age and motherhood: A phenomenological qualitative study.

Mult Scler Relat Disord 2021 Apr 18;51:102938. Epub 2021 Apr 18.

National Centre for Diseases Prevention and Health Promotion, National Institute of Health, Rome, Italy.

Introduction: Multiple Sclerosis (MS) mainly involves women, impacting many aspects related to childbearing age and maternity. Women with MS can have healthy pregnancies and infants. Needs, challenges and concerns of women with MS should be considered in order to improve care pathway, ensuring a patient-centred approach. Read More

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Development and evaluation of a manual segmentation protocol for deep grey matter in multiple sclerosis: Towards accelerated semi-automated references.

Neuroimage Clin 2021 Apr 6;30:102659. Epub 2021 Apr 6.

Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, Amsterdam, NL, Netherlands.

Background: Deep grey matter (dGM) structures, particularly the thalamus, are clinically relevant in multiple sclerosis (MS). However, segmentation of dGM in MS is challenging; labeled MS-specific reference sets are needed for objective evaluation and training of new methods.

Objectives: This study aimed to (i) create a standardized protocol for manual delineations of dGM; (ii) evaluate the reliability of the protocol with multiple raters; and (iii) evaluate the accuracy of a fast-semi-automated segmentation approach (FASTSURF). Read More

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A new deep learning method for blood vessel segmentation in retinal images based on convolutional kernels and modified U-Net model.

Comput Methods Programs Biomed 2021 Apr 8;205:106081. Epub 2021 Apr 8.

Vision, Prediction, Optimisation and Control Systems Department, Science and Technology Research Centre, University of Huelva, Avenida de las Fuerzas Armadas s/n, 21007, Huelva, Spain. Electronic address:

Background And Objective: Automatic monitoring of retinal blood vessels proves very useful for the clinical assessment of ocular vascular anomalies or retinopathies. This paper presents an efficient and accurate deep learning-based method for vessel segmentation in eye fundus images.

Methods: The approach consists of a convolutional neural network based on a simplified version of the U-Net architecture that combines residual blocks and batch normalization in the up- and downscaling phases. Read More

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Investigation of low dimensional feature spaces for automatic sleep staging.

Comput Methods Programs Biomed 2021 Apr 9;205:106091. Epub 2021 Apr 9.

Department of Engineering, Aarhus University, Tabar, Finlandsgade 22, Building 5125, 8200 Aarhus N, Denmark.

Background: Automatic sleep stage classification depends crucially on the selection of a good set of descriptive features. However, the selection of a feature set with an appropriate low computational cost without compromising classification performance is still a challenge. This study attempts to represent sleep EEG patterns using a minimum number of features, without significant performance loss. Read More

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A participatory method for prioritizing invasive species: Ranking threats to Minnesota's terrestrial ecosystems.

J Environ Manage 2021 Apr 18;290:112556. Epub 2021 Apr 18.

Minnesota Invasive Terrestrial Plants and Pests Center, University of Minnesota, 1992 Folwell Ave., St. Paul, MN, 55108-6125, USA; USDA, Forest Service, Northern Research Station, 1561 Lindig Street, St. Paul, MN, 55108-6125, USA. Electronic address:

Terrestrial invasive species threaten the integrity of diverse and highly-valued ecosystems. The Minnesota Invasive Terrestrial Plants and Pests Center (MITPPC) was established by the state of Minnesota to fund research projects aimed at minimizing harms posed by the most threatening terrestrial invasive species to the state's prairies, wetlands, forests, and agriculture. MITPPC used the Analytic Hierarchy Process (AHP) to identify and prioritize diverse invasive species threats. Read More

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Laparoscopic anatomic liver resection of segment 7 using a caudo-dorsal approach to the right hepatic vein.

Surg Oncol 2021 Apr 18;38:101575. Epub 2021 Apr 18.

Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Army Medical University, Chongqing, China. Electronic address:

Background: Laparoscopic anatomic liver resection of segment 7 (S7) is technically challenging because of the posterosuperior location and the lack of clear anatomical landmarks [1-4]. Here, we introduce a caudo-dorsal approach, which may offer a benefit for the difficult procedure.

Methods: The patient was a 53-year-old man with hepatocellular carcinoma located in S7 of the liver. Read More

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Intrahepatic Glissonian approach for robotic right hepatectomy.

Surg Oncol 2021 Apr 14;38:101579. Epub 2021 Apr 14.

Nove de Julho Hospital, São Paulo, Brazil.

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Biodegradation of polylactic acid by yellow mealworms (larvae of Tenebrio molitor) via resource recovery: A sustainable approach for waste management.

J Hazard Mater 2021 Apr 6;416:125803. Epub 2021 Apr 6.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China. Electronic address:

Polylactic acid (PLA) is biodegraded rapidly under composting or thermophilic temperature but slowly under natural conditions with substantial microplastics generated. In this study, we examined the feasibility of PLA biodegradation and developed a novel approach for PLA waste management using yellow mealworms (Tenebrio molitor larvae) to achieve biodegradation and resource recovery simultaneously. Results confirmed PLA biodegradation in mealworms as sole PLA and PLA-bran mixtures (10%, 20%, 30% and 50% PLA, wt/wt). Read More

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Brain state-based detection of attentional fluctuations and their modulation: Brain based attentional state.

Neuroimage 2021 Apr 18:118072. Epub 2021 Apr 18.

Department of Psychiatry, Boston University School of Medicine, Massachusetts, United States, 02118.; Boston Attention and Learning Laboratory, VA Boston Healthcare System, Massachusetts, United States, 02130.; National Center for PTSD, VA Boston Healthcare System, Massachusetts, United States, 02130.

In the search for brain markers of optimal attentional focus, the mainstream approach has been to first define attentional states based on behavioral performance, and to subsequently investigate "neural correlates" associated with these performance variations. However, this approach constrains the range of contexts in which attentional states can be operationalized by relying on overt behavior, and assumes a one-to-one correspondence between behavior and brain state. Here, we reversed the logic of these previous studies and sought to identify behaviorally-relevant brain states based solely on brain activity, agnostic to behavioral performance. Read More

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