23,417 results match your criteria appreciated article

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIb. The 2020 Preemptive Therapy Working Group Report.

Transplant Cell Ther 2021 Apr 6. Epub 2021 Apr 6.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Background: Chronic graft-versus-host disease (GVHD) commonly occurs after allogeneic hematopoietic cell transplantation (HCT) despite standard prophylactic immune suppression. Intensified universal prophylaxis approaches are effective but risk possible over-treatment and may interfere with the graft-vs-malignancy immune response.

Objectives: We summarize conceptual and practical considerations regarding preemptive therapy of chronic GVHD, namely interventions applied after HCT based on evidence that the risk of developing chronic GVHD is higher than previously appreciated. Read More

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A structured reflective process supports student awareness of employability skills development in a science placement module.

FEBS Open Bio 2021 Apr 9. Epub 2021 Apr 9.

Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.

Placements are often an extra-curricular activity of a science degree. This study reports on the outcomes of a final year credit-bearing 6-week placement module that was specifically designed to develop and enhance students' employability skills. A key element of this module was that the student placements were not only evaluated from a science perspective, but also with an emphasis on meaningful reflection and evaluation of employability skills development. Read More

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VvHDZ28 positively regulate SA biosynthesis during seed abortion in Thompson Seedless.

Plant Biotechnol J 2021 Apr 9. Epub 2021 Apr 9.

College of Horticulture, Northwest A&F University, Yangling, Shaanxi, P.R. China.

Seedlessness in grapes is one of the features most appreciated by consumers. However, the mechanisms underlying seedlessness in grapes remain obscure. Here, we observe small globular embryos and globular embryos in Pinot Noir and Thompson Seedless from 20 to 30 days after flowering (DAF). Read More

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Whole genome resequencing and custom genotyping unveil clonal lineages in 'Malbec' grapevines (Vitis vinifera L.).

Sci Rep 2021 Apr 8;11(1):7775. Epub 2021 Apr 8.

Instituto de Biología Agrícola de Mendoza (IBAM, CONICET-UNCuyo), Almirante Brown 500, M5528AHB. Chacras de Coria, Mendoza, Argentina.

Grapevine cultivars are clonally propagated to preserve their varietal attributes. However, genetic variations accumulate due to the occurrence of somatic mutations. This process is anthropically influenced through plant transportation, clonal propagation and selection. Read More

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[Vocal cord dysfunction in athletes: Interest of rehabilitation to effort].

Rev Mal Respir 2021 Apr 5. Epub 2021 Apr 5.

CIC-CRB 1404, unité de physiologie respiratoire et sportive, centre hospitalier universitaire de Rouen, 1, rue de Germont, 76000 Rouen, France.

Introduction: Vocal Cord Dysfunction (VCD) is a syndrome characterized by paradoxical adduction of the vocal folds during breathing. Its non-specific clinical manifestations frequently lead to misdiagnosis and delay in its treatment. The treatment of VCD is not pharmacological but rehabilitative and remains poorly appreciated. Read More

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Process evaluation of the ACTION programme: a strategy for implementing person-centred communication in home care.

BMC Nurs 2021 Apr 8;20(1):56. Epub 2021 Apr 8.

Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Allégatan 1, SE-501 90, Borås, Sweden.

Background: There is currently a strong emphasis on person-centred care (PCC) and communication; however, little research has been conducted on how to implement person-centred communication in home care settings. Therefore, the ACTION (A person-centred CommunicaTION) programme, which is a web-based education programme focusing on person-centred communication developed for nurse assistants (NAs) providing home care for older persons, was implemented. This paper reports on the process evaluation conducted with the aim to describe and evaluate the implementation of the ACTION programme. Read More

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Mucosal Kaposi's sarcoma in HIV-negative patients: a large case series from a single, tertiary referral center in Italy.

Int J Dermatol 2021 Apr 8. Epub 2021 Apr 8.

Dermatology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Background: Mucosal involvement in HIV-negative Kaposi's sarcoma (KS) is uncommon but has potentially serious repercussions on patient care. Evidence regarding its epidemiology and optimal management is limited. Invasive endoscopic staging at diagnosis and periodically during follow-up is currently recommended by major guidelines. Read More

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Children living with long-term conditions illness: A meta-aggregation of parental experiences of partnership nursing.

J Clin Nurs 2021 Apr 7. Epub 2021 Apr 7.

School of Nursing, Midwifery and Public Health, University of Canberra, Bruce, ACT, Australia.

Aim: To explore how parents of children with long-term conditions experience partnership in paediatric and neonatal nursing care and to identify existing partnership barriers and facilitators.

Background: Parent-nurse partnership is fundamental to paediatric and neonatal nursing. Partnership is characterised by five attributes: parental participation, negotiation, mutual trust and respect, shared roles and decision-making, and communication. Read More

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Visualizing the Reading Activity of People Learning to Read.

J Eye Mov Res 2017 Nov 15;10(5). Epub 2017 Nov 15.

Visual Interaction Research Group, TAUCHI Research Center University of Tampere, Finnland.

Several popular visualizations of gaze data, such as scanpaths and heatmaps, can be used independently of the viewing task. For a specific task, such as reading, more informative visualizations can be created. We have developed several such techniques, some dynamic and some static, to communicate the reading activity of children to primary school teachers. Read More

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November 2017

Where did I come from? Where am I going? Functional differences in visual search fixation duration.

J Eye Mov Res 2017 Mar 4;10(1). Epub 2017 Mar 4.

University of Detroit Mercy, Detroit, Michigan, USA.

Real time simulation of visual search behavior can occur only if the control of fixation durations is sufficiently understood. Visual search studies have typically confounded pre- and post-saccadic influences on fixation duration. In the present study, pre- and post-saccadic influences on fixation durations were compared by considering saccade direction. Read More

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The Mental Side of the Injured Athlete.

J Am Acad Orthop Surg 2021 Apr 7. Epub 2021 Apr 7.

From the Division of Sports Medicine, Department of Orthopedic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA (Daley), and the Division of Sports Medicine, Department of Orthopedic Surgery, Boston Children's Hospital, Boston, MA (Griffith, Christino, and Milewski).

The psychosocial benefits of participating in sports have long been appreciated. However, athletes are often faced with circumstances that make them susceptible to psychological challenges unique to the athletic population. One such circumstance is injury in sport, which can be a source of notable distress and may precipitate the emergence of new or exacerbation of underlying psychological disorders. Read More

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Dying in times of the coronavirus: An online survey among healthcare professionals about end-of-life care for patients dying with and without COVID-19 (the CO-LIVE study).

Palliat Med 2021 Apr 7:2692163211003778. Epub 2021 Apr 7.

Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background: During the COVID-19 outbreak restricting measures may have affected the provision of good end-of-life care for patients with and without COVID-19.

Aim: To describe characteristics of patients who died and the care they received, and to examine how patient characteristics, setting and visiting restrictions are related to provided care and evaluation of the dying process.

Design: An open observational online survey among healthcare professionals about their experience of end-of-life care that was provided to a patient with or without COVID-19 who died between March and July 2020. Read More

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Team-based, problem-solving exercises using studies of diarrhea and oral rehydration encourage students to integrate knowledge of systems physiology.

Adv Physiol Educ 2021 Jun;45(2):250-258

School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, United Kingdom.

We describe an inquiry activity that aims to develop students' ability to interpret findings that span whole body systems and so encourage the integration of knowledge. The scenario we choose was the physiological challenge posed by diarrhea and the physiological mechanisms that underpin oral rehydration therapy. Before the staff-facilitated inquiry activity, students engage with an online information resource and complete a formative, but mandatory, prelaboratory quiz. Read More

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A silver bullet? The role of radiology information system data mining in defining gunshot injury trends at a South African tertiary-level hospital.

SA J Radiol 2021 2;25(1):2018. Epub 2021 Mar 2.

Division of Radiodiagnosis, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Background: South Africa (SA) has no national injury surveillance system, and hence, non-fatal gunshot injuries are not routinely recorded. Most firearm-related injuries require multi-detector computer tomography (MDCT) assessment at a tertiary-level facility. MDCT scanning for victims with gunshot injuries thus provide an indication of the societal burden of firearm trauma. Read More

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Causes of short birth interval (kunika) in Bauchi State, Nigeria: systematizing local knowledge with fuzzy cognitive mapping.

Reprod Health 2021 Apr 6;18(1):74. Epub 2021 Apr 6.

CIET-PRAM, Department of Family Medicine, McGill University, 5858 Chemin de la Côte-des-Neiges, 3rd floor, Montreal, QC, H3S 1Z1, Canada.

Background: Short birth intervals, defined by the World Health Organization as less than 33 months, may damage the health and wellbeing of children, mothers, and their families. People in northern Nigeria recognise many adverse effects of short birth interval (kunika in the Hausa language) but it remains common. We used fuzzy cognitive mapping to systematize local knowledge of causes of kunika to inform the co-design of culturally safe strategies to address it. Read More

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Abnormal Cerebellar Development in Autism Spectrum Disorders.

Dev Neurosci 2021 Apr 6:1-10. Epub 2021 Apr 6.

Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.

Autism spectrum disorders (ASD) comprise a group of heterogeneous neurodevelopmental conditions characterized by impaired social interactions and repetitive behaviors with symptom onset in early infancy. The genetic risks for ASD have long been appreciated: concordance of ASD diagnosis may be as high as 90% for monozygotic twins and 30% for dizygotic twins, and hundreds of mutations in single genes have been associated with ASD. Nevertheless, only 5-30% of ASD cases can be explained by a known genetic cause, suggesting that genetics is not the only factor at play. Read More

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The metabolism-modulating activity of IL-17 signaling in health and disease.

J Exp Med 2021 May;218(5)

Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA.

IL-17 was discovered nearly 30 yr ago, but it has only been recently appreciated that a key function of this cytokine is to orchestrate cellular and organismal metabolism. Indeed, metabolic regulation is integrated into both the physiological and the pathogenic aspects of IL-17 responses. Thus, understanding the interplay between IL-17 and downstream metabolic processes could ultimately inform therapeutic opportunities for diseases involving IL-17, including some not traditionally linked to this cytokine pathway. Read More

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Integrative microbiomics in bronchiectasis exacerbations.

Nat Med 2021 Apr 5. Epub 2021 Apr 5.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection. We present an approach to the multi-biome that integrates bacterial, viral and fungal communities in bronchiectasis through weighted similarity network fusion ( https://integrative-microbiomics.ntu. Read More

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Benefits and limitations of telegenetics: A literature review.

J Genet Couns 2021 Apr 4. Epub 2021 Apr 4.

Department of General Genetics, Monash Medical Centre, Melbourne, Victoria, Australia.

Telegenetics involves the use of technology (generally video conferencing) to remotely provide genetic services. A telegenetics platform is critical for those with limitations or vulnerabilities compromising their ability to attend clinic in-person, including individuals in rural areas. As the demand for remote genetics services increases, and amidst the COVID-19 pandemic with social distancing practices in place, we conducted a literature review to examine the benefits and limitations of telegenetics and explore the views of patients and health professionals utilizing telegenetics. Read More

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Recent advances in understanding the Th1/Th2 effector choice.

Fac Rev 2021 15;10:30. Epub 2021 Mar 15.

Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

For over 35 years since Mosmann and Coffman proposed the seminal "type 1 T helper (Th1)/type 2 T helper (Th2)" hypothesis in 1986, the immunological community has appreciated that naïve CD4 T cells need to make important decisions upon their activation, namely to differentiate towards a Th1, Th2, Th17 (interleukin-17-producing T helper), follicular T helper (Tfh), or regulatory T cell (Treg) fate to orchestrate a variety of adaptive immune responses. The major molecular underpinnings of the Th1/Th2 effector fate choice had been initially characterized using excellent reductionist culture systems, through which the transcription factors T-bet and GATA3 were identified as the master regulators for the differentiation of Th1 and Th2 cells, respectively. However, Th1/Th2 cell differentiation and their cellular heterogeneity are usually determined by a combinatorial expression of multiple transcription factors, particularly , where dendritic cell (DC) and innate lymphoid cell (ILC) subsets can also influence T helper lineage choices. Read More

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Simulation of Adult Surgical Cricothyrotomy for Anesthesiology and Emergency Medicine Residents: Adapted for COVID-19.

MedEdPORTAL 2021 04 1;17:11134. Epub 2021 Apr 1.

Professor and Department Chair, Département d'anesthésiologie et de soins intensifs, Faculté de médecine, Université Laval; Chairholder of the Educational Leadership Chair in Health Sciences Simulation, Université Laval and Université Côte d'Azur.

Introduction: In a CICO (cannot intubate, cannot oxygenate) situation, anesthesiologists and acute care physicians must be able to perform an emergency surgical cricothyrotomy (front-of-neck airway procedure). CICOs are high-acuity situations with rare opportunities for safe practice. In COVID-19 airway management guidelines, bougie-assisted surgical cricothyrotomy is the recommended emergency strategy for CICO situations. Read More

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Neurogenic Obesity and Skeletal Pathology in Spinal Cord Injury.

Top Spinal Cord Inj Rehabil 2021 ;27(1):57-67

Division of Endocrinology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.

Spinal cord injury (SCI) results in dramatic changes in body composition, with lean mass decreasing and fat mass increasing in specific regions that have important cardiometabolic implications. Accordingly, the recent Consortium for Spinal Cord Medicine (CSCM) released clinical practice guidelines for cardiometabolic disease (CMD) in SCI recommending the use of compartmental modeling of body composition to determine obesity in adults with SCI. This recommendation is guided by the fact that fat depots impact metabolic health differently, and in SCI adiposity increases around the viscera, skeletal muscle, and bone marrow. Read More

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January 2021

Body Composition and Metabolic Assessment After Motor Complete Spinal Cord Injury: Development of a Clinically Relevant Equation to Estimate Body Fat.

Top Spinal Cord Inj Rehabil 2021 ;27(1):11-22

Spinal Cord Injury and Disorders Center, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia.

Obesity is at epidemic proportions in the population with spinal cord injury (SCI), and adipose tissue (AT) is the mediator of the metabolic syndrome. Obesity, however, has been poorly appreciated in SCI because of the lack of sensitivity that body mass index (BMI) conveys for obesity risk in SCI without measuring AT. The specific objectives were to compare measures of body composition assessment for body fat with the criterion standard 4-compartment (4C) model in persons with SCI, to develop a regression equation that can be utilized in the clinical setting to estimate fat mass (FM), and to determine cardiometabolic risk using surrogates of obesity in a current model of metabolic syndrome. Read More

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January 2021

Untargeted analysis of pure snail slime and snail slime-induced Au nanoparticles metabolome with MALDI FT-ICR MS.

J Mass Spectrom 2021 May;56(5):e4722

Dipartimento di Scienze, Università degli Studi della Basilicata, Potenza, Italy.

Chronic wounds result from the failure of the normal wound healing process. Any delay during the tissue repair process could be defined as chronic wound healing, potentially having a highly detrimental impact on human health. To face this problem, in the last years, the use of different technologies alternative to therapeutic agents is gaining more attention. Read More

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Transcription regulation through nascent RNA folding.

J Mol Biol 2021 Mar 31:166975. Epub 2021 Mar 31.

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. Electronic address:

Folding of RNA into secondary structures through intramolecular base pairing determines an RNA's three-dimensional architecture and associated function. Simple RNA structures like stem loops can provide specialized functions independent of coding capacity, such as protein binding, regulation of RNA processing and stability, stimulation or inhibition of translation. RNA catalysis is dependent on tertiary structures found in the ribosome, tRNAs and group I and II introns. Read More

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The impact of socioeconomic and stimulus inequality on human brain physiology.

Sci Rep 2021 Apr 2;11(1):7439. Epub 2021 Apr 2.

Sapien Labs, 1201 Wilson Drive 27th Floor, Arlington, VA, 22209, USA.

The brain undergoes profound structural and dynamical alteration in response to its stimulus environment. In animal studies, enriched stimulus environments result in numerous structural and dynamical changes along with cognitive enhancements. In human society factors such as education, travel, cell phones and motorized transport dramatically expand the rate and complexity of stimulus experience but diverge in access based on income. Read More

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Fibrinolysis: A Primordial System Linked to the Immune Response.

Int J Mol Sci 2021 Mar 26;22(7). Epub 2021 Mar 26.

Molecular Neurotrauma and Haemostasis Laboratory, Australian Centre for Blood Diseases, Central Clinical School Melbourne, Monash University, Melbourne, VIC 3004, Australia.

The fibrinolytic system provides an essential means to remove fibrin deposits and blood clots. The actual protease responsible for this is plasmin, formed from its precursor, plasminogen. Fibrin is heralded as it most renowned substrate but for many years plasmin has been known to cleave many other substrates, and to also activate other proteolytic systems. Read More

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Elemental and Isotopic Characterization of Tobacco from Umbria.

Metabolites 2021 Mar 22;11(3). Epub 2021 Mar 22.

Technology Transfer Centre, Experiment and Technological Services Department, Fondazione Edmund Mach (FEM), Via E. Mach 1, 38098 San Michele all'Adige, Italy.

Umbrian tobacco of the Virginia Bright variety is one of the most appreciated tobaccos in Europe, and one characterized by an excellent yield. In recent years, the Umbria region and local producers have invested in introducing novel practices (for production and processing) focused on environmental, social, and economic sustainability. Due to this, tobacco from Umbria is a leading commodity in the global tobacco industry, and it claims a high economic value. Read More

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Chemical Screening of Metabolites Profile from Romanian spp.

Plants (Basel) 2021 Mar 12;10(3). Epub 2021 Mar 12.

Cromatec-Plus, Scient Analytics, SCIENT, Research Center for Instrumental Analysis, 077167 Snagov, Romania.

Truffles are the rarest species and appreciated species of edible fungi and are well-known for their distinctive aroma and high nutrient content. However, their chemical composition largely depends on the particularities of their grown environment. Recently, various studies investigate the phytoconstituents content of different species of truffles. Read More

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