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Enhancing Safety During a Pandemic Using Virtual Care Remote Monitoring Technologies and UML Modeling.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Division of Clinical Informatics, Harvard School of Medicine, Harvard University, United States of America.

Objectives: This paper describes a methodology for gathering requirements and early design of remote monitoring technology (RMT) for enhancing patient safety during pandemics using virtual care technologies. As pandemics such as COrona VIrus Disease (COVID-19) progress there is an increasing need for effective virtual care and RMT to support patient care while they are at home.

Methods: The authors describe their work in conducting literature reviews by searching PubMed. Read More

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Investigating the Scientific 'Infodemic' Phenomenon Related to the COVID-19 Pandemic.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Department of Medical Informatics, Amsterdam University Medical Center - University of Amsterdam, Amsterdam Public Health research institute, Amsterdam, The Netherlands.

Objectives: The study aims at understanding the structural characteristics and content features of COVID-19 literature and public health data from the perspective of the 'Language and Meaning in Biomedicine' Working Group (LaMB WG) of IMIA. The LaMB WG has interest in conceptual characteristics, transparency, comparability, and reusability of medical information, both in science and practice.

Methods: A set of methods were used (i) investigating the overall speed and dynamics of COVID-19 publications; (ii) characterizing the concepts of COVID-19 (text mining, visualizing a semantic map of related concepts); (iii) assessing (re)usability and combinability of data sets and paper collections (as textual data sets), and checking if information is Findable, Accessible, Interoperable, and Reusable (FAIR). Read More

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Developing Effective Senior Nurse Leaders: The Impact of an Advanced Leadership Initiative.

J Nurs Adm 2021 May;51(5):271-278

Author Affiliations: Chief Nurse Executive, TriStar Division (Dr Sisk), and Chief Nurse Executive, National Group (Dr Mosier), HCA Healthcare, Nashville, Tennessee; Associate Chief Nurse (Dr Williams), Research, and Statistician (Mr Coppin), Central Texas Veterans Health Care System, Temple; and Regents Professor (Dr Robinson), School of Nursing, College of Health and Human Services, Northern Kentucky University, Highland Heights.

Objective: The aim of this study was to measure structural empowerment (SE) and capture short-term changes in perception for senior nurse leaders before and after a formal development experience.

Background: The body of literature related to SE in senior nurse leaders is limited. Applying the SE concept to senior levels of nursing leadership provides a vehicle to impact nurse leader retention and ultimately the organization beyond singular units. Read More

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A Background-Agnostic Framework with Adversarial Training for Abnormal Event Detection in Video.

IEEE Trans Pattern Anal Mach Intell 2021 Apr 21;PP. Epub 2021 Apr 21.

Abnormal event detection is a complex computer vision problem that has attracted significant attention in recent years. Its complexity arises from the commonly-adopted definition of an abnormal event, that is, a rarely occurring event that typically depends on the surrounding context. We propose a background-agnostic framework that learns from training videos containing only normal events. Read More

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Comparing radiomics models with different inputs for accurate diagnosis of significant fibrosis in chronic liver disease.

Eur Radiol 2021 Apr 21. Epub 2021 Apr 21.

CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, 95 Zhongguancun East Road, Beijing, 100190, China.

Objective: The non-invasive discrimination of significant fibrosis (≥ F2) in patients with chronic liver disease (CLD) is clinically critical but technically challenging. We aimed to develop an updated deep learning radiomics model of elastography (DLRE2.0) based on our previous DLRE model to achieve significantly improved performance in ≥ F2 evaluation. Read More

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Implantation of an Innovative Intracardiac Microcomputer System for Web-Based Real-Time Monitoring of Heart Failure: Usability and Patients' Attitudes.

JMIR Cardio 2021 Apr 21;5(1):e21055. Epub 2021 Apr 21.

Department of Cardiology, Vivantes Hospital Am Urban, Berlin, Germany.

Background: Heart failure (HF) management guided by the measurement of intracardiac and pulmonary pressure values obtained through innovative permanent intracardiac microsensors has been recently proposed as a valid strategy to individualize treatment and anticipate hemodynamic destabilization. These sensors have potential to reduce patient hospitalization rates and optimize quality of life.

Objective: The aim of this study was to evaluate the usability and patients' attitudes toward a new permanent intracardiac device implanted to remotely monitor left intra-atrial pressures (V-LAP, Vectorious Medical Technologies, Tel Aviv, Israel) in patients with chronic HF. Read More

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Twelve tips for applying Moore's Theory of Transactional Distance to optimize online teaching.

Med Teach 2021 Apr 21:1-7. Epub 2021 Apr 21.

Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.

Globally, education has seen increased incorporation of online and distance approaches to teaching and learning across all fields and program levels. As a result, many educators question how best to deliver their content in this format, resulting in a significant demand for professional development resources that focus on the best practices for online teaching. These twelve tips focus on the design, delivery and refinement stages of course development and introduce health professions educators to Moore's Theory of Transactional Distance, with the end goal of identifying concrete opportunities and methods for applying Moore's Theory to their online teaching. Read More

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A safety score for the assessment of driving style.

Traffic Inj Prev 2021 Apr 21:1-16. Epub 2021 Apr 21.

Japan Automobile Research Institute JARI - SAKURA project, Tsukuba.

Objective: Road traffic laws explicitly refer to a safe and cautious driving style as a means of ensuring safety. For automated vehicles to adhere to these laws, objective measurements of safe and cautious behavior in normal driving conditions are required. This paper describes the conception, implementation and initial testing of an objective scoring system that assigns safety indexes to observed driving style, and aggregates them to provide an overall safety score for a given driving session. Read More

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Urinary peptides in heart failure: a link to molecular pathophysiology.

Eur J Heart Fail 2021 Apr 21. Epub 2021 Apr 21.

Mosaiques Diagnostics GmbH, Hannover, Germany.

Aims: Heart failure (HF) is a major public health concern worldwide. The diversity of HF makes it challenging to decipher the underlying complex pathological processes using single biomarkers. We examined the association between urinary peptides and HF with reduced (HFrEF), mid-range (HFmrEF) and preserved (HFpEF) ejection fraction, defined based on European Society of Cardiology guidelines, and the links between these peptide biomarkers and molecular pathophysiology. Read More

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Effects of daily sedation interruption in intensive care unit patients undergoing mechanical ventilation: A meta-analysis of randomized controlled trials.

Int J Nurs Pract 2021 Apr 21:e12948. Epub 2021 Apr 21.

School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.

Aim: This study aimed to assess the effects of daily sedation interruption on the mechanical ventilation duration and relevant outcomes in mechanically ventilated patients in the intensive care unit (ICU).

Background: Previously, three meta-analyses on the association of daily sedation interruption with the mechanical ventilation duration have reported conflicting findings, and these did not support current guideline recommendations that daily sedation interruption can be routinely used in mechanically ventilated adult ICU patients.

Design: This was a systematic review and meta-analysis of randomized controlled studies. Read More

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Stability-Indicating Determination of Tedizolid Phosphate in the Presence of its Active Form and Possible Degradants.

J Chromatogr Sci 2021 Apr 21. Epub 2021 Apr 21.

Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini Street, ET-11562 Cairo, Egypt.

Tedizolid phosphate is an antibiotic prodrug that is metabolized into tedizolid which is used against various resistant bacterial strains. In this study, tedizolid phosphate was subjected to stress degradation conditions, namely, hydrolysis (neutral, acidic and alkaline), thermal, oxidative and photolytic ones. The prodrug was stable toward thermal and photolytic stress conditions, while it showed significant degradation upon applying oxidative and hydrolytic conditions. Read More

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Comprehensive characterization of oligosaccharide conformational ensembles with conformer classification by free-energy landscape reproductive kernel Hilbert space.

Phys Chem Chem Phys 2021 Apr 20. Epub 2021 Apr 20.

Faculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-Ku, Nagoya, Aichi 467-8603, Japan. and Exploratory Research Center on Life and Living Systems (ExCELLS) and Institute for Molecular Science (IMS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, 444-8787, Japan.

Oligosaccharides play versatile roles in various biological systems but are difficult to characterize from a structural viewpoint due to their remarkable degrees of freedom in internal motion. Therefore, molecular dynamics simulations have been widely used to delineate the dynamic conformations of oligosaccharides. However, hardly any methods have thus far been available for the comprehensive characterization of simulation-derived conformational ensembles of oligosaccharides. Read More

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A systematic review of quantitative bias analysis applied to epidemiological research.

Int J Epidemiol 2021 Apr 20. Epub 2021 Apr 20.

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Background: Quantitative bias analysis (QBA) measures study errors in terms of direction, magnitude and uncertainty. This systematic review aimed to describe how QBA has been applied in epidemiological research in 2006-19.

Methods: We searched PubMed for English peer-reviewed studies applying QBA to real-data applications. Read More

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Verifying Clinically Derived Reference Intervals for Daily Excretion Rates of Fractionated Metanephrines Using Modern Indirect Reference Interval Models.

Am J Clin Pathol 2021 Apr 21. Epub 2021 Apr 21.

Department of Pathology, University of Utah Health, and ARUP Laboratories, Salt Lake City, UT, USA.

Objectives: Biochemical testing of urinary metanephrines is useful in the diagnosis and monitoring of pheochromocytoma and paragangliomas. We investigated the feasibility of mixture decomposition (ie, indirect) methods in verifying clinically derived reference intervals for urinary deconjugated metanephrine metabolites.

Methods: Urinary 24-hour metanephrine and normetanephrine excretion results were extracted from our data warehouse and intervals were estimated by the modern variant of the Hoffmann method, maximum likelihood estimation (MLE), and gamma mixture model using R software. Read More

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Uncovering the complexities of biological structures with network-based learning: an application in SARS-CoV-2.

Patterns (N Y) 2021 Apr 15:100259. Epub 2021 Apr 15.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

Network-based learning enables the identification of possible undiscovered interactions in biological systems. Applying these methods to SARS-CoV-2 had revealed potential infection targets of the virus and possible interactions between SARS-CoV-2 proteins and human proteins. Read More

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Functional endoscopy in neurogenic dysphagia: a feasibility study focusing on the esophageal phase of swallowing.

Endosc Int Open 2021 Apr 15;9(4):E646-E652. Epub 2021 Apr 15.

Department of Medicine I, Josephs-Hospital Warendorf, Academic Teaching Hospital, University of Muenster, Warendorf, Germany.

Due to demographic transition, neurogenic dysphagia has become an increasingly recognized problem. Patients suffering from dysphagia often get caught between different clinical disciplines. In this study, we implemented a defined examination protocol for evaluating the whole swallowing process by functional endoscopy. Read More

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Breakpoints for the Classification of Anti- Compounds in Antifungal Screening.

Biomed Res Int 2021 6;2021:6653311. Epub 2021 Apr 6.

Department of Clinic and Social Dentistry, Graduate Program in Natural and Synthetic Bioactive Products (PgPNSB), Center for Health Sciences, Federal University of Paraiba, João Pessoa, PB, Brazil.

Introduction: The absence of a standardized classification scheme for the antifungal potency of compounds screened against species may hinder the study of new drugs. This systematic review proposes a scheme of interpretative breakpoints for the minimum inhibitory concentration (MIC) of bioactive compounds against species in tests.

Materials And Methods: A literature search was conducted in the PubMed, Scopus, Web of Science, Lilacs, and SciFinder databases for the period from January 2015 to April 2020. Read More

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Optimized photochemistry enables efficient analysis of dynamic RNA structuromes and interactomes in genetic and infectious diseases.

Nat Commun 2021 Apr 20;12(1):2344. Epub 2021 Apr 20.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA.

Direct determination of RNA structures and interactions in living cells is critical for understanding their functions in normal physiology and disease states. Here, we present PARIS2, a dramatically improved method for RNA duplex determination in vivo with >4000-fold higher efficiency than previous methods. PARIS2 captures ribosome binding sites on mRNAs, reporting translation status on a transcriptome scale. Read More

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Variation of heart and lung radiation doses according to setup uncertainty in left breast cancer.

Radiat Oncol 2021 Apr 20;16(1):78. Epub 2021 Apr 20.

Department of Radiation Oncology, Ansan Hospital, Korea University, 123 Jeokgeum-ro, Danwon-gu, Ansan, Gyeonggi-do, 15355, Republic of Korea.

Purpose: Breast radiotherapy set-up is often uncertain. Actual dose distribution to normal tissues could be different from planned dose distribution. The objective of this study was to investigate such difference in dose distribution according to the extent of set-up error in breast radiotherapy. Read More

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COVID-19 and Comparative Health Policy Learning; the Experience of 10 Countries.

Arch Iran Med 2021 Mar 1;24(3):260-272. Epub 2021 Mar 1.

Department of Health Management, Policy & Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Since December 2019, the world has been facing one of the most critical health threats of the last decades. In March 2021, the official number of deaths passed 2.6 million worldwide. Read More

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ACOSOG Z-0011 criteria impact on axillary surgery for early breast cancer in clinical practice: Evaluation in a retrospective cohort of 1900 patients.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 9;261:41-45. Epub 2021 Apr 9.

Surgery Department, Institut Cancérologie de L'ouest, Nantes, Saint Herblain, France.

Background: There is a trend towards de-escalation in early breast cancer axillary surgery. In the American College of Surgeons Oncology Group (ACOSOG) Z-0011 trial, observation was shown to be non-inferior in terms of overall survival to complementary axillary lymph node dissection (cALND) in patients with up to two sentinel lymph node (SLN) metastases. The study included patients with T1-T2 invasive breast cancer, clinically node negative, undergoing breast-conserving surgery with SLN biopsy, followed by systemic therapy and radiotherapy. Read More

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Are we measuring the right function outcomes for older adults in reviews by the Cochrane Musculoskeletal Group?

Semin Arthritis Rheum 2021 Apr 3;51(3):523-529. Epub 2021 Apr 3.

Bruyere Research Institute, 43 Bruyère Street, Ottawa K1N 5C8, Ontario, Canada. Electronic address:

Background: Musculoskeletal conditions are the leading cause of years lived with disability for older adults. Limitations in functional ability affect healthy aging for aging populations worldwide. Thus, it is important to assess effects of interventions on the multiple dimensions of function for older adults. Read More

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Non-rigid image registration using a modified fuzzy feature-based inference system for 3D cardiac motion estimation.

Comput Methods Programs Biomed 2021 Apr 6;205:106085. Epub 2021 Apr 6.

Laboratory on Cardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Belgium.

Background And Objective: Non-rigid image registration is a well-established method for estimating cardiac motion on 3D echocardiographic images. However, such images have relatively poor spatio-temporal resolution making registration challenging. Some of the main challenges are extracting features relevant to the registration problem and defining a suitable geometrical transformation to be applied. Read More

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Genomic driven factors enhance biocatalyst-related cellulolysis potential in anaerobic digestion.

Bioresour Technol 2021 Apr 17;333:125148. Epub 2021 Apr 17.

Dept. of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. Electronic address:

Anaerobic digestion (AD) is a promising technology to recover bioenergy from biodegradable biomass, including cellulosic wastes. Through a few fractionation/separation techniques, cellulose has demonstrated its potential in AD, but the performance of the process is rather substrate-specific, as cellulolysis bacteria are sensitive to the enzyme-substrate interactions. Cellulosome is a self-assembled enzyme complex with many functionalized modules in the bacteria which has been gradually studied, however the genomic fingerprints of the culture-specific cellulosome in AD are relatively unclear especially under processing conditions. Read More

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Noise Suppression for Ultrasound Attenuation Coefficient Estimation based on Spectrum Normalization.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Apr 20;PP. Epub 2021 Apr 20.

Ultrasound attenuation coefficient estimation (ACE) has great diagnostic potential for fatty liver detection and assessment. In a previous study, we proposed a reference-phantom-free ACE method, called reference frequency method (RFM), which does not require a calibrated phantom for normalization. The power of each frequency component can be normalized by the power of an adjacent frequency component in the spectrum to cancel system-dependent effects such as focusing and time gain compensation (TGC). Read More

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Neurofibromatosis type 1: Expanded variant spectrum with multiplex ligation-dependent probe amplification and genotype-phenotype correlation in 138 Turkish patients.

Ann Hum Genet 2021 Apr 20. Epub 2021 Apr 20.

Cerrahpaşa Medical Faculty, Department of Pediatric Genetics, Istanbul University-Cerrahpaşa, Istanbul, Turkey.

Objective: To investigate the variant spectrum and genotype-phenotype correlations in a Turkish cohort with Neurofibromatosis Type-1 (NF1).

Materials And Methods:  We retrospectively investigated the clinical and molecular data of 138 NF1 patients from 129 families who had been followed-up for a median of 3.9 (1. Read More

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Thoracoscopic repair of congenital diaphragmatic hernia in neonates: findings of a multicenter study in Japan.

Surg Today 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Purpose: We compared the efficacy of thoracoscopic repair (TR) with that of open repair (OR) for neonatal congenital diaphragmatic hernia (CDH).

Methods: The subjects of this multicenter retrospective cohort study were 524 infants with left-sided isolated CDH, diagnosed prenatally, and treated at one of 15 participating hospitals in Japan between 2006 and 2018. The outcomes of infants who underwent TR and those who underwent OR were compared, applying propensity score matching. Read More

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Leaderboard Design Principles to Enhance Learning and Motivation in a Gamified Educational Environment: Development Study.

JMIR Serious Games 2021 Apr 20;9(2):e14746. Epub 2021 Apr 20.

Department of Industrial Engineering, Kangwon National University, Chuncheon, Republic of Korea.

Background: Gamification in education enhances learners' motivation, problem-solving abilities, decision-making abilities, and social skills such as communication. Numerous ongoing studies are examining the application of gamification design methodology and game mechanics to a learning environment. Leaderboards are a type of game mechanic that assist learners in goal setting and unleash the motivation for learning. Read More

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Surgical handwashing practices of operating room staff: An observational study.

Scand J Caring Sci 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology Nursing, Faculty of Health Sciences, Çukurova University, Adana, Turkey.

Objective: This descriptive and cross-sectional study aims to assess the surgical handwashing practices of operating room staff.

Design: Single-blind study.

Methods: The study was conducted with 66 staff (surgeons and operating room nurses) employed in the surgery department of a university hospital in Turkey. Read More

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Eliminating non-healing wounds: a review.

Damien P Kuffler

Regen Med 2021 Apr 20. Epub 2021 Apr 20.

Institute of Neurobiology, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico 00901, USA.

Non-healing cutaneous wounds, including pressure, diabetic and venous ulcers, are wounds where the skin and underlying tissues die due to ischemia, infection, metabolic conditions, immunosuppression or radiation. Some can be eliminated with relatively straightforward techniques, although they may continue to grow in diameter and depth, becoming increasingly painful and never heal. Others respond more slowly or poorly to treatment, while others are recalcitrant to treatments. Read More

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