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Method for characterization of dynamic ankle stiffness in patients with spasticity.

Gait Posture 2021 Jun 8;88:247-251. Epub 2021 Jun 8.

Motion Analysis Laboratory, Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Electronic address:

Background: Dynamic ankle stiffness has been quantified as the slope of the ankle joint moment-angle curve over the gait interval of the second rocker, defined explicitly as the period of the gait cycle from the first relative maximum plantar flexion in early stance to maximum dorsiflexion in midstance. However, gastrocnemius spasticity may interfere with the second ankle rocker in patients with spasticity. This gait disruption results in stiffness calculations which are misleading. Read More

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Impact of slow versus rapid digesting carbohydrates on substrate oxidation in pre-pubertal children: A randomized crossover trial.

Clin Nutr 2021 May 11;40(6):3718-3728. Epub 2021 May 11.

College of Health Sciences, The University of Texas at El Paso, El Paso, TX, 79968, USA. Electronic address:

Background & Aims: Consumption of rapid digesting sugars by children are under increased scrutiny because of their contribution to unhealthy weight gain. Previous studies in adults and children have suggested that altering the blend of carbohydrates (CHOs) consumed may cause shifts in substrate utilization. The purpose of this study was to examine the effects of consuming a slow digesting carbohydrate (SDC) and rapid digesting carbohydrate (RDC) on CHO and fat oxidation, glucose, and insulin responses at rest, during exercise, and post-exercise rest in pre-pubescent children. Read More

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Flow Structure and Particle Deposition Analyses for Optimization of a Pressurized Metered Dose Inhaler (pMDI) in a Model of Tracheobronchial Airway.

Eur J Pharm Sci 2021 Jun 12:105911. Epub 2021 Jun 12.

Institute of Lung Biology and Disease, Helmholtz Zentrum Muenchen, Neuherberg 85764, Germany; Comprehensive Pneumology Center, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, Munich 81377, Germany. Electronic address:

Inhalation therapy plays an important role in management or treatment of respiratory diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades, pressurized metered dose inhalers (pMDIs) have been the most popular and prescribed drug delivery devices for inhalation therapy. The main objectives of the present computational work are to study flow structure inside a pMDI, as well as transport and deposition of micron-sized particles in a model of human tracheobronchial airways and their dependence on inhalation air flow rate and characteristic pMDI parameters. Read More

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Thiazolidinediones and Glucagon-like Peptide-1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study.

Hepatology 2021 Jun 15. Epub 2021 Jun 15.

CARIM School for Cardiovascular Disease, Maastricht University, Maastricht, the Netherlands.

Thiazolidinediones (TZDs) and glucagon-like peptide-1 (GLP-1) receptor agonists are potential pharmacological treatment options for patients at risk of nonalcoholic fatty liver disease (NAFLD). Therefore, we examined the association between the risk of NAFLD and the use of thiazolidinediones and GLP-1 receptor agonists compared with the use of sulfonylureas (SUs) and insulins. Additionally, we calculated the incidence of hepatocellular carcinoma (HCC) in users of TZDs and GLP-1 receptor agonists. Read More

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Disentangling the contributions of agentic, antagonistic, and neurotic narcissism to drive for thinness and drive for muscularity.

PLoS One 2021 15;16(6):e0253187. Epub 2021 Jun 15.

Institute of Psychology, University of Münster, Münster, Germany.

Body image concerns revolving around body ideals (thin ideal, muscular ideal) are widespread among women. Whereas a stronger preoccupation with ideal physical appearance is often assumed for narcissistic women, previous empirical findings have been mixed. Following a tripartite structure of agentic, antagonistic, and neurotic narcissism facets, we reexamined whether trait narcissism predicted drive for thinness and drive for muscularity. Read More

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Effect of Virtual Reality Perspective-Taking on Related and Unrelated Contexts.

Cyberpsychol Behav Soc Netw 2021 Jun 14. Epub 2021 Jun 14.

Department of Communication, Stanford University, Stanford, California, USA.

Virtual reality perspective-taking (VRPT) experiences effectively increase both empathy and prosocial behaviors toward related social targets (e.g., cutting down a tree in virtual reality increases concern for the environment). Read More

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Robotic-assisted percutaneous iliac screw fixation for destructive lumbosacral metastatic lesions: an early single-institution experience.

Acta Neurochir (Wien) 2021 Jun 15. Epub 2021 Jun 15.

Division of Spine, Department of Neurosurgery, Duke University Medical Center, 200 Trent Drive, Durham, NC, 27710, USA.

Background: Robotic-assisted surgery is becoming more widely applied in surgical subspecialties due to its intraoperative and postoperative advantages such as minimally invasive approach, reduced blood loss, shorter hospital stay, and decreased incidence of postoperative complications. However, robotic devices were only recently introduced in the field of spinal surgery. Specifically, percutaneous approaches involving computer-assisted image guidance are relatively new in iliac screw fixation. Read More

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Treatment Guideline for Patients with Native Culture-negative Pyogenic Vertebral Osteomyelitis.

Clin Orthop Relat Res 2021 Jun 15. Epub 2021 Jun 15.

Spine Center, Department of Orthopedics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Background: With the development of evidence-based guidelines for the diagnosis and antibiotic treatment of patients with pyogenic vertebral osteomyelitis, various nonsurgical and surgical treatment strategies have achieved favorable results. However, sufficient administration of appropriate antibiotics is a prerequisite for treatment success, which cannot be guaranteed in patients with culture-negative pyogenic vertebral osteomyelitis. Unfortunately, previous studies on culture-negative pyogenic vertebral osteomyelitis were limited by small patient groups, short follow-up periods, varied treatment protocols, and inconsistently defined clinical endpoints. Read More

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A Vignette Study Analyzing Contextual Factors that Influence Emerging Adults' Definitions of Virginity Loss in German-Speaking Countries.

J Sex Res 2021 Jun 15:1-15. Epub 2021 Jun 15.

Gender Medicine Unit, Medical University of Innsbruck.

Past research on virginity loss definitions revealed that emerging adults' definitions of virginity loss are associated with emerging adults' own sociodemographic characteristics. However, previous research has not systematically studied whether emerging adults applied different criteria for virginity loss depending on the context of the judged behavior. The current study used vignettes to explore which contextual factors of an intimate partnered behavior influence emerging adults' definition of virginity loss. Read More

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Nanotherapeutics for treating coronavirus diseases.

J Drug Deliv Sci Technol 2021 Jun 10:102634. Epub 2021 Jun 10.

Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Viral diseases have recently become a threat to human health and rapidly become a significant cause of mortality with a continually exacerbated unfavorable socio-economic impact. Coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS-CoV), and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), have threatened human life, with immense accompanying morbidity rates; the COVID-19 (caused by SARS-CoV-2) epidemic has become a severe threat to global public health. In addition, the design process of antiviral medications usually takes years before the treatments can be made readily available. Read More

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Mapping Ethics Education in Accounting Research: A Bibliometric Analysis.

J Bus Ethics 2021 Jun 10:1-22. Epub 2021 Jun 10.

School of Economics and Business, University of Ljubljana, Kardeljeva pl. 17, 1000 Ljubljana, Slovenia.

The attention being paid to ethics education in accounting has been increasing, especially after the corporate accounting scandals at the turn of the century. This paper provides a comprehensive overview of the existing research in the field of ethics education in accounting. To synthesize past research, a bibliometric analysis that references 134 primary studies is performed and three bibliometric methods are applied. Read More

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Structural and compositional analysis of (InGa)(AsSb)/GaAs/GaP Stranski-Krastanov quantum dots.

Light Sci Appl 2021 Jun 15;10(1):125. Epub 2021 Jun 15.

Department of Applied Physics, Eindhoven University of Technology, 5612 AZ, Eindhoven, The Netherlands.

We investigated metal-organic vapor phase epitaxy grown (InGa)(AsSb)/GaAs/GaP Stranski-Krastanov quantum dots (QDs) with potential applications in QD-Flash memories by cross-sectional scanning tunneling microscopy (X-STM) and atom probe tomography (APT). The combination of X-STM and APT is a very powerful approach to study semiconductor heterostructures with atomic resolution, which provides detailed structural and compositional information on the system. The rather small QDs are found to be of truncated pyramid shape with a very small top facet and occur in our sample with a very high density of ∼4 × 10 cm. Read More

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Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo.

Life Sci Alliance 2021 07 14;4(7). Epub 2021 Jun 14.

Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA

Aggregation and accumulation of amyloid-β (Aβ) is a defining feature of Alzheimer's disease pathology. To study microglial responses to Aβ, we applied exogenous Aβ peptide, in either oligomeric or fibrillar conformation, to primary mouse microglial cultures and evaluated system-level transcriptional changes and then compared these with transcriptomic changes in the brains of CRND8 APP mice. We find that primary microglial cultures have rapid and massive transcriptional change in response to Aβ. Read More

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Designing centralized waiting lists for attachment to a primary care provider: Considerations from a logic analysis.

Eval Program Plann 2021 May 29:101962. Epub 2021 May 29.

Departments of Family Medicine and Public Health Sciences, Queen's University, CTAQ Chair in Applied Health Economics/Health Policy, Centre for Health Services and Policy Research, Centre for Studies in Primary Care, Institute for Clinical Evaluative Sciences, Kingston, ON, Canada.

Access to a regular primary care provider is essential to quality care. In Canada, where 15 % of patients are unattached (i.e. Read More

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Differential Alterations in the Attentional Networks of People Living with HIV and Apathy: Preliminary Results and Pharmacoclinical Impact.

CNS Spectr 2021 Apr;26(2):143

Maimonides University, Buenos Aires, Argentina.

Objective: The objective was to determine alterations in the care of people living with human immunodeficiency virus (PLHIV) with depressive disorder without and with apathy to determine differential parameters.

Methods: We studied 69 PLHIV, negativized viral load, of both sexes (19 women and 44 men), with depressive disorder (F32.9-DSM IV), 20 with apathy and 26 without apathy; negativized viral load, in highly effective antiretroviral treatment without therapeutic failure in the last 2 years and without protease inhibitors; without psychopharmacological treatment (except anxiolytics) or dementia due to HIV (American Academy of Neurology) or comorbidities (hepatitis C, CNS or central vascular infections). Read More

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Phytoremediation of azoxystrobin and imidacloprid by wetland plant species , and .

Int J Phytoremediation 2021 Jun 14:1-9. Epub 2021 Jun 14.

Department of Crop and Soil Sciences, North Carolina State University, Raleigh, NC, USA.

Azoxystrobin (strobilurin fungicide) and imidacloprid (neonicotinoid insecticide) have been detected in surface waters near treated agricultural, urban, and mixed landscapes. The hazards of pesticide runoff can be prevented through best management practices, including the establishment of diverse wetland plant barriers that can phytoremediate the chemicals in which they come into contact with. In this study, the wetland plant species softrush (), pickerelweed (), and arrowhead ( were planted in sandy soil containers that were then placed in azoxystrobin or imidacloprid treated water. Read More

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Causal Relationship Between the Risk Factors and Work-Related Musculoskeletal Disorders Among Professional Drivers: A Systematic Review.

Hum Factors 2021 Jun 14:187208211006500. Epub 2021 Jun 14.

26682 Chiang Mai University, Thailand.

Objective: This review evaluates the evidence on the strength of causal relationship between categories of risk factors (RFs) and work-related musculoskeletal disorders (WRMSDs) among professional drivers.

Background: A compilation of evidence on the causal relationship between RFs and WRMSDs among professional drivers is lacking.

Methods: A systematic search of the literature was conducted in major electronic data bases that include Medline (1946 + via OvidSP), Embase (1974 + OvidSP), CINAHL (1982+), AMED, and Web of Science. Read More

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The Termite Fungal Cultivar Combines Diverse Enzymes and Oxidative Reactions for Plant Biomass Conversion.

mBio 2021 Jun 15:e0355120. Epub 2021 Jun 15.

Group of Chemical Biology of Microbe-Host Interactions, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.

Macrotermitine termites have domesticated fungi in the genus as their primary food source using predigested plant biomass. To access the full nutritional value of lignin-enriched plant biomass, the termite-fungus symbiosis requires the depolymerization of this complex phenolic polymer. While most previous work suggests that lignocellulose degradation is accomplished predominantly by the fungal cultivar, our current understanding of the underlying biomolecular mechanisms remains rudimentary. Read More

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Excitation-scan Mirror Array System Advancements to Hyperspectral Imaging Applications.

Proc SPIE Int Soc Opt Eng 2020 Feb 17;11245. Epub 2020 Feb 17.

Chemical and Biomolecular Engineering, University of South Alabama, AL 36688.

Hyperspectral imaging (HSI) technology has been applied in a range of fields for target detection and mixture analysis. While its original applications were in remote sensing, modern uses include agriculture, historical document authentications and medicine. HSI has shown great utility in fluorescence microscopy; however, acquisition speeds have been slow due to light losses associated with spectral filtering. Read More

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February 2020

Intravitreal anti-VEGF use in France: a cross-sectional and longitudinal Nationwide observational study.

Acta Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

EPI-PHARE (French National Agency for Medicines and Health Products Safety (ANSM) and French National Health Insurance (CNAM)), Saint-Denis, France.

Purpose: To describe the sociodemographic, medical and management characteristics of patients using intravitreal (IVT) anti-vascular endothelial growth factors (VEGF) in France.

Methods: An observational study was conducted in patients treated with IVT ranibizumab or aflibercept, aged 18 years or older using the French National Health Insurance Databases covering 99% of the French population. Patients currently treated in 2018 were included in a cross-sectional approach to describe treatment history over the previous 6 years. Read More

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Daily ambient temperature and mortality in Thailand: Estimated effects, attributable risks, and effect modifications by greenness.

Sci Total Environ 2021 Jun 8;791:148373. Epub 2021 Jun 8.

Department of Environmental Health Sciences, Faculty of Public Health, Mahidol University, Bangkok, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), Bangkok, Thailand. Electronic address:

Background: In recent years, many previous studies have examined the association between ambient temperature and mortality in different parts of the world. However, very few studies have explored the mortality burden attributable to temperature, especially those in developing countries. This study aimed to quantify the burden of mortality attributable to non-optimum temperature in Thailand and explore whether greenness, using normalized difference vegetation index (NDVI) as indicator, alleviates the mortality contributed by non-optimum ambient temperature. Read More

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Hippocampal volume as treatment predictor in antidepressant naïve patients with major depressive disorder.

J Psychiatr Res 2021 Jun 7;140:323-328. Epub 2021 Jun 7.

Universidad Autónoma de Nuevo Leon, School of Medicine, Human Anatomy Department, Monterrey, Nuevo León, Mexico. Electronic address:

Major depression disorder (MDD) limits psychosocial functioning and quality of life. One of the biological alterations is a hippocampal volume (HV) reduction. Previous prospective neuroimaging studies present inconsistencies regarding HV reductions and clinical features and response of antidepressant treatment of the participants. Read More

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Free energy landscape of RNA binding dynamics in start codon recognition by eukaryotic ribosomal pre-initiation complex.

PLoS Comput Biol 2021 Jun 14;17(6):e1009068. Epub 2021 Jun 14.

Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.

Specific interaction between the start codon, 5'-AUG-3', and the anticodon, 5'-CAU-3', ensures accurate initiation of translation. Recent studies show that several near-cognate start codons (e.g. Read More

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Therapeutic relationship and professional burnout in psychotherapists: A structural equation model approach.

Clin Psychol Psychother 2021 Jun 14. Epub 2021 Jun 14.

Institute of Psychology, The John Paul II Catholic University of Lublin, Lublin, Poland.

Previous studies on the therapists' burnout have focused on individual and environmental risk factors. This study aimed to analyse whether variables reflecting therapeutic relationship-the therapist experience of relational depth and quality of the therapeutic relationship-can be related to psychotherapist burnout. Four alternative path models were examined. Read More

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Outcomes of redo-isolated tricuspid valve surgery after left-sided valve surgery.

J Card Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Objectives: To compare early and long-term outcomes of redo-isolated tricuspid surgery (RITS) after left-sided valve surgery.

Methods: We retrospectively reviewed 173 patients who underwent RITS for severe tricuspid regurgitation after previous left-sided valve surgery from January 1999 to December 2019. Patients were divided into two groups: RITS by median sternotomy (m-RITS; n = 78) and totally endoscopic approach (e-RITS; n = 95). Read More

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Evidence of Nasal Cooling and Sensory Impairments Driving Patient Symptoms With Septal Deviation.

Laryngoscope 2021 Jun 14. Epub 2021 Jun 14.

Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, U.S.A.

Objectives/hypothesis: About 260,000 septoplasties are performed annually in the US to address nasal septal deviation (NSD). Yet, we do not consistently understand what aspects of NSD result in symptoms.

Study Design: Blinded cohort study. Read More

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COSMO-RS predictions of logP in the SAMPL7 blind challenge.

J Comput Aided Mol Des 2021 Jun 14. Epub 2021 Jun 14.

Dassault Systemes Deutschland GmbH, Imbacher Weg 46, 51379, Leverkusen, Germany.

We applied the COSMO-RS method to predict the partition coefficient logP between water and 1-octanol for 22 small drug like molecules within the framework of the SAMPL7 blind challenge. We carefully collected a set of thermodynamically meaningful microstates, including tautomeric forms of the neutral species, and calculated the logP using the current COSMOtherm implementation on the most accurate level. With this approach, COSMO-RS was ranked as the 6st most accurate method (Measured by the mean absolute error (MAE) of 0. Read More

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Generative Models for Extrapolation Prediction in Materials Informatics.

ACS Omega 2021 Jun 25;6(22):14566-14574. Epub 2021 May 25.

Department of Applied Chemistry, Waseda University, Tokyo 169-8555, Japan.

We report a deep generative model for regression tasks in materials informatics. The model is introduced as a component of a data imputer and predicts more than 20 diverse experimental properties of organic molecules. The imputer is designed to predict material properties by "imagining" the missing data in the database, enabling the use of incomplete material data. Read More

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Gene Expression Profiles of Circular RNAs and MicroRNAs in Chronic Rhinosinusitis With Nasal Polyps.

Front Mol Biosci 2021 28;8:643504. Epub 2021 May 28.

Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Chronic rhinosinusitis (CRS) is often classified primarily on the basis of the absence or presence of nasal polyps (NPs), that is, as CRS with nasal polyps (CRSwNP) or CRS without nasal polyps (CRSsNP). Additionally, according to the percentage of eosinophils, CRSwNP can be further divided into eosinophilic CRSwNP (ECRSwNP) and non-ECRSwNP. CRSwNP is a significant public health problem with a considerable socioeconomic burden. Read More

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Image-Guided Robotic Radiosurgery for the Treatment of Same Site Spinal Metastasis Recurrences.

Front Oncol 2021 28;11:642314. Epub 2021 May 28.

European Cyberknife Center, Munich, Germany.

Background: Due to recent medical advancements, patients suffering from metastatic spinal disease have a prolonged life expectancy than several decades ago, and some will eventually experience relapses. Data for the retreatment of spinal metastasis recurrences occurring at the very same macroscopic spot as the initially treated lesion are limited. Previous studies mainly included recurrences in the boundary areas as well as other macroscopic parts of the initially affected vertebrae. Read More

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