21,932 results match your criteria application synthetic

Impact of dimethylpyrazole-based nitrification inhibitors on soil-borne bacteria.

Sci Total Environ 2021 Jun 15;792:148374. Epub 2021 Jun 15.

Department of Genetics, Physical Anthropology & Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.

Nitrogen (N) input from fertilizers modifies the properties of agricultural soils as well as bacterial community diversity, composition and relationships. This can lead to negative impacts such as the deterioration of system multifunctionality, whose maintenance is critical to normal nutrient cycling. Synthetic nitrification inhibitors (NIs) can be combined with fertilizers to improve the efficiency of N use by reducing N losses. Read More

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Conditional generation of medical images via disentangled adversarial inference.

Med Image Anal 2021 May 24;72:102106. Epub 2021 May 24.

Imagia, Canada; Montréal Institute for Learning Algorithms (MILA), Université de Montréal, Canada; West China Biomedical Big Data Center, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Synthetic medical image generation has a huge potential for improving healthcare through many applications, from data augmentation for training machine learning systems to preserving patient privacy. Conditional Adversarial Generative Networks (cGANs) use a conditioning factor to generate images and have shown great success in recent years. Intuitively, the information in an image can be divided into two parts: 1) content which is presented through the conditioning vector and 2) style which is the undiscovered information missing from the conditioning vector. Read More

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Engineering yeast subcellular compartments for increased production of the lipophilic natural products ginsenosides.

Metab Eng 2021 Jun 18. Epub 2021 Jun 18.

Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, China; National Technology Innovation Center of Synthetic Biology, China. Electronic address:

Eukaryotic yeasts have a variety of subcellular compartments and are ideal platform strains for the construction of complex heterologous natural product biosynthesis pathways. Improving the synthesis efficiency of microbial cell factories through the utilization and modification of subcellular compartments by synthetic biology has good application prospects. Here, we used the yeast PLN1 protein to target the normally endoplasmic reticulum (ER)-localized cytochrome P450 enzyme protopanaxadiol (PPD) synthase (PPDS) to lipid droplets (LDs), which are the storage organelles of the PPDS substrate dammarenediol-II (DD). Read More

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Propolis: properties and composition, health benefits and applications in fish nutrition.

Fish Shellfish Immunol 2021 Jun 18. Epub 2021 Jun 18.

Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt. Electronic address:

Propolis is a viscous, waxy, resinous substance that is produced from the exudates of flowers and buds by the action of salivary enzymes of honey bees. Propolis may differ in color (brown, red or green), with color being influenced by the chemical composition and age of the product. Propolis has a special distinctive odor owing to the high concentration of volatile essential oils. Read More

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Natural and Artificial Chiral-Based Systems for Separation Applications.

Crit Rev Anal Chem 2021 Jun 21:1-19. Epub 2021 Jun 21.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, China.

Chiral separation has attracted much attention for basic research and industrial applications in analytical chemistry. Generally, chiral separations use natural or artificial chiral-based materials as adsorbents. To improve the precision and efficiency of chiral separation, focus has shifted from natural and synthetic adsorbents to binary combinations of materials. Read More

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Diatoms with Invaluable Applications in Nanotechnology, Biotechnology, and Biomedicine: Recent Advances.

ACS Biomater Sci Eng 2021 Jun 21. Epub 2021 Jun 21.

Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University in Olomouc, Slechtitelu 27, 783 71, Olomouc, Czech Republic.

Diatoms are unicellular microalga found in soil and almost every aquatic environment (marine and fresh water). Biogenic silica and diatoms are attractive for biotechnological and industrial applications, especially in the field of biomedicine, industrial/synthetic manufacturing processes, and biomedical/pharmaceutical sciences. Deposition of silica by diatoms allows them to create micro- or nanoscale structures which may be utilized in nanomedicine and especially in drug/gene delivery. Read More

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A Synthetic DNA Construct to Evaluate the Recovery Efficiency of Cell-Free DNA Extraction and Bisulfite Modification.

Clin Chem 2021 Jun 21. Epub 2021 Jun 21.

Department of Surgery-Austin Precinct, The University of Melbourne, Melbourne, Victoria, Australia.

Background: Despite improvements in the genetic and epigenetic analysis of cell-free DNA (cfDNA), there has been limited focus on assessing the preanalytical variables of recovery efficiency following cfDNA extraction and bisulfite modification. Quantification of recovery efficiency after these steps can facilitate quality assurance and improve reliability when comparing serial samples.

Methods: We developed an exogenous DNA Construct to Evaluate the Recovery Efficiency of cfDNA extraction and BISulfite modification (CEREBIS) after cfDNA extraction and/or subsequent bisulfite modification from plasma. Read More

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Stabilization of an enzyme cytochrome in a metal-organic framework against denaturing organic solvents.

iScience 2021 Jun 24;24(6):102641. Epub 2021 May 24.

Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, USA.

Enzymes are promising catalysts with high selectivity and activity under mild reaction conditions. However, their practical application has largely been hindered by their high cost and poor stability. Metal-organic frameworks (MOFs) as host materials show potential in protecting proteins against denaturing conditions, but a systematic study investigating the stabilizing mechanism is still lacking. Read More

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Entomotoxicity of some agro-wastes against cowpea bruchid, (Fab.) [Coleoptera: Chrysomelidae] infesting cowpea seeds in storage.

Heliyon 2021 Jun 2;7(6):e07202. Epub 2021 Jun 2.

Biology Unit, Centre for Continuing Education, Federal University of Technology, P.M.B 704, Akure, Ondo State, Nigeria.

Cowpea, is a popular agricultural produce known as poor man's meat among Africans because it is very cheap and affordable. In spite of its importance, its infestation by cowpea seed bruchid, has been a major constrain hindering its storage. Considering the high level of infestation of cowpea by and the high level of pollution caused by agricultural products, this research investigated the entomotoxicant effectiveness of rice husk, wheat husk and groundnut pod ash and powder in the control of cowpea beetle in storage. Read More

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Integrated Analysis of Cell Cycle-Related and Immunity-Related Biomarker Signatures to Improve the Prognosis Prediction of Lung Adenocarcinoma.

Front Oncol 2021 4;11:666826. Epub 2021 Jun 4.

Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Lung adenocarcinoma (LUAD) is a leading malignancy and has a poor prognosis over the decades. LUAD is characterized by dysregulation of cell cycle. Immunotherapy has emerged as an ideal option for treating LUAD. Read More

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Review of calcium-sulphate-based ceramics and synthetic bone substitutes used for antibiotic delivery in PJI and osteomyelitis treatment.

EFORT Open Rev 2021 May 4;6(5):297-304. Epub 2021 May 4.

Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania.

Infection in orthopaedic and trauma surgery remains a destructive complication with particularly challenging diagnosis and treatment due to bacterial antibiotic resistance and biofilm formation.Along with surgical debridement and systemic antibiotics, an important type of adjuvant therapy is local antibiotic delivery, with the purpose of eliminating bacterial colonization and biofilm development.Calcium sulphate, as a synthetic absorbable biomaterial used for local antibiotic delivery, has experienced an increasing popularity during the last decade, with multiple promoted advantages such as predictable antibiotic elution kinetics, complete and quick biodegradation, good biocompatibility, and limited associated complications. Read More

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A preliminary analysis of AI based smartphone application for diagnosis of COVID-19 using chest X-ray images.

Expert Syst Appl 2021 Nov 12;183:115401. Epub 2021 Jun 12.

School of Mechanical Engineering, SASTRA Deemed to be University, Thanjavur 613 401, Tamil Nadu, India.

The COVID-19 outbreak has catastrophically affected both public health system and world economy. Swift diagnosis of the positive cases will help in providing proper medical attention to the infected individuals and will also aid in effective tracing of their contacts to break the chain of transmission. Blending Artificial Intelligence (AI) with chest X-ray images and incorporating these models in a smartphone can be handy for the accelerated diagnosis of COVID-19. Read More

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November 2021

2D MXenes as Co-catalysts in Photocatalysis: Synthetic Methods.

Nanomicro Lett 2019 Sep 21;11(1):79. Epub 2019 Sep 21.

Key Laboratory of Physics and Technology for Advanced Batteries (Ministry of Education), College of Physics, Jilin University, Changchun, 130012, People's Republic of China.

Since their seminal discovery in 2011, two-dimensional (2D) transition metal carbides/nitrides known as MXenes, that constitute a large family of 2D materials, have been targeted toward various applications due to their outstanding electronic properties. MXenes functioning as co-catalyst in combination with certain photocatalysts have been applied in photocatalytic systems to enhance photogenerated charge separation, suppress rapid charge recombination, and convert solar energy into chemical energy or use it in the degradation of organic compounds. The photocatalytic performance greatly depends on the composition and morphology of the photocatalyst, which, in turn, are determined by the method of preparation used. Read More

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September 2019

Ultra-stable CsPbBr Perovskite Nanosheets for X-Ray Imaging Screen.

Nanomicro Lett 2019 Jun 24;11(1):52. Epub 2019 Jun 24.

Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan, 250022, People's Republic of China.

Wet chemistry methods, including hot-injection and precipitation methods, have emerged as major synthetic routes for high-quality perovskite nanocrystals in backlit display and scintillation applications. However, low chemical yield hinders their upscale production for practical use. Meanwhile, the labile nature of halide-based perovskite poses a major challenge for long-term storage of perovskite nanocrystals. Read More

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Biomass-Derived Porous Carbon-Based Nanostructures for Microwave Absorption.

Nanomicro Lett 2019 Mar 15;11(1):24. Epub 2019 Mar 15.

School of Materials Sciences and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.

Currently, electromagnetic (EM) pollution poses severe complication toward the operation of electronic devices and biological systems. To this end, it is pertinent to develop novel microwave absorbers through compositional and structural design. Porous carbon (PC) materials demonstrate great potential in EM wave absorption due to their ultralow density, large surface area, and excellent dielectric loss ability. Read More

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Low Molecular Weight Supramolecular Hydrogels for Sustained and Localized Drug Delivery.

ACS Appl Bio Mater 2019 Apr 20;2(5):2116-2124. Epub 2019 May 20.

Department of Chemistry, University of Rochester, Rochester, NY 14627.

Supramolecular hydrogels are emerging as next-generation alternatives to synthetic polymers for drug delivery applications. Self-assembling peptides are a promising class of supramolecular gelator for drug delivery that have been slow to be adopted despite advantages in biocompatibility due to the relatively high cost of producing synthetic peptide hydrogels compared to synthetic polymer gels. Herein we describe the development and use of inexpensive low molecular weight cationic derivatives of phenylalanine (Phe) as injectable hydrogels for delivery of an anti-inflammatory drug, diclofenac, for pain mitigation in a mouse model. Read More

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Spectral Embedding Norm: Looking Deep into the Spectrum of the Graph Laplacian.

SIAM J Imaging Sci 2020 30;13(2):1015-1048. Epub 2020 Jun 30.

Halicioğlu Data Science Institute, University of California, San Diego.

The extraction of clusters from a dataset which includes multiple clusters and a significant background component is a non-trivial task of practical importance. In image analysis this manifests for example in anomaly detection and target detection. The traditional spectral clustering algorithm, which relies on the leading eigenvectors to detect clusters, fails in such cases. Read More

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Perspectives for synthetic curcumins in chemoprevention and treatment of cancer: an update with promising analogues.

Eur J Pharmacol 2021 Jun 16:174266. Epub 2021 Jun 16.

Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, 25701, USA. Electronic address:

Curcumin, a pure compound extracted from the flowering plant, turmeric (Curcuma longa. Zingiberaceae), is a common dietary ingredient found in curry powder. It has been studied extensively for its anti-inflammatory, antioxidant, antimicrobial and anti-tumour activities. Read More

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Purification and characterization of antioxidant peptides from hairtail surimi hydrolysates and their effects on beef color stability.

J Food Sci 2021 Jun 19. Epub 2021 Jun 19.

Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, Fujian, China.

The antioxidant peptides extracted from plants or animals have shown great potential in preventing food quality deterioration caused by oxidization. Here, peptide fractions obtained from hairtail surimi hydrolysates (HSH) were investigated for structure and color-protective effect. The results showed the <3 kDa fraction obtained from HSH by ultrafiltration could be separated into five major fractions (A-E) by gel chromatography, among which fraction A possessed the highest antioxidant activities. Read More

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Synthesis of near-infrared absorbing triangular Au nanoplates using biomineralisation peptides.

Acta Biomater 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemical Science and Engineering, Tokyo Institute of Technology, 2-12-1-S1-24, O-okayama, Meguro-ku, Tokyo 152-8552, Japan. Electronic address:

Triangular Au nanoplates (TrAuNPls) possessing strong plasmonic properties can be used as photothermal agents in cancer therapy. However, the preparation of such controlled morphologies typically requires harsh synthetic conditions. Biomolecules offer an alternative route to developing biocompatible synthetic protocols. Read More

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A method and its application to determine the amount of cannabinoids in sewage sludge and biosolids.

Environ Sci Pollut Res Int 2021 Jun 18. Epub 2021 Jun 18.

Clinical and Health Sciences (CHS), Health and Biomedical Innovation, University of South Australia, GPO Box 2471, Adelaide, South Australia, 5000, Australia.

Xenobiotic cannabinoids (phyto and synthetic) are highly lipophilic compounds and have been shown to accumulate within the particulate fraction of wastewater. Limited research has been conducted to investigate the occurrence of cannabinoids in sewage sludge and/or biosolids. The analysis of excreted cannabinoids from sewage sludge or biosolids can provide information about community health, as well as potentially long-term environmental impacts. Read More

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Closure of a large lumbosacral myelomeningocele defect with a human pericardial graft: a case report.

Childs Nerv Syst 2021 Jun 18. Epub 2021 Jun 18.

Neurosurgery Department of Garrahan Hospital, Buenos Aires, Argentina.

Introduction: Myelomeningocele (MMC) is a complex congenital defect resulting from incomplete closure of the neural tube. The aim of this study is to present an unusual technique for the closure of a large defect.

Case Report: Here we report a patient that was prenatally diagnosed with MMC. Read More

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Cell-derived biomimetic nanocarriers for targeted cancer therapy: cell membranes and extracellular vesicles.

Drug Deliv 2021 Dec;28(1):1237-1255

Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, China.

Nanotechnology provides synthetic carriers for cancer drug delivery that protect cargos from degradation, control drug release and increase local accumulation at tumors. However, these non-natural vehicles display poor tumor targeting and potential toxicity and are eliminated by the immune system. Recently, biomimetic nanocarriers have been widely developed based on the concept of 'mimicking nature. Read More

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December 2021

Three dimensional printed nanostructure biomaterials for bone tissue engineering.

Regen Ther 2021 Dec 28;18:102-111. Epub 2021 May 28.

Department of Pharmaceutics & Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

The suffering from organ dysfunction due to damaged or diseased tissue/bone has been globally on the rise. Current treatment strategies for non-union bone defects include: the use of autografts, allografts, synthetic grafts and free vascularized fibular grafts. Bone tissue engineering has emerged as an alternative for fracture repair to satisfy the current unmet need of bone grafts and to alleviate the problems associated with autografts and allografts. Read More

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December 2021

Bicyclo[2.2.0]hexene derivatives as a proaromatic platform for group transfer and chemical sensing.

Nat Commun 2021 Jun 17;12(1):3680. Epub 2021 Jun 17.

Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.

Here we report the design, preparation, synthetic utility, and sensing application of a class of proaromatic structures, namely bicyclo[2.2.0]hexene (BCH) derivatives. Read More

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Regulatory effects of nitric oxide on reproduction and melanin biosynthesis in onion pathogenic fungus Stemphylium eturmiunum.

Fungal Biol 2021 Jul 8;125(7):519-531. Epub 2021 Feb 8.

Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, China. Electronic address:

The formation of propagules is the critical stage for transmission of the pathogenic fungus Stemphylium eturmiunum. However, how the development of these propagules is regulated remains to be fully understood. Here, we show that nitric oxide (NO) is necessary for reproduction in S. Read More

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Perfect adaptation in biology.

Cell Syst 2021 Jun;12(6):509-521

Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. Electronic address:

A distinctive feature of many biological systems is their ability to adapt to persistent stimuli or disturbances that would otherwise drive them away from a desirable steady state. The resulting stasis enables organisms to function reliably while being subjected to very different external environments. This perspective concerns a stringent type of biological adaptation, robust perfect adaptation (RPA), that is resilient to certain network and parameter perturbations. Read More

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Two-Dimensional Black Phosphorus Nanomaterials: Emerging Advances in Electrochemical Energy Storage Science.

Nanomicro Lett 2020 Sep 2;12(1):179. Epub 2020 Sep 2.

Collaborative Innovation Center for Optoelectronic Science and Technology, International Collaborative Laboratory of 2D Materials for Optoelectronic Science and Technology of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, 518060, People's Republic of China.

Two-dimensional black phosphorus (2D BP), well known as phosphorene, has triggered tremendous attention since the first discovery in 2014. The unique puckered monolayer structure endows 2D BP intriguing properties, which facilitate its potential applications in various fields, such as catalyst, energy storage, sensor, etc. Owing to the large surface area, good electric conductivity, and high theoretical specific capacity, 2D BP has been widely studied as electrode materials and significantly enhanced the performance of energy storage devices. Read More

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September 2020

Encapsulation of in alginate beads to sustain bacterial viability and inoculation of under drought stress.

3 Biotech 2021 Jun 24;11(6):293. Epub 2021 May 24.

Department of Life Sciences, Centre for Functional Ecology, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal.

Conventional agricultural practices based on the application of synthetic fertilizers are increasingly considered as unsustainable. Under a forecasted scenario of drought for the next decades, there is a global demand for innovative and sustainable approaches to ameliorate plant performance. Here, encapsulating beneficial microbes (BMs) to promote plant growth is gaining attention. Read More

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Photoinduced post-modification of graphitic carbon nitride-embedded hydrogels: synthesis of 'hydrophobic hydrogels' and pore substructuring.

Beilstein J Org Chem 2021 21;17:1323-1334. Epub 2021 May 21.

Max Planck Institute of Colloids and Interfaces, Department of Colloid Chemistry, Am Mühlenberg 1, 14476 Potsdam, Germany.

Hydrogels are a special class of crosslinked hydrophilic polymers with a high water content through their porous structures. Post-modifications of hydrogels propose an attractive platform so that a variety of fresh functions, which are not arising from initial monomers, could be accessible on a parental network. Photoinduced post-modification of hydrogels by embedding semiconductor nanosheets would be of high interest and novelty. Read More

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