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The Influence of Academic Pedigree on Integrated Plastic Surgery Resident Training Location.

J Surg Educ 2021 May 5. Epub 2021 May 5.

Division of Plastic Surgery, Department of Surgery, UC San Diego Health Center, San Diego, California. Electronic address:

Introduction: Plastic surgery residencies are among the most competitive programs for graduate medical education. While board scores and research output are well-studied indicators of match success, no studies describe the association between an applicant's medical school ranking and subsequent residency ranking.

Methods: A cross-sectional study of integrated plastic surgery residents for the 2019 to 2020 academic year was performed. Read More

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The current state of knowledge on taxonomy, modulating factors, ecological roles, and mode of action of phytoplankton allelochemicals.

Sci Total Environ 2021 Jun 6;773:145681. Epub 2021 Feb 6.

Division of Marine Ecosystems Functioning, Institute of Oceanography, University of Gdańsk, Av. Piłsudskiego 46, 81-378 Gdynia, Poland.

Allelopathy is widespread in marine, brackish, and freshwater habitats. Literature data indicate that allelopathy could offer a competitive advantage for some phytoplankton species by reducing the growth of competitors. It is also believed that allelopathy may affect species succession. Read More

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Discovering of the L ligand impact on luminescence enhancement of Eu(Dibenzoylmethane).L complexes employing transient absorption spectroscopy.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 20;258:119832. Epub 2021 Apr 20.

Department of Physics, Sofia University, 5 J. Bourchier Blvd., 1164 Sofia, Bulgaria; John Atanasoff Center for Bio and Nano Photonics (JAC BNP), 1164 Sofia, Bulgaria.

The effect of luminescent enhancement under exchange of the auxiliary ligand in Europium(III) tris(1,3-diphenyl-1,3-propanedionato) monohydrate was investigated by steady-state and time-resolved transient absorption spectroscopy. The excited state relaxation dynamics of this complex was analysed through a comparison of the experimental data obtained for several model compounds, namely Eu(DBM)·NH, Eu(DBM).EDA, Eu(DBM). Read More

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Interaction of acridinedione dye with a globular protein in the presence of site selective and site specific binding drugs: Photophysical techniques assisted by molecular docking methods.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 20;258:119814. Epub 2021 Apr 20.

Department of Chemistry, D.G. Vaishnav College (Autonomous), 833, Gokul Bagh, E.V.R. Periyar Road, Arumbakkam, Chennai 600106, Tamil Nadu, India. Electronic address:

Photophysical investigations and molecular docking studies of photoinduced electron transfer (PET) based fluorophores of acridine family with a globular protein, Bovine Serum Albumin (BSA) bound to non-narcotic drugs like phenylbutazone (PB) and flufenamic acid (FA) were carried out in aqueous solution. PB and FA are site specific and site selective drugs, wherein PB predominantly binds at the site (I) whereas FA selectively orients towards site (II) of BSA. Acridinedione (AD) dyes, both resorcinol and dimedone based are hydrophobic in nature and exhibits a combination of both hydrophobic and hydrogen-bonding interactions that are based on the binding sites in BSA. Read More

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Molecular recognition patterns between vitamin B12 and human serum albumin explored through STD-NMR and spectroscopic methods.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 20;258:119828. Epub 2021 Apr 20.

School of Chemical Engineering, Sichuan University, Chengdu 610065, China. Electronic address:

Ligand-receptor molecular recognitionis the basis of biological process. The Saturation Transfer Difference-NMR (STD-NMR) technique has been recently used to gain qualitative and quantitative information about physiological interactions at atomic-resolution. The molecular recognition patterns between Vitamin B12 (VB12) and human serum albumin (HSA) were investigated by STD-NMR supplemented by other spectroscopies and molecular docking. Read More

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Watch your neighbor: Strategic competition in waste collection and service quality.

Waste Manag 2021 Apr 27;127:63-72. Epub 2021 Apr 27.

Department of Econometrics, Statistics and Applied Economics, John Keynes 1-11, 08034 Barcelona, Spain. Electronic address:

Public procurement is frequently used to contract solid waste collection services. Incomplete contracts and transaction costs increase the need for monitoring and supervision. In such cases, competition by comparison can be a useful tool. Read More

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Preparation of a novel amino functionalized ion-imprinted hybrid monolithic column for the selective extraction of trace copper followed by ICP-MS detection.

Anal Chim Acta 2021 Jun 8;1162:338477. Epub 2021 Apr 8.

Technical Center for Industrial Product and Raw Material Inspection and Testing, Shanghai Customs, Shanghai, 200135, China. Electronic address:

In this work, a novel amino functionalized Cu(II) ion-imprinted organic-inorganic hybrid monolithic column (Cu(II)-IIHMC) was prepared via one-pot co-condensation and the combination of sol-gel and ion-imprinting techniques in a fused capillary. The Cu(II)-IIHMC was used as solid phase microextraction (SPME) matrix followed by inductively coupled plasma-mass spectrometry (ICP-MS) for the analysis of trace Cu(II). The prepared Cu(II)-IIHMC has good mechanical strength, stable imprinting sites and homogeneous structure of network skeleton with large flow-through pores by optimizing the synthesis process. Read More

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Tensile Deformation and Fracture Behavior of Nickel-Based Superalloy DZ951G.

Materials (Basel) 2021 Apr 27;14(9). Epub 2021 Apr 27.

Shi-Changxu Innovation Center for Advanced Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.

DZ951G is a novel developed nickel-based directional solidified superalloy with an incipient high melting point and low density. Compared with DZ417G superalloy, DZ951G superalloy has a higher ultimate tensile strength. At intermediate temperatures, the plasticity and strength were both markedly improved, and an obviously anomalous yield behavior could be observed where the yield strength reached its maximum at 760 °C. Read More

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The Interaction of Human Glutathione Transferase GSTA1-1 with Reactive Dyes.

Molecules 2021 Apr 20;26(8). Epub 2021 Apr 20.

Laboratory of Enzyme Technology, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, 75 Iera Odos Street, GR-11855 Athens, Greece.

Human glutathione transferase A1-1 (hGSTA1-1) contributes to developing resistance to anticancer drugs and, therefore, is promising in terms of drug-design targets for coping with this phenomenon. In the present study, the interaction of anthraquinone and diazo dichlorotriazine dyes (DCTD) with hGSTA1-1 was investigated. The anthraquinone dye Procion blue MX-R (PBMX-R) appeared to interact with higher affinity and was selected for further study. Read More

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Synthesis of a Coumarin-Based PPARγ Fluorescence Probe for Competitive Binding Assay.

Int J Mol Sci 2021 Apr 14;22(8). Epub 2021 Apr 14.

Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.

Peroxisome proliferator-activated receptor γ (PPARγ) is a molecular target of metabolic syndrome and inflammatory disease. PPARγ is an important nuclear receptor and numerous PPARγ ligands were developed to date; thus, efficient assay methods are important. Here, we investigated the incorporation of 7-diethylamino coumarin into the PPARγ agonist rosiglitazone and used the compound in a binding assay for PPARγ. Read More

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Sustainable stabilization/solidification of the Pb, Zn, and Cd contaminated soil by red mud-derived binders.

Environ Pollut 2021 Apr 19;284:117178. Epub 2021 Apr 19.

Institute of Construction Materials, Technische Universität Dresden, 01062, Dresden, Germany. Electronic address:

Red mud and phosphogypsum are voluminous industrial by-products worldwide. They have long been disposed of in landfills or open storage, leading to a waste of resource and environmental pollution. This study provides a novel approach to recycle these industrial by-products as sustainable red mud-phosphogypsum-Portland cement (RPPC) binders for stabilization/solidification (S/S) of multimetal-contaminated soil. Read More

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Estimation of soil organic matter content based on CARS algorithm coupled with random forest.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 20;258:119823. Epub 2021 Apr 20.

Institute of Water Resources and Hydro-electric Engineering, Xi'an University of Technology, Xi'an, Shaanxi 710048, China.

Soil organic matter (SOM) is an important index used to evaluate soil fertility and nutrient availability, and it is also an important component of precision agriculture. In this study, in order to quickly and efficiently estimate the SOM content of farmland soil, we took 190 farmland soil samples in Jingbian County and measureed the SOM content of the samples in the lab and collected the corresponding Vis-NIR spectroscopy data. Based on the six pretreatment methods, a competitive adaptive weighting algorithm (CARS) is used for characteristic wavelength selection. Read More

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NanoLuc luciferase as a suitable fusion partner of recombinant antibody fragments for developing sensitive luminescent immunoassays.

Anal Chim Acta 2021 May 6;1161:238180. Epub 2021 Jan 6.

Kobe Pharmaceutical University, 4-19-1, Motoyama-Kitamachi, Higashinada-ku, Kobe, 658-8558, Japan. Electronic address:

Enzyme-linked immunosorbent assays (ELISAs) are essential for monitoring various biomarkers. Competitive and noncompetitive (sandwich) assay formats are used to determine hapten and macromolecule levels, respectively. Both formats require more sensitive detection of reporter enzymes for greater assay sensitivities. Read More

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Sensitive 'two-steps' competitive assay for gonadotropin-releasing hormone detection via SPR biosensing and polynorepinephrine-based molecularly imprinted polymer.

Anal Chim Acta 2021 May 6;1161:338481. Epub 2021 Apr 6.

Department of Chemistry "Ugo Schiff", University of Florence, 50019, Sesto Fiorentino (FI), Italy. Electronic address:

The work reports an innovative bioassay for the detection of gonadorelin in urine, a gonadotropin-releasing hormone agonist widely used in fertility medicine and to treat hormonal dysfunctions. Gonadorelin is also a synthetic hormone listed by the World Anti-Doping Agency (WADA) and of interest in anti-doping controls. The main novelty relies on the development of a biocompatible, stable, and low-cost biomimetic receptor alternative to classic antibodies. Read More

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Multistability of delayed fractional-order competitive neural networks.

Neural Netw 2021 Apr 8;140:325-335. Epub 2021 Apr 8.

School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China, Wuhan, China. Electronic address:

This paper is concerned with the multistability of fractional-order competitive neural networks (FCNNs) with time-varying delays. Based on the division of state space, the equilibrium points (EPs) of FCNNs are given. Several sufficient conditions and criteria are proposed to ascertain the multiple O(t)-stability of delayed FCNNs. Read More

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Design, synthesis and biological evaluation of novel FXIa inhibitors with 2-phenyl-1H-imidazole-5-carboxamide moiety as P1 fragment.

Eur J Med Chem 2021 Apr 20;220:113437. Epub 2021 Apr 20.

Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang, 110016, China. Electronic address:

Factor XIa, as a blood coagulation enzyme, amplifies the generation of the last enzyme thrombin in the blood coagulation cascade. It was proved that direct inhibition of factor XIa could reduce pathologic thrombus formation without an enhanced risk of bleeding. WSJ-557, a nonpurine imidazole-based xanthine oxidase inhibitor in our previous reports, could delay blood coagulation during its animal experiments, which prompted us to investigate its action mechanism. Read More

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A highly promising high-nickel low-cobalt lithium layered oxide cathode material for high-performance lithium-ion batteries.

J Colloid Interface Sci 2021 Apr 8;597:334-344. Epub 2021 Apr 8.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address:

Reducing cobalt dependency has attracted great interest for lithium batteries manufacturing due to limited cobalt resources and high prices. A highly promising LiNiCoMnO (NCM60535) high-nickel low cobalt lithium layered oxide cathode material is successfully prepared by systematically examining the two key synthesis conditions of pH and annealing temperature. The obtained materials exhibit a uniform size distribution, good spherical morphology, clear structure, and homogeneous element distribution. Read More

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Highly sensitive fluorescent sensor based on coumarin organic dye for pyrophosphate ion turn-on biosensing in synovial fluid.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Aug 8;257:119792. Epub 2021 Apr 8.

State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325035, PR China; Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Science, Wenzhou 325001, PR China. Electronic address:

Highly sensitive fluorescence detection of pyrophosphate ion (PPi) is in urgent demand but remains a great obstacle, ascribing to scarcity of high-performance materials with promising optical property and high affinity. Herein, we report the design and fabrication of a coumarin-based organic dye (DCCH-TPD) containing both hydrazide group and terpyridine moiety for PPi biosensing through Cu-induced photo-electron transfer (PET) effect and target analyte-switched competitive coordination reaction. Individual DCCH-TPD was found to be highly emissive, and displayed a turn-off response toward Cu due to formation of Cu@DCCH-TPD and PET effect. Read More

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Removal of humic acid and Cr(Ⅵ) from water using ZnO-30N-zeolite.

Chemosphere 2021 Apr 5;279:130491. Epub 2021 Apr 5.

College of Chemical Engineering and Materials, Quanzhou Normal University, Quanzhou, 362000, China.

The mutual influence of humic acid and Cr(Ⅵ) on water purification using ZnO-30N-zeolite was investigated in the laboratory. The removal of humic acid by ZnO-30N-zeolite with both pollutants present reached 90% in 5 min. With humic acid alone, more than one day was required to reach the same level of removal. Read More

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Harnessing Formulation and Clinical Pharmacology Knowledge for Efficient Pediatric Drug Development: Overview and Discussions from M-CERSI Pediatric Formulation Workshop 2019.

Eur J Pharm Biopharm 2021 Apr 17. Epub 2021 Apr 17.

U.S. Food and Drug Administration (FDA), Silver Spring, MD 20993, USA.

A pediatric formulation workshop entitled "Pediatric Formulations: Challenges of Today and Strategies for Tomorrow" was held to advance pediatric drug product development efforts in both pre-competitive and competitive environments. The workshop had four main sessions discussing key considerations of Formulation, Analytical, Clinical and Regulatory. This paper focuses on the clinical session of the workshop. Read More

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Practice and power: the rise and disappearance of the Franzosenärzte, or doctors of the French pox, in Nuremberg, 1495-1560.

J R Coll Physicians Edinb 2021 03;51(1):91-97

10 University Gardens University of Glasgow, Glasgow G12 8QH, Email:

During the late fifteenth century a new category of medical practitioner appeared in the German-speaking lands of the Holy Roman Empire: the Franzosenarzt or French pox doctor. Until now, there has been no dedicated study of these practitioners. Through an analysis of municipal records from Nuremberg (circa 1495 to 1560), this paper offers the first dedicated investigation of the Franzosenärzte in this city, focusing on uncovering their relationships with Nuremberg's civic and medical hierarchies. Read More

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Biosensing strategies for the electrochemical detection of viruses and viral diseases - A review.

Anal Chim Acta 2021 May 12;1159:338384. Epub 2021 Mar 12.

Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil; Instituto Nacional de Ciência e Tecnologia de Bioanalítica-INCTBio, Campinas, SP, 13083-970, Brazil. Electronic address:

Viruses are the causing agents for many relevant diseases, including influenza, Ebola, HIV/AIDS, and COVID-19. Its rapid replication and high transmissibility can lead to serious consequences not only to the individual but also to collective health, causing deep economic impacts. In this scenario, diagnosis tools are of significant importance, allowing the rapid, precise, and low-cost testing of a substantial number of individuals. Read More

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New optofluidic based lab-on-a-chip device for the real-time fluoride analysis.

Anal Chim Acta 2021 May 23;1159:338439. Epub 2021 Mar 23.

Department of Chemistry, Faculty of Science, Taif University, Taif, Saudi Arabia.

A PDMS (Polydimethylsiloxane) microfluidic channel coupled with UV-vis fibre-optic spectrometer and new synthesized colorimetric probe was integrated into an optofluidic based Lab-on-a-chip device for highly sensitive and real-time quantitative measurements of fluoride ions (F¯). An 'S' shaped microchannel in a microfluidic device was designed to act as microreactor to facilitate the continuous reaction between synthetized colorimetric probe (sensor) and F¯ ions. Following this reaction, the UV-vis optical probe in the downstream detection zone of the microfluidic device was used to capture their spectrum and present as F¯ concentration in real-time conditions. Read More

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High capacity aqueous phosphate reclamation using Fe/Mg-layered double hydroxide (LDH) dispersed on biochar.

J Colloid Interface Sci 2021 Mar 24;597:182-195. Epub 2021 Mar 24.

Department of Chemistry, Mississippi State University, Mississippi State, MS 39762, USA. Electronic address:

Phosphate is a primary plant nutrient, serving integral role in environmental stability. Excessive phosphate in water causes eutrophication; hence, phosphate ions need to be harvested from soil nutrient levels and water and used efficiently. Fe-Mg (1:2) layered double hydroxides (LDH) were chemically co-precipitated and widely dispersed on a cheap, commercial Douglas fir biochar (695 m/g surface area and 0. Read More

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Fixed-bed flow experiments with supported green nZVI for the remediation of contaminated waters: Effect of pH and background solution composition.

Chemosphere 2021 Apr 8;279:130472. Epub 2021 Apr 8.

School of Mining and Metallurgical Engineering, National Technical University of Athens, 15780, Greece.

Aim of this study is to evaluate the performance of a nanocomposite material (R-nFe), consisting of nano zero valent iron (nZVI) and a cation exchange resin, for Cr(VI) reduction and heavy metals removal from contaminated water streams. The effect of pH and the background solution composition was investigated by conducting three columns tests. In Column I, the experiments were carried out using NaCl as background electrolyte while in Column II and III the background solution consisted of 50% tertiary effluents of a waste water treatment plant and 50% deionized water. Read More

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Optimizing quantum cloning circuit parameters based on adaptive guided differential evolution algorithm.

J Adv Res 2021 03 17;29:147-157. Epub 2020 Oct 17.

Department of Mathematics, Faculty of Science, Sohag University, Sohag, Egypt.

Introduction: Quantum cloning operation, started with no-go theorem which proved that there is no capability to perform a cloning operation on an unknown quantum state, however, a number of trials proved that we can make approximate quantum state cloning that is still with some errors.

Objectives: To the best of our knowledge, this paper is the first of its kind to attempt using meta-heuristic algorithm such as Adaptive Guided Differential Evolution (AGDE), to tackle the problem of quantum cloning circuit parameters to enhance the cloning fidelity.

Methods: To investigate the effectiveness of the AGDE, the extensive experiments have demonstrated that the AGDE can achieve outstanding performance compared to other well-known meta-heuristics including; Enhanced LSHADE-SPACMA Algorithm (ELSHADE-SPACMA), Enhanced Differential Evolution algorithm with novel control parameter adaptation (PaDE), Improved Multi-operator Differential Evolution Algorithm (IMODE), Parameters with adaptive learning mechanism (PALM), QUasi-Affine TRansformation Evolutionary algorithm (QUATRE), Particle Swarm Optimization (PSO), Gravitational Search Algorithm (GSA), Cuckoo Search (CS), Bat-inspired Algorithm (BA), Grey Wolf Optimizer (GWO), and Whale Optimization Algorithm (WOA). Read More

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PyDiNet: Pyramid Dilated Network for medical image segmentation.

Mourad Gridach

Neural Netw 2021 Mar 26;140:274-281. Epub 2021 Mar 26.

Department of Computer Science, High Institute of Technology, Agadir, Morocco. Electronic address:

Medical image segmentation is an important step in many generic applications such as population analysis and, more accessible, can be made into a crucial tool in diagnosis and treatment planning. Previous approaches are based on two main architectures: fully convolutional networks and U-Net-based architecture. These methods rely on multiple pooling and striding layers leading to the loss of important spatial information and fail to capture details in medical images. Read More

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Temperate and chronic virus competition leads to low lysogen frequency.

J Theor Biol 2021 Apr 9;523:110710. Epub 2021 Apr 9.

Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Mathematics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

The canonical bacteriophage is obligately lytic: the virus infects a bacterium and hijacks cell functions to produce large numbers of new viruses which burst from the cell. These viruses are well-studied, but there exist a wide range of coexisting virus lifestyles that are less understood. Temperate viruses exhibit both a lytic cycle and a latent (lysogenic) cycle, in which viral genomes are integrated into the bacterial host. Read More

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Unified chromatography - Mass spectrometry as a versatile tool for determination of food dyes.

Anal Chim Acta 2021 May 13;1157:338401. Epub 2021 Mar 13.

Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, 17. Listopadu 12, 77146, Olomouc, Czech Republic. Electronic address:

Unified chromatography with mass spectrometric detection was assessed for determination of food dyes. Nineteen substances representing azo, triphenylmethane, xanthone, indigoid, quinoline and polyene classes covering an unprecedented range from nonpolar β-Carotene (logD 13.6) to ionic Tartrazine (logD -7. Read More

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Investigation on conformational variation and activity of trypsin affected by black phosphorus quantum dots via multi-spectroscopy and molecular modeling.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 26;256:119746. Epub 2021 Mar 26.

Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, College of Chemistry and Materials, Nanning Normal University, Nanning 530001, PR China. Electronic address:

Binding interaction between black phosphorus quantum dots (BPQDs) and trypsin was researched deeply to illustrate the variations on conformation and activity of trypsin affected by BPQDs via multi-spectroscopy and molecular modeling. Experimental results implied that inherent fluorescence of trypsin was quenched by BPQDs via static fluorescence quenching mode. BPQDs bound with trypsin to construct ground-state complex under the binding forces of van der Waal interaction and hydrophobic interaction, resulting in the conformational change of trypsin to be more hydrophilic and incompact. Read More

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