6,839 results match your criteria appearance stress

Developmental effects of early-life stress on dopamine D2 receptor and proteins involved in noncanonical D2 dopamine receptor signaling pathway in the prefrontal cortex of male rats.

J Complement Integr Med 2021 May 7. Epub 2021 May 7.

Neurophysiology Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.

Objectives: Dopamine neurotransmission is implicated in multiple neuropsychiatric disorders, most strikingly in Parkinson's disease, bipolar disorder, attention-deficit hyperactivity disorder and schizophrenia. In addition to canonical pathway, D2-receptor (D2R) exerts some of its biological actions through regulating the activity of Akt and GSK3, which in turn were found to be altered in several psychiatric illnesses. The present study examined the impacts of maternal separation, an early-life stress model which has been associated with disturbed neurodevelopment and appearance of many psychiatric disorders, on developmental changes in dopamine concentration and the expression of D2Rs, Akt and GSK-3β in the medial prefrontal cortex (PFC; a key target of stress) in adolescent and young adult male rats. Read More

View Article and Full-Text PDF

Therapeutic Strategies by Regulating Interleukin Family to Suppress Inflammation in Hypertrophic Scar and Keloid.

Front Pharmacol 2021 20;12:667763. Epub 2021 Apr 20.

Department of Plastic and Cosmetic Surgery, The Second Hospital of Dalian Medical University, Dalian, China.

Hypertrophic scar (HS) and keloid are fibroproliferative disorders (FPDs) of the skin due to aberrant wound healing, which cause disfigured appearance, discomfort, dysfunction, psychological stress, and patient frustration. The unclear pathogenesis behind HS and keloid is partially responsible for the clinical treatment stagnancy. However, there are now increasing evidences suggesting that inflammation is the initiator of HS and keloid formation. Read More

View Article and Full-Text PDF

Physiological processes and lipidome dynamics in the soft coral Sinularia heterospiculata under experimental bleaching.

Comp Biochem Physiol B Biochem Mol Biol 2021 May 3:110609. Epub 2021 May 3.

A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russian Federation.

Coral polyps host intracellular symbiotic dinoflagellates (SD). The loss of SD (referred as bleaching) under stressful environmental conditions is the main reason of coral reef destruction, and therefore, intensively studied over the world. Lipids are the structural base of biomembranes and energy reserve of corals and are directly involved in the coral bleaching. Read More

View Article and Full-Text PDF

The mechanism of cytotoxicity of 4-nonylphenol in a human hepatic cell line involves ER-stress, apoptosis, and mitochondrial dysfunction.

J Biochem Mol Toxicol 2021 May 6:e22780. Epub 2021 May 6.

Department of Chemistry and Biology, University of Salerno, Fisciano, Italy.

4-Nonylphenol (4-NP) is an emerging environmental pollutant widely diffused in waters and sediments. It mainly derives from the degradation of alkyl phenol ethoxylates, compounds commonly employed as industrial surfactants. 4-NP strongly contaminates foods and waters for human use; thus, it displays a wide range of toxic effects not only for aquatic organisms but also for mammals and humans. Read More

View Article and Full-Text PDF

Catalysis of the electrochemical oxygen reduction reaction (ORR) by animal and human cells.

PLoS One 2021 5;16(5):e0251273. Epub 2021 May 5.

Laboratoire de Génie Chimique, Université de Toulouse, CNRS, INPT, UPS, 31432, Toulouse, France.

Animal cells from the Vero lineage and MRC5 human cells were checked for their capacity to catalyse the electrochemical oxygen reduction reaction (ORR). The Vero cells needed 72 hours' incubation to induce ORR catalysis. The cyclic voltammetry curves were clearly modified by the presence of the cells with a shift of ORR of 50 mV towards positive potentials and the appearance of a limiting current (59 μA. Read More

View Article and Full-Text PDF

The Optimization Strategy of the Existing Urban Green Space Soil Monitoring System in Shanghai, China.

Int J Environ Res Public Health 2021 Apr 30;18(9). Epub 2021 Apr 30.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.

High concentrations of potentially toxic elements (PTE) create global environmental stress due to the crucial threat of their impacts on the environment and human health. Therefore, determining the concentration levels of PTE and improving their prediction accuracy by sampling optimization strategy is necessary for making sustainable environmental decisions. The concentrations of five PTEs (Pb, Cd, Cr, Cu, and Zn) were compared with reference values for Shanghai and China. Read More

View Article and Full-Text PDF

Mitigation of bacterial spot disease induced biotic stress in Capsicum annuum L. cultivars via antioxidant enzymes and isoforms.

Sci Rep 2021 May 3;11(1):9445. Epub 2021 May 3.

Department of Soil Science, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University, Multan, 60800, Pakistan.

Bacterial spot, caused by a group of Xanthomonads (Xanthomonas spp.), is a devastating disease. It can adversely affect the Capsicum annum productivity. Read More

View Article and Full-Text PDF

What prevents mainstream evolutionists teaching the whole truth about how genomes evolve?

Prog Biophys Mol Biol 2021 Apr 29. Epub 2021 Apr 29.

Department of Physiology, Anatomy & Genetics, University of Oxford, USA. Electronic address:

The common belief that the neo-Darwinian Modern Synthesis (MS) was buttressed by the discoveries of molecular biology is incorrect. On the contrary those discoveries have undermined the MS. This article discusses the many processes revealed by molecular studies and genome sequencing that contribute to evolution but nonetheless lie beyond the strict confines of the MS formulated in the 1940s. Read More

View Article and Full-Text PDF

Melatonin Ameliorates LPS-Induced Testicular Nitro-oxidative Stress (iNOS/TNFα) and Inflammation (NF-kB/COX-2) via Modulation of SIRT-1.

Reprod Sci 2021 Apr 30. Epub 2021 Apr 30.

Pineal Research Lab Reproduction Biology Unit, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Lipopolysaccharide (LPS) - an endotoxin that is being extensively used in laboratory to mimic microbial infection that adversely affects male fertility. This study investigated the protective effects of melatonin on LPS-induced testicular nitro-oxidative stress, inflammation, and associated damages in the testes of male golden hamsters, Mesocricetus auratus. Hamsters were administered with melatonin and LPS for 7 days. Read More

View Article and Full-Text PDF

COVID-19-Related Stress and Anxiety, Body Mass Index, Eating Disorder Symptomatology, and Body Image in Women from Poland: A Cluster Analysis Approach.

Nutrients 2021 Apr 20;13(4). Epub 2021 Apr 20.

Institute of Pedagogy, University of Bielsko-Biala, Willowa 2, 43-309 Bielsko-Biala, Poland.

To limit the spread of the novel coronavirus (COVID-19), many countries have introduced mandated lockdown or social distancing measures. Although these measures may be successful against COVID-19 transmission, the pandemic and attendant restrictions are a source of chronic and severe stress and anxiety which may contribute to the emergence or worsening of symptoms of eating disorders and the development of negative body image. Therefore, in this study, we aimed to: (1) classify different conditions associated with COVID-19-related stress, COVID-19-related anxiety, and weight status; and (2) analyze and compare the severity of dimensions typically related to eating disorders symptomatology and body image in individuals with different COVID-19-related stress, COVID-19-related anxiety, and weight status. Read More

View Article and Full-Text PDF

Bionanocomposite Blown Films: Insights on the Rheological and Mechanical Behavior.

Polymers (Basel) 2021 Apr 5;13(7). Epub 2021 Apr 5.

Dipartimento di Ingegneria, Università di Palermo, Viale Delle Scienze, 90128 Palermo, Italy.

In this work, bionanocomposites based on two different types of biopolymers belonging to the MaterBi family and containing two kinds of modified nanoclays were compounded in a twin-screw extruder and then subjected to a film blowing process, aiming at obtaining sustainable films potentially suitable for packaging applications. The preliminary characterization of the extruded bionanocomposites allowed establishing some correlations between the obtained morphology and the material rheological and mechanical behavior. More specifically, the morphological analysis showed that, regardless of the type of biopolymeric matrix, a homogeneous nanofiller dispersion was achieved; furthermore, the established biopolymer/nanofiller interactions caused a restrain of the dynamics of the biopolymer chains, thus inducing a significant modification of the material rheological response, which involves the appearance of an apparent yield stress and the amplification of the elastic feature of the viscoelastic behavior. Read More

View Article and Full-Text PDF

The COVID-19 Pandemic-an Epidemiological Perspective.

Curr Allergy Asthma Rep 2021 04 28;21(4):29. Epub 2021 Apr 28.

Preventive Medicine and Epidemiology Department, Hospital Clínic-Universitat de Barcelona-ISGlobal, Barcelona, Spain.

Purpose Of Review: The ongoing COVID-19 pandemic is a matter of great concern worldwide. After the first wave, several countries, notably in the European Union, are suffering a very rapid increase in the number of cases in the pandemic second wave. Health systems are under stress; hospital beds and ICU beds are increasingly occupied by COVID-19 patients, and hospitals are struggling to keep their normal operations. Read More

View Article and Full-Text PDF

Legacy Patient-Reported Outcome Measures Can Be Reliably Translated to PROMIS Domains for Use in Adolescent Spinal Deformity.

Spine (Phila Pa 1976) 2021 Apr 23. Epub 2021 Apr 23.

Hospital for Special Surgery, NY, USA Weill Cornell Medical College, NY, USA.

Study Design: Retrospective Cohort Study.

Objective: To determine whether Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Domain scores can be accurately and reliably predicted from legacy patient reported outcome measures (PROMs) for use in adolescent idiopathic scoliosis.

Summary Of Background Data: Previous efforts have been made to develop translational models between PROMIS domains and legacy PROMs in adult spinal deformity, but translational models for pediatric and adolescent patients with spinal deformity have not yet been developed. Read More

View Article and Full-Text PDF

ER stress modulates apoptosis in A431 cell subjected to EtNBSe-PDT via the PERK pathway.

Photodiagnosis Photodyn Ther 2021 Apr 24;34:102305. Epub 2021 Apr 24.

Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China. Electronic address:

Photodynamic therapy (PDT) is a promising modality against various cancers including squamous cell carcinoma (SCC) with which the induction of apoptosis is an effective mechanism. Here, we initially describe the preclinical activity of 5-ethylamino-9-diethylaminobenzo [a] phenoselenazinium(EtNBSe)-mediated PDT treatment in SCC. Results of our studies suggest that EtNBSe-PDT provokes a cellular state of endoplasmic reticulum (ER) stress triggering the PERK/ eIF2α signaling pathway and induces the appearance of apoptosis in A431 cells at the meantime. Read More

View Article and Full-Text PDF

[Midwives and psychologists as profesionals to screen and prevent pregnancy-specific stress.]

Rev Esp Salud Publica 2021 Apr 26;95. Epub 2021 Apr 26.

Centro de Investigación Mente, Cerebro y Comportamiento (CIMCYC). Universidad de Granada. Granada. España.

Events that occur during fetal and perinatal life can have consequences on the health and disease of the offspring. The pioneering work on the "Fetal Programming Hypothesis" focused on pregnant women exposed to a great famine that occurred in the Netherlands at the end of World War II. The intrauterine environment of the babies during that famine caused them to low birthweight and determined the appearance of cardiovascular diseases in themselves when they reached adulthood, a risk that was transmitted even to the following generation. Read More

View Article and Full-Text PDF

Targeting oxidative stress, a crucial challenge in renal transplantation outcome.

Free Radic Biol Med 2021 Apr 21;169:258-270. Epub 2021 Apr 21.

Université Côte d'Azur, CNRS, LP2M, Nice, France; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France. Electronic address:

Disorders characterized by ischemia/reperfusion (I/R) are the most common causes of debilitating diseases and death in stroke, cardiovascular ischemia, acute kidney injury or organ transplantation. In the latter example the I/R step defines both the amplitude of the damages to the graft and the functional recovery outcome. During transplantation the kidney is subjected to blood flow arrest followed by a sudden increase in oxygen supply at the time of reperfusion. Read More

View Article and Full-Text PDF

Full-length SMRT transcriptome sequencing and microsatellite characterization in Paulownia catalpifolia.

Sci Rep 2021 Apr 22;11(1):8734. Epub 2021 Apr 22.

Paulownia Research and Development Center of State Administration of Forestry and Grassland, Zhengzhou, 450003, China.

Paulownia catalpifolia is an important, fast-growing timber species known for its high density, color and texture. However, few transcriptomic and genetic studies have been conducted in P. catalpifolia. Read More

View Article and Full-Text PDF

Identification of potential metabolic biomarkers of rectal cancer and of the effect of neoadjuvant radiochemotherapy.

PLoS One 2021 22;16(4):e0250453. Epub 2021 Apr 22.

Unitat de Recerca Biomèdica, Institut d'Investigació Sanitària Pere Virgili, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Reus, Spain.

We report a pilot study on the feasibility of determinations of circulating levels of paraoxonase-1 (PON1) and compounds related to energy metabolism as biomarkers for the evaluation of patients with rectal cancer (RC), and the effects produced by neoadjuvant radiochemotherapy (NRCT). We studied 32 patients treated with radiotherapy plus capecitabine concomitant chemotherapy and 48 control subjects. We identified pre-NRCT PON1 and α-ketoglutarate as the parameters that best discriminated between RC patients and the control group. Read More

View Article and Full-Text PDF

Pairing of neonatal phencyclidine exposure and acute adolescent stress in male rats as a novel developmental model of schizophrenia.

Behav Brain Res 2021 Apr 16;409:113308. Epub 2021 Apr 16.

Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, 10595, United States. Electronic address:

Improved understanding of the neurophysiological and neurochemical mechanisms underlying schizophrenia is essential for the identification of biological markers and developing new therapeutic targets. The development of behaviorally faithful, predictive animal models is crucial to this endeavor. We have developed a novel two-hit paradigm designed to recapitulate in rodents the developmental process leading to appearance of human schizophrenia symptomatology. Read More

View Article and Full-Text PDF

Sleep deficit in COVID-19 health-care workers may increase the infection risk.

Scand J Public Health 2021 Apr 19:14034948211007679. Epub 2021 Apr 19.

Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), Brazil.

The COVID-19 pandemic has had negative effects on health-care workers. The rapid growth of the disease has led to overwhelmed health-care systems, overcrowded hospitals, an insufficient number of health-care professionals and shortages of medical equipment. The potential exposure of front-line health-care workers during the COVID-19 outbreak has led to self-isolation and the appearance of adverse feelings such as stress, anxiety and fear. Read More

View Article and Full-Text PDF

Proteomic Responses to Alkali Stress in Oats and the Alleviatory Effects of Exogenous Spermine Application.

Front Plant Sci 2021 1;12:627129. Epub 2021 Apr 1.

Institute of Grassland Research of Chinese Academy of Agricultural Sciences, Hohhot, China.

Alkali stress limits plant growth and yield more strongly than salt stress and can lead to the appearance of yellow leaves; however, the reasons remain unclear. In this study, we found that (1) the down-regulation of coproporphyrinogen III oxidase, protoporphyrinogen oxidase, and Pheophorbide a oxygenase in oats under alkali stress contributes to the appearance of yellow leaves (as assessed by proteome and western blot analyses). (2) Some oat proteins that are involved in the antioxidant system, root growth, and jasmonic acid (JA) and indole-3-acetic acid (IAA) synthesis are up-regulated in response to alkalinity and help increase alkali tolerance. Read More

View Article and Full-Text PDF

miRNA and mRNA Profiles in Ventral Tegmental Area From Juvenile Mice With Companion Communication of Improving CUMS-Induced Depression-Like Behaviors.

Front Psychiatry 2021 31;12:634933. Epub 2021 Mar 31.

Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, China.

Under chronic stress, the appearance of depression-like behaviors may be related to the decline of the brain's reward circuit function which caused by long-term lack of reward. However, the effect of reward treatment on depressive-like behaviors induced by chronic stress and its molecular mechanism in the brain remain poorly understood. Here, accompanying with companion was used to imitate a reward to study the effect of reward on depression-like behaviors induced by chronic unpredicted mild stress (CUMS), and high-throughput sequencing was used to analyze the miRNA and mRNA profiles in ventral tegmental area (VTA) harvested from depression-like and resilient behaviors mice. Read More

View Article and Full-Text PDF

Subtle genomic DNA damage induces intraneuronal production of amyloid-β (1-42) by increasing β-secretase activity.

FASEB J 2021 May;35(5):e21569

Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.

Aberrant accumulation of amyloid-β (Aβ) in brain is the major trigger for pathogenesis in Alzheimer's disease (AD). It is imperative to understand how Aβ attains such toxic levels in the brain parenchyma. We detected that a subtle and tolerable amount of DNA damage, related to aging, increased intraneuronal Aβ production both in cultured neuron and in cortex of rodent brain. Read More

View Article and Full-Text PDF

Cellular senescence and tumor promotion: Role of the Unfolded Protein Response.

Adv Cancer Res 2021 16;150:285-334. Epub 2021 Feb 16.

Univ Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France.

Senescence is a cellular state which can be viewed as a stress response phenotype implicated in various physiological and pathological processes, including cancer. Therefore, it is of fundamental importance to understand why and how a cell acquires and maintains a senescent phenotype. Direct evidence has pointed to the homeostasis of the endoplasmic reticulum whose control appears strikingly affected during senescence. Read More

View Article and Full-Text PDF
February 2021

The impact of COVID-19 on surgical training at a tertiary hospital in Greece: a 'hidden infectious enemy' for junior surgeons?

Eur Surg 2021 Apr 8:1-6. Epub 2021 Apr 8.

Department of Surgery, University of Patras, University Hospital of Patras, 26504 Patra, Greece.

Background: Soon after its appearance, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) became a pandemic, with over 111 million cases reported and 2.4 million deaths worldwide. Although the focus of public health systems must lie on patients' care and treatment, SARS-COV‑2 infection has also affected surgical trainees in their academic and professional development, causing significant disruption in all forms of their training. Read More

View Article and Full-Text PDF

Root shape adaptation to mechanical stress derived from unidirectional vibrations in .

Plant Biotechnol (Tokyo) 2020 Dec;37(4):423-428

Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan.

While it is known that plant roots can change their shapes to the stress direction, it remains unclear if the root orientation can change as a means for mechanical reinforcement. When stress in form of a unidirectional vibration is applied to cuttings of for 5 min a day over a period of 20 days, the root system architecture changes. The contribution of roots with a diameter larger than 0. Read More

View Article and Full-Text PDF
December 2020

Novel Wx alleles generated by base editing for improvement of rice grain quality.

J Integr Plant Biol 2021 Apr 13. Epub 2021 Apr 13.

School of Life Sciences, Shandong Normal University, Ji'nan, 250014, China.

Amylose content (AC), which is regulated by the Waxy (Wx) gene, is a major indicator of eating and cooking quality in rice (Oryza sativa). Thus far, only a limited number of mutations in the N-terminal domain of Wx were found to have a major impact on the AC of rice grains and no mutations with such effects were reported for other regions of the Wx protein. Here, nucleotide substitutions in the middle region of Wx were generated by adenine and cytosine base editors. Read More

View Article and Full-Text PDF

Transcutaneous Temperature-Controlled Radiofrequency Treatment: Improvement in Female Genital Appearance, Sexual Dysfunction, and Stress Urinary Incontinence.

Aesthet Surg J 2021 Apr 12. Epub 2021 Apr 12.

Department of Dermatology, Alpert Medical School of Brown University, Providence, RI, USA.

Background: Transcutaneous temperature-controlled radiofrequency (TTCRF) is an emerging modality for vulvovaginal rejuvenation. Still, the clinical experience with this modality is limited.

Objectives: The aim of this study was to examine the efficacy of TTCRF in improving female genital appearance, sexual function, and stress urinary incontinence (SUI). Read More

View Article and Full-Text PDF

Boron-toxicity induced changes in cell wall components, boron forms, and antioxidant defense system in rice seedlings.

Ecotoxicol Environ Saf 2021 Apr 7;216:112192. Epub 2021 Apr 7.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Root Biology Center, College of Natural Resources and Environment, South China Agricultural University, Guangzhou, 510642 Guangdong, PR China. Electronic address:

Boron (B) is an indispensable micronutrient that ensures the optimal growth and productivity of the plant. However, excessive use of B fertilizers results in B toxicity which is relatively difficult to correct as compared to B deficiency. Moreover, underlying mechanisms of B toxicity induced changes in cell wall components and the association of B forms in the appearance of toxicity symptoms in rice seedlings are lacking. Read More

View Article and Full-Text PDF

Grain polydispersity and coherent crystal reorientations are features to foster stress hotspots in polycrystalline alloys under load.

Sci Adv 2021 Apr 9;7(15). Epub 2021 Apr 9.

Departamento de Materiales y Nanotecnología, Facultad de Minas, Universidad Nacional de Colombia-Medellín, Medellín, Colombia.

The mechanical properties of metallic alloys are controlled through the design of their polycrystalline structure via heat treatments. For single-phase microstructures, they aim to achieve a particular average grain diameter to leverage stress hardening or softening. The stochastic nature of the recrystallization process generates a grain size distribution, and the randomness of the crystallographic orientation determines the anisotropy of a mechanical response. Read More

View Article and Full-Text PDF