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3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation.

J Vis Exp 2021 Apr 1(170). Epub 2021 Apr 1.

Department of Biology and Chemical Biology, Stevens Institute of Technology;

Clonogenicity of organoids from the intestinal epithelium is attributed to the presence of stem cells therein. The mouse small intestinal epithelium is compartmentalized into crypts and villi: the stem and proliferating cells are confined to the crypts, whereas the villi epithelium contains only differentiated cells. Hence, the normal intestinal crypts, but not the villi, can give rise to organoids in 3D cultures. Read More

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Normalcy, Race, and Biomedical Technology in Brazil: The Case of Low White Blood Cell Count.

Front Sociol 2019 29;4:75. Epub 2019 Nov 29.

Postgraduate Programme in Social Sciences, Federal University of Bahia, Salvador, Brazil.

This article explores the intersection between low-complexity biomedical technologies and ideas about race in Brazil. Using ethnographic material collected in the northeastern city of Salvador on the clinical management of low white blood cell count (leukopenia), and debates involving doctors, biomedical scientists, and social movement activists on establishing racialized parameters in complete blood count tests, I explore how the notion of normalcy is connected to ideas about racial difference. Taken both at a population and individual bodily level, normalcy serves to contrast local history, portrayed as the result of widespread admixture between groups, with other national contexts, such as that of the United States. Read More

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November 2019

Predicting the risk of fetal macrosomia at pregnancy in Shandong province: a case-control study.

J Matern Fetal Neonatal Med 2021 Apr 18:1-7. Epub 2021 Apr 18.

Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Shandong University, Jinan, China.

Background And Aim: Macrosomia is used to describe an infant born with excessively high weight, and it brings lots of unexpected risks in clinical work. Macrosomia causes considerable challenges for both physicians and pregnant women. Our objectives were to identify factors in gravida to be associated with the risk of macrosomia, to guide clinical prevention and treatment. Read More

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Material and relational asymmetry: The role of receivers' wealth and power status in children's resource allocation.

J Exp Child Psychol 2021 Apr 13;208:105147. Epub 2021 Apr 13.

Collaborative Innovation Center of Assessment for Basic Education Quality, Beijing Normal University, Beijing 100875, People's Republic of China. Electronic address:

Asymmetries in social status, specifically social status related to wealth and relational power, appear to influence the ways in which children allocate resources. However, the impact of wealth and relational power status on children's resource allocation decisions has yet to be examined among children developing within a Chinese cultural context. In addition, how children weight the relative importance of these factors when they exist concurrently is not well understood. Read More

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Medialization of the Hip's Center with Periacetabular Osteotomy: Validation of Assessment with Plain Radiographs.

Clin Orthop Relat Res 2021 May;479(5):1040-1049

L. M. Fowler, J. J. Nepple, C. Devries, J. C. Clohisy, Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA.

Background: Periacetabular osteotomy (PAO) increases acetabular coverage of the femoral head and medializes the hip's center, restoring normal joint biomechanics. Past studies have reported data regarding the degree of medialization achieved by PAO, but measurement of medialization has never been validated through a comparison of imaging modalities or measurement techniques. The ilioischial line appears to be altered by PAO and may be better visualized at the level of the inferior one-third of the femoral head, thus, an alternative method of measuring medialization that begins at the inferior one-third of the femoral head may be beneficial. Read More

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Predicting anthropometric and metabolic traits with a genetic risk score for obesity in a sample of Pakistanis.

Sci Rep 2021 Apr 15;11(1):8320. Epub 2021 Apr 15.

Molecular Biology and Human Genetics Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan.

Obesity is an outcome of multiple factors including environmental and genetic influences. Common obesity is a polygenic trait indicating that multiple genetic variants act synergistically to influence its expression. We constructed a genetic risk score (GRS) based on five genetic variants (MC4R rs17782313, BDNF rs6265, FTO rs1421085, TMEM18 rs7561317, and NEGR1 rs2815752) and examined its association with obesity-related traits in a sample of Pakistanis. Read More

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Utility of three-dimensional and reformatted head computed tomography images in the evaluation of pediatric abusive head trauma.

Pediatr Radiol 2021 Apr 15. Epub 2021 Apr 15.

Department of Radiology, University of Arkansas for Medical Sciences (UAMS), 4301 W. Markham St. Slot 556, Little Rock, AR, 72205, USA.

Skull fractures are common in the pediatric population following head trauma and are estimated to occur post head trauma in 11% of children younger than 2 years. A skull fracture indicates potential underlying intracranial injury and might also help explain the mechanism of injury. Multiple primary and accessory sutures complicate the identification of non-depressed fractures in children younger than 2 years. Read More

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[Gonococcal pelviperitonitis: a diagnostic challenge].

An Sist Sanit Navar 2021 Apr 12;0(0). Epub 2021 Apr 12.

Servicio de Ginecología y Obstetricia. Hospital Universitario Miguel Servet. Zaragoza..

Neisseria gonorrhoeae is the second most common etiological agent of pelvic inflammatory disease and is currently un-derdiagnosed due to its asymptomatic presentation in 50% of cases. When the disease presents, it may appear in the form of acute abdomen and normal imaging tests, making it a major diagnostic challenge. We present four cases of acute gonococcal peritonitis. Read More

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Signal averaged ECG in patients with early repolarization.

J Arrhythm 2021 Apr 5;37(2):432-437. Epub 2021 Mar 5.

Shiraz University of Medical Sciences Shiraz Iran.

Background: Early repolarization (ER) pattern is diagnosed when the J-point is elevated on the patient's electrocardiogram. The aim of this study was to evaluate signal-averaged electrocardiography (SAECG) in patients with ER pattern.

Methods: Subjects were divided into three groups: 1-patients with normal ECG pattern (control group); 2-patients with J-point elevation in the inferior leads; and 3-patients with J-point elevation in non-inferior leads. Read More

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Microscopic features of the rat adrenal gland associated with chronic codeine phosphate administration.

Anat Cell Biol 2021 Apr 14. Epub 2021 Apr 14.

Department of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.

Codeine is an opioid analgesic and antitussive that has been widely abused. Some adverse effects noted with its abuse include adrenocortical insufficiency and activation of the hypothalamic-pituitary-adrenal axis. The structural basis for these dysfunctions is not clearly understood. Read More

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Corpus luteum in ectopic ovarian tissue miming tubal pregnancy.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

University of Medicine and Pharmacology Gr T Popa, Iași, Romania.

We report an extraordinarily rare case of a pregnant patient with history of multiple ovarian cyst surgery. The corpus luteum developed on an ectopic ovarian tissue, miming an tubal pregnancy. One week later after the diagnostic laparoscopy an intrauterine pregnancy was visualised. Read More

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Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease.

Front Neurol 2021 22;12:642604. Epub 2021 Mar 22.

Department of Neurology, University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.

Parkinson's disease (PD) is known to involve the peripheral nervous system (PNS) and the enteric nervous system (ENS). Functional changes in PNS and ENS appear early in the course of the disease and are responsible for some of the non-motor symptoms observed in PD patients like constipation, that can precede the appearance of motor symptoms by years. Here we analyzed the effect of the pesticide rotenone, a mitochondrial Complex I inhibitor, on the function and neuronal composition of the ENS by measuring intestinal contractility in a tissue bath and by analyzing related protein expression. Read More

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The "Missing 6 dB" Revisited: Influence of Room Acoustics and Binaural Parameters on the Loudness Mismatch Between Headphones and Loudspeakers.

Front Psychol 2021 26;12:623670. Epub 2021 Mar 26.

Medizinische Physik and Cluster of Excellence "Hearing4all", Universität Oldenburg, Oldenburg, Germany.

Generations of researchers observed a mismatch between headphone and loudspeaker presentation: the sound pressure level at the eardrum generated by a headphone has to be about 6 dB higher compared to the level created by a loudspeaker that elicits the same loudness. While it has been shown that this effect vanishes if the same waveforms are generated at the eardrum in a blind comparison, the origin of the mismatch is still unclear. We present new data on the issue that systematically characterize this mismatch under variation of the stimulus frequency, presentation room, and binaural parameters of the headphone presentation. Read More

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Effects of Hearing Aid Noise Reduction on Early and Late Cortical Representations of Competing Talkers in Noise.

Front Neurosci 2021 26;15:636060. Epub 2021 Mar 26.

Eriksholm Research Centre, Oticon A/S, Snekkersten, Denmark.

Objectives: Previous research using non-invasive (magnetoencephalography, MEG) and invasive (electrocorticography, ECoG) neural recordings has demonstrated the progressive and hierarchical representation and processing of complex multi-talker auditory scenes in the auditory cortex. Early responses (<85 ms) in primary-like areas appear to represent the individual talkers with almost equal fidelity and are independent of attention in normal-hearing (NH) listeners. However, late responses (>85 ms) in higher-order non-primary areas selectively represent the attended talker with significantly higher fidelity than unattended talkers in NH and hearing-impaired (HI) listeners. Read More

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Semiparametric Mixed-Effects Ordinary Differential Equation Models with Heavy-Tailed Distributions.

J Agric Biol Environ Stat 2021 Apr 5:1-18. Epub 2021 Apr 5.

Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, Canada.

Ordinary differential equation (ODE) models are popularly used to describe complex dynamical systems. When estimating ODE parameters from noisy data, a common distribution assumption is using the Gaussian distribution. It is known that the Gaussian distribution is not robust when abnormal data exist. Read More

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Neurogenic appendicopathy: an underestimated disease-systematic review of the literature.

Int J Colorectal Dis 2021 Apr 10. Epub 2021 Apr 10.

Department of Surgery, HFR Fribourg - Cantonal Hospital, Chemin des Pensionnats 2-6, 1752, Villars-sur-Glâne, Switzerland.

Purpose: Appendectomy is one of the most frequently performed surgeries worldwide, but neurogenic appendicopathy (NA) remains a poorly understood disease with controversial clinical management. The aim of this review was to obtain a clear definition of the disease and summarize its management.

Methods: We performed a systematic review of the literature on NA in PubMed, EMBASE, Web of Science, and Cochrane databases from inception to 19/01/2021 according to PRISMA statement standards. Read More

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A neural noise account of Gilles de la Tourette syndrome.

Neuroimage Clin 2021 Mar 29;30:102654. Epub 2021 Mar 29.

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU, Dresden, Germany; Cognitive Psychology, Faculty of Psychology, Shandong Normal University, Jinan, China.

Tics, often preceded by premonitory urges, are the clinical hallmark of Tourette syndrome. They resemble spontaneous movements, but are exaggerated, repetitive and appear misplaced in a given communication context. Given that tics often go unnoticed, it has been suggested that they represent a surplus of action, or motor noise. Read More

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Hypertrophy of unaffected cardiomyocytes correlates with severity of cardiomyopathy in female patients with Fabry disease.

Orphanet J Rare Dis 2021 Apr 10;16(1):169. Epub 2021 Apr 10.

Department of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, Viale del Policlinico 155, 00161, Rome, Italy.

Aim: To investigate the contribution of unaffected cardiomyocytes in Fabry disease cardiomyopathy.

Findings: Left ventricular (LV) endomyocardial biopsies from twenty-four females (mean age 53 ± 11 ys) with Fabry disease cardiomyopathy were studied. Diagnosis of FD was based on the presence of pathogenic GLA mutation, Patients were divided in four groups according with LV maximal wall thickness (MWT): group 1 MWT ≤ 10. Read More

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A single stiffened nucleus alters cell dynamics and coherence in a monolayer.

Cytoskeleton (Hoboken) 2021 Apr 9. Epub 2021 Apr 9.

Molecular Biophysics and Structural Biology, University of Pittsburgh and Carnegie Mellon University.

Force transmission throughout a monolayer is the result of complex interactions between cells. Monolayer adaptation to force imbalances such as singular stiffened cells provides insight into the initiation of disease and fibrosis. Here, NRK-52E cells transfected with ∆50LA, which significantly stiffens the nucleus. Read More

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Preliminary analysis of whether mosquitoes can carry and transmit African swine fever.

BMC Vet Res 2021 Apr 9;17(1):152. Epub 2021 Apr 9.

College of Animal Science and Technology, Yangzhou University, 225009, Yangzhou, China.

Background: Mosquitoes are important insect vectors, but whether they can carry and transmit African swine fever virus (ASFV) in large-scale pig farms in China is unknown.

Results: In this study, probe-based qPCR analysis was performed on mosquitoes from five pig farms with ASF virus (ASFV). Analysis of ASFV in 463 mosquitoes yielded negative cycle threshold (CT) value), and detection remained negative after mixing samples from all five pig farms. Read More

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Ancient noeggerathialean reveals the seed plant sister group diversified alongside the primary seed plant radiation.

Proc Natl Acad Sci U S A 2021 Mar 8;118(11). Epub 2021 Mar 8.

Indiana Geological and Water Survey, Bloomington, IN 47404;

Noeggerathiales are enigmatic plants that existed during Carboniferous and Permian times, ∼323 to 252 Mya. Although their morphology, diversity, and distribution are well known, their systematic affinity remained enigmatic because their anatomy was unknown. Here, we report from a 298-My-old volcanic ash deposit, an in situ, complete, anatomically preserved noeggerathialean. Read More

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Dietary intake and growth in children with Prader-Willi syndrome.

J Hum Nutr Diet 2021 Apr 9. Epub 2021 Apr 9.

Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

Background: The management of Prader-Willi Syndrome (PWS) requires strict dietary supervision to prevent obesity, avoid micronutrient deficiencies and ensure optimal growth. The present study aimed to examine the growth and dietary intake of children with PWS.

Methods: All children with genetically confirmed PWS attending Children's Health Ireland (CHI) at Tallaght (n = 44) were invited to participate. Read More

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Isotretinoin Use and Risk of Depression in Acne Vulgaris Patients in Riyadh, Saudi Arabia.

Cureus 2021 Mar 3;13(3):e13680. Epub 2021 Mar 3.

Department of Dermatology, College of Medicine, Qassim University, Buraydah, SAU.

Background The association between isotretinoin administration and depression in acne patients remains controversial. We aim to estimate the prevalence of depression among patients with acne vulgaris before and after treatment with isotretinoin in Riyadh, Saudi Arabia. Methods This was a prospective study on patients attending the King Khalid University Hospital (KKUH), a tertiary institution, who were prescribed isotretinoin for the treatment of acne vulgaris for the first time. Read More

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Integrated miRNA-Seq and mRNA-Seq Study to Identify miRNAs Associated With Alzheimer's Disease Using Post-mortem Brain Tissue Samples.

Front Neurosci 2021 23;15:620899. Epub 2021 Mar 23.

Neuroscience, Janssen Research & Development, LLC, Titusville, NJ, United States.

Alzheimer's disease (AD), the leading form of dementia, is associated with abnormal tau and β-amyloid accumulation in the brain. We conducted a miRNA-seq study to identify miRNAs associated with AD in the post-mortem brain from the inferior frontal gyrus (IFG, = 69) and superior temporal gyrus (STG, = 81). Four and 64 miRNAs were differentially expressed (adjusted -value < 0. Read More

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Pediatric radiologic manifestations of COVID-19.

Clin Imaging 2021 Mar 30;75:165-170. Epub 2021 Mar 30.

Department of Radiology, University of Washington and Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, United States of America.

Purpose: While full description of pediatric COVID-19 manifestations is evolving, children appear to present less frequently, and often display a less severe disease phenotype. There is correspondingly less data regarding pediatric radiologic findings. To describe the imaging findings of pediatric COVID-19, we evaluated the radiologic imaging of the initial patient cohort identified at our institution. Read More

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The Transcription Factor bZIP60 Links the Unfolded Protein Response to the Heat Stress Response in Maize.

Plant Cell 2020 Nov;32(11):3559-3575

Plant Sciences Institute, Iowa State University, Ames, Iowa 50011.

The unfolded protein response (UPR) and the heat shock response (HSR) are two evolutionarily conserved systems that protect plants from heat stress. The UPR and HSR occur in different cellular compartments and both responses are elicited by misfolded proteins that accumulate under adverse environmental conditions such as heat stress. While the UPR and HSR appear to operate independently, we have found a link between them in maize (Zea mays) involving the production of the BASIC LEUCINE ZIPPER60 (bZIP60) transcription factor, a pivotal response of the UPR to heat stress. Read More

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November 2020

Association of vitamin D metabolites with cognitive function and brain atrophy in elderly individuals - the Austrian stroke prevention study.

Aging (Albany NY) 2021 Apr 7;13. Epub 2021 Apr 7.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.

Background: Vitamin D is a well-established regulator of calcium and phosphate metabolism that has neurotrophic and neuroprotective properties. Deficiency of vitamin D has been proposed to promote cognitive dysfunction and brain atrophy. However, existing studies provide inconsistent results. Read More

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Study on the safety of human oligodendrocyte precursor cells transplantation in young animals and its efficacy on myelination.

Stem Cells Dev 2021 Apr 6. Epub 2021 Apr 6.

Southern Medical University, 70570, Guangzhou, Guangdong, China;

Oligodendrocyte precursor cells (OPCs) can differentiate into myelinating oligodendrocytes during embryonic development, thereby representing an important potential source for myelin repair or regeneration. To the best of our knowledge, there are very few OPCs from human sources (hOPCs). In this study, we aimed to evaluate the safety and remyelination capacity of hOPCs developed in our laboratory transplanted into the lateral ventricles of young animals. Read More

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Novel Fluorescent Probe toward Fe Based on Rhodamine 6G Derivatives and Its Bioimaging in Adult Mice, , and Plant Tissues.

ACS Omega 2021 Mar 18;6(12):8616-8624. Epub 2021 Mar 18.

Engineering Research Center of Biomass Conversion and Pollution Prevention Anhui Educational Institutions, Fuyang, Anhui 236037, P. R. China.

A new fluorescent probe based on the rhodamine 6G platforms has been designed, synthesized, and characterized, which could recognize Fe effectively in HEPES buffer (10 mM, pH = 7.4)/CHCN (2:3, v/v). And the distinct color change and the rapid emergence of fluorescence emission at 550 nm achieved "naked eye" detection of Fe. Read More

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