228 results match your criteria app n = 42

A qualitative exploration of the patient experience of erosive and non-erosive hand osteoarthritis.

J Patient Rep Outcomes 2021 Feb 3;5(1):18. Epub 2021 Feb 3.

Adelphi Values, Patient-Centered Outcomes, Bollington, Cheshire, UK.

Background: Many patients with hand osteoarthritis (HOA) experience reduced health-related quality of life. This study sought to better understand the disease and treatment experience of individuals with HOA, explore any differences in experiences between erosive and non-erosive HOA sub-types, and evaluate content validity of the Michigan Hand Outcomes Questionnaire (MHQ) in HOA.

Methods: Thirty subjects from the United States (n = 15 erosive HOA; n = 15 non-erosive HOA) participated in semi-structured interviews: concept elicitation explored symptoms/impacts important to patients; cognitive interviews assessed understanding and relevance of the MHQ. Read More

View Article and Full-Text PDF
February 2021

MINDIN Exerts Protumorigenic Actions on Primary Prostate Tumors via Downregulation of the Scaffold Protein NHERF-1.

Cancers (Basel) 2021 Jan 24;13(3). Epub 2021 Jan 24.

Bone Physiopathology Laboratory, Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, CEU Universities, Campus Monteprincipe, 28925 Alcorcón, Spain.

Advanced prostate cancer preferential metastasis to bone is associated with osteomimicry. MINDIN is a secreted matrix protein upregulated in prostate tumors that overexpresses bone-related genes during prostate cancer progression. Na+/H+ exchanger regulatory factor (NHERF-1) is a scaffold protein that has been involved both in tumor regulation and osteogenesis. Read More

View Article and Full-Text PDF
January 2021

Associations between affect, craving, and smoking in Korean smokers: An ecological momentary assessment study.

Addict Behav Rep 2020 Dec 12;12:100301. Epub 2020 Sep 12.

Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Cigarette smoking remains the largest cause of preventable death in the United States and worldwide. In South Korea and other Asian countries, a large proportion of males smoke, increasing the need to examine cigarette smoking in these populations. Research suggests that the association between positive affect and negative affect, and between affect and craving, may differ across cultures, and that it is useful to examine these associations using Ecological Momentary Assessment (EMA). Read More

View Article and Full-Text PDF
December 2020

Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability.

Neuropathol Appl Neurobiol 2020 Oct 29. Epub 2020 Oct 29.

School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth, UK.

Aims: Amyloid β-oligomers (AβO) are potent modulators of Alzheimer's pathology, yet their impact on one of the earliest brain regions to exhibit signs of the condition, the locus coeruleus (LC), remains to be determined. Of particular importance is whether AβO impact the spontaneous excitability of LC neurons. This parameter determines brain-wide noradrenaline (NA) release, and thus NA-mediated brain functions, including cognition, emotion and immune function, which are all compromised in Alzheimer's patients. Read More

View Article and Full-Text PDF
October 2020

Neuroprotective Effects of OMO within the Hippocampus and Cortex in a D-Galactose and A-Induced Rat Model of Alzheimer's Disease.

Evid Based Complement Alternat Med 2020 10;2020:1067541. Epub 2020 Oct 10.

Scientific Research Platform, The Second Clinical Medical College, Guangdong Medical University, Dongguan 523808, China.

F.C. How. Read More

View Article and Full-Text PDF
October 2020

Development and pilot evaluation of a mobile app on parent-child exercises to improve physical activity and psychosocial outcomes of Hong Kong Chinese children.

BMC Public Health 2020 Oct 14;20(1):1544. Epub 2020 Oct 14.

Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F, Ap Lei Chau Clinic, 161 Ap Lei Chau Main Street, Ap Lei Chau, Hong Kong, Hong Kong.

Background: Parent-child exercises involve children and parents to do workout together and have positive effects on physical and mental health. We developed a mobile app on parent-child exercises called Family Move, which combines coaching videos with game features such as points and level system to enhance the health and wellbeing of both children and parents through parent-child exercises. This pilot pre-post study investigated whether the Family Move app-based intervention had a positive effect on children's health-related quality of life (HRQOL), psychosocial wellbeing, and physical activity (PA) level. Read More

View Article and Full-Text PDF
October 2020

Web-based Fully Automated Cephalometric Analysis: Comparisons between App-aided, Computerized, and Manual Tracings.

Turk J Orthod 2020 Sep 11;33(3):142-149. Epub 2020 Aug 11.

Specialist Clinic of Orthodontics, Public Dental Service, Västra Götaland Region, Gothenburg, Sweden.

Objective: To compare the accuracy of cephalometric analyses made with fully automated tracings, computerized tracing, and app-aided tracings with equivalent hand-traced measurements, and to evaluate the tracing time for each cephalometric analysis method.

Methods: Pre-treatment lateral cephalometric radiographs of 40 patients were randomly selected. Eight angular and 4 linear parameters were measured by 1 operator using 3 methods: computerized tracing with software Dolphin Imaging 13. Read More

View Article and Full-Text PDF
September 2020

The experiences and needs of couples affected by prostate cancer aged 65 and under: a qualitative study.

J Cancer Surviv 2021 Apr 24;15(2):358-366. Epub 2020 Sep 24.

Faculty of Health and Life Sciences, Oxford Brookes University, Jack Straws Lane, Oxford, OX3 0FL, UK.

Purpose: Prostate Cancer (PCa) is often considered to be an illness affecting older men, however the prevalence in younger men (<=65 years) is rising. Diagnosis and treatment for PCa can have a significant impact on the lives of both the man with PCa and his partner. This study explored the experiences and needs of younger men and their partners affected by PCa. Read More

View Article and Full-Text PDF

A Multilevel Bayesian Approach to Improve Effect Size Estimation in Regression Modeling of Metabolomics Data Utilizing Imputation with Uncertainty.

Metabolites 2020 Aug 6;10(8). Epub 2020 Aug 6.

Michigan Center for Integrative Research in Critical Care (MCIRCC), University of Michigan, Ann Arbor, MI 48109, USA.

To ensure scientific reproducibility of metabolomics data, alternative statistical methods are needed. A paradigm shift away from the -value toward an embracement of uncertainty and interval estimation of a metabolite's true effect size may lead to improved study design and greater reproducibility. Multilevel Bayesian models are one approach that offer the added opportunity of incorporating imputed value uncertainty when missing data are present. Read More

View Article and Full-Text PDF

A simple and rapid technique for the determination of copper based on air-assisted liquid-liquid microextraction and image colorimetric analysis.

Anal Methods 2020 07;12(27):3490-3498

Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.

In this study, a new, cheap, simple and rapid method for the determination of copper in water and food samples using air-assisted liquid-liquid microextraction and digital image decomposition into the primary colors Red (R), Green (G) and Blue (B) is introduced. In the proposed method, sodium diethyl-dithiocarbamate (Na-DDTC) and carbon tetrachloride (CCl4) were used as the chelating agent and extraction solvent, respectively. The digital images of the extraction phase were obtained using an Android mobile phone and analyzed using a free app (Color Grab). Read More

View Article and Full-Text PDF

Usefulness of mean number of adenomas per positive screenee for identifying meticulous endoscopists among those who achieve acceptable adenoma detection rates.

Endoscopy 2021 Apr 16;53(4):394-401. Epub 2020 Jun 16.

Centre of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology, Division of Gastroenterology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Background:  Adenoma detection rate (ADR) is a quality indicator for colonoscopy. However, many missed adenomas have subsequently been identified after colonoscopies performed by endoscopists with ADR ≥ 25 %. Adenomas per positive participant (APP; mean number of adenomas detected by an endoscopist among screenees with positive findings) correlates well inversely with adenoma miss rate. Read More

View Article and Full-Text PDF

Mood and Stress Evaluation of Adult Patients With Moyamoya Disease in Korea: Ecological Momentary Assessment Method Using a Mobile Phone App.

JMIR Mhealth Uhealth 2020 05 25;8(5):e17034. Epub 2020 May 25.

Mo-Im Kim Nursing Research Institute, Yonsei University College of Nursing, Seoul, Republic of Korea.

Background: Moyamoya disease (MMD) is a known progressive obstructive cerebrovascular disorder. Monitoring and managing mood and stress are critical for patients with MMD, as they affect clinical outcomes. The ecological momentary assessment (EMA) method is a longitudinal study design by which multiple variable assessments can be performed over time to detect momentary fluctuations and changes in psychological dimensions such as mood and stress over time. Read More

View Article and Full-Text PDF

Negative affect, affect-related impulsivity, and receptive syringe sharing among people who inject drugs.

Psychol Addict Behav 2020 Nov 23;34(7):734-744. Epub 2020 Apr 23.

Community Outreach Intervention Projects, School of Public Health, University of Illinois at Chicago.

Receptive syringe sharing (RSS) among people who inject drugs (PWID) is a risk factor for hepatitis C virus and HIV infections. PWID with borderline personality disorder (BPD) have increased risk of RSS, but it remains unclear what drives this association. This study used ecological momentary assessment (EMA) to study characteristics associated with BPD, and RSS among PWID. Read More

View Article and Full-Text PDF
November 2020

Negative affect and emotion dysregulation among people who inject drugs: An ecological momentary assessment study.

Psychol Addict Behav 2020 Sep 9;34(6):650-659. Epub 2020 Apr 9.

Community Outreach Intervention Projects.

This study used ecological momentary assessment (EMA) to measure positive affect (PA) and negative affect (NA) among people who inject drugs (PWID) and examined associations with borderline personality disorder (BPD) symptoms and difficulties with emotion regulation, in the context of injection drug use. We recruited PWID, ages 18-35 years, through syringe exchange program sites in Chicago, Illinois. After completing a baseline interview including a screener for BPD and the Difficulties in Emotion Regulation Scale (DERS), participants used a mobile phone app to report mood, substance use, and injection behavior for 2 weeks. Read More

View Article and Full-Text PDF
September 2020

A Smartphone App (mDASHNa-CC) to Support Healthy Diet and Hypertension Control for Chinese Canadian Seniors: Protocol for Design, Usability and Feasibility Testing.

JMIR Res Protoc 2020 Apr 2;9(4):e15545. Epub 2020 Apr 2.

School of Nursing, Wenzhou Medical University, Wenzhou, China.

Background: This proposed study aims to translate the Dietary Approach to Stop Hypertension with Sodium (Na) Reduction for Chinese Canadians (DASHNa-CC), a classroom-based, antihypertensive, dietary educational intervention, to an innovative smartphone app (mDASHNa-CC). This study will enable Chinese Canadian seniors to access antihypertensive dietary interventions anytime, regardless of where they are. It is hypothesized that senior Chinese Canadians will be satisfied with their experiences using the mDASHNa-CC app and that the use of this app could lead to a decrease in their blood pressure and improvement in their health-related quality of life. Read More

View Article and Full-Text PDF

A Validation Study of Human Epidermal Growth Factor Receptor 2 Immunohistochemistry Digital Imaging Analysis and its Correlation with Human Epidermal Growth Factor Receptor 2 Fluorescence Hybridization Results in Breast Carcinoma.

J Pathol Inform 2020 4;11. Epub 2020 Feb 4.

Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Background: The Visiopharm human epidermal growth factor receptor 2 (HER2) digital imaging analysis (DIA) algorithm assesses digitized HER2 immunohistochemistry (IHC) by measuring cell membrane connectivity. We aimed to validate this algorithm for clinical use by comparing with pathologists' scoring and correlating with HER2 fluorescence hybridization (FISH) results.

Materials And Methods: The study cohort consisted of 612 consecutive invasive breast carcinoma specimens including 395 biopsies and 217 resections. Read More

View Article and Full-Text PDF
February 2020

Blended care in the treatment of subthreshold symptoms of depression and psychosis in emerging adults: A randomised controlled trial of Acceptance and Commitment Therapy in Daily-Life (ACT-DL).

Behav Res Ther 2020 05 22;128:103592. Epub 2020 Feb 22.

Department of Neurosciences, Center for Contextual Psychiatry (CCP), University of Leuven, Leuven, Belgium. Electronic address:

In this study, the feasibility and efficacy of Acceptance and Commitment Therapy in Daily Life (ACT-DL), ACT augmented with a daily life application, was investigated in 55 emerging adults (age 16 to 25) with subthreshold depressive and/or psychotic complaints. Participants were randomized to ACT-DL (n = 27) or to active control (n = 28), with assessments completed at pre- and post-measurement and 6- and 12-months follow-up. It took up to five (ACT-DL) and 11 (control) months to start group-based interventions. Read More

View Article and Full-Text PDF

Contributions of DNA Damage to Alzheimer's Disease.

Int J Mol Sci 2020 Feb 28;21(5). Epub 2020 Feb 28.

Department of Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada.

Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Its typical pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau neurofibrillary tangles. Mutations in the and genes increase Aβ production and aggregation, and thus cause early onset or familial AD. Read More

View Article and Full-Text PDF
February 2020

The Accuracy of iPhone Applications to Monitor Environmental Noise Levels.

Laryngoscope 2021 01 28;131(1):E59-E62. Epub 2020 Feb 28.

University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.

Objective: The Control of Noise at Work Regulations came into force in Great Britain in 2005, requiring all work environments to be monitored for potentially harmful noise exposure levels. This study evaluated the effectiveness of a number of iPhone phone applications (apps) (Apple, Cupertino, CA) to accurately measure noise exposure, which may prove effective when a specialist-calibrated sound level meter is not readily available.

Methods: Suitable apps were identified using the search terms noise and decibel through the App Store (Apple). Read More

View Article and Full-Text PDF
January 2021

Fully Integrated, Simple, and Low-Cost Electrochemical Sensor Array for in Situ Water Quality Monitoring.

ACS Sens 2020 02 18;5(2):412-422. Epub 2020 Feb 18.

Electrical and Computer Engineering , McMaster University , 1280 Main Street W , Hamilton , ON L8S 4K1 , Canada.

Rapid, accurate and inexpensive monitoring of water quality parameters is indispensable for continued water safety, especially in resource-limited areas. Most conventional sensing systems either can only monitor one parameter at a time or lack user-friendly on-site monitoring capabilities. A fully integrated electrochemical sensor array is an excellent solution to this barrier. Read More

View Article and Full-Text PDF
February 2020

Development of a National Caregiver Health Survey for Hematopoietic Stem Cell Transplant: Qualitative Study of Cognitive Interviews and Verbal Probing.

JMIR Form Res 2020 Jan 23;4(1):e17077. Epub 2020 Jan 23.

Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, United States.

Background: Roadmap 1.0 is a mobile health app that was previously developed for caregivers of patients who have undergone hematopoietic stem cell transplantation (HSCT). Formative research targeted toward its end users (caregivers) can help inform app design and development, allowing additional components to be incorporated into the app, which can then be tested in a future randomized controlled trial. Read More

View Article and Full-Text PDF
January 2020

Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C.

J Neuroinflammation 2019 Dec 17;16(1):269. Epub 2019 Dec 17.

Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, 24785 Stewart St, Loma Linda, California, USA.

Background: Niemann-Pick disease type C (NPC) is a progressive neurodegenerative condition that results in early fatality. NPC is inherited in an autosomal recessive pattern from mutations in NPC1 or NPC2 genes. The etiology of NPC is poorly defined. Read More

View Article and Full-Text PDF
December 2019

Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis.

J Neuroinflammation 2019 Nov 13;16(1):215. Epub 2019 Nov 13.

Department of Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.

Background: In multiple sclerosis (MS) and in the experimental autoimmune encephalomyelitis (EAE) model of MS, the Nav1.6 voltage-gated sodium (Nav) channel isoform has been implicated as a primary contributor to axonal degeneration. Following demyelination Nav1. Read More

View Article and Full-Text PDF
November 2019

Atmospheric-pressure plasma treatment toward high-quality solution-processed aluminum oxide gate dielectric films in thin-film transistors.

Nanotechnology 2019 Dec 2;30(49):495702. Epub 2019 Sep 2.

Program in Nano Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Samsung Display Company, Ltd, 181 Samsung-ro, Tangjeong-myeon, Asan-si, Chungcheongnam-Do, Republic of Korea.

We present an atmospheric-pressure plasma (APP) treatment technique to improve the electrical performance of solution-processed dielectric films. This technique can successfully reduce leakage current and frequency dependence of solution-processed dielectric films. The APP treatment contributes to the conversion of metal hydroxide to metal oxide, and in the case of a solution-treated AlO dielectric thin film, it effectively ascribes to the formation of high-quality AlO dielectric thin films. Read More

View Article and Full-Text PDF
December 2019

The First Generation of iPSC Line from a Korean Alzheimer's Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction.

Exp Neurobiol 2019 Jun 14;28(3):329-336. Epub 2019 May 14.

CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seongnam 13488, Korea.

Alzheimer's Disease (AD) is a progressive neurodegenerative disease, which is pathologically defined by the accumulation of amyloid plaques and hyper-phosphorylated tau aggregates in the brain. Mitochondrial dysfunction is also a prominent feature in AD, and the extracellular Aβ and phosphorylated tau result in the impaired mitochondrial dynamics. In this study, we generated an induced pluripotent stem cell (iPSC) line from an AD patient with amyloid precursor protein (APP) mutation (Val715Met; APP-V715M) for the first time. Read More

View Article and Full-Text PDF

Protective effects of melatonin on mitochondrial biogenesis and mitochondrial structure and function in the HEK293-APPswe cell model of Alzheimer's disease.

Eur Rev Med Pharmacol Sci 2019 Apr;23(8):3542-3550

Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China.

Objective: The effects and mechanisms of melatonin on Alzheimer's disease (AD) are still not researched thoroughly. 20E2 cells (HEK293-APPswe cells) are a cellular model of AD. The modulation effects of melatonin on the structure and function of mitochondria in 20E2 cells need to be studied. Read More

View Article and Full-Text PDF

[Niskocząsteczkowe inhibitory szlaku adaptacyjnej odpowiedzi na stres zależnego od kinazy PERK jako nowatorska strategia terapeutyczna w leczeniu choroby Alzheimera].

Pol Merkur Lekarski 2019 Jan;46(271):9-15

Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Poland.

The characteristic hallmark of Alzheimer's disease (AD) are progressive changes in the brain structure and function, caused by aggregation of senile plagues, composed of improperly folded amyloid β(Aβ) protein, in the brain tissue. Recent research has suggested that causes of AD are closely associated with perturbation on the molecular level caused by the activation of the pro-apoptotic, PERKdependent Unfolded Protein Response (UPR) signaling pathway activated under Endoplasmic Reticulum (ER) stress conditions.

Aim: The aims of the study were evaluation of the activity of the smallmolecule inhibitors of PERK kinase, GSK2606414 and LDN-0060609, via the analysis of the level of the phosphorylation of eIF2α as one of the main markers of the UPR signaling pathway activation as well as evaluation of the cytotoxicity of the inhibitor LDN-0060609. Read More

View Article and Full-Text PDF
January 2019

Development and validation of the ID-EC - the ITALIAN version of the identify chronic migraine.

J Headache Pain 2019 Feb 13;20(1):15. Epub 2019 Feb 13.

Department of Clinical and Molecular Medicine, Regional Referral Headache Centre, Sant'Andrea Hospital, Sapienza University, Rome, Italy.

Background: Case-finding tools, such as the Identify Chronic Migraine (ID-CM) questionnaire, can improve detection of CM and alleviate its significant societal burden. We aimed to develop and validate the Italian version of the ID-CM (ID-EC) in paper and as a smart app version in a headache clinic-based setting.

Methods: The study investigators translated and adapted to the Italian language the original ID-CM questionnaire (ID-EC) and further implemented it as a smart app. Read More

View Article and Full-Text PDF
February 2019

The safety, efficacy and cost-effectiveness of the Maxm Skate, a lower limb rehabilitation device for use following total knee arthroplasty: study protocol for a randomised controlled trial.

Trials 2019 Jan 10;20(1):36. Epub 2019 Jan 10.

The International Musculoskeletal Research Institute Inc., Adelaide, South Australia, Australia.

Background: Physical rehabilitation is required to enhance functional outcomes and overall recovery following total knee arthroplasty (TKA). However, there are no universally accepted clinical guidelines available to consistently structure rehabilitation for TKA patients. A common method is rehabilitation provided in an outpatient setting, on a one-to-one treatment basis. Read More

View Article and Full-Text PDF
January 2019

T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.

PLoS One 2018 20;13(12):e0206986. Epub 2018 Dec 20.

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

T-type calcium channels in the brain mediate the pathophysiology of epilepsy, pain, and sleep. Recently, we developed a novel therapeutic candidate, SAK3 (ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopentane-1,3'-imidazo[1,2-a] pyridine]-2-ene-3-carboxylate), for Alzheimer's disease (AD). The cognitive improvement by SAK3 is closely associated with enhanced acetylcholine (ACh) release in the hippocampus. Read More

View Article and Full-Text PDF