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Secretion of signal peptides via extracellular vesicles.

Biochem Biophys Res Commun 2021 May 5;560:21-26. Epub 2021 May 5.

Department of Brain Function, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, 464-8601, Japan; Department of Molecular Pharmacokinetics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 464-8601, Japan.

Signal peptides (SPs) consist of short peptide sequences present at the N-terminal of newly synthesizing proteins and act as a zip code for the translocation of the proteins to the endoplasmic reticulum (ER). It was thought that the SPs are intracellularly degraded after translocation to the ER; however, recent studies showed cleaved SPs have diverse roles for controlling cell functions in auto- and/or intercellular manners. In addition, it still remains obscure how SP fragments translocate away from the site where they are produced. Read More

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World Neurosurg 2021 May 5. Epub 2021 May 5.

Santa Marcelina Hospital; São Paulo/SP, Brazil; Sabará Children's Hospital, São Paulo/SP, Brazil; Faculty of Medicine of ABC, Santo André/SP, Brazil.

Introduction: Late surgical correction of meningoencephalocele is a rare scenario that remains challenging for surgeons. 3D models can mimic the correct anatomical relationships and technological systems have brought advances to medicine.

Objective: This study aims to present a novel preoperative planning modality that combines augmented reality with a hybrid model for complex malformation associated with late correction. Read More

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Cocktail strategy for 'cold' tumors therapy via active recruitment of CD8+ T cells and enhancing their function.

J Control Release 2021 May 5. Epub 2021 May 5.

College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, PR China. Electronic address:

In immunotherapy, 'cold' tumors, with low T cells infiltration, hardly benefit from the treatment of immune checkpoint inhibitors (ICIs). To address this issue, we screened two 'cold' tumor models for mice with high expression of galectin-3 (Gal-3) and designed a cocktail strategy to actively recruit CD8+ T cells into the tumor microenvironment (TME), which reversed 'cold' tumors into 'hot' and remarkably elevated their ICIs-responsiveness. Gal-3, an important driving force of tumorigenesis, inhibits T cell infiltration into tumor tissue that shapes 'cold' tumor phenotype, and promotes tumor metastasis. Read More

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Health-Related Goal Setting and Achievement Among Veterans with High Technology Adoption.

J Gen Intern Med 2021 May 7. Epub 2021 May 7.

eHealth Partnered Evaluation Initiative, VA Bedford Healthcare System, Bedford, MA, USA.

Background: There is increasing recognition of the importance of supporting patients in their health-related goals. Patient-provider discussions and health-related mobile applications (apps) can support patients to pursue health goals; however, their impact on patient goal setting and achievement is not well understood.

Objective: To examine the relationships between the following: (1) patient demographics, patient-provider discussions, and health-related goal setting and achievement, and (2) patient mobile health app use and goal achievement. Read More

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Mobile Apps for Drug-Drug Interaction (DDI) Check in Chinese App Stores: A Systematic Review and Content Analysis.

JMIR Mhealth Uhealth 2021 May 7. Epub 2021 May 7.

Department of Pharmacy, Minhang Hospital, Fudan University, Shanghai, 201203, PR China., 826 Zhangheng Road,, Shanghai, CN.

Background: As the computerized drug-drug interaction (DDI) alert system is not widely implemented in China, healthcare providers are relying on mobile health (mHealth) apps as references for checking drug information such as DDI.

Objective: The main objective of this study was to evaluate the quality and content of mHealth apps supporting DDI checking in Chinese App stores.

Methods: A systematical review was carried out in November 2020, to identify mHealth apps providing DDI checking in both Chinese iOS and Android platforms. Read More

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Antimicrobial stewardship solutions with a smart innovative tool.

J Am Pharm Assoc (2003) 2021 Apr 24. Epub 2021 Apr 24.

Background: Antimicrobial consumption has been increasing lately. Hence, effective strategies are required to control antimicrobial use and decrease the development of antimicrobial resistance.

Objective: To evaluate the impact of the use of a mobile app on the implementation of antimicrobial stewardship program (ASP) interventions. Read More

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A systematic review of the use of virtual reality or dental smartphone applications as interventions for management of paediatric dental anxiety.

BMC Oral Health 2021 May 7;21(1):244. Epub 2021 May 7.

Centre for Public Health, Institute of Clinical Sciences Block B, Royal Victoria Hospital, Queen's University Belfast, Belfast, UK.

Background: Virtual reality (VR) has been used successfully in medicine both as a distraction tool during procedures, and as an acclimatisation tool to prepare for a procedure or experience. It has not yet become widely used in dentistry, but could theoretically have a role in exposure-based acclimatisation for dental experiences.

Methods: To examine the use of VR or bespoke dental smartphone applications pre- or perioperatively in dentistry, to decrease anxiety in a paediatric population attending for dental examination or treatment, compared with children/adolescents who receive no intervention, or more conventional behavioural management techniques. Read More

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Protocol for a family-centered behavioral intervention to reduce early childhood caries: the MySmileBuddy program efficacy trial.

BMC Oral Health 2021 May 7;21(1):246. Epub 2021 May 7.

Mailman School of Public Health, Columbia University Irving Medical Center, 1051 Riverside Drive, Unit 47, New York, NY, 10032, USA.

Background: Although largely preventable through diet management and topical fluoride use, early childhood caries (ECC) often progresses to severity that necessitates surgical repair. Yet repair often fails to mitigate caries progression. Needed is an effective behavioral intervention to address underlying behavioral causes. Read More

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A method for achieving complete microbial genomes and improving bins from metagenomics data.

PLoS Comput Biol 2021 May 7;17(5):e1008972. Epub 2021 May 7.

Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States of America.

Metagenomics facilitates the study of the genetic information from uncultured microbes and complex microbial communities. Assembling complete genomes from metagenomics data is difficult because most samples have high organismal complexity and strain diversity. Some studies have attempted to extract complete bacterial, archaeal, and viral genomes and often focus on species with circular genomes so they can help confirm completeness with circularity. Read More

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Digital Clinics and Mobile Technology Implementation for Mental Health Care.

Curr Psychiatry Rep 2021 May 7;23(7):38. Epub 2021 May 7.

Division of Digital Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02446, USA.

Purpose Of Review: Interest in digital mental health, especially smartphone apps, has expanded in light of limited access to mental health services and the need for remote care during COVID-19. Digital clinics, in which apps are blended into routine care, offer a potential solution to common implementation challenges including low user engagement and lack of clinical integration of apps.

Recent Findings: While the number of mental health apps available in commercial marketplaces continues to rise, there are few examples of successful implementation of these apps into care settings. Read More

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IntAct App: a Cytoscape application for molecular interaction network visualisation and analysis.

Bioinformatics 2021 May 7. Epub 2021 May 7.

EMBL-EBI, IntAct Team, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.

Summary: IntAct App is a Cytoscape 3 application that grants in-depth access to IntAct's molecular interaction data. It builds networks where nodes are interacting molecules (mainly proteins, but also genes, RNA, chemicals…) and edges represent evidence of interaction. Users can query a network by providing its molecules, identified by different fields, and optionally include all their interacting partners in the resulting network. Read More

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Mobile Health-Based Thermometer for Monitoring Wound Healing After Endovascular Therapy in Patients With Chronic Foot Ulcer: Prospective Cohort Study.

JMIR Mhealth Uhealth 2021 May 7;9(5):e26468. Epub 2021 May 7.

Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Background: Foot temperature may increase after endovascular therapy, but the relationship between foot temperature and wound healing is unclear.

Objective: This study was performed to evaluate the feasibility of a mobile health (mHealth)-based thermometer for foot temperature monitoring in patients with chronic foot ulcer before and after endovascular therapy and to determine the association between temperature change and wound healing time.

Methods: This was a prospective cohort study. Read More

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Commercially Available Apps to Support Healthy Family Meals: User Testing of App Utility, Acceptability, and Engagement.

JMIR Mhealth Uhealth 2021 May 7;9(5):e22990. Epub 2021 May 7.

Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.

Background: Parents juggling caregiving and paid employment encounter a range of barriers in providing healthy food to their families. Mobile apps have the potential to help parents in planning, purchasing, and preparing healthy family food. The utility and acceptability of apps for supporting parents are unknown. Read More

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Postmarketing Safety Monitoring After Influenza Vaccination Using a Mobile Health App: Prospective Longitudinal Feasibility Study.

JMIR Mhealth Uhealth 2021 May 7;9(5):e26289. Epub 2021 May 7.

PhD Programme Epidemiology, Hannover Biomedical Research School, Hannover Medical School, Hannover, Germany.

Background: For the safety monitoring of vaccinations postlicensure, reports of adverse events after immunization (AEFIs) are crucial. New technologies such as digital mobile apps can be used as an active approach to capture these events. We therefore conducted a feasibility study among recipients of the influenza vaccination using an app for assessment of the reporting of AEFIs. Read More

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The Smartphone App haMSter for Tracking Patient-Reported Outcomes in People With Multiple Sclerosis: Protocol for a Pilot Study.

JMIR Res Protoc 2021 May 7;10(5):e25011. Epub 2021 May 7.

Department of Neurology, Medical University of Vienna, Vienna, Austria.

Background: Treatment and monitoring decisions in people with multiple sclerosis (MS) are based commonly on clinician-reported outcomes. These reflect physical and radiological disease activity and are the most relevant endpoints in clinical trials. Over the past few years, the number of studies evaluating so-called patient-reported outcomes (PROs) has been increasing. Read More

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Views on Mobile Health Apps for Skin Cancer Screening in the General Population: An In-Depth Qualitative Exploration of Perceived Barriers and Facilitators.

Br J Dermatol 2021 May 7. Epub 2021 May 7.

Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Background: Mobile health (mHealth) applications (apps) integrated with artificial Intelligence (AI) for skin cancer screening are increasingly reimbursed by health insurers. However, an in-depth exploration of the general public's views towards these apps is lacking.

Objectives: To explore the perceived barriers and facilitators towards mHealth apps for skin cancer screening among the Dutch general population. Read More

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Hypoxia Constructing the Prognostic Model of Colorectal Adenocarcinoma and Related to the Immune Microenvironment.

Front Cell Dev Biol 2021 20;9:665364. Epub 2021 Apr 20.

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Hypoxia is a common phenomenon in solid tumors, which plays an important role in tumor proliferation, apoptosis, angiogenesis, invasion and metastasis, energy metabolism and chemoradiotherapy resistance. However, comprehensive analysis of hypoxia markers in colorectal adenocarcinoma (COAD) is still lacking. And there is a need for mechanism exploration and clinical application. Read More

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Development and rapid rollout of The QUiPP App Toolkit for women who arrive in threatened preterm labour.

BMJ Open Qual 2021 May;10(2)

Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK.

Background: Often the first opportunity for clinicians to assess risk of preterm birth is when women present with threatened preterm labour symptoms (such as period-like pain, tightening's or back ache). However, threatened preterm labour symptoms are not a strong predictor of imminent birth. Clinicians are then faced with a complex clinical dilemma, the need to ameliorate the consequences of preterm birth requires consideration with the side-effects and costs. Read More

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Improving rib fracture management in Morriston hospital: using QI to develop an erector spinae plane catheter service.

Tom Rees Arthur Ee

BMJ Open Qual 2021 May;10(2)

Anaesthesia, Royal Gwent Hospital, Newport, UK.

Introduction: Trauma audit research network (TARN) data for 2018 indicated that we admitted 100 patients with chest wall injuries in our District General Hospital (DGH). Our own retrospective audit of pain team referrals confirmed long length of stay (median 14 days), with 59% requiring level 2/3 care and 11% mortality risk. We noticed that Regional anaesthesia was offered to less than 25% of patients despite 63% reporting severe pain and decided to introduce an erector spinae plane (ESP) catheter service for rib fractures. Read More

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Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy.

Mol Neurodegener 2021 May 6;16(1):32. Epub 2021 May 6.

Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, University of Florida, FL, 32611, Gainesville, USA.

Introduction: Passive immunotherapies targeting Aβ continue to be evaluated as Alzheimer's disease (AD) therapeutics, but there remains debate over the mechanisms by which these immunotherapies work. Besides the amount of preexisting Aβ deposition and the type of deposit (compact or diffuse), there is little data concerning what factors, independent of those intrinsic to the antibody, might influence efficacy. Here we (i) explored how constitutive priming of the underlying innate activation states by Il10 and Il6 might influence passive Aβ immunotherapy and (ii) evaluated transcriptomic data generated in the AMP-AD initiative to inform how these two cytokines and their receptors' mRNA levels are altered in human AD and an APP mouse model. Read More

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[Apps on Prescription in the Medical Office, but how? A Case-based Problem Outline of Medical-ethical Implications of DHA Usage].

Gesundheitswesen 2021 May 6. Epub 2021 May 6.

Institut für Geschichte und Ethik der Medizin, Technische Universität München, München, Deutschland.

Background: Since the approval of the digital care law (Digitale-Versorgung-Gesetz-DVG) on 19.12.2019, physicians have been able to prescribe digital health applications (DHA). Read More

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Mindfulness Effects in Obstetric and Gynecology Patients During the Coronavirus Disease 2019 (COVID-19) Pandemic: A Randomized Controlled Trial.

Obstet Gynecol 2021 May 6. Epub 2021 May 6.

Department of Obstetrics and Gynecology, University of Arizona College of Medicine, and the Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Phoenix, Arizona.

Objective: To assess the effect of a consumer-based mobile meditation application (app) on wellness in outpatient obstetric and gynecology patients during the coronavirus disease 2019 (COVID-19) pandemic.

Methods: We conducted a randomized controlled trial at a university outpatient clinic of obstetric and gynecology patients during the COVID-19 pandemic. Women were randomly assigned to the intervention group, who was prescribed a mobile meditation app for 30 days, or the control group, which received standard care. Read More

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Integrated bioinformatic analysis and experiment confirmation of the antagonistic effect and molecular mechanism of ginsenoside Rh2 in metastatic osteosarcoma.

J Pharm Biomed Anal 2021 Apr 19;201:114088. Epub 2021 Apr 19.

Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China. Electronic address:

This study aimed to compare the gene expression variation of clinical primary osteosarcoma (OS) and metastatic OS, identify expression profiles and signal pathways related to disease classification, and systematically evaluate the potential anticancer effect and molecular mechanism of ginsenoside Rh2 on OS. A raw dataset (GSE14359), which excluded GSM359137 and GSM359138, was downloaded from the Gene Expression Omnibus. Differentially expressed genes (DEGs) and principal component analysis (PCA) were obtained with limma. Read More

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An observational study of a cross platform risk assessment mobile application in a forensic inpatient setting.

J Psychiatr Res 2021 Apr 30;138:388-392. Epub 2021 Apr 30.

Department of Computer Science and Applied Physics, Galway-Mayo Institute of Technology, Ireland.

Consumer-focused healthcare mobile applications have seen widespread adoption in recent years. Enterprise mobile applications in hospital settings have been slower to gain traction. In this study we examine the Dynamic Appraisal of Situational Aggression: Inpatient version (DASA), a short-term risk assessment tool which is well validated and widely used in the prediction of violent incidents, within an inpatient forensic setting. Read More

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Clozapine affects the pharmacokinetics of risperidone and inhibits its metabolism and P-glycoprotein-mediated transport in vivo and in vitro: A safety attention to antipsychotic polypharmacy with clozapine and risperidone.

Toxicol Appl Pharmacol 2021 May 3:115560. Epub 2021 May 3.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, PR China.

Antipsychotic polypharmacy (APP), as one maintenance treatment strategy in patients with schizophrenia, has gained popularity in real-world clinical settings. Risperidone (RIS) and clozapine (CLZ) are the most commonly prescribed second-generation antipsychotics, and they are often used in combination as APP. In this study, the pharmacokinetics of RIS and CLZ in rats were examined after co-administration to explore the reliability and rationality of co-medication with RIS and CLZ. Read More

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eHealth for the prevention of healthcare-associated infections: a scoping review.

J Hosp Infect 2021 May 3. Epub 2021 May 3.

Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.

Background: The increase in smartphone use and mobile health applications (apps) holds potential to use apps to reduce and detect healthcare-associated infections (HAIs) in clinical practice.

Aim: To obtain an overview of available apps for HAI prevention, by selecting the clinically relevant apps and scoring functionality, quality and usefulness.

Methods: This scoping review of available apps in the iOS and Android app stores uses an in-house-developed tool (scraper https://holtder. Read More

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MiR-216a-5p ameliorates learning-memory deficits and neuroinflammatory response of Alzheimer's disease mice via regulation of HMGB1/NF-κB signaling.

Peng Shao

Brain Res 2021 May 3:147511. Epub 2021 May 3.

Department of Rehabilitation Medicine, Yantaishan Hospital, Yantai 264001, China. Electronic address:

Objective: The objective of this study was to explore whether miR-216a-5p could affect the learning-memory ability and inflammatory response of Alzheimer's disease (AD) mice via regulation of the HMGB1/NF-κB pathway.

Methods: Mice were divided into the normal (wild-type C57BL/6 mice), AD (APP/PS1 double-transgenic mice), AD + miR-216a-5p, and AD + vector groups. The Morris water maze test was used to examine learning and memory ability. Read More

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Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual participant data.

Lancet Psychiatry 2021 May 3. Epub 2021 May 3.

Department of Clinical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway.

Background: Internet cognitive behavioural therapy (iCBT) is a viable delivery format of CBT for depression. However, iCBT programmes include training in a wide array of cognitive and behavioural skills via different delivery methods, and it remains unclear which of these components are more efficacious and for whom.

Methods: We did a systematic review and individual participant data component network meta-analysis (cNMA) of iCBT trials for depression. Read More

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Capsulation of AuNCs with AIE Effect into Metal-Organic Framework for the Marriage of a Fluorescence and Colorimetric Biosensor to Detect Organophosphorus Pesticides.

Anal Chem 2021 May 6. Epub 2021 May 6.

Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, People's Republic of China.

Organophosphorus pesticides (OPs) can inhibit the activity of acetylcholinesterase (AChE) to induce neurological diseases. It is significant to exploit a rapid and sensitive strategy to monitor OPs. Here, a metal-organic framework (MOF) acted as a carrier to encapsulate AuNCs, which can limit the molecular motion of AuNCs, trigger the aggregation-induced emission (AIE) effect, and exhibit a strong fluorescence with a fluorescence lifetime and quantum yield of 6. Read More

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Outdoor cycling activity affected by COVID-19 related epidemic-control-decisions.

PLoS One 2021 6;16(5):e0249268. Epub 2021 May 6.

Sport Ecology, Bayreuth Center of Ecology and Environmental Research (BayCEER) & Department of Sport Science, University of Bayreuth, Bayreuth, Bavaria, Germany.

Aim: The lockdown of sports infrastructure due to the COVID-19 pandemic has substantially shifted people's physical activity towards public green spaces. With Germany's lockdown as one of the more severe governmentally imposed epidemic-control-decisions, we tested to what extent the frequency of outdoor cycling activities changed from March to June 2020.

Methods: User behaviour and frequency in 15 urban and 7 rural German public green spaces was quantified using cycling data from the fitness application Strava. Read More

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