660 results match your criteria apnea feeding

Focusing on Autism Spectrum Disorder in Xia-Gibbs Syndrome: Description of a Female with High Functioning Autism and Literature Review.

Children (Basel) 2021 May 26;8(6). Epub 2021 May 26.

Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, 56128 Calambrone, Italy.

Background: Xia-Gibbs syndrome (XGS) is a rare disorder caused by de novo mutations in the AT-Hook DNA binding motif Containing 1 () gene, which is characterised by a wide spectrum of clinical manifestations, including global developmental delay, intellectual disability, structural abnormalities of the brain, global hypotonia, feeding problems, sleep difficulties and apnoea, facial dysmorphisms, and short stature.

Methods: Here, we report on a girl patient who shows a peculiar cognitive and behavioural profile including high-functioning autism spectrum disorder (ASD) without intellectual disability and provide information on her developmental trajectory with the aim of expanding knowledge of the XGS clinical spectrum. On the basis of the current clinical case and the literature review, we also attempt to deepen understanding of behavioural and psychiatric manifestations associated with XGS. Read More

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[Recommendations for the clinical management of the child in the postoperative adenoamygdalectomy].


Arch Argent Pediatr 2021 06;119(3):S67-S76

Obstructive sleep apnea and hypopnea syndrome is associated with decreased quality of life, poor school performance and, in up to 40 % of children, behavioral problems such as hyperactivity, enuresis, anxiety and depression. Several studies have shown that adenoamygdalectomy is effective in improving or resolving sleepdisordered breathing. While this surgery has beneficial results, it is not without risks. Read More

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The association of sleep problem, dietary habits and physical activity with weight status of adolescents in Nepal.

BMC Public Health 2021 05 17;21(1):938. Epub 2021 May 17.

School of Allied and Public Health Professions, Canterbury Christ Church University, Canterbury, Kent, UK.

Background: Overweight/obesity among adolescents is an emerging public health issue worldwide. However, the evidence on the determinants of body weight status and lifestyle behaviors among Nepalese adolescents is limited. This study aims to explore the sleep characteristics, dietary habits, and physical activity and its association with body mass index (BMI) among Nepalese adolescents. Read More

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Achievement of maturational milestones among very low birth weight infants.

J Neonatal Perinatal Med 2021 Apr 30. Epub 2021 Apr 30.

Department of Pediatrics, Division of Neonatology, University of Virginia School of Medicine, Charlottesville, VA, USA.

Background: Very low birth weight (VLBW) infants must achieve several maturational milestones to be discharged home from the NICU.

Objective: Describe the timing of maturational milestones in VLBW infants and the impact of clinical variables and milestone achievement on postmenstrual age (PMA) at discharge.

Methods: For VLBW infants without severe lung disease discharged home from a level IV NICU, we assessed PMA at the achievement of thermoregulation, cardiorespiratory stability, feeding, and discharge. Read More

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Metanalysis of alloplastic materials versus autologous fat for injection augmentation pharyngoplasty treatment of velopharyngeal insufficiency.

Int J Pediatr Otorhinolaryngol 2021 Jul 28;146:110738. Epub 2021 Apr 28.

Tufts Medical Center, Boston, MA, USA.

Background: Velopharyngeal insufficiency (VPI) can cause resonance, speech and feeding problems. While reconstructive palatoplasty and surgical pharyngoplasty techniques are the mainstay of treatment for severe VPI, injection augmentation pharyngoplasty offers a minimally invasive approach in patients with mild-to-moderate VPI.

Methods: We conducted a systematic review of the literature available on PubMed and Embase from 1990 to 2019 including studies that addressed VPI, incompetence, or dysfunction managed with injection augmentation. Read More

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Effects of Different Onset Times of Early Caffeine Treatment on Mesenteric Tissue Oxygenation and Necrotizing Enterocolitis: A Prospective, Randomized Study.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Division of Neonatology, Department of Pediatrics, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.

Objective:  Caffeine treatment is routinely used in premature infants to prevent development of apnea and bronchopulmonary dysplasia. Although a limited number of studies have reported that early caffeine treatment may cause development of necrotizing enterocolitis (NEC) by reducing mesenteric blood flow, this issue is still under discussion. The aim of this study is to investigate the possible effect of different onset times of early caffeine treatment on mesenteric tissue oxygen saturation and NEC development in premature infants. Read More

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Sleep-related eating disorder associated with zolpidem: cases compiled from a literature review.

Sleep Med X 2020 Dec 18;2:100019. Epub 2020 Jul 18.

Department of Pharmacy Practice, Texas A&M University, Irma Lerma Rangel College of Pharmacy, Houston, TX, USA.

Objective: Zolpidem is associated with sleep-related eating disorder (SRED). We compiled case reports and performed a descriptive study to identify etiology and aggravating factors.

Methods: A literature search on PubMed's MeSH search feature, CINAHL, and SciFinder was performed using search terms "Zolpidem," "Feeding and Eating Disorders/chemically induced," "Dyssomnias," "sleep eating disorder," and "sleep-related eating disorder. Read More

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December 2020

Mandibular Distraction Osteogenesis as a Primary Intervention in Infants With Pierre Robin Sequence.

Ann Plast Surg 2021 Jun;86(6S Suppl 5):S545-S549

Division of Plastic Surgery, University of Alabama at Birmingham, Birmingham, AL.

Background: Pierre Robin sequence (PRS) is a triad of congenital facial abnormalities that can present as a syndrome (syndromic PRS [sPRS]) or an isolated entity (isolated PRS [iPRS]). Patients with PRS can develop airway and feeding problems that may result in failure to thrive. Mandibular distraction osteogenesis (MDO) is a method for improving the functional issues associated with breathing and feeding. Read More

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The effect of 4-h versus 6-h time restricted feeding on sleep quality, duration, insomnia severity and obstructive sleep apnea in adults with obesity.

Nutr Health 2021 Mar 24:2601060211002347. Epub 2021 Mar 24.

Department of Kinesiology and Nutrition, 12247University of Illinois at Chicago, USA.

Background: Time restricted feeding (TRF) involves deliberately restricting the times during which energy is ingested. Preliminary findings suggest that 8-10-h TRF improves sleep. However, the effects of shorter TRF windows (4-6 h) on sleep, remain unknown. Read More

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Effect of Early Parent Participation Program on Physiological Stability in Preterm Infants: A Randomized Controlled Trial.

Am J Perinatol 2021 Mar 23. Epub 2021 Mar 23.

Department of Neonatology, Kerala Institute of Medical Sciences, Thiruvananthapuram, Kerala, India.

Objective:  This research aimed to study the impact of early parent participation program (EPPP) for preterm infants in neonatal intensive care unit (NICU) on physiological instability, breastmilk feeding rates, and discharge timing.

Materials And Methods:  Families of 147 infants born between 28 and 33 weeks' gestation were randomized at birth to EPPP group or conventional care (CC). Families in the EPPP group were trained soon after admission by using a structured education program and encouraged to spend more time with their baby. Read More

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[Perinatal conditions of late preterm twins versus early term twins].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Mar;23(3):242-247

Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China.

Objective: To study the perinatal complications of late preterm twins (LPTs) versus early term twins (ETTs).

Methods: A retrospective analysis was performed for the complications of 246 LPTs, 496 ETTs, and their mothers. The risk factors for late preterm birth were analyzed. Read More

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Clinico-Epidemiological Profile, Etiology, and Imaging in Neonatal Stroke: An Observational Study from Eastern India.

Neurol India 2021 Jan-Feb;69(1):62-65

Department of Pediatric Medicine, Institute of Child Health, Kolkata, West Bengal, India.

Aim: The aim of this study was to assess the clinico-epidemiological profile, etiology, and imaging findings in neonatal stroke (NS).

Materials And Methods: This was a retrospective, observational study on neonates presenting with stroke between August 2014 and July 2016 to a tertiary care hospital in eastern India.

Results: In all, 43 neonates were analyzed, with a male-to-female ratio of 2. Read More

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Neonatal PURA syndrome: a case report and literature review.

Transl Pediatr 2021 Jan;10(1):194-203

Department of Pediatrics, Peking University Shenzhen Hospital, Shenzhen, China.

The study's purpose is to investigate the clinical characteristics and research progress of PURA syndrome. It will also provide new ideas and methods for the diagnosis of neonatal hypotonia etiology. A case of PURA syndrome admitted to Shenzhen Hospital of Peking University was analyzed retrospectively. Read More

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January 2021

Evaluating the risks and benefits of ketorolac in transoral robotic surgery.

J Robot Surg 2021 Jan 16. Epub 2021 Jan 16.

Department of Otolaryngology, Head and Neck Surgery, Indiana University School of Medicine, 1130 W. Michigan Street, Suite 400, Indianapolis, IN, 46202, USA.

Transoral Robotic Surgery (TORS) is increasingly used for oropharyngeal neoplasms and obstructive sleep apnea. Post-operative pain and bleeding remain concerns. Ketorolac has proved to be a safe alternative or addition to narcotics in other operations, but has not been thoroughly evaluated in TORS. Read More

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January 2021

Functional outcomes in patients with facial dysostosis and severe upper airway obstruction.

Int J Oral Maxillofac Surg 2021 Jul 15;50(7):915-923. Epub 2020 Dec 15.

Department of Paediatric Intensive Care, Sophia Children's Hospital - Erasmus Medical Centre, Rotterdam, The Netherlands.

An increased risk of upper airway obstruction (UAO) is seen in up to 95% of patients with facial dysostosis. Secondary to respiratory problems are feeding difficulties and increased nutritional requirements. Little has been described regarding these outcomes in this patient population. Read More

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Noninvasive mechanical ventilation in the COVID-19 era: Proposal for a continuous positive airway pressure closed-loop circuit minimizing air contamination, oxygen consumption, and noise.

Artif Organs 2020 Dec 16. Epub 2020 Dec 16.

PoliToBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.

Noninvasive continuous positive airway pressure (NIV-CPAP) is effective in patients with hypoxemic respiratory failure. Building evidence during the COVID-19 emergency reported that around 50% of patients in Italy treated with NIV-CPAP avoided the need for invasive mechanical ventilation. Standard NIV-CPAP systems operate at high gas flow rates responsible for noise generation and inadequate humidification. Read More

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December 2020

An extensive posterior circulation infarction secondary to primary hyperthyroidism accompanied with superior mesenteric artery syndrome: A case report and description of patho-physiological association.

Medicine (Baltimore) 2020 Nov;99(46):e22664

Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou.

Introduction: Hyperthyroidism-related anterior circulation ischemic events have been well documented; however, posterior circulation infarction is rarely reported, not to mention with superior mesenteric artery syndrome (SMAS), which has never been reported concurrently. We describe, to the best of our knowledge, the first case of hyperthyroidism-related cerebellar infarction accompanied with SMAS.

Patient Concerns: A 22-year-old women presented with palpitation, postprandial vomiting, and acute body weight loss. Read More

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November 2020

HFD and HFD-provoked hepatic hypoxia act as reciprocal causation for NAFLD via HIF-independent signaling.

BMC Gastroenterol 2020 Nov 3;20(1):366. Epub 2020 Nov 3.

Siming Branch, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, 361003, China.

Background: The occurrence of non-alcoholic fatty liver disease (NAFLD) is found to be higher in patients with obstructive sleep apnea (OSA), which is characterized by intermittent hypoxia. Activation of hypoxia-inducible factors has been shown in the development and progression of NAFLD, implying a cause and effects relationship between NAFLD and hypoxia. The present study was designed to investigate the interaction of lipotoxicity and hypoxia in the pathogenesis of NAFLD using mice model with high-fat diet (HFD) feeding or hypoxic treatment. Read More

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November 2020

(Rad 8)Caffeine prophylaxis to improve intermittent hypoxaemia in infants born late preterm: a randomised controlled dosage trial (Latte Dosage Trial).

BMJ Open 2020 10 20;10(10):e038271. Epub 2020 Oct 20.

Department of Paediatrics: Child and Youth Health, The University of Auckland, Auckland, New Zealand.

Introduction: Infants born late preterm (34+0 to 36+6 weeks' gestational age) have frequent episodes of intermittent hypoxaemia compared with term infants. Caffeine citrate reduces apnoea and intermittent hypoxaemia and improves long-term neurodevelopmental outcomes in infants born very preterm and may have similar effects in late preterm infants. Clearance of caffeine citrate increases with gestational age and late preterm infants are likely to need a higher dose than very preterm infants. Read More

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October 2020

Unravelling the disease mechanism for TSPYL1 deficiency.

Hum Mol Genet 2020 12;29(20):3431-3442

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven 3000, Belgium.

We describe a lethal combined nervous and reproductive systems disease in three affected siblings of a consanguineous family. The phenotype was characterized by visceroautonomic dysfunction (neonatal bradycardia/apnea, feeding problems, hyperactive startle reflex), severe postnatal progressive neurological abnormalities (including abnormal neonatal cry, hypotonia, epilepsy, polyneuropathy, cerebral gray matter atrophy), visual impairment, testicular dysgenesis in males and sudden death at infant age by brainstem-mediated cardiorespiratory arrest. Whole-exome sequencing revealed a novel homozygous frameshift variant p. Read More

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December 2020

The Pathophysiology of Rett Syndrome With a Focus on Breathing Dysfunctions.

Physiology (Bethesda) 2020 11;35(6):375-390

Center for Integrative Brain Research, Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, Washington.

Rett syndrome (RTT), an X-chromosome-linked neurological disorder, is characterized by serious pathophysiology, including breathing and feeding dysfunctions, and alteration of cardiorespiratory coupling, a consequence of multiple interrelated disturbances in the genetic and homeostatic regulation of central and peripheral neuronal networks, redox state, and control of inflammation. Characteristic breath-holds, obstructive sleep apnea, and aerophagia result in intermittent hypoxia, which, combined with mitochondrial dysfunction, causes oxidative stress-an important driver of the clinical presentation of RTT. Read More

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November 2020

Leptin: Master Regulator of Biological Functions that Affects Breathing.

Compr Physiol 2020 07 8;10(3):1047-1083. Epub 2020 Jul 8.

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Obesity is a global epidemic in developed countries accounting for many of the metabolic and cardiorespiratory morbidities that occur in adults. These morbidities include type 2 diabetes, sleep-disordered breathing (SDB), obstructive sleep apnea, chronic intermittent hypoxia, and hypertension. Leptin, produced by adipocytes, is a master regulator of metabolism and of many other biological functions including central and peripheral circuits that control breathing. Read More

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An Adolescent with a Rare Distal Trisomy 6p and Distal Monosomy 6q Chromosomal Combination.

Case Rep Genet 2020 31;2020:8857628. Epub 2020 Aug 31.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

We report on a 12-year-old female with both a partial duplication and deletion involving chromosome 6. The duplication involves 6p25.3p24. Read More

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Major complications after tongue-tie release: A case report and systematic review.

Int J Pediatr Otorhinolaryngol 2020 Nov 1;138:110356. Epub 2020 Sep 1.

Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, USA. Electronic address:

Introduction: The diagnosis of ankyloglossia, or tongue-tie, and the number of frenotomies performed has increased over 10-fold from 1997 to 2012 in the United States. The sharpest increase has been in neonates. For parents considering frenotomy for their breastfeeding newborn, there is controversy surrounding the evaluation of tongue-tie and the benefit of a frenotomy. Read More

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November 2020

Nonketotic Hyperglycinemia in Tunisia. Report upon a Series of 69 Patients.

Neuropediatrics 2020 10 20;51(5):349-353. Epub 2020 Aug 20.

Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Aim: The aim of the study is to report on epidemiological, clinical, and biochemical characteristics of nonketotic hyperglycinemia (NKH) in Tunisia.

Methods: Patients diagnosed with NKH in Laboratory of Biochemistry at Rabta hospital (Tunis, Tunisia) between 1999 and 2018 were included. Plasma and cerebrospinal fluid (CSF) free amino acids were assessed by ion exchange chromatography. Read More

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October 2020

Utility of polysomnography and video swallow studies in the management of pediatric patients with congenital idiopathic bilateral vocal fold dysfunction.

Int J Pediatr Otorhinolaryngol 2020 Nov 25;138:110273. Epub 2020 Jul 25.

College of Medicine, The Ohio State University, Columbus, OH, USA. Electronic address:

Objectives: Congenital idiopathic bilateral vocal fold dysfunction (BVFD) is an uncommon cause of neonatal stridor and respiratory distress postnatally. Approximately 50% of affected neonates or infants will historically require tracheostomy for this condition. Timing and candidacy for tracheostomy in BVFD patients is often subjective and poorly understood. Read More

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November 2020