179 results match your criteria apex completion

Early efficacy of teprotumumab for the treatment of dysthyroid optic neuropathy: A multicenter study.

Am J Ophthalmol Case Rep 2021 Sep 14;23:101111. Epub 2021 May 14.

Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.

Purpose: To study post-interventional findings in patients with dysthyroid optic neuropathy (DON) treated with teprotumumab.

Observations: In this multicenter observational Case series patients with DON were treated with teprotumumab, an insulin-like growth factor I receptor inhibitor (10 mg/kg for the first infusion then 20 mg/kg for subsequent infusions, every three weeks for a total 8 infusions). This study included patients with acute and chronic thyroid eye disease (TED) with DON who had failed conventional therapies and were not candidates for surgical decompression. Read More

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September 2021

Tooth formation age dataset for early childhood bioarchaeological and medical studies.

Data Brief 2021 Jun 14;36:107141. Epub 2021 May 14.

Department of Archaeology, Max Planck Institute for the Science of Human History, Kahlaische Str. 10, Jena 07745, Germany.

We compiled data from histological sources on the formation ages for human mandibular and maxillary permanent first molars, lateral and central incisors and canines. From this we summarised the data by reporting weighted means for cusp initiation, crown completion and apex completion. This provides a reference for bioarchaeological and medical studies investigating early childhood. Read More

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Integrating Patient Reported Outcome Measures (PROMs) into routine nurse-led primary care for patients with multimorbidity: a feasibility and acceptability study.

Health Qual Life Outcomes 2021 Apr 26;19(1):133. Epub 2021 Apr 26.

Health Services and Policy Research, Exeter Collaboration for Academic Primary Care (APEx), University of Exeter, Magdalen Campus, Smeall Building, Room JS02, Exeter, EX1 2LU, UK.

Background: The use of Patient Reported Outcome Measures (PROMS) in clinical practice has the potential to promote patient-centred care and improve patients' quality of life. Individualized PROMs may be particularly helpful in identifying, prioritizing and monitoring health problems of patients with multimorbidity. We aimed to develop an intervention centred around PROMs feedback as part of Primary Care annual reviews for patients with multimorbidity and evaluate its feasibility and acceptability. Read More

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Advancing the Patient EXperience (APEX) in COPD Registry: Study Design and Strengths.

J Am Board Fam Med 2021 Jan-Feb;34(1):22-31

From the University of Minnesota, Minneapolis, MN (BPY); COPD Foundation, Washington DC (BPY); Observational and Pragmatic Research Institute, Singapore, Singapore (AK, JWHK, DBP); Family Physician Airways Group of Canada, Stouffville, Canada (AK); University of Toronto, Toronto, Canada (AK); DARTNet Institute, Aurora, CO (WDP, CF, GGa, ZKP, ARR); University of Colorado, Denver, CO (WDP); General Practitioners Research Institute, Groningen, Netherlands (JWHK); Optimum Patient Care, Cambridge, UK (LB, VAC, CLE, MK, CELL, CP, BS, DBP); College of Medicine, University of Florida, Gainesville, FL (KLC); University at Buffalo, Buffalo, NY (CF); Boehringer Ingelheim, Ridgefield, CT (GGo, CDM, AS); University of Michigan, Ann Arbor, MI (MKH); Department of Medicine, National Jewish Health, Denver, CO (BM); Thomas Jefferson University, Jenkintown, PA (NS); Abington Jefferson Health, Jenkintown, PA (NS); Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK (DBP).

The Advancing the Patient Experience (APEX) in Chronic Obstructive Pulmonary Disease (COPD) registry (https://www.apexcopd.org/) is the first primary care health system-based COPD registry in the United States. Read More

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Effect of Adaptive, Rotary, and Manual Root Canal Instrumentation in Primary Molars: A Triple-Armed, Randomized Controlled Clinical Trial.

Biology (Basel) 2021 Jan 10;10(1). Epub 2021 Jan 10.

Department of Endodontology, The Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

This clinical trial focused on collating the instrumentation time and quality of root canal obturation in primary molars treated with three instrumentation techniques: adaptive, rotary, and manual. A triple-armed, randomized controlled clinical trial was performed on 75 primary molars requiring pulpectomy treatment, divided into three groups ( = 25 per group). The teeth in Group 1 were instrumented with an adaptive technique (XP-endo Shaper, FKG Dentaire, La Chaux-de-Fonds, Switzerland), Group 2 with pediatric rotary files (Kedo-S; D1 and E1), and Group 3 with a manual technique (hand K-files). Read More

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January 2021

Development of the Advancing the Patient Experience in COPD Registry: A Modified Delphi Study.

Chronic Obstr Pulm Dis 2021 Jan;8(1)

Optimum Patient Care, Cambridge, United Kingdom.

Background: Chronic obstructive pulmonary disease (COPD) is commonly managed by family physicians, but little is known about specifics of management and how this may be improved. The Advancing the Patient Experience in COPD (APEX COPD) registry will be the first U.S. Read More

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January 2021

Apical extrusion of debris with different rotary and reciprocating single-file endodontic instrumentation systems: a systematic review and meta-analysis protocol.

BMJ Open 2020 09 14;10(9):e038502. Epub 2020 Sep 14.

Department of Conservative Sciences, College of Dentistry, Qassim University, Buraydha, Saudi Arabia.

Introduction: Root canal treatment is one of the oldest dental procedures for the treatment of endodontic infection. Extrusion of debris beyond the root apex during root canal instrumentation and subsequent persistence of pain are common complications. A systematic review of the evidence on reciprocating single-file instrumentation systems and their comparison with rotary single-file systems, with apical extrusion of debris as primary outcome, will be done through this study. Read More

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September 2020

Outcomes of a Telephone-Based Questionnaire for Follow-up of Patients Who Have Completed Curative-Intent Treatment for Oral Cancers.

JAMA Otolaryngol Head Neck Surg 2020 12;146(12):1102-1108

Department of Head & Neck Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.

Importance: Follow-up assessment of patients who had treatment for head and neck cancer is critical and an important part of the overall treatment program. During each visit to the hospital, patients are evaluated by a physician and may undergo additional tests. Because it has been observed that the symptoms mentioned by patients often guide the treating clinicians in identifying cancer recurrence, an appropriately constructed questionnaire can help clinicians determine which patients need further testing as a result of a recurrence and which patients can continue to be monitored remotely. Read More

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December 2020

The effect of cervical preflaring on the apical debris extrusion of single or multiple rotary Ni-Ti files.

B Gunes K Y Yeter

Niger J Clin Pract 2020 Apr;23(4):510-514

Department of Endodontics, Faculty of Dentistry, Eskisehir Osmangazi University, Eskişehir, Turkey.

Background: There were no comparing data about the effect of recently developed file system OneCurve on apical debris extrusion.

Aim: The aim of this in vitro study was to compare the influence of the rotary nickel-titanium (Ni-Ti) files on apical debris extrusion after cervical preflaring.

Materials And Methods: Sixty-six lower incisor teeth with a single root canal were used in this study. Read More

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A retrospective matched-cohort study of 3994 lower extremity wounds of multiple etiologies across 644 institutions comparing a bioactive human skin allograft, TheraSkin, plus standard of care, to standard of care alone.

Int Wound J 2020 Feb 15;17(1):55-64. Epub 2019 Nov 15.

Apex Research Services LLC, Apex, North Carolina.

Most chronic wounds are related to comorbidities, for which no clinical trials are performed. This retrospective propensity matched-cohort study examined data from 2 074 000 lower extremity wounds across 644 institutions to determine the effectiveness of TheraSkin plus standard of care (SOC; n = 1997) versus SOC alone (n = 1997). Multivariate modelling comparing outcomes such as healing rates, percent area reductions (PARs), amputations, recidivism, treatment completion, and medical transfers were evaluated. Read More

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February 2020

Incidence of tuberculosis among HIV infected individuals on long term antiretroviral therapy in private healthcare sector in Pune, Western India.

BMC Infect Dis 2019 Aug 13;19(1):714. Epub 2019 Aug 13.

Department of Microbiology, Infectious Disease Clinic, Dhule, Maharashtra, India.

Background: Despite rapid scale up of antiretroviral therapy (ART), Tuberculosis (TB) remains the commonest opportunistic infection and cause of death among HIV infected individuals in resource limited settings like India. Incidence of TB in individuals on ART in private healthcare sector in India is infrequently studied.

Methods: This retrospective cohort study conducted between 1st March 2009 and 1st March 2017 aimed to evaluate rate of incident TB in individuals initiated on ART at 3 private sector ART clinics in Pune, India. Read More

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Improving the Efficacy of the Data Entry Process for Clinical Research With a Natural Language Processing-Driven Medical Information Extraction System: Quantitative Field Research.

JMIR Med Inform 2019 Jul 16;7(3):e13331. Epub 2019 Jul 16.

Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: The growing interest in observational trials using patient data from electronic medical records poses challenges to both efficiency and quality of clinical data collection and management. Even with the help of electronic data capture systems and electronic case report forms (eCRFs), the manual data entry process followed by chart review is still time consuming.

Objective: To facilitate the data entry process, we developed a natural language processing-driven medical information extraction system (NLP-MIES) based on the i2b2 reference standard. Read More

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Pulmonary tuberculosis mimicking radiation pneumonitis in a patient with neck malignancy: A case report.

Medicine (Baltimore) 2019 Jul;98(27):e16398

Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.

Rationale: Primary or reactivation pulmonary tuberculosis (TB) is frequent in immunocompromised patients such as those with human immunodeficiency virus (HIV) infection, chronic renal failure, poorly controlled diabetes, and hematologic malignancy. Immune system of patients with solid-organ cancer can be also altered by malignancy itself or chemotherapy. However, information on the effect of radiation on patient's immunity is scarce. Read More

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Comparative Evaluation of Depth of Penetration of Root Canal Irrigant After Using Manual, Passive Ultrasonic, and Diode Laser-Assisted Irrigant Activation Technique.

J Pharm Bioallied Sci 2019 May;11(Suppl 2):S216-S220

Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Aim: The aim of this study was to compare and evaluate the penetration depth of irrigant after using manual, passive ultrasonic, and diode laser-assisted irrigant activation technique.

Materials And Methods: Ninety extracted single-rooted human mandibular premolars were selected ( = 90). Teeth were decoronated and working length was standardized for 12 mm. Read More

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Three-dimensional image analysis of developing mandibular third molars apices for age estimation: A study using CBCT data enhanced with Mimics & 3-Matics software.

Leg Med (Tokyo) 2019 Jul 27;39:9-14. Epub 2019 May 27.

Department of Paediatric Dentistry & Orthodontics, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

Three-dimensional imaging has improved the method of analysis in many forensic science investigations. The study aimed to derive regression equation for age estimation by investigating the relationship between chronological age and surface area of the developing mandibular 3rd molars apices. Furthermore, other predictor variables: ethnicity (Malay and Chinese), gender and status of the root development completion (open/closed apices) were also investigated in terms of fit to the age estimation model. Read More

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Forme Fruste in Recurring Mid-Ventricular Variant of Takotsubo Cardiomyopathy.

Am J Case Rep 2019 Mar 24;20:385-389. Epub 2019 Mar 24.

Department of Medicine, Saint Vincent Hospital, Worcester, MA, USA.

BACKGROUND Takotsubo cardiomyopathy (TC) is characterized as acute left ventricular dysfunction precipitated by intense emotional or physiological stress. The mid-ventricular variant of TC usually has akinesis, with or without ballooning of the mid-ventricular segment, and a hyperdynamic base and apex. Recurrence of the typical and atypical (reversed and mid-ventricular type) forms has been reported in only a very small number of cases. Read More

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Anthracycline induced inconsistent left ventricular segmental systolic function variation in patients with lymphoma detected by three-dimensional speckle tracking imaging.

Int J Cardiovasc Imaging 2019 May 25;35(5):771-779. Epub 2019 Jan 25.

Department of Echocardiography, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

Chemotherapy contained anthracycline inevitably cause declines of cardiac function. This study evaluated the deterioration of left ventricular segmental systolic function in patients with lymphoma received anthracycline chemotherapy detected by echocardiographic three dimensional speckle tracking imaging (3D-STI). Sixty patients with newly diagnosed diffuse large B-cell lymphoma who received R-CHOP chemotherapy were enrolled. Read More

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Comparisons of Functional Apical Support After Sacral Hysteropexy Versus Sacral Colpopexy: A Cadaveric Study.

Female Pelvic Med Reconstr Surg 2020 11;26(11):664-667

From the Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX.

Objectives: Prolapse procedures with uterine preservation offer an alternative to colpopexy with hysterectomy. Few studies have examined the differences in anatomic or subjective outcomes following sacral hysteropexy versus sacral colpopexy with hysterectomy. This study sought to compare the ability of sacral hysteropexy and sacral colpopexy with hysterectomy to resist downward traction as an estimate of apical support in human cadavers. Read More

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November 2020

Status of Mandibular Third Molar Development as Evidence in Legal Age Threshold Cases.

J Forensic Sci 2019 May 8;64(3):680-697. Epub 2018 Oct 8.

Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AD, U.K.

The completion of the third molar roots has played an important role in ascertaining whether individuals may be at or over a legal threshold of age, often taken as 18 years. This study demonstrates that root apex completion in the third molar is relatively uninformative regarding the threshold of age 18 years in a sample of 1184 males, where mean age-of-attainment of root apex completion for third mandibular molars is about 19.4 years. Read More

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Isolated optic neuritis with a concurrent abnormal trigeminal nucleus on imaging: case report of a rare complication of herpes zoster ophthalmicus.

BMC Neurol 2018 Oct 4;18(1):165. Epub 2018 Oct 4.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.

Background: Herpes zoster ophthalmicus (HZO) is an inflammation related to reactivation of the latent varicella zoster virus (VZV), involving the ophthalmic branch of the trigeminal nerve. Optic neuritis (ON), a rare ocular complication following HZO, has been reported in 1.9% of HZO-affected eyes. Read More

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October 2018

Effects of Different Glide Path Files on Apical Debris Extrusion in Curved Root Canals.

J Endod 2018 Jul 5;44(7):1191-1194. Epub 2018 Jun 5.

Department of Endodontics, Faculty of Dentistry, University of Osmangazi, Eskişehir, Turkey.

Introduction: Creating a glide path before root canal preparation with nickel-titanium rotary files is essential to prevent the file fracture and to maintain the original root canal configuration. Both rotary glide path files and manual K-files are used to create a glide path. The aim of this study was to compare the amount of apically extruded debris after using different glide path files before preparing curved root canals with the WaveOne Gold single-file reciprocating system (Dentsply Maillefer, Ballaigues, Switzerland). Read More

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Assessment of toxicology knowledge in the fourth-year medical students: Three years of data.

World J Emerg Med 2018 ;9(3):191-194

Department of Emergency Medicine University of Colorado School of Medicine, Aurora, Denver, CO 80204, USA.

Background: Pharmacology and toxicology are core content knowledge for physicians. Medical students should demonstrate understanding of general pharmacology and basic treatment of poisoning. The objective of this study was to measure the knowledge of the 4th-year medical students (MS4) on these topics over 3 years. Read More

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January 2018

Effect of episiotomy training with beef tongue and sponge simulators on the self-confidence building of midwifery students.

Nurse Educ Pract 2018 May 9;30:1-6. Epub 2018 Feb 9.

Department of Obstetrics and Gynecology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.

This study assesses the efficacy of simulation-based episiotomy training (SBET) with beef tongue and sponge models in terms of the self confidence of midwifery students while performing episiotomy. Third-year midwifery students from Cumhuriyet University in the fall semesters of 2011 and 2012 were enrolled in the sponge and beef tongue model groups (n = 36 and n = 37, respectively). A checklist was prepared on the required skills for performing episiotomy which can be broken into three main parts, namely preparation, cutting and repairing and completion. Read More

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Orbital Apex Metastasis from Adenoid Cystic Carcinoma: Acute Loss of Vision and Subsequent Recovery with the Radiation.

Cureus 2017 Nov 22;9(11):e1869. Epub 2017 Nov 22.

Department of Radiation Oncology, St. Mary's Medical Center.

Orbital apex metastasis from adenoid cystic carcinoma (ACC) is rare. We present a patient with known metastatic ACC presented with a rapidly declining vision with visual acuity oculus dexter (OD) equal to counting fingers at two feet. On imaging, she was found to have a right orbital apex tumor causing compressive optic neuropathy. Read More

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November 2017

Clinical Findings of a Cantilever Iliac Bone Graft for Secondary Correction of Cleft Lip-Nose Deformities.

J Craniofac Surg 2018 May;29(3):741-746

Department of Oral-Maxillofacial Surgery, University of Tokyo Hospital, Tokyo.

The authors performed a cantilever iliac bone graft for the secondary correction of severe cleft lip-nose deformities after the completion of growth. For the purpose of clarifying effects of the cantilever iliac bone grafts and the adverse events with regard to their time course changes after this procedure, the authors retrospectively surveyed long-term morphologic changes in 65 cleft lip, alveolus, and palate patients in whom cleft lip-nose deformities were treated with a cantilever iliac bone graft (age at surgery: 14-45 years old). All postsurgical documents of facial photographs and radiologic images were reviewed to evaluate the effects and adverse events. Read More

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Intracranial Ewing sarcoma: four pediatric examples.

Childs Nerv Syst 2018 03 28;34(3):441-448. Epub 2017 Dec 28.

Department of Neurosurgery, The University of Colorado School of Medicine, 12605 E. 16th Avenue, Aurora, CO, 80045, USA.

Background: Ewing sarcoma typically arises in bone and is unrelated to intraparenchymal small blue cell embryonal central nervous system (CNS) tumors previously designated primitive neuroectodermal tumors (PNETs). When the CNS is impacted, it is usually secondary to local extension from either the epidural space, skull, or intracranial or spinal metastases. Primary examples within the cranial vault are rare, usually dural-based, and are largely case reports in the literature. Read More

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Oil sands tailings pond sediment toxicity to early life stages of northern pike (Esox lucius).

Sci Total Environ 2018 May 19;624:567-575. Epub 2017 Dec 19.

Environment and Climate Change Canada, 867 Lakeshore Road, Burlington, ON L7S 1A1, Canada.

The Athabasca River in Alberta flows through natural sources of eroding oil sands bitumen and oil sands mining operations that may result in low level contamination of surface waters. Northern pike (Esox lucius) are apex predators and important food and game fish species native to the Athabasca River system. This species has the potential to be exposed to both natural and anthropogenic sources of contamination from oil sands related materials throughout its life cycle. Read More

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Sexual reproduction in plagiogrammacean diatoms: First insights into the early pennates.

PLoS One 2017 16;12(8):e0181413. Epub 2017 Aug 16.

Institut de biologie intégrative et des systèmes, Université Laval, Québec, Québec, Canada.

The genera Plagiogramma and Dimeregramma are members of a small, but evolutionarily important group of diatoms, the "basal" araphids. They are sister to all other pennates, both araphid and raphid taxa. Thus, their phylogenetic position carries the potential for providing insights into the earliest pennates. Read More

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October 2017

Three-dimensional evaluation of molar buccolingual inclinations after orthodontic treatment using edgewise mechanics.

Int Orthod 2017 Sep 10;15(3):529-542. Epub 2017 Aug 10.

Department of Orthodontics and Oral Facial Genetics, Indiana University School of Dentistry, Indianapolis, IN, USA. Electronic address:

Objectives: The purpose of this study was to measure changes in buccolingual inclination and in thickness of maxillary and mandibular buccal and lingual bone of maxillary and mandibular molars following orthodontic treatment using edgewise mechanics.

Materials And Methods: Cone-beam computed tomography scans of 48 patients taken before and after completion of comprehensive orthodontic treatment were collected for this retrospective study. Buccolingual molar inclinations were reported as angular measurements using the long axis of the teeth and inferior border of the nasal floor and inferior border of the mandible, respectively. Read More

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September 2017

Potential to induce dentinal cracks during retreatment procedures of teeth treated with "Russian red": An ex vivo study.

Medicina (Kaunas) 2017 7;53(3):166-172. Epub 2017 Jun 7.

Centre of Bioinformatics and Biostatistics, Department of Human and Medical Genetics, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Objective: The aim of this study was to compare the impact of treatment procedures on roots previously treated with resorcinol-formaldehyde resin and analyze the effectiveness of dye and magnification for the detection of dentin cracks.

Materials And Methods: Distal roots of 80 permanent first mandibular molars with a single canal were sectioned at 3mm and 9mm from the anatomical apex. Two groups were formed according to the method used for root canal penetration: group 1 (K-file and Pro Taper instruments) and group 2 (Ultrasound with Pro Ultra and Pro Taper files). Read More

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September 2019