23,452 results match your criteria aortic wall


Endovascular repair for abdominal aortic aneurysm rupture with neurofibromatosis type 1.

Ann Vasc Surg 2021 Oct 11. Epub 2021 Oct 11.

Second Department of Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan.

Background: Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is a rare congenital disorder with an autosomal dominant inheritance. Severe perioperative complications owing to the congenital fragility of the vascular wall in NF1 patients have been reported. The optimal vascular surgical approach remains controversial. Read More

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October 2021

Stress analysis in AAA does not predict rupture location correctly in patients with intraluminal thrombus.

Ann Vasc Surg 2021 Oct 11. Epub 2021 Oct 11.

Mines Saint-Etienne, Univ Lyon, INSERM, U 1059 Sainbiose, Centre CIS, F - 42023 Saint-Etienne France. Electronic address:

Objectives: A biomechanical approach to the rupture risk of an abdominal aortic aneurysm (AAA) could be a solution to ensure a personalized estimate of this risk. It is still difficult to know in what conditions, the assumptions made by biomechanics, are valid. The objective of this work was to determine the individual biomechanical rupture threshold and to assess the correlation between their rupture sites and the locations of their maximum stress comparing two computed tomography scan (CT) before and at time of rupture. Read More

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October 2021

Investigations into the Potential of using of Open Source CFD to analyze the Differences in Hemodynamic Parameters for Aortic Dissections (Healthy vs. Stanford Type A and B).

Ann Vasc Surg 2021 Oct 11. Epub 2021 Oct 11.

Asahikawa Medical University, Asahikawa, Japan.

Objective: The objective of this study was to develop a method to evaluate the effects of an aortic dissection on hemodynamic parameters by conducting a comparison with that of a healthy (non-dissected) aorta. Opensource software will be implemented, no proprietary software/application will be used to ensure accessorily and repeatability, in all the data analysis and processing. CT images of aortic dissection are used for the model geometry segmentation. Read More

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October 2021

Effect of anastomosis angles on retrograde perfusion and hemodynamics of hybrid treatment for thoracoabdominal aortic aneurysm.

Ann Vasc Surg 2021 Oct 11. Epub 2021 Oct 11.

Institute of Civil Engineering and Architecture, Sichuan University of Science and Technology, Chengdu 610000, China. Electronic address:

Introuction: Hemodynamic effects on the retrograde visceral reconstruction (RVR) for TAAA treatment by anastomotic angle remains unclear. This study aims to qualitatively and quantitatively investigate the effects of different anastomotic angles on hemodynamics and patency.

Methods: Three RVR models with 45-degree, 60-degree and 90-degree anastomotic angles were reconstructed respectively by manipulating apostoperative patient-specific model. Read More

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October 2021

Prevention of vascular calcification by the endogenous chromogranin A-derived mediator that inhibits osteogenic transdifferentiation.

Basic Res Cardiol 2021 Oct 13;116(1):57. Epub 2021 Oct 13.

Institute of Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.

The adrenal glands participate in cardiovascular (CV) physiology and the pathophysiology of CV diseases through their effects on sodium and water metabolism, vascular tone and cardiac function. In the present study, we identified a new adrenal compound controlling mesenchymal cell differentiation that regulates osteoblastic differentiation in the context of vascular calcification. This peptide was named the "calcification blocking factor" (CBF) due to its protective effect against vascular calcification and is released from chromogranin A via enzymatic cleavage by calpain 1 and kallikrein. Read More

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October 2021

Hydrogen sulfide prevents arterial medial calcification in rats with diabetic nephropathy.

BMC Cardiovasc Disord 2021 Oct 13;21(1):495. Epub 2021 Oct 13.

Department of Physiology, Nanjing Medical University, 101 Longmian Road, Nanjing, 211166, Jiangsu, China.

Background: Arterial medial calcification (AMC) is associated with a high incidence of cardiovascular risk in patients with type 2 diabetes and chronic kidney disease. Here, we tested whether hydrogen sulfide (HS) can prevent AMC in rats with diabetic nephropathy (DN).

Methods: DN was induced by a single injection of streptozotocin and high-fat diet (45% kcal as fat) containing 0. Read More

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October 2021

Application of the VORTEC Technique in Creating a Proximal Inflow Conduit in the Circumferentially-Calcified or "Lead-Pipe" Aorta.

Ann Vasc Surg 2021 Oct 10. Epub 2021 Oct 10.

Riverside Community Hospital, 4445 Magnolia Ave., RIVERSIDE, CALIFORNIA, 92501; University of California, Riverside School of Medicine, 900 University Ave., RIVERSIDE, CALIFORNIA, 92521.

A heavily calcified or "lead-pipe" aorta can present many challenges to any surgeon. There is higher risk of vessel wall rupture or disruption, distal embolization, and prolonged ischemia time of visceral organs due to longer clamp times. Hybrid revascularization techniques, which were originally described in visceral revascularization during complex aortic procedures, can be potentially utilized for lower extremity bypasses. Read More

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October 2021

Paucicellular Fibroma of the Ascending Aorta.

Aorta (Stamford) 2021 Oct 12. Epub 2021 Oct 12.

Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York.

Primary tumors of the aorta are extremely rare. To the best of our knowledge, herein, we present the first case in the literature of a paucicellular fibroma originating from the aortic wall. Read More

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October 2021

Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy.

J Pineal Res 2021 Oct 11:e12766. Epub 2021 Oct 11.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

Adopting an integrative approach, by combining studies of cardiovascular function with those at cellular and molecular levels, this study investigated whether maternal treatment with melatonin protects against programmed cardiovascular dysfunction in the offspring using an established rodent model of hypoxic pregnancy. Wistar rats were divided into normoxic (N) or hypoxic (H, 10% O ) pregnancy ± melatonin (M) treatment (5 μg·ml .day ) in the maternal drinking water. Read More

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October 2021

Valve Abnormalities, Risk Factors for Heart Valve Disease and Valve Replacement Surgery in Spondyloarthritis. A Systematic Review of the Literature.

Front Cardiovasc Med 2021 24;8:719523. Epub 2021 Sep 24.

Rheumatology Department, Hospital Dos de Maig, Barcelona, Spain.

Evaluate the evidence on the abnormalities of the aortic root and heart valves, risk and prognostic factors for heart valve disease and valve replacement surgery in spondyloarthritis. A systematic literature review was performed using Medline, EMBASE and Cochrane databases until July 2021. Prevalence, incidence, risk and prognostic factors for heart valve disease; dimension, morphology, and pathological abnormalities of the valves were analyzed. Read More

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September 2021

Successful transcatheter arterial embolization for pseudoaneurysm of the deep femoral artery in a patient with presumptive ACTA2-related vasculopathy.

Radiol Case Rep 2021 Dec 1;16(12):3652-3654. Epub 2021 Oct 1.

Department of Radiology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

ACTA2-related vasculopathy is an autosomal dominant genetic disorder characterized by aortic aneurysms and dissection, and limb artery lesions are rare. We report a case of transcatheter arterial embolization for a pseudoaneurysm of a deep femoral artery in a patient with presumptive ACTA2-related vasculopathy. A 58-year-old woman was presumed to have an mutation based on her history of aortic diseases and family history of mutations. Read More

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December 2021

Towards personalized antithrombotic management with drugs and devices across the cardiovascular spectrum.

Eur Heart J 2021 Oct 8. Epub 2021 Oct 8.

Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.

Intravascular thrombus formation and embolization are among the most frequent events leading to a number of cardiovascular conditions with high morbidity and mortality. The underlying causes are stasis of the circulating blood, genetic and acquired coagulation disorders, and reduced antithrombotic or prothrombotic properties of the vascular wall (Virchow's triad). In the venous system, intravascular thrombi can cause venous thrombosis and pulmonary and even peripheral embolism including ischaemic stroke [through a patent foramen ovale (PFO)]. Read More

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October 2021

The role of in obesity, diabetes and atherosclerosis.

J Med Microbiol 2021 Oct;70(10)

Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Alteration in the composition of the gut microbiota can lead to a number of chronic clinical diseases. is an anaerobic bacteria constituting 3-5% of the gut microbial community in healthy adults. This bacterium is responsible for degenerating mucin in the gut; its scarcity leads to diverse clinical disorders. Read More

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October 2021

Induction of Heme Oxygenase-1 Is Linked to the Severity of Disease in Human Abdominal Aortic Aneurysm.

J Am Heart Assoc 2021 Oct 8:e022747. Epub 2021 Oct 8.

Division of Vascular and Endovascular Surgery Department of Visceral, Thoracic and Vascular Surgery University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.

Background Rupture of abdominal aortic aneurysm (rAAA) is associated with high case fatality rates, and risk of rupture increases with the AAA diameter. Heme oxygenase-1 (gene , protein HO-1) is a stress-induced protein and induction has protective effects in the vessel wall. mice are more susceptible to angiotensin II-induced AAA formation, but the regulation in human nonruptured and ruptured AAA is only poorly understood. Read More

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October 2021

Percutaneous closure of left ventricular pseudoaneurysm using simultaneous transseptal and transapical approach: a case report.

Eur Heart J Case Rep 2021 Sep 20;5(9):ytab311. Epub 2021 Sep 20.

Cedars-Sinai Medical Center, Department of Cardiology, Smidt Heart Institute, Third Floor, Suite A3100, Los Angeles, CA 90048, USA.

Background : Left ventricular (LV) pseudoaneurysm (PSA), also referred to as contained LV wall rupture, is a clinically uncommon but potentially life-threatening condition that can occur after myocardial infarction or cardiac surgery. If the anatomic characteristics of LV PSA are not eligible for the transfemoral approach, percutaneous closure of LV PSA can be technically difficult and appropriate approach selection may contribute to procedural success.

Case Summary : An enlarging LV PSA was discovered in a 65-year-old man with Marfan syndrome and three prior cardiothoracic surgeries. Read More

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September 2021

Acute myocardial infarction and extensive systemic thrombosis in thrombotic thrombocytopenic purpura: A case report and review of literature.

World J Clin Cases 2021 Sep;9(27):8104-8113

Department of Cardiology, Institute of Cardiovascular Diseases, "Prof. Dr. George I.M. Georgescu," Iasi 700503, Romania.

Background: Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterized by the pentad of hemolytic anemia, fever, thrombocytopenia, renal failure, and neurological dysfunction. The formation of microthrombi in the arterioles and capillaries of various organs is one of the main pathophysiological mechanisms. Clinical manifestations of cardiac involvement in TTP patients are variable. Read More

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September 2021

Effects of a Short-Term Left Ventricular Assist Device on Hemodynamics in a Heart Failure Patient-Specific Aorta Model: A CFD Study.

Front Physiol 2021 21;12:733464. Epub 2021 Sep 21.

School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian, China.

Patients with heart failure (HF) or undergoing cardiogenic shock and percutaneous coronary intervention require short-term cardiac support. Short-term cardiac support using a left ventricular assist device (LVAD) alters the pressure and flows of the vasculature by enhancing perfusion and improving the hemodynamic performance for the HF patients. However, due to the position of the inflow and outflow of the LVAD, the local hemodynamics within the aorta is altered with the LVAD support. Read More

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September 2021

Intraventricular Vector Flow Imaging with Blood Speckle Tracking in Adults: Feasibility, Normal Physiology and Mechanisms in Healthy Volunteers.

Ultrasound Med Biol 2021 Oct 4. Epub 2021 Oct 4.

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; Department of Cardiology, St. Olav Hospital/Trondheim University Hospital, Trondheim, Norway.

This study examines the feasibility of blood speckle tracking for vector flow imaging in healthy adults and describes the physiologic flow pattern and vortex formation in relation to the wall motion in the left ventricle. The study included 21 healthy volunteers and quantified and visualized flow patterns with high temporal resolution down to a depth of 10-12 cm without the use of contrast agents. Intraventricular flow seems to originate during the isovolumetric relaxation with a propagation of blood from base to apex. Read More

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October 2021

N-acetylcysteine inhibits aortic stenosis progression in a murine model by blocking shear-induced activation of platelet latent TGF-β1.

Antioxid Redox Signal 2021 Oct 8. Epub 2021 Oct 8.

Oklahoma Medical Research Foundation, 6190, 825 NE 13th Street, Oklahoma City, Oklahoma, United States, 73104-5097;

Objective: Aortic stenosis (AS) is characterized by narrowing of aortic valve opening, resulting in peak blood flow velocity that induces high wall shear stress (WSS) across the valve. Severe AS leads to heart failure and death. There is no treatment available for AS other than valve replacement. Read More

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October 2021

Cardiac Ultrasound for Pediatric Emergencies.

Pediatr Ann 2021 Oct 1;50(10):e424-e431. Epub 2021 Oct 1.

Cardiac point-of-care ultrasound (POCUS) provides real-time views of the heart to answer specific questions in a timely manner. This is a valuable tool for managing pediatric patients, from those with congenital heart disease to those who are critically ill. The main echocardiographic findings of pericardial tamponade consist of a pericardial effusion, diastolic right ventricular collapse, systolic right atrial collapse, and a plethoric inferior vena cava with minimal respiratory variation. Read More

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October 2021

[F] FDG PET/CT can improve the diagnostic accuracy for aortic endograft infection.

Acta Cardiol 2021 Oct 7:1-9. Epub 2021 Oct 7.

Department of Cardiovascular and Thoracic Surgery, Surgical Research Center (GIGA-Cardiovascular Science Unit), University Hospital of Liège, Liège, Belgium.

Purpose: Aortic endograft infection (EI) can result in potentially life-threatening vascular complications. Unfortunately, it is difficult to obtain a correct diagnosis at an early stage in many patients. This report aims at validating the use of [F] FDG PET/CT imaging for suspected endograft infections in a prospectively collected cohort of patients treated with EVAR and TEVAR. Read More

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October 2021

The Aortic Pathologies: How Far We Understand It and Its Implications on Thoracic Aortic Surgery

Braz J Cardiovasc Surg 2021 08 6;36(4):535-549. Epub 2021 Aug 6.

School of Medicine, University of Liverpool, Liverpool, United Kingdom.

Thoracic aortic diseases contribute to a major part of cardiac surgeries. The severity of pathologies varies significantly from emergency and life-threatening to conservatively managed conditions. Life-threatening conditions include type A aortic dissection and rupture. Read More

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Computational analysis of endovascular aortic repair proximal seal zone preservation with endoanchors: A case study in cylindrical neck anatomy.

JVS Vasc Sci 2021 24;2:170-178. Epub 2021 Jun 24.

Section of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Chicago, Chicago, Ill.

Background: Endovascular aortic repair is the common approach for abdominal aortic aneurysms, but endoleaks remain a significant problem with long-term success. Endoanchors have been found to reduce the incidence of type 1A endoleaks and can treat intraoperative type 1a endoleaks. However, little is known about the optimal number and position of endoanchors to achieve the best outcome. Read More

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Intraluminal thrombus: Innocent bystander or factor in abdominal aortic aneurysm pathogenesis?

Authors:
April J Boyd

JVS Vasc Sci 2021 18;2:159-169. Epub 2021 May 18.

Department of Vascular Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.

Background: Abdominal aortic aneurysms (AAAs) represent a complex multifactorial hemodynamic, thrombotic, and inflammatory process that can ultimately result in aortic rupture and death. Despite improved screening and surgical management of AAAs, the mortality rates have remained high after rupture, and little progress has occurred in the development of nonoperative treatments. Intraluminal thrombus (ILT) is present in most AAAs and might be involved in AAA pathogenesis. Read More

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Resolving the biological paradox of aneurysm formation in children with tuberous sclerosis complex.

JVS Vasc Sci 2021 24;2:72-78. Epub 2021 May 24.

Department of Clinical Sciences, Pediatric Cardiac Surgery, Lund University and Skåne University Hospital, Lund, Sweden.

Aortic aneurysms are rare manifestations in children with tuberous sclerosis complex (TSC) with life threating implications. Although an association between TSC, aortic and other aneurysms has been recognized, mechanistic insights explaining the pathophysiology behind aneurysm development and genetic aberrations in TSC have so far been lacking. Here, we summarize existing knowledge on aneurysms in TSC and present a case of a 2-year-old boy with an infrarenal aortic aneurysm, successfully treated with open aortic reconstruction. Read More

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Whole genome sequencing identifies loci specifically associated with thoracic aortic wall defects and abdominal aortic aneurysms in patients with European ancestry.

JVS Vasc Sci 2020 22;1:233-245. Epub 2020 Oct 22.

Icahn School of Medicine at Mount Sinai, New York, NY.

Objective: The objective of this study was to better understand the pathophysiology and underlying genetic mechanisms behind two abdominal aortic aneurysm (AAA) subtypes using computed tomographic imaging in combination with whole genome sequencing.

Methods: Patients with a known AAA and European ancestry were included in this investigation and underwent genetic and image analysis. Patients with AAAs and indications of descending thoracic aortic pathology (aortic dissection, penetrating aortic ulcers, intramural hematoma, atheromas, ulcerative plaque, and intramural ulceration, and intimal flaps/tears) were classified as having thoracic aortic disease, grouped together, and compared with patients with an AAA and a normal descending thoracic aorta. Read More

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October 2020

K-134, a phosphodiesterase 3 inhibitor, reduces vascular inflammation and hypoxia, and prevents rupture of experimental abdominal aortic aneurysms.

JVS Vasc Sci 2020 22;1:219-232. Epub 2020 Oct 22.

Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Objective: Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease, which frequently results in fatal rupture; however, no pharmacologic treatment exists to inhibit AAA growth and prevent rupture. In this study, we investigated whether K-134, a novel phosphodiesterase 3 inhibitor, could limit the progression and rupture of AAA using multiple experimental models.

Methods: A hypoperfusion-induced AAA rat model was developed by inserting of a small catheter and via tight ligation of the infrarenal aorta. Read More

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October 2020

Increased matrix metalloproteinase 9 activity correlates with flow-mediated intraluminal thrombus deposition and wall degeneration in human abdominal aortic aneurysm.

JVS Vasc Sci 2020 22;1:190-199. Epub 2020 Oct 22.

Department of Surgery, University of Manitoba, Manitoba, Canada.

Objective: We have previously demonstrated that human abdominal aortic aneurysm (AAA) rupture occurs in zones of low wall shear stress where flow recirculation and intraluminal thrombus (ILT) deposition are increased. Matrix metalloproteinase-9 (MMP-9) is involved in the pathogenesis of AAA via its lytic effect on collagen and elastin. We hypothesize that flow-mediated ILT deposition promotes increased local inflammatory and MMP-9 activity that leads to AAA wall degeneration. Read More

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October 2020

Molecular and Cellular Dynamics of Aortic Aneurysms Revealed by Single-Cell Transcriptomics.

Arterioscler Thromb Vasc Biol 2021 Oct 7:ATVBAHA121315852. Epub 2021 Oct 7.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX.

The aorta is highly heterogeneous, containing many different types of cells that perform sophisticated functions to maintain aortic homeostasis. Recently, single-cell RNA sequencing studies have provided substantial new insight into the heterogeneity of vascular cell types, the comprehensive molecular features of each cell type, and the phenotypic interrelationship between these cell populations. This new information has significantly improved our understanding of aortic biology and aneurysms at the molecular and cellular level. Read More

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October 2021

Vascular Stiffening Mediated by Rho-Associated Coiled-Coil Containing Kinase Isoforms.

J Am Heart Assoc 2021 Oct 6:e022568. Epub 2021 Oct 6.

Section of Cardiology Department of Medicine University of Chicago IL.

Background The pathogenesis of vascular stiffening and hypertension is marked by non-compliance of vessel wall because of deposition of collagen fibers, loss of elastin fibers, and increased vascular thickening. Rho/Rho-associated coiled-coil containing kinases 1 and 2 (ROCK1 and ROCK2) have been shown to regulate cellular contraction and vascular remodeling. However, the role of ROCK isoforms in mediating pathogenesis of vascular stiffening and hypertension is not known. Read More

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October 2021