Cardiovasc Pathol 2022 May 16:107433. Epub 2022 May 16.
The University of Sydney, Sydney Medical School, Faculty of Medicine and Health, Camperdown, New South Wales, Australia; Royal Prince Alfred Hospital, Department of Cardiology, Camperdown, New South Wales, Australia.
Background: Whilst a combination of genetically mediated vulnerability and haemodynamic insult is suspected to contribute to bicuspid aortic valve (BAV) aortopathy, the underlying pathophysiological mechanisms are poorly understood.
Methods: Utilising RT-qPCR, we compared the expression of 28 potentially relevant long non-coding RNA (lncRNA) in aortic tissue from BAV patients undergoing aortic surgery for aortopathy, to healthy controls. Relative lncRNA expression was measured using ΔΔCT, with fold-change calculated as RQ=2. Read More