80,711 results match your criteria anxiolytic effects

Overview of the Neuroprotective Effects of the MAO-Inhibiting Antidepressant Phenelzine.

Cell Mol Neurobiol 2021 Apr 10. Epub 2021 Apr 10.

Department of Psychiatry (Neurochemical Research Unit), University of Alberta, 12-105B Clinical Sciences Building, Edmonton, AB, T6G 2G3, Canada.

Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic properties. This multifaceted drug has a number of pharmacological and neurochemical effects in addition to inhibition of MAO, and findings on these effects have contributed to a body of evidence indicating that PLZ also has neuroprotective/neurorescue properties. These attributes are reviewed in this paper and include catabolism to the active metabolite β-phenylethylidenehydrazine (PEH) and effects of PLZ and PEH on the GABA-glutamate balance in brain, sequestration of reactive aldehydes, and inhibition of primary amine oxidase. Read More

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Putative anxiolytic-like behavioral effects of acute paracetamol in adult zebrafish.

Behav Brain Res 2021 Apr 7:113293. Epub 2021 Apr 7.

Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA. Electronic address:

Typically triggered by stress, anxiety disorders are most common and widespread mental illnesses. The zebrafish (Danio rerio) is rapidly becoming an important aquatic model species in stress research and central nervous system (CNS) drug screening. Paracetamol is currently the most prescribed medication for pain and fever, and is among the most commonly used drugs globally. Read More

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Disruption of model-based decision making by silencing of serotonin neurons in the dorsal raphe nucleus.

Curr Biol 2021 Mar 31. Epub 2021 Mar 31.

Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo 060-8638, Japan.

Adapting to changing environmental conditions requires a prospective inference of future actions and their consequences, a strategy also known as model-based decision making. In stable environments, extensive experience of actions and their consequences leads to a shift from a model-based to a model-free strategy, whereby behavioral selection is primarily governed by retrospective experiences of positive and negative outcomes. Human and animal studies, where subjects are required to speculate about implicit information and adjust behavioral responses over multiple sessions, point to a role for the central serotonergic system in model-based decision making. Read More

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Diet supplements of banana fruit pulp mitigates repeated noise stress induced behavioral deficits and oxidative stress.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2293-2300

Department of Chemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.

The current study was designed to determine the outcome of banana fruit pulp (BFP) on repeated noise stress exposure (NSE)-induced behavioral deficits and oxidative stress in male mice. BFP (600mg/kg b.w) was administered orally once daily for 2 weeks prior exposure to noise stress. Read More

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September 2020

Eugenol and liposome-based nanocarriers loaded with eugenol protect against anxiolytic disorder via down regulation of neurokinin-1 receptors in mice.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2275-2284

HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi.

Anxiety disorder is a psychiatric disorder characterized by extreme fear or worry. It is highly prevalent worldwide which affects daily life and is also an enormous health burden. Neurokinin 1 receptor (NK1R) is a G protein coupled receptor, expressed in both central and peripheral nervous system, involved in affective behaviors. Read More

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September 2020

Ameliorative effects of the aqueous extract of Khaya anthotheca (Welw.) C.DC (Meliaceae) in vanadium induced anxiety, memory loss and pathologies in the brain and ovary of mice.

J Ethnopharmacol 2021 Apr 5:114099. Epub 2021 Apr 5.

Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Ibadan, Ibadan 20001, Nigeria. Electronic address:

Ethnopharmacological Relevance: Ethnobotanical enquiries have revealed that Khaya anthotheca (Welw.) C.DC (Meliaceae) has anxiolytic properties and is used to alleviate vaginal dryness in postmenopausal women in Cameroon. Read More

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Interactions between the nitrergic and the endocannabinoid system in rats exposed to the elevated T maze.

Acta Neuropsychiatr 2021 Apr 5:1-14. Epub 2021 Apr 5.

Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Objective: the aim of this study was to test the hypothesis that synthesis of nitric oxide (NO) and activation of CB1 receptors have opposite effects in a behavioural animal model of panic and anxiety.

Methods: to test the hypothesis male Wistar rats were exposed to the elevated T maze (ETM) model under the following treatments: L-Arginine (L-Arg) was administered before treatment withWIN55,212-2, a CB1 receptor agonist ; AM251, a CB1 antagonist, was administered before treatment with L-Arg. All treatments were by intraperitoneal route. Read More

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Evaluating cannabidiol (CBD) expectancy effects on acute stress and anxiety in healthy adults: a randomized crossover study.

Psychopharmacology (Berl) 2021 Apr 4. Epub 2021 Apr 4.

Department of Psychology and Neuroscience, Dalhousie University, Life Sciences Centre, 1355 Oxford Street, PO Box 15000, Halifax, Nova Scotia, B3H 4R2, Canada.

Rationale: Cannabidiol (CBD) has been reported to attenuate stress and anxiety, but little is known about the extent to which such effects result from pharmacological versus expectancy factors.

Objectives: We evaluated whether CBD expectancy alone could influence stress, anxiety, and mood, and the extent to which beliefs regarding CBD effects predicted these responses.

Methods: In this randomized crossover study, 43 health adults (23 women) attended two experimental laboratory sessions, where they self-administered CBD-free hempseed oil sublingually. Read More

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Reply to Abdulzahra.

J Perianesth Nurs 2021 04;36(2):107

Department of Anesthesiology, Mahabad Imam Khomeini Hospital, Urmia University of Medical Science, Mahabad, Iran.

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The Effect of Vasopressin Antagonists on Maternal-Separation-Induced Ultrasonic Vocalization and Stress-Hormone Level Increase during the Early Postnatal Period.

Brain Sci 2021 Mar 30;11(4). Epub 2021 Mar 30.

Institute of Experimental Medicine, 1085 Budapest, Hungary.

In adults, vasopressin exerts an anxiogenic effect, but less is known about the perinatal period. As a sign of distress, rat pups emit ultrasonic vocalizations when they are separated from their mothers, known as maternal separation-induced ultrasonic vocalization (MS-USV). Previously, reduced MS-USV was reported in 7-8-day-old genetically vasopressin-deficient Brattleboro rats. Read More

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Anxiolytic and Antidepressant-Like Effects of Aqueous Extract in the Scopolamine Rat Model.

Plants (Basel) 2021 Mar 29;10(4). Epub 2021 Mar 29.

Department of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I, No. 11, 700506 Iasi, Romania.

is a plant widely used in traditional medicine in Morocco for the treatment of varied health challenges. However, to the best of our knowledge, there is no scientific study justifying the traditional use of extract as an anxiolytic and antidepressant agent. Moreover, data regarding the polyphenolic fraction is limited. Read More

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Quali-Quantitative Characterization of Volatile and Non-Volatile Compounds in (Aubl.) Marchand Resin by GC-MS Validated Method, GC-FID and HPLC-HRMS.

Molecules 2021 Mar 7;26(5). Epub 2021 Mar 7.

Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Pietro Giuria 5, 10125 Torino, Italy.

(Aubl.) Marchand (PH) trees are endemic to the tropical region of South America, mostly Brazil. Antibacterial, antinociceptive, anti-inflammatory, anxiolytic, antidepressant and anti-hyperlipidemic/anti-hypercholesterolemic effects were reported for its resinous exudate resin (PHR). Read More

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Pharmacological characterisation of anticonvulsant effects elicited by erythrartine.

J Pharm Pharmacol 2021 Mar;73(1):93-97

Department of Biotechnology, University of Ribeirão Preto, Ribeirão Preto, SP, Brazil.

Objectives: The erythrinan alkaloids erythravine and 11α-hydroxy-erythravine from Erythrina verna (Vell.) have been extensively investigated for their anxiolytic and anticonvulsant effects. Both are structurally similar to the erythrartine that also exhibit anxiolytic effects, but there is no report on its anticonvulsant potential. Read More

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Testosterone works through androgen receptors to modulate neuronal response to anxiogenic stimuli.

Neurosci Lett 2021 Mar 27;753:135852. Epub 2021 Mar 27.

Psychology Department, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, United States; Neuroscience Program, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, United States.

Testosterone (T) exerts anxiolytic effects through functional androgen receptors (ARs) in rodents. T treatment of castrated mice reduces anxiety-like behavior in wild-type (WT) males, but not males with a spontaneous mutation that renders AR dysfunctional (testicular feminization mutation, Tfm). Using Cre-LoxP technology we created males carrying induced dysfunctional AR allele (induced TFM; iTfm) to determine the brain regions responsible for T-induced anxiolysis. Read More

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The association between generalized anxiety disorder and resting-state prefrontal cortex oxygenation is modified by self-reported physical activity: results from The Irish Longitudinal Study on Ageing.

J Gerontol A Biol Sci Med Sci 2021 Mar 29. Epub 2021 Mar 29.

The Irish Longitudinal Study on Ageing, Trinity College Dublin, Ireland.

Individuals with anxiety disorders exhibit lower intrinsic functional connectivity between prefrontal cortical areas and subcortical regions. The prefrontal cortex (PFC) is sensitive to the acute and chronic effects of physical activity (PA), while the anxiolytic effects of PA are well known. The current study examined the association of generalised anxiety disorder (GAD), and its interaction with PA, with resting-state left PFC oxygenation. Read More

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Involvement of GABAergic and nitrergic systems in the anxiolytic and hypnotic effects of : its interaction with anxiolytic-hypnotics.

Drug Metab Pers Ther 2020 Dec 29. Epub 2020 Dec 29.

Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Lagos State, Nigeria.

Objectives: Concurrent use of herbs with drugs have become a major healthcare problem. Herb-drug interactions could lead to therapeutic failure or toxicity. Hence, this study seeks to evaluate the impact of combining rhizome (CL) with selected anxiolytic and hypnotic drugs. Read More

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December 2020

Prospects for the Use of Cannabinoids in Psychiatric Disorders.

Front Psychiatry 2021 12;12:620073. Epub 2021 Mar 12.

Laboratory of Palliative Medicine, Department of Social Medicine and Public Health, Medical University of Warsaw, Warsaw, Poland.

Increasing evidence suggests an essential role of the endocannabinoid system in modulating cognitive abilities, mood, stress, and sleep. The psychoactive effects of cannabis are described as euphoric, calming, anxiolytic, and sleep-inducing and positively affect the mood, but can also adversely affect therapy. The responses to cannabinoid medications depend on the patient's endocannabinoid system activity, the proportion of phytocannabinoids, the terpenoid composition, and the dose used. Read More

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A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and anxiogenic-like effects of a high-fat/high-fructose diet in mice.

J Pharm Pharmacol 2021 Mar;73(5):673-681

Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

Objective: While chronic feeding with high-fat or high-sugar diets is known related to obesity and type 2 diabetes, later data have indicated that it is also related to depression and anxiety appearance. In this regard, multi-target drugs raise considerable interest as promising therapeutic solutions to complex diseases. Considering the pharmacological effects of the imidazopyridine-derivative moiety imidazo[1,2-a]pyridine and the organoselenium molecules, the combination of both could be a feasible strategy to develop efficient drugs to handle obesity and related comorbidities, for example dyslipidemia and mood disorders. Read More

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Recreational Nitrous Oxide Abuse: Prevalence, Neurotoxicity, and Treatment.

Neurotox Res 2021 Mar 26. Epub 2021 Mar 26.

Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 JingWu Road, 250021, Jinan, Shandong, People's Republic of China.

Nitrous oxide (NO), also known as "laughing gas," is a colorless, nonirritating gas. Clinically, it is widely used as an inhaled anesthetic, analgesic, and anxiolytic. In recent years, recreational abuse of NO has become increasingly common, especially among young adults and adolescents, but many of them lack awareness of the possible side effects associated with this drug. Read More

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[Observation of effective dosage of remimazolam tosilate used for moderate-to-deep sedation in fiberoptic bronchoscopy].

Zhonghua Yi Xue Za Zhi 2021 Mar;101(11):813-816

Department of Anesthesiology, Affiliated Hainan Cancer Hospital of Hainan Medical College, Hai Kou 570100, China.

To estimate the safety and efficacy of remimazolam tosilate used for moderate-to-deep sedation in fiberoptic bronchoscopy with its 50% effective dosage (ED50) and 95% effective dosage (ED95) calculated. A total of 50 patients aged from 18 to 65 years and classified as Class Ⅰ or Ⅱ according to the American Society of Anesthesiologists (ASA) Classification who underwent fiberoptic bronchoscopy in Hainan Cancer Hospital from April to August of 2020 were included in this study. For each patient, bronchoscopy was only started when the eyelash reflex disappeared and MOAA/S score was<1 after a trial dose of remimazolam tosilate combined with 0. Read More

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Transcutaneous Auricular Neurostimulation (tAN): A Novel Adjuvant Treatment in Neonatal Opioid Withdrawal Syndrome.

Front Hum Neurosci 2021 8;15:648556. Epub 2021 Mar 8.

Department of Psychiatry & Behavioral Sciences, Brain Stimulation Division, Medical University of South Carolina, Charleston, SC, United States.

Maternal opioid use during pregnancy is a growing national problem and can lead to newborns developing neonatal opioid withdrawal syndrome (NOWS) soon after birth. Recent data demonstrates that nearly every 15 min a baby is born in the United States suffering from NOWS. The primary treatment for NOWS is opioid replacement therapy, commonly oral morphine, which has neurotoxic effects on the developing brain. Read More

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A National Survey of Self-Prescription of Beta-Blockers and Their Relation to Undiscovered Anxiety Among Medical and Pharmacological Students in Saudi Arabia.

Neuropsychiatr Dis Treat 2021 17;17:797-807. Epub 2021 Mar 17.

Professor of Medicine, Department of Medicine, School of Medicine, Taif University, Taif, 21944, Saudi Arabia.

Background: The development of beta-blocker (BB) medications is considered one of the most critical milestones of drug research. Several trials showed possible anti-anxiety effects of BBs. Our primary goal is to investigate the prevalence of anxiety disorder and the use of BBs as anxiolytic without medical prescription among medical and pharmacological students in Saudi Arabia. Read More

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Water-Soluble Carbon Dots in Cigarette Mainstream Smoke: Their Properties and the Behavioural, Neuroendocrinological, and Neurotransmitter Changes They Induce in Mice.

Int J Nanomedicine 2021 16;16:2203-2217. Epub 2021 Mar 16.

Beijing Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.

Background: It is well known that smoking is harmful to health; however, it can also ameliorate anxiety. To date, it is unclear whether any nanoparticles found in cigarette mainstream smoke (CS) contribute to this effect.

Aim: The aim of this study was to assess the particle composition of CS to identify novel anti-anxiety components. Read More

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1-Boc-Piperidine-4-Carboxaldehyde Prevents Binge-Eating Behaviour and Anxiety in Rats.

Pharmacology 2021 Mar 23:1-11. Epub 2021 Mar 23.

Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Ciudad Universitaria, Aguascalientes, Mexico,

Background: Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers and insect venoms. Piperidines are also produced in the human body, and their actions seem to be related to wakefulness/sleep and other cognitive phenomena. Piperidines have been minimally characterized for therapeutic applications. Read More

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Higher prescription of antidepressants and/or anxiolytics among chronic obstructive pulmonary disease patients.

Ther Adv Respir Dis 2021 Jan-Dec;15:1753466620961696

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, 3508 TC, The Netherlands.

Background: Chronic obstructive pulmonary disease (COPD) is often accompanied by psychiatric problems, such as depression and anxiety, affecting both treatment outcomes and mortality. Evidence for the number of COPD patients using medication for these disorders is sparse. In this study, chronic antidepressant (ATD) and anxiolytic (ANX) drug use - to identify depression and anxiety - among COPD patients was compared with subjects with or without other chronic diseases. Read More

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Synthesis and characterization of molecularly imprinted polymers for the selective extraction of oxazepam from complex environmental and biological samples.

Anal Bioanal Chem 2021 Mar 22. Epub 2021 Mar 22.

Laboratory of Analytical, Bioanalytical Sciences and Miniaturization, Chemistry, Biology and Innovation (CBI) UMR 8231, ESPCI Paris PSL, CNRS, PSL University, 75005, Paris, France.

Oxazepam, one of the most frequently prescribed anxiolytic drugs, is not completely removed from wastewater with conventional treatment processes. It can thus be found at trace levels in environmental water, with human urine constituting the major source of contamination. This study focused on the development and characterization of molecularly imprinted polymers (MIPs) for the selective solid-phase extraction of oxazepam at trace levels from environmental water and human urine samples. Read More

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Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects of in Rats.

Dose Response 2021 Jan-Mar;19(1):1559325821998486. Epub 2021 Mar 4.

Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.

The current study was planned to investigate the pharmacological basis of extract (SV.CR) pertaining to anxiolytic, antidepressant and memory-enhancing effects in rats. The SV. Read More

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Inhibitory Effects of Selenium on Arsenic-Induced Anxiety-/Depression-Like Behavior and Memory Impairment.

Biol Trace Elem Res 2021 Mar 20. Epub 2021 Mar 20.

Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan.

Elevated arsenic (As) contamination in drinking water was detected in many areas of Pakistan. The intoxication of As causes various neurological diseases in humans, which can be inhibited by the administration of potent antioxidants. Trace elements are also found in drinking water such as selenium (Se), which possess antioxidant potential. Read More

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The therapeutic potential of GLP-1 analogues for stress-related eating and role of GLP-1 in stress, emotion and mood: a review.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Mar 16;110:110303. Epub 2021 Mar 16.

Department of Medicine (St Vincent's), University of Melbourne, Victoria, Australia; Dept. of Endocrinology, Austin Health, Victoria, Australia. Electronic address:

Stress and low mood are powerful triggers for compulsive overeating, a maladaptive form of eating leading to negative physical and mental health consequences. Stress-vulnerable individuals, such as people with obesity, are particularly prone to overconsumption of high energy foods and may use it as a coping mechanism for general life stressors. Recent advances in the treatment of obesity and related co-morbidities have focused on the therapeutic potential of anorexigenic gut hormones, such as glucagon-like peptide 1 (GLP-1), which acts both peripherally and centrally to reduce energy intake. Read More

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